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Undescended epididymo-testicular metastasis from prostatic carcinoma

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Asian Journal of Andrology 2006年第2期8卷 251-252页

作者： li-Ping Xie jie qin Xiang-Yi Zheng Zhao-Dian Chen Department of Urology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

Dear Sir, Metastasis of prostatic carcinoma to testis is un- common in the clinical situation, and the involvement of the epididymis is even rarer. Heidrich et al. [1] found only 80 cases of testicular involvement in prostate cancer in published reports. In 1993, Wiebe et al. [2] found only 14 previous cases of epididymal metastasis from prostatic carcinoma in published work. The simulta- neous involvement of testis and epididymis was reported by Suhler and Blanchard in 1980 [3]. To our knowledge, this was the first documented case of a prostatic carcinoma metastasizing to undescended testis and epididymis.

关键词： Adenocarcinoma Aged, 80 and over Cryptorchidism Humans Male Prostatic Neoplasms Testicular Neoplasms

A review on Acinetobacter baumannii

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Journal of Acute Disease 2019年第1期8卷 16-20页

作者： Xin Wang li-jie qin Department of Emergency Henan Provincial People's HospitalZhengzhouHenanChina

Acinetobacter baumannii is a major cause of nosocomial infections worldwide. By summarizing the epidemiology, molecular and drug resistance mechanisms, diagnosis and treatment strategies of Acinetobacter baumannii, th... 详细信息

关键词： Acinetobacter baumannii Resistance mechanism Progress in treatment

阿尔茨海默病中膜脂改变与Aβ异常相关的研究进展

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上海交通大学学报（医学版） 2016年第12期36卷 1809-1811,1816页

作者：李沁洁钟远上海交通大学附属第六人民医院老年科上海200233

细胞膜脂质主要包括鞘脂类、甘油磷脂类以及固醇类3种,它们在大脑中含量丰富且广泛。目前已有许多研究发现了机体中膜脂质类的代谢紊乱参与了阿尔茨海默病(AD)的病理生理,尤其与β淀粉样蛋白(Aβ)及其相关代谢酶异常息息相关。该文针对A... 详细信息

细胞膜脂质主要包括鞘脂类、甘油磷脂类以及固醇类3种,它们在大脑中含量丰富且广泛。目前已有许多研究发现了机体中膜脂质类的代谢紊乱参与了阿尔茨海默病(AD)的病理生理,尤其与β淀粉样蛋白(Aβ)及其相关代谢酶异常息息相关。该文针对AD病程中涉及的膜脂改变与Aβ异常相关的研究作一综述,从细胞膜脂质代谢的角度为AD相关发病机制的研究提供新的视角和思路。

关键词：细胞膜脂质鞘磷脂甘油磷脂胆固醇阿尔茨海默病

Systemic analysis of pre-hospital trauma emergency treatment in Zhengzhou

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Journal of Acute Disease 2019年第1期8卷 34-37页

作者： Xiao-Peng Shi li-jie qin Yu-Xia Chang Fa-liang li Peng Wang Department of Emergency Henan Provincial People's HospitalZhengzhouHenanChina

Objective: To analyze the data of pre-hospital emergency treatment in zhengzhou from 2007 to 2016, and evaluate the current situation of pre-hospital trauma emergency treatment, in order to provide a scientific basis for effective use of first aid resources and enhance success rate of trauma emergency treatment. Methods: Retrospective analysis was conducted based on pre-hospital emergency resources of Zhengzhou Emergency Medical Rescue Center from 2007 to 2016. Results: The total number of pre-hospital emergency treatment cases was 9305687 from 2007 to 2016 in Zhengzhou, of which 418882 were trauma cases. The top five causes of injury were traffic accident injury, cutting injury, beating injury, crushing injury and falling injury. The top five emergency treatments used were oxygen, hemostasis, dressing and fixation, fluid supplementation, analgesics and sputum aspiration. According to different directions of diagnosis, the pre-hospital emergency patients were divided into four groups:emergency treatment group, emergency observation group, admission to general ward group and admission to ICU group. There was no statistical difference in the ages among the four groups (P>0.05). There were significantly statistical differences in gender composition among the four groups, with more males than females (P0.05), but the mortality of the trauma, the average arrival time, and the mean treatment time were significantly different (Plittle. CRAMS score is important for the patients triage. Through the training of primary trauma care, the constituent ratio of death was reduced, and the average treatment time was short

