Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities
作者机构：Qingdao C1 Refinery Engineering Research CenterQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101ShandongChina CAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055China Shenzhen Powered Carbon Biotechnology Co.LtdShenzhen518055China School of Life SciencesQingdao Agricultural UniversityQingdao266109ShandongChina School of Biological Science and TechnologyUniversity of JinanJinan250022ShandongChina
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2024年第9卷第1期
页 面：19-25页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学]
基 金：supported by the Shenzhen Science and Technology Program(Grant No.JCYJ20210324101014036)
主 题：Genetic engineering Clostridium autoethanogenum Gas fermentation Carbon fixation Biofuel
摘 要：Excessive mining and utilization fossil fuels has led to drastic environmental consequences,which will contribute to global warming and cause further climate change with severe consequences for the human *** magnitude of these challenges requires several approaches to develop sustainable alternatives for chemicals and fuels *** this context,biological processes,mainly microbial fermentation,have gained particular *** example,autotrophic gas-fermenting acetogenic bacteria are capable of converting CO,CO_(2) and H_(2) into biomass and multiple metabolites through Wood-Ljungdahl pathway,which can be exploited for large-scale fermentation processes to sustainably produce bulk biochemicals and biofuels(*** and ethanol)from *** autoethanogenum is one representative of these chemoautotrophic bacteria and considered as the model for the gas ***,the development of synthetic biology toolbox for this strain has enabled us to study and genetically improve their metabolic capability in gas *** this review,we will summarize the recent progress involved in the understanding of physiological mechanism and strain engineering for ***,and provide our perspectives on the future development about the basic biology and engineering biology of this strain.
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