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Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment

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Neural Regeneration Research 2019年第7期14卷 1152-1157页

作者： Chao Ren Yong-Qiang Ji Hong liu Zhe Wang Jia-Hui Wang Cai-Yi Zhang li-na guan Pei-Yuan Yin Department of Neurology and Suzhou Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow University Department of Neurology Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Nephrology Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Clinical Laboratory Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Central Laboratory Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Emergency and Rescue Medicine Xuzhou Medical University Department of Neurosurgical Intensive Care Unit the Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Blood Supply Yantai Center Blood Station

Stem cell transplantation has brought new hope for the treatment of neurological *** key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve *** the differentiation of stem cells in vitro and in vivo is affected by multiple factors,the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are ***,the optimal microenvironment for inducing stem cell differentiation is a hot ***761 is extracted from the leaves of the Ginkgo biloba *** is used worldwide and is becoming one of the focuses of stem cell *** have shown that EGb761 can antagonize oxygen free radicals,stabilize cell membranes,promote neurogenesis and synaptogenesis,increase the level of brain-derived neurotrophic factors,and replicate the environment required during the differentiation of stem cells into nerve *** offers the possibility of using EGb761 to induce the differentiation of stem cells,facilitating stem cell *** provide a comprehensive reference for the future application of EGb761 in stem cell therapy,we reviewed studies investigating the influence of EGb761 on stem *** started with the composition and neuropharmacology of EGb761,and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial microenvironment for stem cell transplantation.

关键词： nerve regeneration Ginkgo biloba extract Ginkgolide B traditional Chinese medicine stem cells induction of differentiation stem cell transplantation synaptic plasticity pharmacological effect neurological diseases nervous systems neural regeneration

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Diabetes onset at an earlier age and high HbA1c levels as risk factors of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 269-276页

作者： Rui-Fang Feng Hai-Yang liu Ya-Lu liu Qing Xu Lei Qiao Chao-Ju Gong Yi-Peng Zhang Jie li li-na guan Wei Fan Mei-li li Wen-Jin li Su-Yan li Department of Ophthalmology the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou First People’s HospitalXuzhou Eye Disease Prevention and Treatment InstituteXuzhou 221116Jiangsu ProvinceChina

AIM:To assess the effect of age at diabetes onset and uncontrollable high Hb A1 c levels on the development of diabetic retinopathy(DR)among Chinese type 2 diabetes mellitus(DM)***:This was a cross-sectional survey of diabetic patients in Subei district,*** covering physical measurements,fasting blood-glucose(FBG),glycosylated hemoglobin(Hb A1 c),blood lipid,urinary albumin/creatinine ratio(UACR),ocular fundus examination,and diabetes treatment records were *** independent sample t-test were used to analyze differences.A Logistic regression analysis was applied to study the independent risk factors of ***:A total of 1282 patients with type 2 DM were enrolled,and 191 cases had DR(14.9%).The age at diabetes onset,education level,alcohol consumption,Hb A1 c level,UACR level,and hypoglycemic drugs were independent influencing factors for *** older the onset of diabetes,the less likely to develop DR(OR:0.958,95%CI:0.942-0.975,P=0.000).Patients were then divided in terms of age at diabetes onset as follows:lin injection(52.5%)in patients with diabetes onsetlier age and uncontrollable high Hb A1 c level could be independent risk factors for DR.

关键词： diabetic retinopathy age diabetes mellitus risk factors HbA1c

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Therapies for children with cerebral palsy A Web of Science-based literature analysis

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Neural Regeneration Research 2012年第33期7卷 2632-2639页

作者： Yaping Mu na li lijun guan Chunnan Wang Shuyun Shang Yan Wang Shenyang Children's Hospital Shenyang 110032 Liaoning Province China

OBJECTIVE： To identify global research trends in three therapies for children with cerebral palsy. DATA RETRIEVAL： We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA： Inclusion criteria：（a） peer-reviewed published articles on botulinum toxin, constraint-induced movement therapy, or acupuncture for children with cerebral palsy indexed in Web of Science; （b） original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items; and （c） publication between 2002 and 2011. Exclusion criteria：（a） articles that required manual searching or telephone access; （b） documents that were not published in the public domain; and （c） a number of corrected papers from the total number of articles. MAIN OUTCOME MEASURES：（1） Number of publications on the three therapies; （2） annual publication output, distribution by journals, distribution by institution, and top-cited articles on botulinum toxin; （3） annual publication output, distribution by journal, distribution by institution, and top-cited articles on constraint-induced movement therapy; （4） annual publication, distribution by journal, distribution by institution, and top-cited articles on acupuncture. RESULTS： This analysis, based on Web of Science articles, identified several research trends in studies published over the past 10 years of three therapies for children with cerebral palsy. More articles on botulinum toxin for treating children with cerebral palsy were published than the articles regarding constraint-induced movement therapy or acupuncture. The numbers of publications increased over the 10-year study period. Most papers appeared in journals with a focus on neurology, such as Developmental Medicine and Child Neurology and Journal of Child *** institutes publishing on botulinum toxin treatments for this population are mostly in the Neth

关键词： constraint-induced movement therapy botulinum toxin acupuncture cerebral palsy nerve injury infant children brain Web of Science bibliometric neural regeneration

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu guan Mengting Qiu na li Zhengxiang Zhou Ru Ye liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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康柏西普联合25G玻璃体手术及小梁切除术治疗继发于PDR伴VH的NVG

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国际眼科杂志 2020年第8期20卷 1399-1404页

