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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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冠心病患者动脉粥样硬化与人巨细胞病毒检测结果的相关性分析

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标记免疫分析与临床 2016年第12期23卷 1379-1381,1412页

作者：杜立平朱淑芬内蒙古医科大学附属医院内蒙古呼和浩特010059

目的观察人巨细胞病毒(HCMV)在冠心病患者动脉粥样硬化发病过程的相关性。方法选取我院2014年8月至2016年4月心内科收治的动脉粥样硬化患者136例为观察对象,其中冠心病(CHD)患者103例,非CHD患者33例。使用多普勒超声对颈动脉内膜—中层... 详细信息

目的观察人巨细胞病毒(HCMV)在冠心病患者动脉粥样硬化发病过程的相关性。方法选取我院2014年8月至2016年4月心内科收治的动脉粥样硬化患者136例为观察对象,其中冠心病(CHD)患者103例,非CHD患者33例。使用多普勒超声对颈动脉内膜—中层厚度(IMT)进行监测,酶联免疫吸附试验法对血清HCMV-Ig M进行检测。结果HCMV感染组心肌梗死发生几率明显高于非HCMV感染组。HCMV感染组冠状动脉多支病变的发生几率亦显著高于非HCMV感染组。病变过程中HCMV感染和患者颈动脉IMT的相关性发现:HCMV感染患者颈动脉IMT(1.31±0.27)mm,非HCMV感染(1.14±0.22)mm,P<0.05,差异有统计学意义;HCMV感染组的MMP-9以及软斑组织水平明显高于非HCMV感染组。将HCMV感染作因变量,将其他因素作自变量,筛选出3个影响因素,即:颈动脉IMT、MMP-9、软斑组织。结论冠心病动脉粥样硬化与HCMV感染呈正相关,作为其影响因素可能会增加HCMV感染的几率。

关键词：动脉粥样硬化人巨细胞病毒检测

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Fabrication of carbon-supported Al2O3 nanoparticles via spontaneous cross-linking to enhance selective hydrogenation of furfural

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Journal of Energy Chemistry 2025年第1期100卷 612-620页

作者： Weiwei Yu Xinbao Zhang Hongyu Chen Yanan Wang Shaoguo li Fucun Chen Zhenni liu Xiujie li Xiangxue zhu State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Selective hydrogenation of furfural to furfuryl alcohol is a great challenge in the hydrogenation field due to thermodynamic preference for hydrogenation of C=C over C=***,a novel Al2O3/C-u hybrid catalyst,composed of N-modified dendritic carbon networks supporting Al2O3nanoparticles,was successfully prepared via carbonizing the freeze-dried gel from spontaneous cross-linking of alginate,Al3+and *** obtained carbon-supported Al2O3hybrid catalyst has a high ratio （31%） of Al species in pentahedral-coordinated *** introduction of urea enhances the surface N content,the ratio of pyrrolic N,and specific surface area of catalyst,leading to improved adsorption capacity of C=O and the accessibility of active *** the furfural hydrogenation reaction with isopropyl alcohol as hydrogen donor,Al2O3/C-u catalyst achieved a 90%conversion of furfural with 98.0% selectivity to furfuryl alcohol,outperforming that of commercial γ-***,Al2O3/C-u demonstrates excellent catalytic stability in the recycling tests attributed to the synergistic effect of abundant weak Lewis acid sites and the anchoring effect of the carbon network on *** work provides an innovative and facile strategy for fabrication of carbon-supported Al2O3hybrid catalysts with rich AlVspecies,serving as a high selective hydrogenation catalyst through MPV reaction route.

