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Extramedullary plasmacytoma with the uvula as first affected site:A case report

World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-Ke Tu Min li Kui song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue Ren Ying Tang Qi Yang Tian-Tian Meng song li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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Microstructural evolution and mechanical properties of Ni-45Ti-5Al-2Nb-1Mo alloy subjected to different heat treatments

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Rare Metals 2023年第8期42卷 2774-2780页

作者： Xiao-Yun song Yan li fei Zhang State Key Laboratory of Nonferrous Metals and Processes GRIMAT Engineering Institute Co.LtdBeijing 101407China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The effects of solution and aging heat treatment on microstructural evolution and room temperature tensile properties for as-forged Ni-45Ti-5Al-2Nb-1Mo alloy were investigated through scanning electron microscopy(SEM),transmission electron microscopy(TEM)and tensile *** results show that the microstructure of solution-treated alloy comprises NiTi matrix,Ti_(2)Ni and(Nb,Ti)ss *** aging treatment at 700℃for 6 and100 h,the distribution of Ti_(2)Ni and(Nb,Ti)ss precipitates increases in *** new type of precipitate is observed in the specimen aged at 700℃.After aging at800℃for 100 h,numerous nanosized Ni_(2)TiAl phases are precipitated within the *** and aging treatments improve the tensile properties at room *** strength and ductility are improved after solution treatment at 1100℃plus aging treatment at 800℃for 6 h or 700℃for 100 *** aging time prolonging to 100 h at 800℃,the precipitation of fine Ni2TiAl particles leads to the improvement in tensile strength and deterioration of elongation.

关键词： NiTi-Al-based alloy Intermetallics Microstructure Mechanical properties Heat treatment

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大理出口农产品种植基地质量监管体系建设研究

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中国口岸科学技术 2022年第S01期4卷 20-23页

作者：李松飞薛靖孙娟朱文丹昆明海关技术中心昆明650228

对大理白族自治州备案的出口植物源性食品种植场和注册登记的出境水果果园采用"危害分析和关键控制点"的方法确定监管的关键控制点,通过建立环境质量评价体系、农药使用管理体系、产品质量监测体系,对各关键控制点实施有效监管,以确保... 详细信息

对大理白族自治州备案的出口植物源性食品种植场和注册登记的出境水果果园采用"危害分析和关键控制点"的方法确定监管的关键控制点,通过建立环境质量评价体系、农药使用管理体系、产品质量监测体系,对各关键控制点实施有效监管,以确保出口农产品质量安全.

关键词：农产品种植基地危害分析和关键控制点质量监管体系

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Prediction of mechanical properties of cold rolled strip based on improved extreme random tree

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Journal of Iron and Steel Research International 2023年第2期30卷 293-304页

作者： Yun-bao Zhao Yong song fei-fei li Xian-le Yan Institute of Engineering Technology University of Science and Technology BeijingBeijing100083China

Taking the 2130 cold rolling production line of a steel mill as the research object,feature dimensionality reduction and decoupling processing were realized by fusing random forest and factor analysis,which reduced the generation of weak decision trees while ensured its *** base learner used a weighted voting mechanism to replace the traditional average method,which improved the prediction ***,the analysis method of the correlation between steel grades was proposed to solve the problem of unstable prediction accuracy of multiple steel *** experimental results show that the improved prediction model of mechanical properties has high accuracy:the prediction accuracy of yield strength and tensile strength within the error of±20 MPa reaches 93.20%and 97.62%,respectively,and that of the elongation rate under the error of±5%has reached 96.60%.

