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Cuproptosis mediates copper-induced testicular spermatogenic cell death

Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-jun Yu jun-jun li yao Xiao Guang-Sen li Fang Yang liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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TOPK Activation Exerts Protective Effects on Cisplatin-induced Acute Kidney Injury

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Current Medical Science 2022年第4期42卷 742-753页

作者： Hui ZHANG Qing-qing DONG Hua-pan SHU Yu-chi TU Qian-qian liAO li-jun yao Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:T-LAK-cell-originated protein kinase(TOPK),a PSD95-Disc large-ZO1(PDZ)binding kinase(PBK),is a novel member of the mitogen-activated protein kinase(MAPK)*** have shown that TOPK plays a critical role in the function of tumor cells,including apoptosis and ***,little is known on the effect of TOPK in cisplatin-induced acute kidney injury(CP-AKI).This study aimed to investigate the role and mechanism of TOPK in ***:Cisplatin was administered to C57BL/6 mice and cultured kidney tubular epithelial cells(TECs)to establish the CP-AKI murine or cellular *** were then stimulated with the specific inhibitor of TOPK OTS514 or transfected with the recombinant-activated plasmid TOPK-T9E to inhibit or activate *** TECs were treated with AKT inhibitorⅧfollowing stimulation with OTS514 or *** blotting and flow cytometry were used to evaluate the cell cycle and apoptosis of ***:The analysis revealed that the TOPK activity was significantly suppressed by cisplatin,both in vivo and in ***,the pharmacological inhibition of TOPK by OTS514,a specific inhibitor of TOPK,exacerbated the cisplatin-induced cell cycle arrest in the G2/M phase and apoptosis of cultured ***,the TOPK activation via the TOPK-T9E plasmid transfection could partially reverse the cell cycle arrest at the G2/M phase and apoptosis of cisplatin-treated *** addition,AKT/protein kinase B(PKB),as a TOPK target protein,was inhibited by cisplatin in cultured *** pharmaceutical inhibition of AKT further aggravated the apoptosis of TECs induced by cisplatin or TOPK *** systematically mediated the apoptosis via the AKT pathway in the CP-AKI cell ***:These results indicate that TOPK activation protects against CP-AKI by ameliorating the G2/M cell cycle arrest and cell apoptosis.

关键词： acute kidney injury cisplatin cell cycle apoptosis T-LAK-cell-originated protein kinase/PSD95-Disc large-ZO1 binding kinase

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Effects of soil metal(loid)s pollution on microbial activities and environmental risks in an abandoned chemical smelting site

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Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： Hao li jun yao Jianli liu Ning Min Geoffrey Sunahara Dongyang Men Robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandoned chemical smelting sites containing toxic substances can seriously threaten and pose a risk to the surrounding ecological *** samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microbial *** potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging between 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and probably not arsenic)contributed to the highest environmental risk.A modified combined pollution risk index(MCR)combining total content and mobile proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental *** the near-surface samples(S-0 and D-1 layers),the MCR considered that As,Cd,Pb,Sb,and Zn achieved high and alarming degrees of contamination,whereas Fe,Mn,and Ti were negligible or low to moderate pollution *** microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microbial metabolic activity *** analysis elucidated the relationship between metal(loid)s exchangeable fraction or content and microbial activity characteristics(plic activity in the D-1 layer was low presumably due to heavy metal *** activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microbial activities in abandoned chemical smelting sites.

关键词： Abandoned chemical smelting sites Microbial activities Modified combined pollution risk Microcalorimetry Enzymatic activities

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Primary biliary cholangitis presenting with granulomatous lung disease misdiagnosed as lung cancer:A case report

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World Journal of Clinical Cases 2024年第2期12卷 354-360页

作者： Shan-li Feng jun-yao li Chun-ling Dong Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis(PBC).No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been *** SUMMARY A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed *** underwent left lobectomy,and the pathology of the nodules showed granulomatous inflammation,which was then treated with ***,a new nodule *** investigation with lung biopsy and liver serology led to the diagnosis of PBC,and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic *** Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.

关键词： Granulomatous lung diseases Primary biliary cirrhosis Differential diagnosis Misdiagnosis Lung cancer Case report

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M^(6)A modification in cardiovascular disease:With a focus on programmed cell death

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Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen li yao liu Ruiyan Xu Yuan Zong Lu He jun Hu Guohua li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

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Phase behavior of gas condensate in porous media using real-time computed tomography scanning

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Petroleum Science 2024年第2期21卷 1032-1043页

作者： Wen-Long Jing Lei Zhang Ai-Fen li jun-Jie Zhong Hai Sun Yong-Fei Yang Yu-Long Cheng jun yao Institute of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina

The phase behavior of gas condensate in reservoir formations differs from that in pressure-volume-temperature(PVT)cells because it is influenced by porous media in the reservoir *** was used as a sample to investigate the influence of porous media on the phase behavior of the gas *** pore structure was first analyzed using computed tomography(CT)scanning,digital core technology,and a pore network *** sandstone core sample was then saturated with gas condensate for the pressure depletion *** each pressure-depletion state was stable,realtime CT scanning was performed on the *** scanning results of the sample were reconstructed into three-dimensional grayscale images,and the gas condensate and condensate liquid were segmented based on gray value discrepancy to dynamically characterize the phase behavior of the gas condensate in porous *** network models of the condensate liquid ganglia under different pressures were built to calculate the characteristic parameters,including the average radius,coordination number,and tortuosity,and to analyze the changing mechanism caused by the phase behavior change of the gas *** types of condensate liquid(clustered,branched,membranous,and droplet ganglia)were then classified by shape factor and Euler number to investigate their morphological changes dynamically and *** results show that the dew point pressure of the gas condensate in porous media is 12.7 MPa,which is 0.7 MPa higher than 12.0 MPa in PVT *** average radius,volume,and coordination number of the condensate liquid ganglia increased when the system pressure was between the dew point pressure(12.7 MPa)and the pressure for the maximum liquid dropout,Pmax(10.0 MPa),and decreased when it was below *** volume proportion of clustered ganglia was the highest,followed by branched,membranous,and droplet *** study provides crucial experimental evidence for the phase behavior chan

