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Mixed Reality-based Interactive Technology for Aircraft Cabin Assembly

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Chinese Journal of Mechanical Engineering 2009年第3期22卷 403-409页

作者： li Shiqi peng Tao wang Junfeng XU Chi School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Due to the narrowness of space and the complexity of structure, the assembly of aircraft cabin has become one of the major bottlenecks in the whole manufacturing process. To solve the problem, at the beginning of aircraft design, the different stages of the lifecycle of aircraft must be thought about, which include the trial manufacture, assembly, maintenance, recycling and destruction of the product. Recently, thanks to the development of the virtual reality and augmented reality, some low-cost and fast solutions are found for the product assembly. This paper presents a mixed reality-based interactive technology for the aircraft cabin assembly, which can enhance the efficiency of the assemblage in a virtual environment in terms of vision, information and operation. In the mixed reality-based assembly environment, the physical scene can be obtained by a camera and then generated by a computer. The virtual parts, the features of visual assembly, the navigation information, the physical parts and the physical assembly environment will be mixed and presented in the same assembly scene. The mixed or the augmented information will provide some assembling information as a detailed assembly instruction in the mixed reality-based assembly environment. Constraint proxy and its match rules help to reconstruct and visualize the restriction relationship among different parts, and to avoid the complex calculation of constraint＇s match. Finally, a desktop prototype system of virtual assembly has been built to assist the assembly verification and training with the virtual hand.

关键词： virtual assembly human-computer interaction mixed reality information augmentation constraints navigation

Abnormal expression of miR-331 leads to impaired heart function

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Science Bulletin 2019年第14期64卷 1011-1017页

作者： Jin-Jing Zhang li-peng wang Rong-Chang li Meng wang Zeng-Hui Huang Min Zhu Jia-Xing wang Xiu-Jie wang Shi-Qiang wang Ming Xu Department of Cardiology Institute of Vascular Medicine Peking University Third Hospital NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether miR-331 regulates cardiac function under physiological and pathological conditions still remains unknown. In the present study, we investigated the function and underlying mechanisms of miR-331 in a pressure overload-induced heart failure model and miR-331 transgenic rat model. First, we found that the expression of miR-331-3p exhibited a 1.7-fold increase in hypertrophy compared with that in the sham group (Pling efficiency were observed. Luciferase assays showed that miR-331-3p suppressed JPH2 expression by binding to the coding region of JPH2 mRNA. Finally, in the miR-331 transgenic rat model, JPH2 expression was suppressed at both the mRNA and protein levels in vivo, which resulted in impairment of both the E-C coupling efficiency of cardiomyocytes and systolic function of the heart. This finding mechanistically linked miR-331 to JPH2 downregulation and suggested an important role for the abnormal expression of miR-331 leading to the dysfunction of E-C coupling in heart failure.

关键词： MiR-331 Excitation-contraction coupling Junctophilin 2 Heart function

Optimum Production and Characterization of an Acid Protease from Marine Yeast Metschnikowia reukaufii W6b

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Journal of Ocean University of China 2010年第4期9卷 359-364页

作者： li Jing peng Ying wang Xianghong CHI Zhenming UNESCO Chinese Center of Marine Biotechnology Ocean University of China Qingdao 266003 P. R. China

The marine yeast strain W6b isolated from sediment of the South China Sea was found to produce a cell-bound acid *** crude acid protease produced by this marine yeast showed the highest activity at pH 3.5 and 40 ℃.The optimal pH and temperature for the crude acid protease were in agreement with those for acid protease produced by the terrestrial *** optimal medium of the acid protease production was seawater containing 1.0% glucose, 1.5% casein, and 0.5% yeast extract, and the optimal cultivation conditions of the acid protease production were pH 4.0, a temperature of 25 ℃ and a shaking speed of 140 *** the optimal conditions, 72.5 UmL-1 of acid protease activity could be obtained in cell suspension within 48 h of fermentation at shake flask *** acid protease production was induced by high-molecular-weight nitrogen sources and repressed by low-molecu-lar-weight nitrogen ***-milk-clotting test showed that the crude acid protease from the cell suspension of the yeast W6b had high skimmed milk *** acid protease produced by *** W6b may have highly potential applications in cheese, food and fermentation industries.

关键词： acid protease marine yeasts Metschnikowia reukaufii milk coagulability

Effects of early oral feeding after radical total gastrectomy in gastric cancer patients

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World Journal of Gastroenterology 2020年第36期26卷 5508-5519页

作者： Yi-Xun Lu Yan-Jun wang Tian-Yu Xie Shuo li Di Wu Xiong-Guang li Qi-Ying Song li-peng wang Da Guan Xin-Xin wang Department of General Surgery Chinese PLA General HospitalBeijing 100853China Department of Surgical Intensive Care Unit Children’s Hospital Affiliated to Zhengzhou UniversityChildren’s Hospital of Henan ProvenceZhengzhou 450018Henan ProvinceChina

