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Journal of Electronic Science and Technology 2024年第2期22卷 16-23页

作者： Cheng-Wei Zhang Zhi-Qin Zhao Wei Yang li-lai zhou Hai-Yu Zhu Southwest China Institute of Electronic Technology Chengdu610036China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Tencent Company Shenzhen518054China

Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is *** the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing ***,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing *** using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as *** is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.

关键词： Multi graphics processing unit Radar imaging Sea-ship Shooting and bouncing rays

In Situ Coupling of Highly Dispersed Ni/Fe Metal-NC Sites and N-Doped 3D Carbon Fibers Toward Free-Standing Bifunctional Cathode for Flexible Zinc-Air Battery

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Energy & Environmental Materials 2024年第1期7卷 121-130页

作者： Chenglong lai Mengjun li Yi Shen Min zhou Wei Wang Kai Jiang Haomiao li Kangli Wang State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhanHubei 430074China Engineering Research Center of Power Safety and Efficiency Ministry of EducationWuhanHubei 430074China

Designing flexible free-standing air-electrode with efficient OER/ORR performance is of vital importance for the application of Zinc-air batteries in flexible ***,a flexible free-standing electrode(Ni/Fe-NC/NCF/CC)is synthesized by in-situ coupling of binary Ni/Fe-NC nanocubes and N-doped carbon nanofibers(NCF)rooted on carbon *** highly dispersed binary Ni/Fe-NC sites ensure excellent ORR activity and create efficient OER active sites relative to Ni-NC and *** in-situ coupling of Ni/Fe-NC and NCF constructs a 3D interconnected network structure that not only provides abundant and stabilized reactive sites but also guarantees fast electron transfer and gas transportation,thus achieving efficient and fast operation of ORR/***,Ni/Fe-NC/NCF/CC displays a much positive potential(0.952 V)at 4.0 mA cm^(-2)for ORR and a low OER overpotential(310 mV)at 50 mA cm^(-2).The Zinc-air battery with Ni/Fe-NC/NCF/CC air-electrode exhibits excellent battery performance with outstanding discharge/charge durability for 2150 *** flexible Zn-air batteries with foldable mechanical properties display a high power density of 105.0 mW cm^(-2).This work widened the way to prepare flexible bifunctional air-electrode by designing composition/structure and in-situ coupling.

关键词： binary Ni/Fe-NC sites in-situ coupling synergistic catalytic effect Zn-air battery

Genome-edited rabbits:Unleashing the potential of a promising experimental animal model across diverse diseases

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Zoological Research 2024年第2期45卷 253-262页

作者： Yang Han Jiale zhou Renquan Zhang Yuru liang liangxue lai Zhanjun li Key Laboratory of Zoonosis Research Ministry of EducationCollege of Animal ScienceJilin UniversityChangchunJilin 130062China CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineSouth China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdong 510530China Guangzhou Regenerative Medicine and Health Guang Dong Laboratory(GRMH-GDL) GuangzhouGuangdong 510005China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Animal models are extensively used in all aspects of biomedical research,with substantial contributions to our understanding of diseases,the development of pharmaceuticals,and the exploration of gene *** field of genome modification in rabbits has progressed ***,recent advancements,particularly in CRISPR/Cas9-related technologies,have catalyzed the successful development of various genome-edited rabbit models to mimic diverse diseases,including cardiovascular disorders,immunodeficiencies,agingrelated ailments,neurological diseases,and ophthalmic *** models hold great promise in advancing biomedical research due to their closer physiological and biochemical resemblance to humans compared to *** review aims to summarize the novel gene-editing approaches currently available for rabbits and present the applications and prospects of such models in biomedicine,underscoring their impact and future potential in translational medicine.

关键词： Genome editing Animal model Rabbit CRISPR/Cas9 Genetic diseases

Research on the technical scheme of multi-stack common rail fuel cell engine based on the demand of commercial vehicle

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Energy and AI 2024年第2期16卷 241-255页

作者： Bo li Qianya Xie Jun li Ziliang Zhao Junming lai Kang li Fojin zhou Wuhan University of Technology Automotive Engineering CollegeWuhan430070China National energy key laboratory for new hydrogen-ammonia energy technologies Foshan Xianhu LaboratoryFoshan528200China Tsinghua University Beijing266590China Shandong University of Science and Technology Qingdao266590China

At present,most fuel cell engines are single-stack systems,and high-power single-stack systems have bottlenecks in meeting the power requirements of heavy-duty trucks,mainly because the increase in the single active area and the excessive number of cells will lead to poor distribution uniformity of water,gas and heat in the stack,which will cause local attenuation and reduce the performance of the *** paper introduces the design concept of internal combustion engine,takes three-stack fuel cell engine as an example,designs multi-stack fuel cell system scheme and serialized high-voltage *** Intelligent control technology of independent hydrogen injection based on multi-stack coupling,the hydrogen injection inflow of each stack is controlled online according to the real-time anode pressure to achieve accurate fuel injection of a single stack and ensure the consistency between multiple *** the performance advantage of multi-stack fuel cell engine through theoretical design,intelligent control and test verification,and focuses on analyzing the key technical problems that may exist in multi-stack *** research results provide a reference for the design of multi-stack fuel cell engines,and have important reference value for the powertrain design of long-distance heavy-duty and high-power fuel cell trucks.