关键词： Pre-hospital first aid Trauma CRAMS Primary trauma care

Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study

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World Journal of Emergency Medicine 2022年第5期13卷 355-360页

作者： Fei Shao Xian Shi Shu-hua Huo qing-yu liu Ji-xue Shi Jian Kang Ping Gong Sheng-tao Yan Guo-xing Wang li-jie qin Fei Wang Ke Feng Feng-ying Chen Yong-jie Yin Tao Ma Yan li Yang Wu Hao Cui Chang-xiao Yu Song Yang Wei Gan Sai Wang liu-ye-zi Du Ming-chen Zhao Zi-ren Tang Shen Zhao Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Medicine Hebei Yanda HospitalLangfang 065201China Department of Emergency Medicine Beijing Huairou HospitalBeijing 101400China Department of Emergency Medicine the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Emergency Medicine the Second Affi liated Hospital of Shandong First Medical UniversityTai’an 271000China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China Department of Emergency Medicine Henan Provincial People’s HospitalZhengzhou 450003China Department of Emergency Medicine Beijing Tsinghua Changung HospitalBeijing 102218China Department of Emergency Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Emergency Medicine the Affi liated Hospital of Inner Mongolia Medical UniversityHohhot 010050China Department of Emergency Medicine the Second Hospital of Jilin UniversityChangchun 130021China Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Department of Emergency Medicine the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Big Data Research Goodwill Hessian Health Technology Co.Ltd.Beijing 100085China School of Public Health Peking UniversityBeijing 100083China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:This study aimed to establish an eff ective nomogram to predict the survival of heat stroke(HS)based on risk ***:This was a retrospective,observational multicenter cohort *** analyzed patients diagnosed with HS,who were treated between May 1 and September 30,2018 at 15 tertiary hospitals from 11 cities in Northern ***:Among the 175 patients,32 patients(18.29%)died before hospital *** the univariate analysis,mechanical ventilation,initial mean arterial pressurelished for predicting 7-d and 14-d survival in the training *** nomogram exhibited a concordance index(C-index)of 0.880(95%confidence interval[95%CI]0.831-0.930)by bootstrapping validation(B=1,000).Furthermore,the nomogram performed better when predicting 14-d survival,compared to 7-d *** prognostic index cut-off value was set at 2.085,according to the operating characteristic curve for overall survival *** model showed good calibration ability in the internal and external validation ***:A novel nomogram,integrated with prognostic factors,was proposed;it was highly predictive of the survival in HS patients.

关键词： Heat stroke Nomogram Survival Prognosis

转铁蛋白阿霉素脂质体的制备及其对人肝癌细胞系的杀伤活性

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世界华人消化杂志 2007年第12期15卷 1441-1445页

作者：秦历杰刘占举河南省人民医院急诊科河南省郑州市450003 郑州大学第二附属医院消化内科河南省郑州市450014

目的:利用正常肝细胞和肝癌细胞表面转铁蛋白受体以及亲和力的差异,用转铁蛋白修饰脂质体,使脂质体具有导向肝癌细胞的靶向性,分析其对肝癌细胞系的杀伤作用.方法:超声法制备阿霉素脂质体,暴露脂质体上的巯基,然后用双功能交联剂N-琥珀... 详细信息

