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Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/m TOR Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 251-259页

作者： YAO Jun-peng FENG Xiu-mei WANG Lu li yan-qiu ZHU Zi-yue yan Xiang-yun yanG Yu-qing li Ying ZHANG Wei Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Rehabilitation Medicine Guanghan People’s HospitalGuanghanSichuan Province618399China Academic Affairs Office Chengdu University of Traditional Chinese MedicineChengdu611137China

Objective:To explore the mechanism of electroacupuncture(EA) in promoting recovery of the facial function with the involvement of autophagy,glial cell line-derived neurotrophic factor(GDNF),and phosphatidylinositol-3-kinase(PI3K)/mammalian target of rapamycin(mTOR) signaling ***:Seventy-two male Sprague-Dawley rats were randomly allocated into the control,sham-operated,facial nerve injury(FNI),EA,EA+3-methyladenine(3-MA),and EA+GDNF antagonist groups using a random number table,with 12 rats in each *** FNI rat model was established with facial nerve crushing *** intervention was conducted at Dicang(ST 4),Jiache(ST 6),Yifeng(SJ 17),and Hegu(li 4) acupoints for 2 *** Simone’s 10-Point Scale was utilized to monitor the recovery of facial *** histopathological evaluation of facial nerves was performed using hematoxylin-eosin(HE) *** levels of Beclin-1,light chain 3(LC3),and P62 were detected by immunohistochemistry(IHC),immunofluorescence,and reverse transcriptionpolymerase chain reaction,***,IHC was also used to detect the levels of GDNF,Rai,PI3K,and ***:The facial functional scores were significantly increased in the EA group than the FNI group(Plin sheaths,which were destroyed immediately after the injury,were recovered with EA *** expressions of Beclin-1 and LC3 were significantly elevated and the expression of P62 was markedly reduced in FNI rats(P<0.01);however,EA treatment reversed these abnormal changes(P<0.01).Meanwhile,EA stimulation significantly increased the levels of GDNF,Rai,PI3K,and mTOR(P<0.01).After exogenous administration with autophagy inhibitor 3-MA or GDNF antagonist,the repair effect of EA on facial function was attenuated(P<0.05 or P<0.01).Conclusions:EA could promote the recovery of facial function and repair the facial nerve damages in a rat model of *** may exert this neuroreparative effect through

关键词： electroacupuncture facial nerve injury autophagy glial cell line-derived neurotrophic factor phosphatidylinositol-3-kinase/mammalian target of rapamycin Chinese medicine

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Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm

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Chinese Journal of Integrative Medicine 2024年第11期30卷 993-1000页

作者： XU Yu-ying li qiu-yan YI Dan-hui CHEN Yue ZHAI Jia-wei ZHANG Tong SUN ling-yun yanG Yu-fei Department of Oncology Xiyuan Hospital China Academy of Chinese Medical Sciences School of Statistics Renmin University of China Graduate School Beijing University of Chinese Medicine

Objective: To establish the dynamic treatment strategy of Chinese medicine(CM) for metastatic colorectal cancer(m CRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for m CRC. Methods: From the outpatient cases of m CRC in the Department of Oncology at Xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment(CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment(CM combined with intravenous regimen of Western medicine). The survival time of patients undergoing CM intervention was taken as the final evaluation index. Factors affecting the choice of CM intervention scheme were screened as decision variables. The dynamic CM intervention and treatment strategy for m CRC was explored based on the cost-sensitive classification learning algorithm for survival(CSCLSurv). Patients' survival was estimated using the Kaplan-Meier method, and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment plan. Results: Using the survival time of patients undergoing CM intervention as the evaluation index, a dynamic CM intervention therapy strategy for m CRC was established based on *** CM intervention strategies for m CRC can be selected according to dynamic decision variables, such as gender, age, Eastern Cooperative Oncology Group score, tumor site, metastatic site, genotyping, and the stage of Western medicine treatment at the patient's first visit. The median survival time of patients who received the modelrecommended treatment plan was 35 months, while those who receive the actual treatment plan was 26.0 months(P=0.06). Conclusions:

