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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang min ming li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng Ma Chuanlei zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-Ke Tu min li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong liang Weipeng li Chengjian zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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基于linux的网络信息内容分析与监管技术

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计算机科学 2003年第4期30卷 67-69,75页

作者：李方敏周祖德刘泉武汉理工大学信息工程学院

With the development of computer network, network security has become a very Important problem that must be solved by us. A distributed and layered skeleton has been presented, which can be deployed over all the country easily. The monitor and management system can recognize the illegal information and automatically take action according the analysis result. As a sample, an illegal VPN(Virtual Private Network) monitor and management system have been implemented based on linux, which can dynamically find illegal IPSec tunnels and then filter them.

关键词：计算机网络网络安全信息安全 linux 网络信息内容分析监管技术

保护动机干预模式对腰椎间盘突出症患者预后及生活质量的影响

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国际护理学杂志 2017年第3期36卷 371-374页

作者：张玲张筝李敏祝艳红徐州医学院附属医院江苏徐州221000

目的探讨保护动机干预模式对腰椎间盘突出症患者预后及生活质量的影响。方法2014年1月至2015年1月选取本院经手术治疗后的腰椎间盘突出症患者120例为研究对象，根据抽签法将患者分为观察组（n=60）及对照组（n：60）。住院期间对照组应... 详细信息

目的探讨保护动机干预模式对腰椎间盘突出症患者预后及生活质量的影响。方法2014年1月至2015年1月选取本院经手术治疗后的腰椎间盘突出症患者120例为研究对象，根据抽签法将患者分为观察组（n=60）及对照组（n：60）。住院期间对照组应用常规性护理，观察组应用保护动机干预模式实施护理。出院后随访6个月，对比分析两组干预前后功能障碍指数评分（ODI）、腰椎间盘突出症知识评分及生活质量评分。结果观察组干预1个月、3个月、6个月时ODI评分显著高于对照组（P〈0．05）。观察组干预6个月后运动知识、疾病知识、康复护理知识、日常生活知识、饮食知识及总评分均高于对照组（P〈0．05）。观察组干预后总体健康、心理功能、生理职能、社会功能、健康精神、情感职能等方面评分显著高于对照组（P〈0．05）。结论保护动机干预模式能有效提高腰椎间盘突出症患者疾病知识，改善患者胸椎功能，进而提高患者生活质量。

关键词：保护动机干预模式腰椎间盘突出症预后生活质量

漠河盆地南缘塔木兰沟组火山岩锆石U-Pb定年、地球化学特征及其地质意义

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地质与资源 2015年第6期24卷 526-531页

作者：李伫民石绍山李愈华王宇利时建民江山吉林大学地球科学学院吉林长春130061 中国地质调查局沈阳地质调查中心(沈阳地质矿产研究所) 辽宁沈阳110034 中国地质大学地球科学与资源学院北京100083

对大兴安岭北段漠河盆地南缘的塔木兰沟组玄武安山岩进行锆石LA-ICP-MS U-Pb定年以及岩石地球化学研究,以便限定其形成时代以及火山活动和漠河断陷盆地演化之间的关系.测年结果显示该地区塔木兰沟组玄武安山岩的形成时代为129~147 Ma,... 详细信息

对大兴安岭北段漠河盆地南缘的塔木兰沟组玄武安山岩进行锆石LA-ICP-MS U-Pb定年以及岩石地球化学研究,以便限定其形成时代以及火山活动和漠河断陷盆地演化之间的关系.测年结果显示该地区塔木兰沟组玄武安山岩的形成时代为129~147 Ma,为早白垩世早期.塔木兰沟组火山岩主要为高钾钙碱性火山岩系列,具有富集大离子亲石元素（liLE）和轻稀土元素（LREE）,亏损高场强元素（HFSE）的特征.岩浆源区为富集型地幔源区,上升过程中可能受上地壳物质混染.地球化学特征及构造背景显示,研究区塔木兰沟组火山岩形成于大陆板内拉张环境,与中生代漠河盆地断陷构造有关.

关键词：塔木兰沟组火山岩 U-Pb锆石定年地球化学大兴安岭北段漠河盆地

腹腔CT影像学检查在腹膜透析相关非感染性腹腔并发症中的诊断价值

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中西医结合学报 2008年第5期6卷 478-481页

作者：王琴倪兆慧朱铭力牟姗曹励欧方炜上海交通大学医学院仁济医院肾脏科上海200127

目的:初步探讨腹腔CT影像学检查在诊断持续性非卧床腹膜透析(continuous ambulatory peritoneal dialy-sis,CAPD)患者非感染性腹腔并发症中的应用价值。方法:前瞻性地对2005年至2007年间在我院进行CAPD治疗且临床高度怀疑为透析相关非... 详细信息

目的:初步探讨腹腔CT影像学检查在诊断持续性非卧床腹膜透析(continuous ambulatory peritoneal dialy-sis,CAPD)患者非感染性腹腔并发症中的应用价值。方法:前瞻性地对2005年至2007年间在我院进行CAPD治疗且临床高度怀疑为透析相关非感染性腹腔并发症的患者进行腹腔CT影像学检查。结合临床资料,综合分析患者是否存在腹腔渗漏、疝气、局部腹透液的聚集和大网膜包裹等情况,评估腹腔CT影像学检查的应用价值。结果:腹腔CT造影检查发现,11例CAPD患者中有9例出现异常情况,其中包括腹股沟疝气3例,睾丸鞘膜积液1例,脐疝1例,导管出口处渗漏2例,大网膜包裹2例;其中8例(腹股沟疝气2例,睾丸鞘膜积液1例,脐疝1例,导管出口处渗漏2例,大网膜包裹2例)有手术条件的患者经过手术均得到证实。结论:在一些存在可疑腹膜透析相关非感染性腹腔并发症的CAPD患者中,腹腔CT影像学检查可能是一种无创、可靠且灵敏度较高的检查技术,操作简便易行,有助于明确诊断,值得进一步研究。

关键词：腹腔体层摄影术 X线计算机腹膜透析持续不卧床

Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can zhu Yiyang Wang Lei Meng Beibei Qiu Jing li Shucheng Qin Ke Hu Xin Jiang Wenbin Lai minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： zhuozhou Xie zhu zhuo Zi-Ang Nan Qing li Xiufang li Zi-Xiu Lu linzhe Lü Jin liu Luyao liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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