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Rare autonomic nervous system dysfunction: Alternating bilateral mydriasis

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World Journal of Emergency Medicine 2021年第4期12卷 330-331页

作者： Peng Xu Jing Wu li-da su Fang Qian Hu-qiang Wan Yue Yu Min li Ying-hong Hu Man Huang Department of Neuroscience Care Unit the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of General Intensive Care Unit the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Intensive Care Unit Severe Burn Wards the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Dear editor,Pupillary abnormalities, i.e., mydriasis, pupillary arefl exia, and/or anisocoria, may indicate the occurrence of acute clinical events in intensive care units (ICUs),which are particularly seen in severe patients with brain and/or cervical spinal cord injury. The pathophysiology of benign episodic mydriasis is still not completely clear. We present a patient with severe burns presented with temporary alternating bilateral pupil enlargement accompanied by paroxysmal increases in respiration,heart rate, and blood pressure.

关键词： editor sis bilateral

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Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires pre- and post-synaptic cascades

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Long-term potentiation at cerebellar parallel fiber-Purkinje...

中国神经科学学会第十届全国学术会议

作者： De-Juan Wang li-da su Cheng-Long sun Ying Shen Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of HealthZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine

A postsynaptically expressed long-term potentiation(LTP) is demonstrated at the parallel fiber-Purkinje cell synapse,which is dependent of 1 Hz parallel fiber stimulation and nitro oxide ***,the biochemical mechanism for this LTP remains *** importance of lipid signaling in synaptic mechanisms becomes increasingly *** has been reported that PLA2 is involved in cerebellar postsynaptic long-term depression(LTD)on Purkinje *** the present study,using genetic and pharmacological manipulations,we showed the involvement of cPLAα/arachidonic acid/2-arachidonoylglycerol(2-AG) pathway in 1 Hz parallel fiber-stimulated LTP *** found that the cPLAα knock-out blocked the LTP ***,application of presynaptic CB1 receptor by AM251 also blocked the LTP ***,we demonstrated that the activation of CBl receptor induced the increase of NO production,the inhibition of which is sufficient to block the LTP *** results suggest a novel mechanism responsible for the 1 Hz parallel fiber-stimulated LTP induction in cerebellar Purkinje cells.

关键词： long-term potentiation cPLA2α arachidonic acid Purkinje cell parallel fiber cannabinoids

Cytosolic phospholipase A2 alpha/arachidonic acid pathway mediates depolarization-induced suppression of excitation at cerebellar parallel fiber-Purkinje cell synapses

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Cytosolic phospholipase A2 alpha/arachidonic acid pathway me...

中国神经科学学会第十届全国学术会议

作者： De-Juan WANG Cheng-Long suN li-da su Dong YANG Qiong li Xin-Xin WANG Ying SHEN Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of HealthZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine Neuroscience Care Unit The Second Affiliated Hospital of Zhejiang University School of Medicine

Objective Depolarization-induced suppression of excitation(DSE) at parallel fiber to Purkinje cell synapses is an endocannabinoid-mediated short-term retrograde *** Ca elevation is critical for the endocannabinoid production and ***,what biochemical pathways are evoked by elevated Ca and are involved in the synthesis and release of endocannabinoids is not *** the present study,we aimed to elucidate the mechanisms by which the brief depolarization induces DSE at parallel fiber to Purkinje cell *** Using slice whole-cell patch-clamp combined with pharmacological applications,electrophysiological experiments were developed at parallel fiber-Purkinje cell *** In the present work,we measured DSE at parallel fiber-Purkinje cell synapses in wild type and phospholipase A alpha(cPLA) knock-out *** data showed that DSE is inhibited in cPLA knock-out mice,which can be rescued by the bath application of arachidonic acid,which is freed from phospholipids by *** also show that DSE at parallel fiber-Purkinje cell synapses is blocked by internal K,but not affected by the antagonists of purinergic P2X7 receptor(P2X7R),protein kinase C(PKC) and cAMP-dependent protein kinase(PKA).Conclusion Our data showed that cPLA/arachidnoic acid pathway is required for DSE *** data first suggest a novel mechanism for the brief depolarization-induced DSE at parallel fiber to Purkinje cell *** also show that DSE at this synapse is blocked by internal K,but not affected by the ectopic activation of P2X7R and presynaptic PKC and PKA.

关键词： DSE cPLA2α arachidonic acid Purkinje cell parallel fiber

Ablation of TFR1 in Purkinje cells inhibits mGlu1 trafficking and impairs motor coordination, but not autistic-like behaviors

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Ablation of TFR1 in Purkinje cells inhibits mGlu1 traffickin...

