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苝二酰亚胺共价有机框架超级还原剂用于高效光催化芳基卤化物还原反应

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Chinese Journal of Catalysis 2024年第2期57卷 171-183页

作者：金昱丞刘小琳曲琛李长骏王海龙詹晓宁曹昕怡李晓锋于宝秋张琪齐冬冬姜建壮北京科技大学化学系功能分子与晶态材料科学与应用北京市重点实验室北京材料基因组工程高级创新中心北京100083 北京化工大学材料科学与工程学院有机-无机复合材料国家重点实验室北京100029

自由基离子型分子光催化剂被证实是具有很强还原能力的可见光超级还原剂,它们在促进惰性的有机反应(例如将芳基卤化物还原为芳基自由基)方面具有突出的催化能力.然而,由于分子聚集严重地降低其催化活性,因而针对非均相超级还原剂的研究... 详细信息

自由基离子型分子光催化剂被证实是具有很强还原能力的可见光超级还原剂,它们在促进惰性的有机反应(例如将芳基卤化物还原为芳基自由基)方面具有突出的催化能力.然而,由于分子聚集严重地降低其催化活性,因而针对非均相超级还原剂的研究较少.本文提出了一种新的方法来解决上述问题,通过溶剂热反应将具有连续光诱导电子转移机制的苝二亚胺超级还原剂(PDI)异质化为二维给体-受体(D-A)共价有机框架(COFs).即以N,N'-双(3-戊基)-2,5,8,11-四(4-甲酰基苯基)苝二酰亚胺(TFPDI)与1,3,6,8-四(4-氨基苯基)芘\(Py-TA)或2,3,6,7-四(4-氨基基苯基)四硫富瓦烯(TTF-TA)为原料,通过溶剂热反应分别制备了两种高晶态二维D-A型COF结构:USTB-21和USTB-22,并用于芳基氯化物、芳基溴化物和芳基碘化物的光催化还原反应.X射线衍射和理论模拟结果表明,USTB-21和USTB-22具有二维共价键连接的层状结构,分别呈现AA和AB的堆积方式.在各自最佳反应条件下,COFs显示出与均相催化剂相媲美的可见光催化性能,可高效地还原一系列芳基氯化物、芳基溴化物和芳基碘化物.其中,USTB-22在可见光驱动不同的芳香卤化物还原时,3 h内的转化率高达99%.瞬态吸收光谱结果表明,相比于均相催化剂(N,N'-双(2,6-二异丙基苯基)苝二酰亚胺),自由基阴离子激发态寿命是150 ps,USTB-21和USTB-22具有更长的激发态寿命,分别为210和260 ps.顺磁共振波谱测试结果证明,自由基阴离子光催化剂异质化成晶态D-A型COFs能够有效地促进电荷分离效率和延长激发态寿命.上述结果说明,USTB-22具有良好的光催化性能主要是因为其激发态寿命较长以及电荷分离效率较好.理论模拟结果表明,所制备的材料具有D-A型的电子结构.对COF的模型片段进行理论计算,揭示了各步反应路径中吉布斯自由能的变化,从而进一步阐明了光催化机理.在催化反应过程中,芳基卤化物还原途径可分为两个阶段:第一阶段为双光子能量输入和光驱电子转移,包括光子捕获和(TTF-PDI•−)^(*)产生以及光驱动电子转移到4-溴苯乙酮底物;第二阶段为能量输出,用于还原4-溴苯乙酮底物生成苯乙酮.综上所述,本文通过溶剂热反应将具有连续光诱导电子转移机制的苝二亚胺超级还原剂异质化为二维D-A型COFs结构.该结构在芳基氯化物、芳基溴化物和芳基碘化物等的光催化还原反应中,可很好地促进电子从光催化剂转移到反应物,进而显著提高光催化反应的活性和选择性;本研究对于未来设计新型自由基离子型高效光催化剂提供了新的思路.