关键词： Gas condensate Pressure depletion Real-time micro-computed tomography scanning Distribution of condensate liquid

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Boosting High-Voltage Practical lithium Metal Batteries with Tailored Additives

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Nano-Micro Letters 2024年第12期16卷 23-41页

作者： Jinhai You Qiong Wang Runhong Wei li Deng Yiyang Hu li Niu Jingkai Wang Xiaomei Zheng junwei li yao Zhou jun-Tao li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China Magnetism Key Laboratory of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Chemical Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium(li)metal anode is widely regarded as an ideal anode material for high-energy-density ***,uncontrolled li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader ***,an ether-based electrolyte(termed FGN-182)is formulated,exhibiting ultra-stable li metal anodes through the incorporation of liFSI and liNO3 as dual *** synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast li+transport ***,li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin li chips(25μm),and lean electrolytes(5 g Ah-1)demonstrate outstanding cycling performance,retaining 80%capacity after 125 *** address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricyanohexane is incorporated with FGN-182;the resulting high-voltage LCO||li(4.4 V)pouch cells can cycle steadily over 93 *** study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

关键词： li metal anode li dendrites liNO_(3) 1,3,6-tricyanohexane Pouch cells

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ligation-assisted endoscopic submucosal resection following unroofing technique for small esophageal subepithelial lesions originating from the muscularis propria

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World Journal of Gastroenterology 2024年第32期30卷 3748-3754页

作者： Quan Lu Quan-Zhou Peng jun yao li-Sheng Wang De-Feng li Department of Gastroenterology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Pathology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518020Guangdong ProvinceChina The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518020Guangdong ProvinceChina

BACKGROUND The majority of esophageal subepithelial lesions originating from the muscularis propria(SEL-MPs)are benign in nature,although a subset may exhibit malignant *** endoscopic resection techniques are time-consuming and lack efficacy for small *** To evaluate the efficacy and safety of ligation-assisted endoscopic submucosal resection(ESMR-L)following unroofing technique for small esophageal *** From January 2021 to September 2023,17 patients diagnosed with esophageal SEL-MPs underwent ESMR-L following unroofing technique at the endoscopy center of Shenzhen People’s *** of clinicopathological characteristics and clinical outcomes were collected and *** The mean age of the patients was 50.12±12.65 *** mean size of the tumors was 7.47±2.83 mm and all cases achieved en bloc resection *** average operation time was 12.2 minutes without any *** identified 2 Lesions(11.8%)as gastrointestinal stromal tumors at very low risk,12 Lesions(70.6%)as leiomyoma and 3 Lesions(17.6%)as smooth muscle *** recurrence was found during the mean follow-up duration of 14.18±9.62 *** ESMR-L following roofing technique is an effective and safe technique for management of esophageal SEL-MPs smaller than 20 mm,but it cannot ensure en bloc resection and may require further treatment.

关键词： Subepithelial lesions Muscularis propria Esophagus ligation Endoscopic submucosal resection

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热塑性聚氨酯弹性体中的氢键作用──动态力学分析

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高等学校化学学报 2001年第5期22卷 844-846页

作者：陈大俊李瑶君中国纺织大学纤维材料改性国家重点实验室上海200051

采用动态力学分析方法研究了一系列由聚四氢呋喃 (Mn=2 0 0 0 )、 4 ,4 -二苯基甲烷二异氰酸酯以及N-甲基二乙醇胺、 1 ,4 -丁二醇和 1 ,2 -丙二胺三种不同的扩链剂合成的 TPU中的氢键作用 .发现这种氢键作用符合 Arrhenius型的温度依... 详细信息

采用动态力学分析方法研究了一系列由聚四氢呋喃 (Mn=2 0 0 0 )、 4 ,4 -二苯基甲烷二异氰酸酯以及N-甲基二乙醇胺、 1 ,4 -丁二醇和 1 ,2 -丙二胺三种不同的扩链剂合成的 TPU中的氢键作用 .发现这种氢键作用符合 Arrhenius型的温度依赖性 .从弹性模量

关键词：热塑性聚氨酯弹性体氢键作用物理交联温度依赖性动态力学分析

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Mechanical and Frost-resistance Properties of Rural Area Building Waste Hollow Bricks

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 1017-1021页

作者：刘军 School of Material Science and Engineering Shenyang Jianzhu University

Serving as recycled coarse aggregate,the pretreated rural building waste was added into the concrete hollow bricks in the varying replacement of 0,20%,40%,60%,80% and 100%.By testing its compressive strength,flexural strength,mass and strength loss after freeze-thaw cycles,the impact of the different replacement on mechanical and frost-resistance properties of concrete hollow bricks was presented through SEM *** experimental results show that,with the increase in recycled coarse aggregate replacement rate,the mechanical and frost-resistance properties show a downward trend;when the replacement rate is 40%,28 d compressive strength and flexural strength of concrete hollow brick demonstrate the good peak value which meet the requirement of the national standard for ordinary small concrete hollow bricks;the interfacial structures of the pretreated recycled concrete is more complicated than those of concrete made of natural aggregate,but the former enjoys better interface bonding and tight structure.

关键词： replacement rate waste clay brick mechanical properties frost-resistance properties microstructure

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