关键词： Heavy truck Multi-stack Fuel cell engine Three stack Performance Consistency

Micromechanism and mathematical model of stress sensitivity in tight reservoirs of binary granular medium

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Petroleum Science 2024年第3期21卷 1780-1795页

作者： Jian-Bang Wu Sheng-lai Yang Qiang li Kun Yang Can Huang Dao-Ping Lv Wei zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China Laboratoire de G eologie Ecole Normale Sup erieure/CNRS UMR8538PSL Research UniversityParis75005France Research Institute of Exploration and Development Xinjiang Oilfield CompanyKaramay834000XinjiangChina

Research on reservoir rock stress sensitivity has traditionally focused on unary granular structures,neglecting the binary nature of real reservoirs,especially tight *** the stresssensitive behavior and mathematical characterization of binary granular media remains a challenging *** this study,we conducted online-NMR experiments to investigate the permeability and porosity evolution as well as stress-sensitive control mechanisms in tight sandy conglomerate *** results revealed stress sensitivity coefficients between 0.042 and 0.098 and permeability damage rates ranging from 65.6%to 90.9%,with an average pore compression coefficient of 0.0168—0.0208 MPa ***-scale compression occurred in three stages:filling,compression,and compaction,with matrix pores playing a dominant role in pore *** stress sensitivity of binary granular media was found to be influenced by the support structure and particle *** stress sensitivity was associated with small fine particle size,high fines content,high uniformity coefficient of particle size,high plastic deformation,and low Young's ***-supported samples exhibited a high irreversible permeability damage rate(average=74.2%)and stress sensitivity coefficients(average=0.089),with pore spaces more *** contrast,grain-supported samples showed low stress sensitivity coefficients(average=0.021)at high stress *** on the experiments,we developed a mathematical model for stress sensitivity in binary granular media,considering binary granular properties and nested interactions using Hertz contact deformation and Poiseuille *** describing the change in activity content of fines under stress,we characterized the non-stationary state of compressive deformation in the binary granular structure and classified the reservoir into three *** model was applied for production prediction using actual data from the Mahu reservoir in China,showing that the e

关键词： Stress sensitivity Binary granular medium Tight reservoir Online-NMR Reservoir energy retention rate

Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities

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Synthetic and Systems Biotechnology 2024年第1期9卷 19-25页

作者： Sai Wan Mingchi lai Xinyu Gao Mingxin zhou Song Yang Qiang li Fuli li lin Xia Yang Tan Qingdao C1 Refinery Engineering Research Center Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101ShandongChina CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055China Shenzhen Powered Carbon Biotechnology Co. LtdShenzhen518055China School of life Sciences Qingdao Agricultural UniversityQingdao266109ShandongChina School of Biological Science and Technology University of JinanJinan250022ShandongChina

Excessive mining and utilization fossil fuels has led to drastic environmental consequences,which will contribute to global warming and cause further climate change with severe consequences for the human *** magnitude of these challenges requires several approaches to develop sustainable alternatives for chemicals and fuels *** this context,biological processes,mainly microbial fermentation,have gained particular *** example,autotrophic gas-fermenting acetogenic bacteria are capable of converting CO,CO_(2) and H_(2) into biomass and multiple metabolites through Wood-Ljungdahl pathway,which can be exploited for large-scale fermentation processes to sustainably produce bulk biochemicals and biofuels(*** and ethanol)from *** autoethanogenum is one representative of these chemoautotrophic bacteria and considered as the model for the gas ***,the development of synthetic biology toolbox for this strain has enabled us to study and genetically improve their metabolic capability in gas *** this review,we will summarize the recent progress involved in the understanding of physiological mechanism and strain engineering for ***,and provide our perspectives on the future development about the basic biology and engineering biology of this strain.