关键词：苝酰亚胺共价有机骨架光催化剂均相芳基卤化物的还原

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CAV1在消化道肿瘤中的研究进展

中国比较医学杂志 2024年第7期34卷 110-120页

作者：吴志航唐明政李晓凤荣耀崔岩潘海邦甘肃中医药大学第一临床医学院甘肃省中药新产品创制工程实验室甘肃省中医方药挖掘与创新转化重点实验室兰州730000

消化道肿瘤是目前全球最常见的癌症之一,包括食管癌、胃癌、肝癌、胰腺癌和结直肠癌等,其预后不佳,治疗方法仍需进一步改进。小窝蛋白-1(caveolin⁃1,CAV1)在消化道肿瘤中具有双重调节作用,既是肿瘤抑制因子又是致癌因子。CAV1对消化道... 详细信息

消化道肿瘤是目前全球最常见的癌症之一,包括食管癌、胃癌、肝癌、胰腺癌和结直肠癌等,其预后不佳,治疗方法仍需进一步改进。小窝蛋白-1(caveolin⁃1,CAV1)在消化道肿瘤中具有双重调节作用,既是肿瘤抑制因子又是致癌因子。CAV1对消化道肿瘤的细胞增殖、侵袭、转移、血管生成和药物耐受性等方面具有重要作用,调节CAV1蛋白及其相关信号通路可能成为治疗消化道肿瘤的策略之一。因此,本综述就CAV1的结构、功能、表达调控以及调节消化道肿瘤上皮-间充质转换(epithelial⁃mesenchymal transition,EMT)及其耐药性等方面分析CAV1与消化道肿瘤的关系,以期为临床消化道肿瘤的诊疗提供新的思路。

关键词： CAV1 消化道肿瘤 EMT 耐药

A multi-source information fusion layer counting method for penetration fuze based on TCN-LSTM

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Defence Technology（防务技术） 2024年第3期33卷 463-474页

作者： Yili Wang Changsheng li xiaofeng Wang Nanjing University of Science and Technology Nanjing 210094JiangsuChina State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of *** address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent *** leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration *** analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,*** model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target *** maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed ***,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.

关键词： Penetration fuze Temporal convolutional network(TCN) Long short-term memory(LSTM) Layer counting Multi-source fusion

肺缺血-再灌注核心基因介导的竞争性内源性RNA网络的构建

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器官移植 2024年第1期15卷 70-81页

作者：李晓凤唐明政刘禧禧宋子晴张国欣杨开银张凌云甘肃中医药大学第一临床医学院兰州730000 甘肃中医药大学基础医学院甘肃省中医院麻醉科

目的分析肺缺血-再灌注损伤发生的核心基因并构建竞争性内源性RNA(ceRNA)网络。方法从基因表达综合(GEO)数据库下载GSE145989的原始数据当作训练集,GSE172222和GSE9634数据集作为验证集,并鉴定差异表达基因(DEG)。进行基因本体(GO)、京... 详细信息

目的分析肺缺血-再灌注损伤发生的核心基因并构建竞争性内源性RNA(ceRNA)网络。方法从基因表达综合(GEO)数据库下载GSE145989的原始数据当作训练集,GSE172222和GSE9634数据集作为验证集,并鉴定差异表达基因(DEG)。进行基因本体(GO)、京都基因与基因组百科全书(KEGG)富集分析。构建蛋白质-蛋白质相互作用(PPI)网络,筛选核心基因并分析核心基因的诊断价值、免疫细胞的免疫浸润水平。构建并验证ceRNA网络。分析基于ceRNA网络的靶向药物。结果共检测到179个DEG,其中61个下调基因,118个上调基因。GO分析结果显示,DEG与细胞迁移、分化和调节等生物学过程有关;与内吞囊泡膜、浆膜和膜筏等细胞成分有关;与趋化因子受体、G蛋白偶联受体、免疫受体活性和抗原结合等分子功能有关。KEGG分析显示DEG参与肿瘤坏死因子(TNF)、Wnt、白细胞介素(IL)-17和核因子(NF)-κB等信号通路。PPI网络提示CD8A、IL2RG、STAT1、CD3G和SYK是肺缺血-再灌注损伤的核心基因。ceRNA网络提示miR-146a-3p、miR-28-5p和miR-593-3p与CD3G的表达相关;miR-149-3p、miR-342-5p、miR-873-5p和miR-491-5p与IL2RG表达相关;miR-194-3p、miR-512-3p、miR-377-3p和miR-590-3p与SYK表达相关;miR-590-3p和miR-875-3p与CD8A表达相关;miR-143-5p、miR-1231、miR-590-3p、miR-875-3p与STAT1表达相关。CD3G有13种靶向药物,IL2RG有4种靶向药物,SYK有28种靶向药物,lncRNA MUC2有3种靶向药物,未发现CD8A、STAT1和其他ceRNA网络基因的靶向药物。结论CD8A、IL2RG、STAT1、CD3G和SYK是肺缺血-再灌注损伤的核心基因,对核心基因进行研究分析可能有助于肺缺血-再灌注损伤的诊断,并提供新的研究思路和治疗靶点。

