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Effect of propofol on generation of inflammatory mediator of monocytes

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 940-945页

作者： Yun Nie Yan-Xi Lu li-hong lv Operating Room First People's Hospital of Ji'nan

Objective:To evaluate the effect of propofol with different concentrations on the expression of inflammatory mediators of mterleukin and tumor-necrosis factor- α(TNF- α) by stimulating the mouse primary monocytes and human monocytic cell line with lipopolysaccharide(LPS)and also discuss the effeet of propofol on the secretion of inflammatory mediator and its possible molecular ***:The mononuclear cells of mouse spleen were separated and then purified to obtain the primary *** dose-effect relationship of production of pro-inflammatory cytokines by monocytes which were stimulated by LPS,namely the monocytes were stimulated by the dose of 0-500 ng/mL for 24 *** was employed to detect the concentration of IL-6,TL-8 and TNF-α.The effect of propofol on the secretion of above pro-inflammatory cytokines by the monocytes was *** were divided into the control group,the 0.1%DMSO group,the LPS group and the treatment group with LPS + different dose of propofol(propofol 1-100 μg/mL).EliSA was employed to detect the concentration of IL-6,IL-8 and TNF-α.The change in the expression of important signaling molecules in Toll-like receptor and NF-κ B signaling pathway was detected after THP-1 cells were treated with ***:The concentration of TNF- α was(3 863±153)pg/mL after 12 h of stimulation by LPS and then its concentration was decreased *** the concentration of IL-6 and IL-8 was relatively high after 24 h of stimulation by LPS,(5 627±330) pg/mL and(1 626±200) pg/mL,*** propofol could inhibit the expression of IL-6,IL-8 and TNF- α caused by *** the intervention treatment of 50 μg/mL propofol,the concentration of IL-6,IL-8 and TNF-α was significantly decreased(P<0.01).Conclusions:The propofol can inhibit the expression of TLR-4 and NF-κ B to inhibit the activation of p38 and the expression of pro-inflammatory cytokines.

关键词： Propofol LPS IL-6 IL-8 TNF-α Anti-inflammation

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Spontaneous expulsion of a duodenal lipoma after endoscopic biopsy: A case report

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World Journal of Gastroenterology 2022年第34期28卷 5086-5092页

作者： Zhi-Hao Chen li-hong lv Wen-Sheng Pan Yi-Miao Zhu Department of Gastroenterology Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Affiliated Hospital People’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Gastroenterology Xianju County People’s HospitalTaizhou 317300Zhejiang ProvinceChina

BACKGROUND Gastrointestinal(GI)lipomas are benign submucosal tumors of mature adipocytes that arise mainly in the colon and stomach,sometimes in the ileum and jejunum,and rarely in the *** with symptomatic lipomas require endoscopic or surgical *** expulsion of lipomas after biopsy is a rare condition that has limited case *** SUMMARY A 56-year-old man presented to our hospital with intermittent postprandial epigastric ***(EGD)revealed a 10-mm soft yellowish submucosal lesion with the“pillow sign,”located in the second portion of *** ultrasonography(EUS)using a 12-MHz catheter probe showed a hyperechoic,homogenous,and round solid lesion(OLYMPUS EUS EUME2,UM-DP12-25R,12-MHz radial miniprobe,Olympus Corporation,Tokyo,Japan).Deep biopsy was performed using the bite-on-bite technique with *** examination was compatible with submucosal *** lesion spontaneously expelled 12 d after the ***-up EUS performed after 2 mo confirmed this *** Deep biopsy could lead to spontaneous GI lipoma *** might be the first step in lipoma diagnosis and treatment.

关键词： lipoma Duodenal neoplasms Spontaneous expulsion Endoscopic biopsy Adipose tissue Case report

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Design and modification of metal sulfide-based catalysts for lithiumsulfur batteries

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Particuology 2024年第3期86卷 86-100页

作者： Yufei Zhao Chuannan Geng li Wang Haotian Yang Wei lv Quan-hong Yang Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyNational Industry-Education Integration Platform of Energy Storageand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin300072China Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon MaterialsTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China

Metal sulfide(MS)have good conductivity,strong adsorption ability,and excellent catalytic activity for the conversion of sulfur species,and thus,show great promise as the catalysts in lieS ***,the relationship between their properties and electrochemical performance is still ***,further in-depth discussions are required to improve their design in li-S *** review systematically summarizes the basic structural and electrochemical properties of MSs and highlights the advantages that guarantee them as high-performance catalysts in li-S ***,various modification strategies for MSs to enhance the catalytic activity,efficiency,and stability are also *** last,future opportunities for MS catalysts in li-S batteries are proposed.

关键词： lithium-sulfur battery Metal sulfide Catalysis

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High incidence of biliary complications in rat liver transplantation:Can we avoid it?

