检索结果-南通市图书馆

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

引用

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu li-fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Configuration Reversion of the Metal Chelates of N-hydroxyethyl Ethylenediaminetriacetic Acid——Dynamic NMR Study

引用

Chemical Research in Chinese Universities 1992年第2期8卷 129-131页

作者： li fei, song Rui-fang and li liang (Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)

The intramolecular acetate rearrangement of the aminocarboxylate metal chelates with the hexdentate-coordinate has been investigated by dynamic NMR in recent years. However, the intramolecular processes of the metal q... 详细信息

关键词： Intramolecular rearrangement Mechanism Dynamic NMR Metal che-late Quinquedentate HEDTA ligand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constraints on holographic QCD phase transitions from PTA observations

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： fei-Yu Zhao Guo-Wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epigenetic regulation of the inflammatory response in stroke

引用

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical Characteristics and Prognosis of Peri-strut Low-intensity Area Detected by Optical Coherence Tomography

引用

Chinese Medical Journal 2015年第23期128卷 3132-3137页

作者： De-Wei Wu Meng-Yue Yu Hai-Yang Gao Zhe He Jing Yao Cheng Ding Bo Xu li Zhang fei song Qing-Rong liu Yong-Jian Wu Coronary Heart Disease Center State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Peri-strut low-intensity area （PliA） is a typical image pattern ofneointima detected by optical coherence tomography （OCT） after stent implantation. However, few studies evaluated the predictors and prognosis of the PliA; therefore, we aimed to explore the genesis and prognosis of PliA detected by OCT in this study.Methods： Patients presenting neointimal hyperplasia documented by OCT reexamination after percutaneous coronary intervention were prospectively included from 2009 to 2011. Peri-strut intensity was analyzed and classified into two patterns： Low-intensity and high-intensity. Clinical characteristics were analyzed to assess their contribution to peri-strut intensity patterns. Follow-up were performed in patients who did not receive revascularization during OCT reexamination, and the prognosis of the patients was evaluated.Results： There were 128 patients underwent OCT reexamination after stent implantation included in the study. PliA was detected in 22 （17.2%） patients. The incidence of PliA was positively correlated with serum triglyceride （odds ratio [OR]： 2.11, 95% confidence interval [CI]： 1.14-3.90, P = 0.017）, low-density lipoprotein （OR： 2.61, 95% CI： 1.22-5.66, P = 0.015）, history of cerebrovascular disease （OR： 101.11, 95% CI： 6.54-1562.13, P 〈 0.001）, and initial clinical presentation of acute coronary syndrome （ACS, OR： 18.77, 95% CI： 2.73-128.83, P = 0.003） while negatively correlated with stent implantation time （OR： 0.57, 95% CI： 0.33-0.98, P = 0.043）. The median follow-up was longer than 3.8 years. Major adverse cardiovascular events （MACEs） occurred in 7 （7.3%） patients while showed no correlation with PliA. A total of 17 （17.7%） patients experienced unstable angina （UA） and showed significant correlation with PliA （hazard ratio： 6.16, 95% CI： 1.25-30.33, P = 0.025）.Conclusions： PliA detected by OCT was positively correlated with higher serum lipid level, history ofcerebrovascular disease and initial presentation of ACS, and

关键词： Optical Coherence Tomography Peri-strut Low-intensity Area Unstable Angina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

N掺杂MgZnO薄膜的p型导电稳定性研究

引用

液晶与显示 2015年第6期30卷 925-929页

作者：高丽丽李淞菲曹天福张雪北华大学物理学院吉林吉林132013

利用磁控溅射技术,以Mg0.06Zn0.94O为陶瓷靶材,制备了N掺杂p型Mg0.1 3Zn0.8 7O薄膜,薄膜的电阻率为42.45Ω·cm,载流子浓度为3.70×1017/cm3,迁移率为0.40cm2·V-1·s-1。研究了该薄膜p型导电性质在室温空气下随时间的变化情况。实验结... 详细信息

利用磁控溅射技术,以Mg0.06Zn0.94O为陶瓷靶材,制备了N掺杂p型Mg0.1 3Zn0.8 7O薄膜,薄膜的电阻率为42.45Ω·cm,载流子浓度为3.70×1017/cm3,迁移率为0.40cm2·V-1·s-1。研究了该薄膜p型导电性质在室温空气下随时间的变化情况。实验结果表明,薄膜的电阻率逐渐升高,载流子浓度降低,五个月以后,薄膜转变为n型导电,电阻率为85.58Ω·cm,载流子浓度为4.53×1016/cm3,迁移率为1.61cm2·V-1·s-1。真空热退火后重新转变为p型。结果显示,其p型导电类型的转变与在空气中吸附H2O或H2等形成浅施主有关。

关键词：射频磁控溅射 MgZnO薄膜 p型稳定性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene expression profiling and bioinformatic analysis of rat sciatic nerve injury in Wallerian degeneration

Gene expression profiling and bioinformatic analysis of rat ...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Deng-Bing YAO,Mei-Yuan li,fei DING,Xiao-song GU~* Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Nantong 226001,China