关键词：肺移植缺血-再灌注损伤核心基因竞争性内源性RNA(ceRNA) 微小RNA 长链非编码RNA 环状RNA 信号通路

Mineral Chemistry of Biotite and Its Petrogenesis Implications in ca.2.5 Ga Wangjiazhuang Granitic Pluton,North China Craton

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Journal of Earth Science 2022年第6期33卷 1535-1548页

作者： Junpeng Wang Kang Jiang Deng Xiao Fenfang li Fupeng li xiaofeng li Song Jin Guanghuo Tao School of Earth Sciences Center for Global TectonicsChina University of GeosciencesWuhan430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan430078China Hebei Institute of Geological Survey Shijiazhuang050081China

The Wangjiazhuang granitic pluton is located in the central Zanhuang Domain,the central part of the North China Craton,which is mainly composed of biotite monzogranite with few mafic microgranular *** is an important ferromagnesian mineral in most of the intermediatefelsic igneous rocks,and its mineral chemistry can record the properties of magma and the petrogenetic physicochemical *** this study,we carried out a detailed petrographic study by electric probe microanalysis on biotite for the biotite monzogranite and mafic microgranular enclaves,to discuss the source,physicochemical conditions,and the magma mingling/mixing processes of the Wangjiazhuang *** results show significantly different chemical compositions from the biotite monzogranite and mafic microgranular *** crystallization of these biotite grains from the biotite monzogranite and mafic microgranular enclaves all occurred in low oxygen *** biotite grains in biotite monzogranite are rich in Fe,poor in Mg,which belong to *** ratios of[(Fe^(3+)+Fe^(2+))/(Fe^(3+)+Fe^(2+)+Mg2+)]are between 0.78 and *** average of FeOT(total FeO)/MgO of biotite grains in biotite monzogranite is *** MF values[2×Mg/(Fe^(2+)+Mg+Mn)]of biotite monzogranite are between 0.31 and 0.47,suggesting biotite monzogranite derived from crustal source rocks(metasedimentary rocks).The formation of granitic rocks including the Wangjiazhuang granite was related to the subduction event at ca.2.5 Ga which resulted in the melting event,and then induced the early partial melting of TTGs and metasedimentary *** biotite in mafic microgranular enclaves varies from siderophyllite to ferrobiotite,and MF values range from 0.63 to 1.06,suggesting that magma of mafic microgranular enclaves had experienced magma mixing/mingling in various *** monzogranite and parts of mafic microgranular enclaves have a similar crystallized condition,while other mafic microgranular

关键词： biotite mineral chemistry crystallization magma mixing Wangjiazhuang granite Zanhuang Massif North China Craton

基于数据驱动的分布式光伏发电功率预测方法研究进展

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电网与清洁能源 2024年第1期40卷 8-17,28页

作者：董明李晓枫杨章常益任明张崇兴焦在滨西安交通大学电力设备电气绝缘国家重点实验室陕西西安710049

从综述的角度,以分布式光伏系统为对象,分析了功率预测技术的发展情况、存在的难点以及主要影响因素,梳理了应用数据驱动方法实现功率准确预测的技术路线。再以空间相关性、历史出力功率以及气象等影响因素为切入点,梳理了光伏系统数据... 详细信息

从综述的角度,以分布式光伏系统为对象,分析了功率预测技术的发展情况、存在的难点以及主要影响因素,梳理了应用数据驱动方法实现功率准确预测的技术路线。再以空间相关性、历史出力功率以及气象等影响因素为切入点,梳理了光伏系统数据驱动的功率预测研究现状,分析其相应的数据增强、时空图信息以及特征融合的手段,讨论了技术的优缺点。最后给出了功率预测数据驱动方法研究方向和发展建议。

关键词：分布式光伏出力特性数据驱动数据增强时空图信息特征融合

Aerosol Transmission of SARS-CoV-2 in Two Dormitories——Hubei and Shandong Provinces,China,2020

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China CDC weekly 2022年第14期4卷 298-301,I0001-I0003页

作者： xiaofeng li Fan Yang Ziyi Su li liu Borong lin Department of Building Science School of ArchitectureTsinghua UniversityBeijingChina

Summary What is already known about this topic?Aerosol transmission is one route for the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,uncertainty remains on the threshold of ventilation rate in its *** is added by this report?Based on two cases in Shandong Province and Hubei Province,the effect of wearing masks and the minimum ventilation required to reduce coronavirus disease 2019(COVID-19)aerosol transmission was determined.