关键词： Selective hydrogenation Furfural Furfuryl alcohol Cross-linking MPV route

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di Zhao Lemei zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei zhu lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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典型冻土路基变形调控措施应用效能分析

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公路交通科技 2017年第10期34卷 34-41页

作者：樊凯俞祁浩李金平朱东鹏中交第一公路勘察设计研究院有限公司高寒高海拔地区道路工程安全与健康国家重点实验室陕西西安710064 中国科学院西北生态环境资源研究院甘肃兰州730000

为了解决多年冻土区路基变形控制与稳定性问题,满足高海拔多年冻土区路基调控措施的选型需求,以青藏公路、国道214线共和至玉树公路、中科院北麓河高等级试验公路中已试验应用的一些典型路基调控措施为研究对象,采用实测数据分析、数值... 详细信息

为了解决多年冻土区路基变形控制与稳定性问题,满足高海拔多年冻土区路基调控措施的选型需求,以青藏公路、国道214线共和至玉树公路、中科院北麓河高等级试验公路中已试验应用的一些典型路基调控措施为研究对象,采用实测数据分析、数值模拟等方法,将实体试验工程长时间序列监测数据反映的情形与数值模拟结果对照,并结合道路运营状态调查等技术手段对各类典型调控措施的长期作用效能进行验证,探讨其在高等级公路中的适应性。研究表明:隔热层工程措施、热棒工程措施、空心块护坡工程措施等基于温度调控的冻土路基变形调控措施,主要通过减少路基基底吸热、调控路基基底温度场的变化趋势与强度,实现对冻土路基变形进行调控,它们对路基自身结构安全与稳定性要求较高,长期作用效能没有达到设计预期,该类调控措施在路基变形调控应用中不宜单独使用,应注重与其他调控措施组合使用;块石路基、通风管路基、全断面通风路基等主要基于水、热同时调控的工程措施,它们通过减弱水的影响,对流换热增加基底冷储量,减少路基体水热影响作用明显,虽然也存在有些措施热效能不足、路基基底整体处于净吸热状态的问题,但其自身结构力学稳定性和水稳定性较好,综合使用效能经长期观察是积极的,路基变形能基本达到设计预期。

关键词：道路工程效能分析数值模拟路基变形典型调控措施多年冻土

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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产生2元de Bruijin序列的一个新算法

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通信技术 2002年第2X期35卷 60-62页

作者：李平朱士信合肥工业大学应用数学系合肥230009

２元ｎ级ｄｅＢｒｕｉｊｎ序列是由ｎ级移位寄存器产生的周期为２ｎ的移位寄存器序列，给出了２元ｄｅＢｒｕｉｊｎ序列的一个新的生成算法，该算法能生成２ｓ·ｇ（ｎ，ｓ）个ｎ级如ｄｅ　Ｂｒｕｉｊｉｎ序列，其中，０≤ｓ≤２（ｎ－... 详细信息

２元ｎ级ｄｅＢｒｕｉｊｎ序列是由ｎ级移位寄存器产生的周期为２ｎ的移位寄存器序列，给出了２元ｄｅＢｒｕｉｊｎ序列的一个新的生成算法，该算法能生成２ｓ·ｇ（ｎ，ｓ）个ｎ级如ｄｅ　Ｂｒｕｉｊｉｎ序列，其中，０≤ｓ≤２（ｎ－７）／３；当２ｌ－１＜ｓ≤２Ｌ时，ｇ（ｎ，ｓ）＝ｎ－３Ｌ－６－［（ｎ－２Ｌ－６）／（Ｌ＋１）］。

关键词： de Bruijn序列补轮换移位寄存器状态图并圈桥状态

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新媒体环境下的公共图书馆参考咨询服务

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农业图书情报学刊 2016年第10期28卷 188-190页

作者：马丽萍朱慧山西省图书馆山西太原030021 山西日报社山西太原030012

参考咨询工作是现代公共图书馆的一项重要工作,也是公共图书馆未来发展战略中的一项非常关键的核心工作。论述了新媒体环境下图书馆参考咨询工作面临的挑战和存在的问题,提出了新媒体环境下公共图书馆参考咨询工作的创新思路和发展前景。

关键词：公共图书馆参考咨询服务新媒体

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