＜正＞Objective Wallerian degeneration（WD） is still a subject of modern *** occurs in peripheral nervous system（PNS） which is a process that nerve fiber is cut or *** is also known as anterograde degeneration,or orthograde degeneration,or secondary *** WD,the distal axons begins degeneration and macrophages enter the distal axons area to remove the myelin and axonal debris of *** cells,accompanied by Schwann cells clear the debris from the *** is rapid and supported by Schwann cells through growth factors release of a lesion follows degeneration in PNS.A large number of genes are differentially regulated during the stages of WD in the development and pathology of WD in the peripheral nerve injury initiating these responses has remained largely *** In this study,we analyzed gene expression patterns of short-term（0,0.5,1,6,12,24 h） and long-term（0,1,4,7,14,21,28 d） series carrying the WD of the distal nerve stump after rat sciatic nerve injury using gene chip *** of differential genes;analysis of gene expression trends;Gene Ontology（GO）,Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway and signal-flow analysis;real-time PCR,Western blot and *** GO classification indicated enrichment in genes related to cell adhesion,extracellular matrix,microglial cell activation,positive regulation of synaptic plasticity,positive regulation of chemokine production,positive regulation of acute inflammatory response, nerve development and positive regulation of neuron differentiation,*** pathway analysis showed high expression of genes relating to T cell receptor signaling pathway,Jak-STAT signaling pathway,apoptosis, cytokine-cytokine receptor interaction,toll-like receptor signaling pathway and p53 signaling *** data were validated with real-time PCR,Western blot,and *** These results will help to much better underst

关键词： Wallerian degeneration sciatic nerve microarrays expression profiling rat

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

高剂量氨基酸和脂肪乳肠外营养对合并感染的早产患儿营养状况的影响研究

引用

中华医院感染学杂志 2017年第5期27卷 1159-1162页

作者：曹献云李岩剧松丽宋菲徐雁郑州大学附属南阳市中心医院儿科河南南阳473009

目的探究不同肠外营养方式对其营养状况的临床实际影响,为早产合并感染患儿的临床研究实践提供借鉴和参考。方法选取2013年12月-2015年12月收治的早产合并感染患儿88例,根据肠外营养的方式不同将患儿分成高剂量组和低剂量组,各44例;以... 详细信息

目的探究不同肠外营养方式对其营养状况的临床实际影响,为早产合并感染患儿的临床研究实践提供借鉴和参考。方法选取2013年12月-2015年12月收治的早产合并感染患儿88例,根据肠外营养的方式不同将患儿分成高剂量组和低剂量组,各44例;以两组患儿的住院时间、恢复出生体质量时间、恢复出生体质量后体质量增长、肠外营养时间、出院体质量以及并发症发生情况等为观察指标。结果高剂量组患儿住院时间、恢复出生体质量时间和肠外营养时间分别为(12.43±2.51)d、(6.41±1.41)d和(7.41±1.11)d,明显少于低剂量组(14.98±3.49)d、(10.18±3.02)d和(10.29±3.20)d;高剂量组恢复出生体质量后体质量增长情况和出院体质量分别为(28.71±2.51)g/kg/d和(2066.43±244.32)g,明显高于低剂量组(17.02±4.32)g/kg/d和(1901.23±300.21)g;高剂量组和低剂量组患儿并发症发生率分别为0.00%和11.36%,差异有统计学意义(P<0.05)。结论在给予患儿抗菌药物治疗的基础上,采用高剂量氨基酸和脂肪乳的肠外营养方式可以显著改善早产合并感染患儿的营养状况,提升临床的综合治疗效果。

关键词：早产合并感染高剂量氨基酸脂肪乳肠外营养营养状况

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

大熊猫胃肠道中消化酶活力的分析

引用

四川动物 2009年第3期28卷 397-400页

作者：郑玉才费立松李峰牛李丽张志和西南民族大学生命科学与技术学院成都610041 成都大熊猫繁育研究基地成都动物园

为了研究大熊猫对食物的化学性消化特点和机制,测定了9只大熊猫唾液和3只大熊猫胃肠道中主要消化酶的活力,并与其他动物进行了比较。结果显示,大熊猫唾液呈碱性,蛋白酶和淀粉酶等消化酶活力低;肠道中淀粉酶活力高,而脂肪酶活力明显低于... 详细信息

为了研究大熊猫对食物的化学性消化特点和机制,测定了9只大熊猫唾液和3只大熊猫胃肠道中主要消化酶的活力,并与其他动物进行了比较。结果显示,大熊猫唾液呈碱性,蛋白酶和淀粉酶等消化酶活力低;肠道中淀粉酶活力高,而脂肪酶活力明显低于棕熊。大熊猫小肠粘膜中存在显著量的蔗糖酶、乳糖酶和麦芽糖酶活力。另外,在1只大熊猫胃和直肠液中检测到了少量纤维素酶活力。研究结果提示,大熊猫唾液直接参与食物消化的作用可能很弱;大熊猫对淀粉类食物有很好的消化能力,但对脂肪类食物消化能力相对不高。大熊猫胃肠道消化酶的活力特点适应其消化天然食物中的营养物质。

关键词：大熊猫胃肠道消化酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：