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World Journal of Gastroenterology 2011年第26期17卷 3140-3144页

作者： Guo-lin li li-hong lv Jian-Dong Yu Yong-Heng Huang Jun Min Hao-Ming lin Yun-Le Wan Tian-Zhu Long Department of Hepa-tobiliary Surgery Sun Yat-sen Memorial Hospital Sun Yat-senUniversity Haizhu District Guangzhou 510260 GuangdongProvince China Department of Breast Surgery GuangzholWomen and Children＇s Medical Center Guangzhou 510260Guangdong Province China

MM： To investigate how to reduce the incidence of biliary complications in rat orthotopic liver transplantation. METHODS： A total of 165 male Wistar rats were ran- domly divided into three groups： Group A, orthotropic liver transplantation with modified ＂two-cuff＂ technique; Group B, bile duct was cut and reconstructed without transplantation; and Group C, only laparotomy was performed. Based on the approaches used for biliary reconstruction, Group A was divided into two sub-groups： A1 （n = 30）, duct-duct reconstruction, and A2 （n = 30）, duct-duodenum reconstruction. To study the influence of artery reconstruction on bile duct complication, Group B was divided into four sub-groups： B1 （n = 10）, duct-duct reconstruction with hepatic artery ligation, B2 （n = 10）, duct-duct reconstruction without hepatic artery ligation, B3 （n = 10）, duct-duodenum reconstruction with hepatic artery ligation, and B4 （n = 10）, duct-duodenum recon- struction without hepatic artery ligation. The samples were harvested 14 d after operation or at the time when significant biliary complication was found. RESULTS： In Group A, the anhepatic phase was 13.7 ＋ 1.06 min, and cold ischemia time was 50.5 ＋ 8.6 min. There was no significant difference between A1 and A2 in the operation duration. The time for biliary reconstruction was almost the same among all groups. The success rate for transplantation was 98.3% （59/60）. Significant differ- ences were found in the incidence of biliary complications in Groups A （41.7%）, B （27.5%） and C （0%）. A2 was more likely to have biliary complications than A1 （50% vs 33.3%）. B3 had the highest incidence of biliary complica- tions in Group B. CONCLUSION： Biliary complications are almost in- evitable using the classical ＂two cuff＂ techniques, and duct-duodenum reconstruction is not an ideal option in rat orthotopic liver transplantation.

关键词： Rat liver transplantation Biliary complication Animal model

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Design of double protograph LDPC codes based JSCC systems via the ACE-PEG algorithm

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Science China(Information Sciences) 2024年第7期67卷 339-340页

作者： Yijie lv Jiguang HE Shaohua hong Department of Information and Communication Engineering Xiamen University Technology Innovation Institute Centre for Wireless Communications Oulu University

In this study, we present a state-of-the-art design of double protograph low-density parity-check (DP-LDPC) codes based on progressive edge-growth (PEG) algorithm with approximated cycle extrinsic message degree (ACE)... 详细信息

关键词： Benchmarking

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Numerical Study on Local Flow and Heat Transfer Characteristics of Supercritical CO_(2) in PCHE with Sinusoidal Channels

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Journal of Thermal Science 2024年第1期33卷 41-55页

作者： WENZhexi lv Yigao li Qing WU Jinglin School of Energy Science and Engineering Central South UniversityChangsha 410083China

Local heat transfer and flow characteristics,which is crucial to the overall performance of supercritical CO_(2) recuperators,is rarely examined in details in reported *** this paper,the local heat transfer and flow characteristics of supercritical CO_(2) in sinusoidal channel printed circuit heat exchangers are numerically investigated under the working conditions of *** on the simplified physical model constituted by10 pitches,the variations of Re,heat flux,Nu,secondary flow and other relevant parameters along the flow direction are analyzed *** is further made between the high and low temperature recuperators(HTR and LTR).It's observed that the local heat transfer and flow characteristics vary greatly from the inlet to the outlet,especially in the *** of 127.5% and 61.7% can be observed on the cold side of the LTR for Re and heat transfer coefficient h, *** indicate that the temperature difference and heat transfer coefficient h should not be regarded as constant and the distribution of h should be carefully considered in the design of the *** complicated interactions among the varying thermophysical properties,buoyancy and the periodically changed centrifugal force are believed to be the key that shapes the flow ***,the changes of the wavy angle θ are found to have greater influence than the changes of mass flow rate in reshaping the flow field when θ>25°.Though gravity direction strongly affects the local heat transfer and flow characteristics,it's also found that the effects on the overall thermal-hydraulic performance are relatively *** the installation direction that yields a_y=g should better be avoided for the sinusoidal channel printed circuit heat exchanger.