作者：杨柳李甦雁刘海洋徐青刘亚鲁范巍管莉娜李婕中国江苏省徐州市第一人民医院眼科徐州医科大学附属徐州市立医院眼科徐州市眼病防治研究所221116

目的:比较不同围手术时期给予玻璃体腔内注射康柏西普联合25G微创玻璃体手术(PPV)及小梁切除术治疗继发于增生型糖尿病视网膜病变(PDR)伴玻璃体积血(VH)的新生血管性青光眼(NVG)的手术效果及并发症。方法:前瞻性随机对照临床试验。纳入2... 详细信息

目的:比较不同围手术时期给予玻璃体腔内注射康柏西普联合25G微创玻璃体手术(PPV)及小梁切除术治疗继发于增生型糖尿病视网膜病变(PDR)伴玻璃体积血(VH)的新生血管性青光眼(NVG)的手术效果及并发症。方法:前瞻性随机对照临床试验。纳入2016-11/2019-04在我院确诊的PDR伴VH的Ⅲ期NVG患者28例30眼。所有患者均接受25G PPV联合小梁切除术。将其随机分为两组:第1组12例14眼患者于术前3d玻璃体腔内注射康柏西普,第2组16例16眼于25G玻璃体手术及小梁切除术毕玻璃体腔内注射康柏西普(IVC)0.5mg/0.05mL。比较两组患者手术时间、术中出血及术后并发症的发生率。观察术后疼痛缓解、虹膜新生血管(INV)消退和最佳矫正视力(BCVA)以及眼压(IOP)控制率情况。结果:第1、2组均完成手术并分别随访12.40±2.21mo和12.23±2.11mo(P>0.05)。第1组术中出血和术后早期前房出血发生率(29%、14%)低于第2组(75%、56%,均P0.05)。术后3d所有患者疼痛缓解。第1组IVC后3d(即手术日)93%的INV完全消退,第2组PPV术后7d 94%INV完全消退。末次随访两组患者各有1眼残余少许萎缩的INV。术后1wk,1、3、6mo IOP控制率,第1组依次为93%、79%、64%、57%,第2组依次为94%、75%、50%、44%,两组患者各时间段比较无差异(P>0.05)。两组术后不同时间点IOP与术前相比均明显降低(P0.05)。结论:术前IVC预处理与术毕IVC联合25G PPV及小梁切除术治疗继发于PDR伴VH的NVG相比,术中出血和术后早期前房出血的发生率较低。两种方法IOP控制率相当,虽然随着时间逐渐减低,但是经过及时处理最终可以获得较好的疗效。

关键词：康柏西普新生血管性青光眼增生型糖尿病视网膜病变微创玻璃体切割术小梁切除术

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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In/Sb掺杂SnO_2纳米薄膜的H_2S气敏特性

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仪表技术与传感器 2009年第11期 1-3,10页

作者：赵俊李冠娜周东祥郝永德华中科技大学教育部敏感陶瓷工程中心湖北武汉430074

采用溶胶-凝胶浸渍提拉法(Sol-Gel Dip-Coating,SGDC)制备SnO2纳米晶薄膜气敏传感器。较系统地研究了掺杂量、镀膜层次和热处理温度等制备工艺对薄膜表面形貌、晶粒大小及气敏性能的影响。研究结果表明:铟的最佳掺杂量为4at%,最佳镀膜... 详细信息

采用溶胶-凝胶浸渍提拉法(Sol-Gel Dip-Coating,SGDC)制备SnO2纳米晶薄膜气敏传感器。较系统地研究了掺杂量、镀膜层次和热处理温度等制备工艺对薄膜表面形貌、晶粒大小及气敏性能的影响。研究结果表明:铟的最佳掺杂量为4at%,最佳镀膜层数为7层,最佳热处理温度为600℃.气敏传感器最佳工作温度为165℃,在此工作温度下,薄膜的灵敏度分别为26.3(137 ppm H2S)和2.5(2.74 ppm H2S),薄膜的响应恢复时间较短分别为8 s和22 s,对H2S气体有较好的选择性。

关键词：气敏薄膜二氧化锡铟掺杂硫化氢溶胶-凝胶法

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Enhancing insights into Global Cancer Statistics 2022: implications for cancer control

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Science China life Sciences 2025年第1期 294-296页

作者： Jingtong Xu Runtian Wang Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical University

Globally, there has been a marked escalation in tumor morbidity and mortality,cementing tumors as the predominant cause of death in numerous *** the current tumor burden across various regions is imperative to discern potential risk factors and formulate efficacious strategies for tumor ***, the International Agency for Research on Cancer(IARC) provided a status report on the global tumor burden,estimating the incidence and mortality of 36 cancers in 185 countries(Bray et al.,2024).

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si Rna knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity

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Science China(life Sciences) 2021年第7期64卷 1077-1086页

作者： Ya-na guan Yue li Moom Roosan Qing Jing Shanghai Jiao Tong University School of Medicine(SJTUSM)&CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of Sciences(CAS)Shanghai 200031China Chapman University IrvineCA 92618USA

Mural cells(MCs)wrap around the endothelium,and participate in the development and homeostasis of *** have been reported as heterogeneous population morphologically and ***,the transcriptional heterogeneity of MCs was rarely *** this study,we illustrated the transcriptional heterogeneity of MCs with different perspectives by using publicly available single-cell dataset ***,MCs are transcriptionally different from other cell types,and ligand-receptor interactions of different cells with MCs ***-clustering of MCs identified five distinct *** heterogeneity of MCs in tissues was reflected by MC coverage,various distribution of MC subclusters,and ligand-receptor interactions of MCs and parenchymal *** transcriptomic diversity of MCs revealed in this article will help facilitate further research into MCs.

关键词： mural cells single-cell analysis heterogeneity

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