关键词： Chinese medicine cost sensitive classification learning for survival dynamic treatment strategy metastatic colorectal cancer

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机械敏感性离子通道Piezo在消化系统疾病中的作用

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生物化学与生物物理进展 2024年第8期51卷 1883-1894页

作者：王司琦鄢香芸李艳秋罗芳丽姚俊鹏马沛涛侯雨君秦海燕石云舟李瑛成都中医药大学针灸推拿学院成都610075

Piezo蛋白是一种非选择性机械敏感性阳离子通道,能够响应压力、剪切应力等机械刺激,将机械信号转化为胞内的生物电活动,引起特定的生物学效应。在消化系统中,Piezo有助于维持消化吸收、物质代谢和免疫调节等正常生理活动,但Piezo的异常... 详细信息

Piezo蛋白是一种非选择性机械敏感性阳离子通道,能够响应压力、剪切应力等机械刺激,将机械信号转化为胞内的生物电活动,引起特定的生物学效应。在消化系统中,Piezo有助于维持消化吸收、物质代谢和免疫调节等正常生理活动,但Piezo的异常状态能够促进内脏高敏感、肠黏膜屏障功能障碍、免疫炎症等多个病理环节,参与消化系统疾病的发生发展。故本文对Piezo蛋白的结构、生理特性,及其在消化系统肿瘤、炎性疾病、纤维化疾病和功能性疾病中的作用进行综述,以期为消化系统疾病的机制研究和潜在治疗靶点的探索提供新的思路。

关键词： Piezo 消化系统疾病机械敏感性离子通道

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针刺治疗功能性便秘的机制研究进展

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针刺研究 2024年第1期49卷 79-87页

作者：李艳秋姚俊鹏鄢香芸杨婉卿陈敏唐太春李瑛成都中医药大学针灸推拿学院成都610075 成都中医药大学附属医院成都610075

针刺治疗功能性便秘(FC)疗效确切,具有早期起效迅速、远期疗效稳定和整体性调节的特点。本文检索并总结近年来针刺治疗FC的相关文献,结果显示针刺能从促进肠道动力、调节肠道菌群、调节脑-肠轴、减轻肠道炎性反应、改善直肠低敏感性等... 详细信息

针刺治疗功能性便秘(FC)疗效确切,具有早期起效迅速、远期疗效稳定和整体性调节的特点。本文检索并总结近年来针刺治疗FC的相关文献,结果显示针刺能从促进肠道动力、调节肠道菌群、调节脑-肠轴、减轻肠道炎性反应、改善直肠低敏感性等多角度、多途径发挥作用。未来研究可深入挖掘针刺改善直肠低敏感性的机械传感机制、明确针刺调控的关键肠道菌属及代谢特征、探究不同作用机制间的网络关系,并阐明不同针刺治疗方案的效应差异机制,以期更好地优化临床治疗方案,提高针刺治疗FC的临床疗效。

关键词：功能性便秘针刺机制综述

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Adaptation of Nitraria sphaerocarpa to wind-blown sand environments at the edge of a desert oasis

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Journal of Environmental Sciences 2007年第4期19卷 482-487页

作者： li qiu-yan ZHAO Wen-zhi FANG Hai-yan Chinese Ecosystem Network Research linze Inland River Basin Research Station Laboratory of Hydrology and Applied Ecology Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China. Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

This study addresses the adaptation of Nitraria sphaerocarpa to blown sand at the edge of a desert oasis with regard to the aspects of soil seed banks, seedlings, and population. Horizontally, the total number of seeds per unit area decreased from the shrub canopy center to intershrub areas, and most seeds were found under shrub canopies. Vertically, the highest proportion of seeds was found at depths of 5-10 cm. The emergence percentage, seedling mass, and seedling height, which were significantly affected by both burial depth and seed size, were highest at the optimal burial depth of 2 cm, and decreased with increasing burial depth in each seed size-class. Although seedling mass was usually greatest for large seeds and least for small seeds at each burial depth, little difference was observed in seedling height at shallow burial depths of 0-3 cm. The population shows a patchy and discontinuous distribution pattern. Population height increases with increasing sand depth. Also the density increases with increasing depth of sand in the desert; however, there is a steady decrease when the depth of sand is more than 100 cm. This result indicates that the depth of sand that is most suitable for the growth of Nitraria sphaerocarpa is 100 cm. The size of the population is significantly correlated with the sand depth, which increases with increasing depth in the desert.