关键词： printed circuit heat exchanger supercritical CO_(2) sinusoidal channel heat transfer recuperator

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A Generalized MSST Algorithm for Counting Points of Elliptic Curves over F_(p)^(n)

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Journal of Systems Science & Complexity 2024年第4期37卷 1738-1754页

作者： li Xiao lv Chang PAN Zhizhong Key Laboratory of Cyberspace Security Defense Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100085China Huawei Technologies Co. Ltd.Shenzhen 518129China

Elliptic curve cryptography is an important part of nowaday's public key *** points of elliptic curves over finite fields is of great significance to the selection of safety *** present,there are many p-adic algorithms,such as SST algorithm,generalized AGM algorithm,Kedlaya algorithm,etc.,which can deal with the situation of finite fields of small *** this paper,the authors generalize the MSST algorithm of characteristic 2 to general fields of odd characteristic,and propose the generalized MSST *** generalized MSST algorithm is achieved by combining the advantages of the SST algorithm and the generalized AGM *** the time complexity of the multiplication of two n-bit numbers is denoted as O((n)^(μ)),then the time complexity of the generalized MSST algorithm is O(n^(2μ+1/1+μ)),which is the same as the improved SST *** practical experiments,the running time of the generalized MSST algorithm is less than that of the improved SST algorithm.

关键词： Elliptic curve generalized AGM algorithm generalized MSST algorithm SST algorithm

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An air combat maneuver pattern extraction based on time series segmentation and clustering analysis

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Defence Technology（防务技术） 2024年第6期36卷 149-162页

作者： Zhifei Xi Yingxin Kou Zhanwu li Yue lv You li Air Force Engineering University No.1 Baling RoadBaqiao DistrictXi'anShaanxi ProvinceChina

Target maneuver recognition is a prerequisite for air combat situation awareness,trajectory prediction,threat assessment and maneuver *** get rid of the dependence of the current target maneuver recognition method on empirical criteria and sample data,and automatically and adaptively complete the task of extracting the target maneuver pattern,in this paper,an air combat maneuver pattern extraction based on time series segmentation and clustering analysis is proposed by combining autoencoder,G-G clustering algorithm and the selective ensemble clustering analysis ***,the autoencoder is used to extract key features of maneuvering trajectory to remove the impacts of redundant variables and reduce the data dimension;Then,taking the time information into account,the segmentation of Maneuver characteristic time series is realized with the improved FSTS-AEGG algorithm,and a large number of maneuver primitives are extracted;Finally,the maneuver primitives are grouped into some categories by using the selective ensemble multiple time series clustering algorithm,which can prove that each class represents a maneuver *** maneuver pattern extraction method is applied to small scale air combat trajectory and can recognize and correctly partition at least 71.3%of maneuver actions,indicating that the method is effective and satisfies the requirements for engineering *** addition,this method can provide data support for various target maneuvering recognition methods proposed in the literature,greatly reduce the workload and improve the recognition accuracy.

关键词： Maneuver pattern extraction Data mining Fuzzy segmentation Selective ensemble clustering

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Transcriptomic analysis reveals the effects of maternal exposure to bisphenol AF on hypothalamic development in male neonatal mice

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Journal of Environmental Sciences 2024年第7期141卷 304-313页

作者： lin lv Yuanyuan li Xuanyue Chen Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Fragmented data suggest that bisphenol AF(BPAF),a chemical widely used in a variety of products,might have potential impacts on the ***,we employed male neonatal mice following maternal exposure to explore the effects of low-dose BPAF on hypothalamic development by *** found that maternal exposure to approximately 50μg/(kg·day)BPAF from postanal day(PND)0 to PND 15 altered the hypothalamic transcriptome,primarily involving the pathways and genes associated with extracellular matrix(ECM)and intercellular adhesion,neuroendocrine regulation,and neurological *** RNA analysis confirmed the changes in the expression levels of concerned ***,we further revealed that low-dose BPAF posed a stimulatory impact on pro-opiomelanocortin(POMC)neurons in the arcuate nucleus of the hypothalamus and induced the browning of inguinal white adipose *** findings indicate that developmental exposure to low-dose BPAF could interfere with hypothalamic development and thereby lead to alterations in the ***,5000μg/(kg·day)BPAF caused slighter,non-significant or even inverse alterations than the low dose of 50μg/(kg·day),displaying a dose-independent *** observations suggest that the the dose-independent effects of BPAF might be associated with oxidative stress and inflammatory responses caused by the high ***,our study highlights a risk of low-dose BPAF to human neuroendocrine regulation and metabolism.

关键词： Bisphenol AF Hypothalamus Transcriptomic alteration Pro-opiomelanocortin(POMC)neurons White adipose tissue browning

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun li Fang-Zhou Sun Chun-Xiao li hong-Nan Mo Yan-Tong Zhou Dan lv Jing-Tong Zhai Hai-li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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