BACKGROUND Gastric cancer(GC)is a heavy burden in *** support for GC patients is closely related to postoperative ***,the role of early oral feeding after laparoscopic radical total gastrectomy in GC patients is unclear and high-quality research evidence is *** To prospectively explore the safety,feasibility and short-term clinical outcomes of early oral feeding after laparoscopic radical total gastrectomy for GC *** This study was a prospective cohort study conducted between January 2018 and December 2019 based in a high-volume tertiary hospital in China.A total of 206 patients who underwent laparoscopic radical total gastrectomy for GC were *** which,105 patients were given early oral feeding(EOF group)after surgery,and the other 101 patients were given the traditional feeding strategy(control group)after *** clinical data were recorded and *** primary endpoints were gastrointestinal function recovery time and postoperative complications,and the secondary endpoints were postoperative nutritional status,length of hospital stay and expenses,*** Compared with the control group,patients in the EOF group had a significantly shorter postoperative first exhaust time(2.48±1.17 d vs 3.37±1.42 d,P=0.001)and first defecation time(3.83±2.41 d vs 5.32±2.70 d,P=0.004).In addition,the EOF group had a significant shorter postoperative hospitalization duration(5.85±1.53 d vs 7.71±1.56 d,Plization expenses(16.60±5.10 K¥vs 21.00±7.50 K¥,P=0.014).On the 5th day after surgery,serum prealbumin level(214.52±22.47 mg/L vs 204.17±20.62 mg/L,P=0.018),serum gastrin level(246.30±57.10 ng/L vs 223.60±55.70 ng/L,P=0.001)and serum motilin level(424.60±68.30 ng/L vs 409.30±61.70 ng/L,P=0.002)were higher in the EOF ***,there was no significant difference in the incidence of total postoperative complications between the two groups(P=0.507).CONCLUSION Early

关键词： Gastric cancer Laparoscopic surgery Early oral feeding

Role of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 782-790页

作者： Tian-Yu Xie Di Wu Shuo li Zhao-Yan Qiu Qi-Ying Song Da Guan li-peng wang Xiong-Guang li Feng Duan Xin-Xin wang School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery Chinese PLA General HospitalBeijing 100853China

BACKGROUND Gastric cancer is the second most common malignant tumor in China,ranking third among all malignant tumor mortality *** intraperitoneal chemotherapy(HIPEC)has been shown to increase significantly the effectiveness of intraperitoneal chemotherapeutic drugs,prolong the action time of these drugs on intraperitoneal tumor cells,and enhance their diffusion in tumor *** may be one of the best choices for the eradication of residual cancer cells in the abdominal *** The aim of this study was to study the role of preventive HIPEC after radical *** A prospective analysis was performed with patients with c T4 N0-3 M0 gastric cancer to compare the effects of postoperative prophylactic HIPEC plus intravenous chemotherapy with those of routine adjuvant ***’medical records were analyzed,and differences in the peritoneal recurrence rate,diseasefree survival time,and total survival time between groups were *** The first site of tumor recurrence was the peritoneum in 11 cases in the conventional adjuvant chemotherapy group and in 2 cases in the HIPEC group(P=0.020).The 1-year and 3-year disease-free survival rates were 91.9%and 60.4%,respectively,in the conventional adjuvant chemotherapy group and 92.1%and 63.0%,respectively,in the HIPEC *** 1-year and 3-year overall survival rates were 95.2%and 66.3%,respectively,in the conventional adjuvant chemotherapy group and 96.1%and 68.6%,respectively,in the HIPEC *** significant difference in postoperative or chemotherapy complications was observed between *** In patients with c T4 N0-3 M0 gastric cancer,prophylactic HIPEC after radical tumor surgery is beneficial to reduce peritoneal tumor recurrence and prolong survival.

关键词： Hyperthermic intraperitoneal chemotherapy Gastric cancer Prognosis Locally advanced Overall survival Disease-free survival

Key technologies of new malicious code developments and defensive measures in communication networks

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 69-73页

作者： li peng,wang Ru-chuan ,ZHANG Wei College of Computer,Nanjing University of Posts and Telecommunications,Nanjing 210003,China [a] College of Computer Nanjing University of Posts Telecommunications Nanjing 210003 China

This article is focused on analyzing the key technologies of new malicious code and corresponding defensive measures in the large-scale communication networks. Based on description of the concepts and development of the malicious code, the article introduces the anti-analysis technology, splitting and inserting technology, hiding technology, polymorph virus technology, and auto production technology of the malicious code trends with intelligence, diversity and integration. Following that, it summarizes the security vulnerabilities of communication networks from four related layers aspects, according to the mechanisms of malicious code in the communication networks. Finally, it proposes rapid response disposition of malicious code attacks from four correlated steps： building up the network node monitoring system, suspicious code feature automation analysis and extraction, rapid active malicious code response technique for unknown malicious code, and malicious code attack immunity technique. As a result, it actively defenses against the unknown malicious code attacks and enhances the security performance of communication networks.