关键词： Nitraria sphaerocarpa soil seed bank seedling growth sand burial adaptation

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白音诺尔铅锌矿低碱选锌技术工业优化试验

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有色矿冶 2024年第1期40卷 25-27页

作者：第旺平李艳秋尹万里赤峰中色白音诺尔矿业有限公司内蒙古赤峰025473 铁岭选矿药剂有限公司辽宁铁岭112000

针对中色白音诺尔矿业有限公司选锌流程采用高碱度浮选工艺,选矿成本高,白灰用量大,导致泡沫发粘,影响选矿指标,回水pH值过高,影响循环使用等问题。研究在低碱条件下提高锌回收率的工艺和技术,实现资源高效利用同时提高了矿山经济效益... 详细信息

针对中色白音诺尔矿业有限公司选锌流程采用高碱度浮选工艺,选矿成本高,白灰用量大,导致泡沫发粘,影响选矿指标,回水pH值过高,影响循环使用等问题。研究在低碱条件下提高锌回收率的工艺和技术,实现资源高效利用同时提高了矿山经济效益。通过实验室试验和工业试验验证,形成了中色白矿低碱选锌的药剂制度。与高碱选锌药剂制度对比,选矿成本降低0.25元/t,锌精矿品位和回收率分别提高了4.24%和1.59%,并改善了充填系统溢流水回用水质,回水处理系统可以缓建或者不建,取得了明显的经济效益。

关键词：低碱选锌捕收剂 T-601 经济效益

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A new nonfullerene acceptor with an extended π conjugation core enables ternary organic solar cells approaching 19%efficiency

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Nano Research 2024年第5期17卷 4062-4068页

作者： Chunyan liu Nailiang qiu Zhengjin li yan Lu School of Materials Science and Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric DevicesMinistry of EducationTianjin University of TechnologyTianjin 300384China School of Chemistry Chemical Engineering and MaterialsJining UniversityQufu 273155China

In organic solar cells(OSCs),it is an effective way to improve the power conversion efficiency(PCE)by adding a guest component with appropriate absorption and energy levels in the host ***,a new nonfullerene acceptor(NFA)named TBF-2Cl was developed by the strategy of expanding theπconjugated core of 2,2’-(((4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b’]dithiophene-2,7-diyl)bis(methaneylylidene))bis(5,6-dichloro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(IDT-4Cl)with two benzene *** increase of benzene units,TBF-2Cl exhibits higher lowest unoccupied molecular orbital(LUMO)level of-3.75 eV than that of one benzene unit based NFA IDT-4Cl and fluorene core based NFA F-2Cl,which facilitates enhancing the open-circuit voltage(V_(oc))of ternary ***,TBF-2Cl film shows a medium optical bandgap with the absorption range from 500-800 nm,being well complementary with the wide bandgap polymer donor D18 and narrow bandgap NFA ***,a remarkable PCE of 18.92%with a high short-circuit current density(J_(sc))of 27.40 mA·cm^(-2),a fill factor(FF)of 0.749,especially an outstanding V_(oc) of 0.922 V was achieved for the optimal ternary device based on D18:TBF-2Cl:CH-6F,surpassing the binary counterpart(17.08%).The findings provide insight into the development of new guest acceptors for obtaining more efficient OSCs.