关键词： Shandong Hubei ventilation

Maillard reaction-derived laser lithography for printing functional inorganics

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Science China Chemistry 2022年第7期65卷 1306-1314页

作者： Xiao Dai Yining Jiang Xiaohan Wang Fengnan Chen liang Gao xiaofeng li Guifu Zou School of Energy School of Optoelectronic Science and EngineeringKey Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China School of Optical and Electronic Information Suzhou City UniversitySuzhou 215104China Research Institute of Superconductor Electronics College of Engineering and Applied ScienceNanjing UniversityNanjing 210023China

Photopolymerization-based additive printing of functional inorganics has drawn great attention in recent years and one important challenge is the photoresin loading with diverse inorganics. Here, we introduce a Maillard reaction-derived laser lithography strategy for an unprecedented direct printing of diverse inorganic compounds. The sugar-assisted laser lithography(SLL) is powerful to carry choice metal ions and versatile for the generation of patterned inorganic materials comprising metal oxides,metal sulfides, and metal nitrides, characterized by ferroelectric, magnetic, semiconductivity, superconductivity, or other properties. The material architecture is flexibly manipulated by the laser intensity, power, printing speed, precursor solution, and computer-aided design to satisfy the practical requirements. This work demonstrates a new possibility for the further development of laser lithography in the directly printing of feature-rich inorganic materials and devices.

关键词： functional inorganics inorganic nanomaterials printing nanostructures

乳鼠志贺杆菌分泌蛋白GroEL多克隆抗体的制备与鉴定

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中国病原生物学杂志 2024年第2期19卷 137-143页

作者：刘梦琦贾雪娇刘洋刘长城李小凤胡屹硕赵微锦州医科大学基础医学院病原生物学实验室辽宁锦州121000

目的制备志贺杆菌分泌蛋白GroEL多克隆抗体,为探究乳鼠志贺杆菌上清蛋白GroEL在乳鼠肠道内的功能奠定基础。方法利用分子克隆技术构建原核表达蛋白质粒Pet28a(+)-GroEL,转化Escherichia coil BL21(DE3)后采用不同浓度IPTG诱导表达,优化... 详细信息

目的制备志贺杆菌分泌蛋白GroEL多克隆抗体,为探究乳鼠志贺杆菌上清蛋白GroEL在乳鼠肠道内的功能奠定基础。方法利用分子克隆技术构建原核表达蛋白质粒Pet28a(+)-GroEL,转化Escherichia coil BL21(DE3)后采用不同浓度IPTG诱导表达,优化诱导时间和温度,确定最佳蛋白表达条件;利用His标签亲和层析法纯化GroEL蛋白。将纯化蛋白与佐剂按照等比例充分混合后免疫C57BL/6小鼠,制备多克隆抗体血清,采用EliSA检测血清抗体的效价、灵敏度及特异性。构建真核表达质粒pcDNA3.1(+)-GroEL并转染293T细胞,48 h后采用制备的GroEL多克隆抗体进行Western blot验证。结果Pet28a(+)-GroEL转化*** BL21(DE3)菌在28℃、0.4 mmol/L IPTG诱导12h获得最佳蛋白表达,表达的重组蛋白分子质量约为63 ku,纯化后的蛋白浓度为0.735 mg/mL。Western blot检测显示该蛋白能被抗His标签鼠单克隆抗体识别。EliSA检测显示制备的抗GroEL多克隆抗体血清效价为1∶128000;Western blot检测显示该抗体可识别GroEL蛋白。结论重组表达的GroEL蛋白具有抗原性,制备的鼠抗GroEL多克隆抗体血清具有特异性且效价高,为研究乳鼠志贺杆菌GroEL蛋白与肠道病毒之间的作用机制奠定了基础。

关键词：志贺菌 GroEL蛋白蛋白纯化多克隆抗体制备轮状病毒