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World Journal of Emergency Medicine 2022年第2期13卷 130-134页

作者： Yan-qing liu Xiao-xia Lu Kai-xun Hu Xiao-bo Peng Yun Jiang li-mei han Zhi-qiang Ma Ming-fei Peng Kun Wan Xi-gang Zhang Ze-wu Qiu Poisoning Treatment Department Department of Hematologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Academy of Military Medical Sciences Academy of Military SciencesBeijing 100850China

Colchicine is a neutral lipophilic tricyclic alkaloid toxic to human cells containing tubulin,[1-2]and primarily stops the proliferation of active cells in the mitotic metaphase,such as intestinal mucosal cells and hematopoietic *** is widely used in treating gout and familial Mediterranean fever,while it is also used in establishing animal and plant experimental model.[3]In the recent study,treatment of patients affected by coronavirus disease 2019(COVID-19)with colchicine may prove a viable path.[4]The course of colchicine poisoning can be divided into three stages,[5]and most of the patients died in the second stage(2-7 d,the multiple organ injury stage).The cause of death was heart failure[6]and bone marrow hematopoietic failure in the terminal phase.[7]Hematopoiesis is a classic sign of colchicine *** cases of colchicine poisoning have been comprehensively reported,and the target organs included heart,digestive tract,muscle,lung,kidney,hematopoietic system,etc.[8-11]This study aimed to investigate the injury of bone marrow hematopoietic system after colchicine poisoning and evaluate the therapeutic effect of bone marrow hematopoietic stimulation drugs.

关键词： establishing neutral alkaloid

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei Zhang Wenhao li Yangfei Chen Yang Jiang Xiaofei Guo han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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中学政治课程目标建设的回顾与展望

四川师范大学学报（社会科学版） 2021年第6期48卷 27-34页

作者：李寒梅山东师范大学马克思主义学院

中学政治课程目标的变革经历了新中国成立17年的改造和建立、“文化大革命”10年遭受破坏、改革开放以来调整与发展的三个发展阶段,表现出主导意识形态教育的显著性与一贯性、逐渐关照个体的成长需要、实践性指向逐渐增强等特点。中学... 详细信息

中学政治课程目标的变革经历了新中国成立17年的改造和建立、“文化大革命”10年遭受破坏、改革开放以来调整与发展的三个发展阶段,表现出主导意识形态教育的显著性与一贯性、逐渐关照个体的成长需要、实践性指向逐渐增强等特点。中学政治课程目标的未来发展需要在一体化建设背景下,继续坚持主导意识形态教育、体现国家课程的育人功能,重视学生的个体发展、遵循教育的内在要求,借鉴目标理论的科学性、构建一体化框架下的目标体系。

关键词：中学政治课程课程目标回顾与展望

Emodin ameliorates intestinal barrier dysfunction in severe acute pancreatitis:A potential pharmacologic mechanism and therapeutic advantages

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Emodin ameliorates intestinal barrier dysfunction in severe ...

中华医学会急诊医学分会第17次全国急诊医学学术年会

作者： Shilin Du Xin li li-mei han Jian-xin Wang Chaoyang Tong 复旦大学附属中山医院

Aim Chinese rhubarb is a traditional drug used to treat pancreatitis and has been demonstrated to attenuate severe acute pancreatitis in certain animal *** is proved to be a main active constituent of ***,the effects of emodin on pancreatitisinduced intestinal barrier dysfunction are yet to be fully *** study aimed to

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改革开放以来中学政治课程研究的现状与反思

四川师范大学学报（社会科学版） 2008年第6期35卷 88-94页

作者：李寒梅北京师范大学哲学与社会学学院北京100875

改革开放以来,中学政治课程研究不断深入。文章通过对我国中学政治课程研究成果的回顾,总结了课程研究的发展历程、课程研究的问题与观点,并认为中学政治课程研究中存在着局限于教学论视域、忽视课程基础理论的反思性研究、研究定位的... 详细信息

改革开放以来,中学政治课程研究不断深入。文章通过对我国中学政治课程研究成果的回顾,总结了课程研究的发展历程、课程研究的问题与观点,并认为中学政治课程研究中存在着局限于教学论视域、忽视课程基础理论的反思性研究、研究定位的政策化模式、缺乏对课程发展历史的理性探讨等问题,提出了以基础理论研究为指导增强课程的综合研究能力、在社会转型背景下总结课程发展的特点与规律、在比较研究中探讨本土化的课程发展模式等研究视点。

