Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment

作     者：Chao Ren Yong-Qiang Ji Hong Liu Zhe Wang Jia-Hui Wang Cai-Yi Zhang Li-Na Guan Pei-Yuan Yin 

作者机构：Department of Neurology and Suzhou Clinical Research Center of Neurological Diseasethe Second Affiliated Hospital of Soochow University Department of NeurologyAffiliated Yantai Yuhuangding Hospital of Qingdao University Department of NephrologyAffiliated Yantai Yuhuangding Hospital of Qingdao University Department of Clinical LaboratoryAffiliated Yantai Yuhuangding Hospital of Qingdao University Department of Central LaboratoryAffiliated Yantai Yuhuangding Hospital of Qingdao University Department of Emergency and Rescue MedicineXuzhou Medical University Department of Neurosurgical Intensive Care Unitthe Affiliated Yantai Yuhuangding Hospital of Qingdao University Department of Blood SupplyYantai Center Blood Station 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第7期

页      面：1152-1157页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China,No.81501185(to CR) the Key Research&Development Project of Shandong Province of China,No.2017GSF218043(to CR) the Science and Technology Planning Project of Yantai of China,No.2016WS017(to LNG),2017WS105(to HL) 

主　　题：nerve regeneration Ginkgo biloba extract Ginkgolide B traditional Chinese medicine stem cells induction of differentiation stem cell transplantation synaptic plasticity pharmacological effect neurological diseases nervous systems neural regeneration 

摘      要：Stem cell transplantation has brought new hope for the treatment of neurological *** key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve *** the differentiation of stem cells in vitro and in vivo is affected by multiple factors,the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are ***,the optimal microenvironment for inducing stem cell differentiation is a hot ***761 is extracted from the leaves of the Ginkgo biloba *** is used worldwide and is becoming one of the focuses of stem cell *** have shown that EGb761 can antagonize oxygen free radicals,stabilize cell membranes,promote neurogenesis and synaptogenesis,increase the level of brain-derived neurotrophic factors,and replicate the environment required during the differentiation of stem cells into nerve *** offers the possibility of using EGb761 to induce the differentiation of stem cells,facilitating stem cell *** provide a comprehensive reference for the future application of EGb761 in stem cell therapy,we reviewed studies investigating the influence of EGb761 on stem *** started with the composition and neuropharmacology of EGb761,and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial microenvironment for stem cell transplantation.