关键词： network security malicious code network attack and defense malicious code defense

Image-based Virtual Exhibit and Its Extension to 3D

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International Journal of Automation and computing 2007年第1期4卷 18-24页

作者： Ming-Min Zhang Zhi-Geng Pan li-Feng Ren peng wang State Key Laboratory of CAD＆CG Zhejiang University Hangzhou 310027 PRC

In this paper we introduce an image-based virtual exhibition system especially for clothing product. It can provide a powerful material substitution function, which is very useful for customization clothing-built. A novel color substitution algorithm and two texture morphing methods are designed to ensure realistic substitution result. To extend it to 3D, we need to do the model reconstruction based on photos. Thus we present an improved method for modeling human body. It deforms a generic model with shape details extracted from pictures to generate a new model. Our method begins with model image generation followed by silhouette extraction and segmentation. Then it builds a mapping between pixels inside every pair of silhouette segments in the model image and in the picture. Our mapping algorithm is based on a slice space representation that conforms to the natural features of human body.

关键词： Virtual exhibition color substitution texture morphing reflection component decomposition virtual reality.

Reproducibility of RTVue retinal nerve fiber layer thickness and optic nerve head measurements in normal and glaucoma eyes

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Chinese Medical Journal 2010年第14期123卷 1898-1903页

作者： li Ji-peng wang Xiao-zhen Fu Jing li Shu-ning wang Ning-li Tongren Eye Center Beijing Tongren Hospital Capital Medical University Ophthalmology and Visual Science Key Laboratory China Beijing 100730 China

Background RTVue spectral-domain optical coherence tomography （OCT） is a new, ultra high-speed and high-resolution instrument, potentially to measure the presence of glaucoma or its progression accurately. The objective of this study was to evaluate its reproducibility of retinal nerve fiber layer （RNFL） thickness and optic nerve head （ONH） measurements in normal and glaucoma eyes. Methods This study was an observational clinical study. One eye was selected randomly from each of 89 normal individuals and 63 glaucoma patients in a range of severity. RNFL thickness and ONH were measured 3 times on the same day to determine intrasession variability. The same instrument was used by the same operator for all scans. Intrasession within-subject standard deviation （Sw）, precision （1.96xSw）, coefficient of variation （CVw, 100xSw/overall mean）, and intraclass coefficient （ICC） were calculated to evaluate reproducibility. Results RTVue OCT demonstrated double hump patterns in the RNFL profiles. High reproducibility was observed in all ONH parameters. For normal eyes, the value of ICC ranged between 0.98 and 1.00. For eyes with different extent of glaucoma, it ranged between 0.94 and 1.00. High reproducibility was also observed in RNFL thickness measurements. The values of ICC for averaged RNFL thickness ranged between 0,95 and 1.00 in all cases. For regional parameters, it ranged from 0,94 to 0.98 for normal eyes, 0.94 to 1.00 for mild glaucoma eyes, 0.87 to 1.00 for moderate glaucoma eyes, and 0.77 to 0.97 for severe glaucoma eyes. The nasal regions of severe glaucoma appeared to be most variable, as nasal lower region and inferior nasal region had the ICC values of 0.77 and 0.87. Conclusion Reproducibility of RTVue RNFL and ONH measurements was excellent in normal and glaucoma groups.

关键词： diagnostic techniques ophthalmological, instrumentation optical coherence tomography standards reproducibility

Telomerase reverse transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant glioma cells

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Chinese Journal of Cancer 2011年第8期30卷 574-580页

作者： Jian Tan Wei li peng wang Department of Nuclear Medicine General Hospital ofTianjin Medical University Tianjin 300052 P. R. China.

Radioiodine i s a routine therapy for differentiated thyroid ***-thyroid cancers can intake radioiodine after transfection of the human sodium iodide symporter (hNIS) *** human telomerase reverse transcriptase (hTERT) promoter,an excellent tumor-specific promoter,has potential value for targeted gene therapy of *** used the hTERT promoter to drive the expression of the hNIS and human thyroid peroxidase (hTPO) gene as a primary step for testing the effects of radioiodine therapy on malignant *** U87 and U251 cells were co-transfected with two adenoviral vectors,in which the hNIS gene had been coupled to the hTERT promoter and the hTPO gene had been coupled to the CMV promoter,***,we performed Western blot,125I intake and efflux assays,and clonogenic assay with cancer *** also did 99mTc tumor imaging of nude mice *** co-transfection with Ad-hTERT-hNIS and Ad-CMV-hTPO,glioma cells showed the 125I intake almost 1.5 times higher than cells transfected with Ad-hTERT-hNIS *** blots revealed bands of approximately 70 kDa and 110 kDa,consistent with the hNIS and hTPO *** clonogenic assay,approximately 90% of cotransfected cells were killed,compared to 50% of control cells after incubated with 37 MBq of *** results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in *** hNIS and hTPO genes can result in increased intake and longer retention of *** mice harboring xenografts transfected with Ad-hTERT-NIS can take 99mTc scans.

关键词：人端粒酶逆转录酶特异性启动子胶质瘤细胞放射性碘基因转染基因治疗恶性驱动