关键词：改革开放中学政治课程研究历程研究观点

Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123

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Acta Pharmacologica Sinica 2006年第6期27卷 747-753页

作者： li-mei han Jie GUO li-jun ZhanG Qing-song WANG Xiao-ling FANG~2 Department of Pharmaceutics.School of Pharmacy,Fudan University,Shanghai 200032,China DepartmentofPharmaceutics SchoolofPharmacyFudanUniversityShanghai200032China

Aim:To investigate the preparation,in vitro release,in vivo pharmacokineticsand tissue distribution of a novel polymeric micellar formulation of paclitaxel(PTX)with Pluronic ***:The polymeric micelles of paclitaxel with PluronicP123 were prepared by a solid dispersion *** characteristics of micellesincluding particle size distribution,morphology and in vitro release of PTX frommicelles were carried ***-loaded micellar solutions were administered throughthe tail vein to healthy Sprague-Dawley rats and Kunming strain mice to assessthe pharmacokinetics and tissue distribution of PTX,***,thecommercially available intravenous formulation of PTX,was also administered ***:By using a dynamic light scattering sizer and a transmissionelectron microscopy,it was shown that the PTX-loaded micelles had a mean sizeof approximately 25 nm with narrow size distribution and a spherical *** continuously released from Pluronic P 123 micelles in release medium contain-ing 1 mol/L sodium salicylate for 24 h at 37℃.In the pharmacokinetic assessment,t1/2βand AUC of micelle formulation were 2.3 and 2.9-fold higher than that of *** the PTX-loaded micelles increased the uptake of PTX in the plasma,ovary and uterus,lung,and kidney,but decreased uptake in the liver and brain inthe biodistribution ***:Polymeric micelles using Pluronic P123can effectively solubilize PTX,prolong blood circulation time and modify thebiodistribution of PTX.

关键词： paclitaxel micelle Pluronic P123 pharmacokinetics biodistribution

外国文学课程中性别语言差异及社会性别意识改观研究——以后现代女性主义为视角

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黑龙江高教研究 2016年第1期34卷 149-152页

作者：段成李美涵成都理工大学外国语学院四川成都610059

文学是历史和生活的缩影,与意识形态和权利建构息息相关,根据后现代女性主义理论可知要改变性别歧视现状需要利用后现代思想进行解构和主体再建构。文章在此视域下尝试研究该时代文学作品中的性别语言差异特点并深入探求其背后的原因。... 详细信息

文学是历史和生活的缩影,与意识形态和权利建构息息相关,根据后现代女性主义理论可知要改变性别歧视现状需要利用后现代思想进行解构和主体再建构。文章在此视域下尝试研究该时代文学作品中的性别语言差异特点并深入探求其背后的原因。将后现代女性主义的价值观取其精华去其糟粕,融入到教学中能够顺应两性和谐的社会发展趋势,帮助学生树立正确的两性平等观念,这一举措具有理论和现实的双重价值。

关键词：后现代女性主义外国文学性别语言差异主体建构社会性别意识

MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang Mingjie Wang Zijie li Ken Chen Jiatian mei Shu Zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

基于资金现值约束的双目标项目组合选择模型研究

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运筹与管理 2016年第6期25卷 139-143页

作者：李星梅魏涵静华北电力大学经济与管理学院北京102206 北京北重汽轮电机有限责任公司北京100040

近年来,项目组合选择问题已引起人们越来越多的关注,如何从众多项目中选择合适项目以满足企业长期发展战略已成为企业面临的重要问题。因此,本文在考虑项目可打断的基础上构建了一个净现值和效用并存的双目标项目组合选择模型,同时把模... 详细信息

近年来,项目组合选择问题已引起人们越来越多的关注,如何从众多项目中选择合适项目以满足企业长期发展战略已成为企业面临的重要问题。因此,本文在考虑项目可打断的基础上构建了一个净现值和效用并存的双目标项目组合选择模型,同时把模型中的资金约束转变为资金现值约束,并通过理论给予证明,使模型得以简化。最后,通过实际算例进行分析。结果表明:基于双目标的项目组合选择模型比单一目标更加符合企业长期发展战略,该模型也为投资决策者进行项目组合选择提供了较完善的理论依据。

关键词：项目组合选择净现值效用资金现值

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area