Effects of early oral feeding after radical total gastrectomy in gastric cancer patients

作     者：Yi-Xun Lu Yan-Jun Wang Tian-Yu Xie Shuo Li Di Wu Xiong-Guang Li Qi-Ying Song Li-Peng Wang Da Guan Xin-Xin Wang 

作者机构：Department of General SurgeryChinese PLA General HospitalBeijing 100853China Department of Surgical Intensive Care UnitChildren’s Hospital Affiliated to Zhengzhou UniversityChildren’s Hospital of Henan ProvenceZhengzhou 450018Henan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第36期

页      面：5508-5519页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastric cancer Laparoscopic surgery Early oral feeding 

摘      要：BACKGROUND Gastric cancer(GC)is a heavy burden in *** support for GC patients is closely related to postoperative ***,the role of early oral feeding after laparoscopic radical total gastrectomy in GC patients is unclear and high-quality research evidence is *** To prospectively explore the safety,feasibility and short-term clinical outcomes of early oral feeding after laparoscopic radical total gastrectomy for GC *** This study was a prospective cohort study conducted between January 2018 and December 2019 based in a high-volume tertiary hospital in China.A total of 206 patients who underwent laparoscopic radical total gastrectomy for GC were *** which,105 patients were given early oral feeding(EOF group)after surgery,and the other 101 patients were given the traditional feeding strategy(control group)after *** clinical data were recorded and *** primary endpoints were gastrointestinal function recovery time and postoperative complications,and the secondary endpoints were postoperative nutritional status,length of hospital stay and expenses,*** Compared with the control group,patients in the EOF group had a significantly shorter postoperative first exhaust time(2.48±1.17 d vs 3.37±1.42 d,P=0.001)and first defecation time(3.83±2.41 d vs 5.32±2.70 d,P=0.004).In addition,the EOF group had a significant shorter postoperative hospitalization duration(5.85±1.53 d vs 7.71±1.56 d,P0.001)and lower postoperative hospitalization expenses(16.60±5.10 K¥vs 21.00±7.50 K¥,P=0.014).On the 5th day after surgery,serum prealbumin level(214.52±22.47 mg/L vs 204.17±20.62 mg/L,P=0.018),serum gastrin level(246.30±57.10 ng/L vs 223.60±55.70 ng/L,P=0.001)and serum motilin level(424.60±68.30 ng/L vs 409.30±61.70 ng/L,P=0.002)were higher in the EOF ***,there was no significant difference in the incidence of total postoperative complications between the two groups(P=0.507).CONCLUSION Early