关键词： medium optical bandgap high lowest unoccupied molecular orbital(LUMO)level the third component ternary organic solar cell high open-circuit voltage

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Complete genome sequence of Bacillus thuringiensis Bt185, a potential soil insect biocontrol agent

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Journal of Integrative Agriculture 2017年第3期16卷 749-751页

作者： li yan-qiu SHU Chang-long SHAN Yue-ming GENG li-li SONG Fu-ping ZHANG Jie School of life Science Northeast Agricultural University State Key Laboratory of Biology for Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences

Bacillus thuringiensis Bt185 and its insecticidal spectrum-expanded engineering strains are considered as potential biocontrol agents to soil insect Holotrichia parallela,Holotrichia oblita or Anomala *** we reported ... 详细信息

关键词： Bacillus thuringiensis soil insect biocontrol agent

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Colorimetric Detection of Acid Phosphatase and Malathion Using NiCo_(2)O_(4)Nanosheets as Peroxidase-Mimicking Activity

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Journal of Analysis and Testing 2024年第2期8卷 170-179页

作者： Jia Chen Zerong Long yan li Hongdeng qiu Xinjiang Uygur Autonomous Product Quality Supervision and Inspection Institute Urumqi830000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The establishment of a low-cost and facile approach for the assay of acid phosphatase(ACP)and its inhibitor is a research *** this paper,we successfully synthesized NiCo_(2)O_(4)nanosheets with peroxidase-mimicking activity in alkaline deep eutectic solvents(DESs)composed of NaOH and PEG-200,which can catalyze 3,3',5,5'-tetramethylbenzidine(TMB)to the oxidation state TMB(ox-TMB)in the presence of *** to L-ascorbic acid-2-phosphate can be hydrolyzed into ascorbic acid by ACP,the peroxidase-like activity of NiCo_(2)O_(4)nanosheets is ***,the addition of malathion,an inhibitor of ACP,can inhibit the activity of ACP and thus limit the production of ascorbic acid(AA).Therefore,a colorimetric approach can be established for highly sensitive and selective detection of ACP and malathion with detection limits of 0.032 U/L and 0.65 nmol/L,*** importantly,this method can be successfully applied to malathion detection in environmental samples tap water and food cucumber juice,indicating that it has potential application prospects in environmental and agricultural fields.

关键词： NiCo_(2)O_(4)nanosheets Acid phosphatase Malathion Peroxidase-mimicking activity Colorimetric

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Generation of pigs with a Belgian Blue mutation in MSTN using CRISPR/Cpf1-assisted ssODN-mediated homologous recombination

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Journal of Integrative Agriculture 2019年第6期18卷 1329-1336页

作者： ZOU Yun-long li Zhi-yuan ZOU Yun-jing HAO Hai-yang HU Jia-xiang li Ning li qiu-yan State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest UniversityChongqing 400715P.R.China State Key Laboratory for Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100193P.R.China College of Veterinary Medicine China Agricultural UniversityBeijing 100193P.R.China

CRISPR/Cpf1 has emerged recently as an effective tool for genome editing in many organisms,but its use in pigs to generate precise genetic modifications has seldom been ***(MSTN)is a well-characterized negative regulator of muscle development,and natural mutations in this gene cause a double-muscled phenotype in many ***,to the best of our knowledge,no naturally occurring mutation in MSTN has been found in *** addition,no living pig models with sophisticated modifications orthologous to natural mutations in MSTN have yet been *** this study,we exploited the CRISPR/Cpf1 system to introduce a predefined modification orthologous to the natural MSTN mutation found in Belgian Blue cattle(thus known as the Belgian Blue mutation).Our research demonstrated that the cutting efficiency of CRISPR/Cpf1 was 12.3%in mixed porcine fetal fibroblasts in drug free medium,and 41.7%in clonal colonies obtained using G418 ***,the Cpf1-sgRNA vector,ssODN template,and a self-excision cassette were co-transfected into porcine fetal *** G418 selection,8 clonal colonies were examined and 5 with genetic modification were *** these 5,2 harbored the precise 11-bp *** 1 heterozygous clonal colony,2 cloned Duroc piglets were successfully generated,which was heterozygous for the Belgian Blue *** summary,our results demonstrate that CRISPR/Cpf1 system can be used efficiently to generate double-stranded breaks,and also to mediate homologous recombination to introduce precise genomic modifications in pigs.

关键词： MSTN CRISPR/Cpf1 Belgian Blue mutation genetically modified pigs single stranded oligodeoxynucleotide

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