关键词： Genetic engineering Clostridium autoethanogenum Gas fermentation Carbon fixation Biofuel

Multiscale and Auto-Tuned Semi-Supervised Deep Subspace Clustering and Its Application in Brain Tumor Clustering

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Computers, Materials & Continua 2024年第6期79卷 4741-4762页

作者： Zhenyu Qian Yizhang Jiang zhou Hong lijun Huang Fengda li Khin Wee lai Kaijian Xia School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China Department of Medical Imaging The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Department of Neurosurgery The Changshu Affiliated Hospital of Soochow UniversityChangshu215500China Department of Scientific Research The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Changshu Key Laboratory of Medical Artificial Intelligence and Big Data Suzhou215500China Department of Biomedical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data,particularly in the field of medical *** deep subspace clustering algorithms,which are mostly unsupervised,are limited in their ability to effectively utilize the inherent prior knowledge in medical *** MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process,thereby enhancing the discriminative power of the feature ***,the multi-scale feature extraction mechanism is designed to adapt to the complexity of medical imaging data,resulting in more accurate clustering *** address the difficulty of hyperparameter selection in deep subspace clustering,this paper employs a Bayesian optimization algorithm for adaptive tuning of hyperparameters related to subspace clustering,prior knowledge constraints,and model loss *** experiments on standard clustering datasets,including ORL,Coil20,and Coil100,validate the effectiveness of the MAS-DSC *** results show that with its multi-scale network structure and Bayesian hyperparameter optimization,MAS-DSC achieves excellent clustering results on these ***,tests on a brain tumor dataset demonstrate the robustness of the algorithm and its ability to leverage prior knowledge for efficient feature extraction and enhanced clustering performance within a semi-supervised learning framework.

关键词： Deep subspace clustering multiscale network structure automatic hyperparameter tuning semi-supervised medical image clustering

Plasma membrane-anchored fluorescent tracker based on boron-dipyrromethene

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Chinese Journal of Chemical Engineering 2024年第8期72卷 220-225页

作者： Yucong Gong Xiangli li Daqing Ma lai Wang lin zhou Caiwei Lu Yi Xiao Xinfu Zhang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian 116024China China Academy of Safety Science and Technology Beijing 100012China

The construction of a stable-membrane tracker has significant implications for the visualization of the membrane in live ***,most current plasma trackers are not suitable for tracking plasma membranes for a long time due to their limited retention ***,Mem580-F-Sulfo is designed to target and anchor cell membranes and therefore track cell membranes for a longer *** tracker is composed of a lipophilic boron-dipyrromethene(BODIPY)derivative and a hydrophilic zwitterion to form an amphiphilic structure,which enables its targeting ability toward cell ***,a reactive ester group is included to bind with proteins through covalent bonds in cell membranes nonspecifically,which extends retention time in cell ***580-F-Sulfo shows intense brightness(94600),with a high molar absorption coefficient of up to about 100000 L·mol^(-1)·cm^(-1)and a fluorescence quantum yield of up to *** shows fast cell membrane targeting ability and long retention up to 90 *** brief,this work has not only developed a tracker with good cell membrane targetability but also provided a new strategy for improving the targeting stability of cell membranes.

关键词： Plasma membrane Protein Tracker Imaging Microstructure

Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： Qing Yang Qiang Cao Yue Yu Xianxin lai Jiahao Feng Xinjie li Yinan Jiang Yazhou Sun Zhong-Wei zhou Xin li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methylation and hydroxymethylation play important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly,could rescale the epigenetic landscape,potentially contributing to dysregulated gene expression during brain *** this study,we characterize and compare the DNA methylome/hydroxymethylome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-type(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hydroxymethylcytosine(5hmC)level,primarily in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently decreased expression are essential for neurodevelopment and brain ***,genes displaying a delayed accumulation of 5hmC in Mcph1-del mice are significantly associated with the establishment and maintenance of the nervous system during the adult *** findings reveal that aberrant cerebral cortex development in the early stages profoundly alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome Transcriptome

Interference-induced suppression of particle emission from a Bose-Einstein condensate in lattice with time-periodic modulations

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Chinese Physics B 2024年第10期33卷 153-158页

作者： Long-Quan lai Zhao li School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730China

Emission of matter-wave jets from a parametrically driven condensate has attracted significant experimental and theoretical attention due to the appealing visual effects and potential metrological *** this work,we investigate the collective particle emission from a Bose-Einstein condensate confined in a one-dimensional lattice with periodically modulated interparticle *** give the regimes for discrete modes,and find that the emission can be distinctly *** configuration induces a broad band,but few particles are ejected due to the interference of the matter *** further qualitatively model the emission process and demonstrate the short-time *** engineering provides a way to manipulate the propagation of particles and the corresponding dynamics of condensates in lattices,and may find application in the dynamical excitation control of other nonequilibrium problems with time-periodic driving.

关键词： Bose-Einstein condensate matter-wave jet periodic modulation