中国神经科学学会第十二届全国学术会议

作者： Jia-Huan Zhou liang Zhou Xin-Tai Wang lin Zhou Fang-Xiao Xu li-da su Chris De Zeeuw Ying Shen Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health Zhejiang University School of Medicine Neuroscience Care Unit Second Affiliated Hospital of Zhejiang University School of Medicine Department of Neuroscience Erasmus MC Netherlands Institute for Neuroscience Royal Dutch Academy for Arts & Sciences

Group 1 metabotropic glutamate receptors（m Glu1/5） are critical to synapse formation and participate in synaptic long-term potentiation（LTP） and long-term depression（LTD） in the brain. m Glu1/5 signaling alterations have been documented in cognitive impairment, neurodegenerative disorders, and psychiatric diseases, but the underlying mechanisms for its modulation are not clear. Here, we report that transferrin receptor 1（TFR1）, a trans-membrane protein of the clathrin complex, modulates the trafficking of m Glu1 in cerebellar Purkinje cells（PCs）. We show that conditional knockout of TFR1 in PCs does not affect the cyto-architecture of PCs, but reduces mGlu1 expression at synapses. This regulation by TFR1 acts in concert with that by Rab8 and Rab11, which modulate the internalization and recycling of m Glu1, respectively. TFR1 can bind to Rab proteins and facilitate their expression at synapses. PC ablation of TFR1 inhibits parallel fiber-PC LTD, whereas parallel fiber-PC LTP and PC intrinsic excitability are not affected. Finally, we demonstrate that PC ablation of TFR1 impairs motor coordination, but does not affect social behaviors in mice. Together, these findings underscore the importance of TFR1 in regulating mGlu1 trafficking, and suggest that mGlu1 and mGlu1-dependent parallel fiber-LTD are associated with regulation of motor coordination, but not autistic behaviors.

关键词： Transferrin receptor Metabotropic glutamate receptor Trafficking Purkinje cell Autism Motor coordination

C-terminal domain of ICA69 interacts with PICKl and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity

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C-terminal domain of ICA69 interacts with PICKl and acts on ...

中国神经科学学会第十届全国学术会议

作者： Zhen WANG Cheng-Long suN Ya-Nan WANG Dong YANG li-da su Ya-Jun XIE lin ZHOU Yin WANG Ying SHEN Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of HealthZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine Department of Neurobiology Center of Scientific TechnologyCranial Cerebral Disease LabNingxia Medical University

Objective The role of C-terminal Domain of ICA69（ICAC） in regulating trafficking of of PICK1-PKCa Complex and Cerebellar Plasticity remains *** experiments try to identify how the ICAC of ICA69 affect PICK1 trafficking and induction of long-term *** The interaction between ICA69 or ICAC and PICK1 was identified by co-immunoprecipition,immunostaining and FRET *** ICAC domain of ICA69 affects binding of PICK1-PKCa was measured by Time-lapse imaging *** proteins affects induction of long-term depression of Purkinje cells by electrophysiology *** ICAC inhibited the trafficking of PICK1 to the plasma membrane mediated by activated PKCa and the induction of long-term depression in cerebellar Purkinje *** ICAC is an important domain for ICA69-PICK1 interaction and plays an important role in PICK1-mediated neuronal plasticity.

关键词： ICA69 PICK1 PKCa plasticity traffickin

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei li Jian-Hong Shi Tan li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Distinct functions of nuclear distribution proteins liS1,Ndel1 and NudCL in regulating axonal mitochondrial transport

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Distinct functions of nuclear distribution proteins LIS1,Nde...

中国神经科学学会第十届全国学术会议

作者： Chong-Yu SHAO Jia ZHU Ya-Jun XIE Zheng WANG Ya-Nan WANG Yin WANG li-da su liang ZHOU Tian-Hua ZHOU Ying SHEN Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of Medicine Department of Medical Microbiology Medical College of Jiaxing University Department of Neurobiology Basic Medical CollegeCenter of Scientific TechnologyNingxia Medical University Neuroscience Care Unit The Second Affiliated Hospital of Zhejiang University School of Medicine

Objective Neurons critically depend on the long-distance transport of *** proteins kinesin and dynein control anterograde and retrograde mitochondrial transport respectively in *** regulatory molecules that link them to mitochondria need to be better *** distribution（Nud） family proteins liSl,Ndell and NudCL are critical components of cytoplasmic dynein *** of these Nud proteins in neuronal mitochondrial transport are *** we report distinct functions of liSl,Ndell and NudCL on axonal mitochondrial transport in cultured hippocampal *** Mitochondria movements were observed using live cell time-lapse imaging after kocking down of liSl,NudCL,*** interaction among liSl,NudCL,Ndell was was measured by ***（1） liSl interacted with kinsein family protein *** of liSl enormously suppressed mitochondrial motility in both anterograde and retrograde directions.（2） Inhibition of either Ndell or NudCL only partially reduced retrograde mitochondrial motility.（3） Kocking down both Ndell and NudCL almost blocked retrograde mitochondrial *** liSl,Ndell and NudCL may work together to regulate retrograde mitochondrial transport through linking dynein-liSl complex.

关键词： mitochondron Ndell NudCL liS1 kinesin

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping li Zhi-Xin liu Jia-Wei su Ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing Cheng Peiqiang su Yong Wan Xiang li Department of Spine surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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