关键词： Cold strip rolling Mechanical property prediction Extreme random tree Factor analysis Random forest Correlation analysis Steel grade

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Microstructure and tensile properties of isothermally forged Ni–43Ti–4Al–2Nb–2Hf alloy

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Rare Metals 2013年第5期32卷 475-479页

作者： Xiao-Yun song Yan li fei Zhang State Key Laboratory of Nonferrous Metals & Processes General Research Institute for Nonferrous Metals Key Laboratory of Aerospace Materials and Performance (Ministry of Education) Beijing University of Aeronautics and Astronautics

NiTi-Al-based alloys are promising high-tem- perature structural materials for aerospace and astronautics applications. A new NiTi-Al-based alloy Ni--43Ti-4AI- 2Nb-2Hf （at%） was processed via isothermal forging. The microstructure and mechanical properties at room temperature and high temperature were investigated through scanning electron microscope （SEM）, X-ray diffraction （XRD）, and tensile tests. Results show that the micro- structure of as-forged Ni-43Ti--4AI-2Nb-2Hf alloy con- sists of NiTi matrix, Ti2Ni phase, and Hf-rich phase. The simultaneous addition of Nb and Hf, which have strong affinities for Ti sites, promotes the precipitation of Hf-rich phases along the grain boundaries. The tensile strengths of Ni-43Ti-4A1-2Nb-2Hf alloy are dramatically increased compared with the ternary Ni-46Ti-4A1 alloy. At room temperature and 650℃, the yield stress of Ni--43Ti-4Al- 2Nb-2Hf alloy reaches 1,070 and 610 MPa, respectively, which are 30 % and 150 % higher than those of Ni--46Ti- 4Al alloy. The improved tensile property results from the solid solution strengthening by Nb and Hf, as well as the dispersion hardening of the Ti2Ni and Hf-rich phases.

关键词： Intermetallics NiTi-Al alloy Isothermal forging Tensile property Microstructure

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孤儿核受体Nur77对缺/复氧损伤中心肌细胞自噬的调节

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现代生物医学进展 2018年第2期18卷 219-221,258页

作者：游晓华董斐斐李松华刘夙璇赵仙先第二军医大学长海医院心血管内科上海200433

目的:研究孤儿核受体Nur77对缺/复氧损伤中心肌细胞自噬的调节作用。方法:差速贴壁法分离乳鼠心肌细胞,经免疫荧光染色鉴定纯度。缺氧(1%O_2、5%CO_2和94%N_2)培养12 h后,常氧培养2 h构建心肌细胞缺/复氧损伤。实时定量PCR和western blo... 详细信息

目的:研究孤儿核受体Nur77对缺/复氧损伤中心肌细胞自噬的调节作用。方法:差速贴壁法分离乳鼠心肌细胞,经免疫荧光染色鉴定纯度。缺氧(1%O_2、5%CO_2和94%N_2)培养12 h后,常氧培养2 h构建心肌细胞缺/复氧损伤。实时定量PCR和western blot的方法检测Nur77的表达变化。通过siRNA转染抑制心肌细胞nur77表达,通过自噬标志蛋白表达改变作为细胞自噬水平的变化。结果:原代分离的心肌细胞纯度95%以上。缺氧12 h和缺/复氧(12 h/2 h)刺激后,心肌细胞中Nur77表达都明显升高(P<0.01)。与缺氧组相比,缺/复氧组细胞质中的水平明显增加(P<0.01),细胞核中Nur77水平无明显变化。抑制Nur77后,缺/复氧组自噬水平明显降低,缺氧组心肌细胞自噬水平无明显变化。结论:Nur77参与缺/复氧损伤中心肌细胞自噬水平的调节。

关键词：孤儿核受体77 心肌细胞缺复氧损伤自噬

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Tuning macrophages for atherosclerosis treatment

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Regenerative Biomaterials 2023年第1期10卷 280-293页

作者： fei Fang Crystal Xiao Chunli li Xiaoheng liu song li Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA Department of Medicine University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Atherosclerosis is a chronic inflammatory vascular disease and a leading cause of death *** play an important role in inflammatory responses,cell-cell communications,plaque growth and plaque rupture in atherosclerotic ***,we review the sources,functions and complex phenotypes of macrophages in the progression of atherosclerosis,and discuss the recent approaches in modulating macrophage phenotype and autophagy for atherosclerosis *** then focus on the drug delivery strategies that target macrophages or use macrophage membrane-coated particles to deliver therapeutics to the lesion *** biomaterial-based approaches that target,modulate or engineer macrophages have broad applications for disease therapies and tissue regeneration.

关键词： macrophages atherosclerosis drug delivery system immune engineering

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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-Feng Fu li-Fen Yang Lei Tian song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

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