目的:利用正常肝细胞和肝癌细胞表面转铁蛋白受体以及亲和力的差异,用转铁蛋白修饰脂质体,使脂质体具有导向肝癌细胞的靶向性,分析其对肝癌细胞系的杀伤作用.方法:超声法制备阿霉素脂质体,暴露脂质体上的巯基,然后用双功能交联剂N-琥珀酰亚胺-3-(2-吡啶二硫代)丙酸酯(SPDP)交联HTf(Fe)_2和脂质体,制备成HTf(Fe)_2-阿霉素脂质体.用MTT法分析HTf(Fe)_2-阿霉素脂质体对人肝癌细胞系SMMC-7721的杀伤力.结果:实验检测HTf(Fe)_2与脂质体的交联率为73.5%,电镜观察修饰后的脂质体呈单层状,平均直径56±38 nm,未用HTf(Fe)_2修饰的脂质体直径平均为54±30 nm,两者无显著差异.SPDP修饰和脂质体交联不影响HTf(Fe)_2的活力.MTT法分析发现,当浓度为0.10 mg/L时HTf(Fe)_2阿霉素脂质体、无HTf(Fe)_2阿霉素脂质体及游离阿霉素对肝癌细胞的杀伤率分别为64.52%,22.12%和37.82%,前一组与后两组之间有显著差异(P<0.05).结论:HTf(Fe)_2阿霉素脂质体体外杀伤肝癌细胞系SMMc-7721具有用药量小、高效、特异性强等优点,为体内应用治疗肝癌提供了实验依据.

关键词：转铁蛋白脂质体靶向作用肝细胞癌阿霉素

Effect of HMW-GS 5+10 on Quality Parameters in Four Leading Wheat Cultivars

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Agricultural Sciences in China 2003年第5期2卷 483-488页

作者： ZHANG Yan-bin, SUN lian-fa, XIN Wen-li, SONG qin-jie, ZHANG Chun-li, ZHAO Hai-bin, XIAO Zhi-min and QI Shi-yuCrop Breeding Institute , Heilongjiang Academy of Agricultural Sciences , Harbin 150086 , P. R. China Crop Breeding Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 P. R. China

HMW-GS 5 + 10 was introduced to four major wheat cultivars Kehan9, Kefeng3, Longmai20 and Kenda4 through 5 or 6 consecutive backcrosses. No significant difference in protein content and dry gluten content was observed between cultivars containing 5 + 10 and 2 + 12 or 3 + 12 (P>0.1). In cultivars containing HMW-GS 5 + 10, the ratio of wet gluten content to dry gluten content was 2. 9 - 5.0% (Plity in wheat cultivars was discussed.

关键词： Wheat HMW glutenin subunits Selective backcross Quality

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-qin liu jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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果糖与氧嗪酸钾联用建造高尿酸血症大鼠模型

基因组学与应用生物学 2018年第2期37卷 667-674页

作者：刘杰李琴刘先俊蒋雪重庆医科大学基础医学院生物化学与分子生物学教研室重庆400016

本研究采用果糖和氧嗪酸钾（oxonic acid potassium salt,OAPS）联用以期建立稳定持久肝肾损伤小的动物模型,为高尿酸血症的研究提供稳定的模型基础。将雄性Sprague-Dawley（SD）大鼠40只,随机分为空白组（n=10）、5%果糖＋OAPS组（n=1... 详细信息

本研究采用果糖和氧嗪酸钾（oxonic acid potassium salt,OAPS）联用以期建立稳定持久肝肾损伤小的动物模型,为高尿酸血症的研究提供稳定的模型基础。将雄性Sprague-Dawley（SD）大鼠40只,随机分为空白组（n=10）、5%果糖＋OAPS组（n=10）、5%果糖组（n=10）、OAPS组（n=10）,空白组给予标准饮食,5%果糖＋OAPS组给予5%果糖水＋早晚皮下注射OAPS乳悬液100 mg·kg^-1·d^-1）,5%果糖组给予5%果糖水,OAPS组早晚皮下注射OAPS乳悬液100 mg·kg^-1·d^-1,持续18周,于不同时间点取血检测大鼠血尿酸、尿素氮、肌酐水平,结束时取大鼠肝、肾做病理组织切片。第1周时,5%果糖＋OAPS组血尿酸即显著高于其他各组（p均〈0.01）,持续稳定至18周,5%果糖组、OAPS组仅第2周时血尿酸高于空白组（p〈0.01）;血清尿素氮、肌酐水平实验组与空白组比较差异均无统计学意义（p均〉0.05）,肝、肾组织切片观察未见明显损伤。这表明5%果糖水与OAPS联用能建立稳定持久几乎未见肝肾损伤的高尿酸血症动物模型。

关键词： 5%果糖水氧嗪酸钾大鼠高尿酸血症