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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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从需求分析到行业评分标准:LSP测试探讨

重庆交通大学学报（社会科学版） 2011年第1期11卷 141-144页

作者：李梦莉宁波大学外语学院浙江宁波315211

LSP(专门用途语言)测试是语言测试的一个分支,属于交际语言测试和标准参照测试。LSP测试的特点是需求分析、专业针对性、真实性、行业评分标准。以澳大利亚日语导游测试的设计过程为例,说明LSP测试的设计过程和特点。

关键词：专门用途语言测试特点设计过程

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外语教师对课堂互动的认知误区分析

云南农业大学学报（社会科学版） 2011年第1期5卷 63-66页

作者：李梦莉宁波大学外语学院浙江宁波315211

讨论了外语课堂互动的理论依据和课堂互动对二语习得的影响,分析了外语教师对课堂互动的认知误区,这些误区包括:把课堂互动等同于行为互动;重交际教学,忽视语法教学;过分强调输出,忽略影响输出效果的因素;对互动任务设置的复杂性缺乏认... 详细信息

讨论了外语课堂互动的理论依据和课堂互动对二语习得的影响,分析了外语教师对课堂互动的认知误区,这些误区包括:把课堂互动等同于行为互动;重交际教学,忽视语法教学;过分强调输出,忽略影响输出效果的因素;对互动任务设置的复杂性缺乏认识。在此基础上提出了外语课堂有效互动的评判标准,即是否促进了学习者的外语学习。

关键词：课堂互动认知误区评判标准

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多媒体EFL课堂互动缺失的深层归因

安徽工业大学学报（社会科学版） 2009年第2期26卷 112-114页

作者：李梦莉宁波大学外语学院浙江宁波315211

为改进多媒体EFL课堂教学,增强课堂互动的有效性,教师应树立正确的语言观、语言教学观,对学习者和学习有科学的认识,发挥课堂教学在学生学习中的重要作用。

关键词：多媒体 EFL课堂互动语言观教学观

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新托福网络口试的真实性研究

重庆邮电大学学报（社会科学版） 2010年第4期22卷 132-136页

作者：李梦莉宁波大学外语学院浙江宁波315211

新托福网络口试是基于网络化人机对话平台的口语测试,作为一种半直接口语测试,其真实性广受争议。首先探讨了新托福网络口试的任务特征和测试效度、信度,然后分析了新托福网络口试的真实性,包括文本真实性、测试任务和情景的真实性、受... 详细信息

新托福网络口试是基于网络化人机对话平台的口语测试,作为一种半直接口语测试,其真实性广受争议。首先探讨了新托福网络口试的任务特征和测试效度、信度,然后分析了新托福网络口试的真实性,包括文本真实性、测试任务和情景的真实性、受试者与测试任务互动的真实性、评价标准及评分过程的真实性,从而得出结论,口试的真实性取决于其构念定义以及考生和考试任务之间的交互作用。从这个意义上说,新托福网络口试具有较高真实性。

关键词：新托福网络口试半直接口试有效性真实性

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大学英语教师自主性的影响因素和实现途径

高教论坛 2009年第9期 92-95,107页

作者：李梦莉宁波大学外语学院浙江宁波315211

本文首先分析了影响大学英语教师自主的内因和外因。内因包括:知识结构不合理和科研意识缺乏;教师效能感相对较低。外因包括:大学英语教学的特殊性;缺乏科研条件和学术带头人。并提出了实现大学英语教师自主的途径,包括:构建合理的知识... 详细信息

本文首先分析了影响大学英语教师自主的内因和外因。内因包括:知识结构不合理和科研意识缺乏;教师效能感相对较低。外因包括:大学英语教学的特殊性;缺乏科研条件和学术带头人。并提出了实现大学英语教师自主的途径,包括:构建合理的知识结构,处理好与外部制约的关系,成为终身学习者。大学英语教师实现自主是大学英语教学成功的关键,也是实现学习者自主的前提。

关键词：大学英语教师自主内因外因途径

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语境化策略与外语口语教学

湖北教育学院学报 2007年第10期24卷 132-134页

作者：李梦莉宁波大学外语学院浙江宁波315211

本文从四个方面分析了语境化策略在外语口语教学中的应用:语境化的语言输入和输出;语境化思维模式的培养;语境化的课堂教学模式;应用现代化技术创设外语口语教学语境,同时还指出了外语口语教学中使用语境化策略应当注意的问题,总结了语... 详细信息

本文从四个方面分析了语境化策略在外语口语教学中的应用:语境化的语言输入和输出;语境化思维模式的培养;语境化的课堂教学模式;应用现代化技术创设外语口语教学语境,同时还指出了外语口语教学中使用语境化策略应当注意的问题,总结了语境化策略在外语口语教学中的作用。

关键词：外语口语教学语境化策略应用

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach