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运用六西格玛管理方法缩短腰椎间盘突出症患者平均住院日的研究

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中国医院统计 2018年第1期25卷 5-9页

作者：孙兆忠朱锴李瑞郑振阳刘鑫滨州医学院附属医院脊柱外科 256603

目的探讨运用六西格玛管理方法以缩短腰椎间盘突出症患者的平均住院日。方法根据六西格玛管理方法,通过DMAIC流程,探讨导致腰椎间盘突出症患者平均住院日延长的原因,寻找高度相关且可控的因素,明确影响住院日的关键点,制定针对性的解决... 详细信息

目的探讨运用六西格玛管理方法以缩短腰椎间盘突出症患者的平均住院日。方法根据六西格玛管理方法,通过DMAIC流程,探讨导致腰椎间盘突出症患者平均住院日延长的原因,寻找高度相关且可控的因素,明确影响住院日的关键点,制定针对性的解决措施进行改进。结果研究显示影响平均住院日的关键点有院内会诊、节假日等待、治疗方案、高龄、术后并发症等。针对可控措施我科进行了改进,腰椎间盘突出症患者的平均住院日由原来的(8.83±4.23)天下降到(7.12±3.16)天。结论应用六西格玛的管理方法,找出关键问题,优化住院后诊疗流程,提高工作效率,可以缩短腰椎间盘突出症患者的平均住院日。

关键词：六西格玛管理腰椎间盘突出症平均住院日质量管理

基于三轴不排水有效应力路径的结构性剑桥模型的修正研究

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岩土工程学报 2025年第1期47卷 115-124页

作者：加瑞李逸群雷华阳姜宇轩天津大学建筑工程学院天津300350 天津大学滨海土木工程结构与安全教育部重点实验室天津300350

室内外试验和工程实践都表明天然沉积黏土具有一定的结构性,因此建立结构性本构模型对准确预测天然黏土的力学响应和解决实际岩土工程问题具有重要意义。首先,基于结构性黏土的三轴固结不排水试验的有效应力路径对结构性剑桥(SCC)模型... 详细信息

室内外试验和工程实践都表明天然沉积黏土具有一定的结构性,因此建立结构性本构模型对准确预测天然黏土的力学响应和解决实际岩土工程问题具有重要意义。首先,基于结构性黏土的三轴固结不排水试验的有效应力路径对结构性剑桥(SCC)模型进行了两点改进:(1)对附加孔隙比Δe的计算公式进行了修正,可以准确模拟结构性黏土超过临界状态线后的有效应力路径;(2)考虑了屈服面内的塑性即亚屈服特性,可以较好地模拟屈服面内的有效应力路径然后,利用修正结构性剑桥(MSCC)模型对结构性黏土的侧限压缩试验、三轴固结不排水和三轴固结排水试验进行了模拟计算,并与试验结果和SCC模型的计算结果进行了对比分析,结果表明MSCC模型可以更好地模拟结构性黏土的三轴不排水有效应力路径以及侧限压缩和三轴固结排水试验的应力应变曲线。最后,对MSCC模型中的参数β(屈服面内塑性变形参数)、p'_(yi)(初始结构屈服应力)、Δe_i(初始附加孔隙比)、b(结构破损速率)、γ(剪切引起结构破损的参数)和ω(反映结构性对塑性流动准则的影响)进行了参数敏感性分析,结果表明参数β影响结构性黏土屈服面内的有效应力路径,参数p'_(yi)影响峰值强度,参数Δe_i影响残余强度,参数b和γ影响峰值后的强度衰减速率,参数ω影响强度开始衰减时的偏应变大小。

关键词：结构性黏土结构性剑桥模型有效应力路径亚屈服附加孔隙比

Preparation of mesoporous alumina with large pore size and their supported rhenium oxide catalysts in metathesis of 1-butene and 2-butene to propene

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Journal of Natural Gas Chemistry 2012年第3期21卷 352-359页

作者： Lei Sang Sheng-li Chen Guimei Yuan zheng Zhou rui li Aicheng Chen Min zheng Ju You State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China

Mesoporous γ-aluminas with large pore size （up to 19 nm, denoted as MAI9） are prepared from dispersed pseudo-boehmite using pluronic P123 as template. It is found that these mesoporous alumina supported rhenium oxide catalysts were more active and have far longer working life-span in gas-phase metathesis of 1-butene and 2-butene to propene than rhenium oxide on conventional alumina with small pore size （5 nm）. At 60 ℃ and atmospheric pressure with WHSV = 1 h^-1, the similar stable conversions of butene （ca. 55%） for all the 13 wt% Re207/alumina catalysts were obtained near the chemical equilibrium, and the stable working life-spans of Re2OT/MA19 were far longer than that of Re2O7/A1203, being about 70 h and 20 h, respectively.

关键词： mesoporous alumina rhenium oxide metathesis butene propene

Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils

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Nano Research 2020年第9期13卷 2556-2563页

作者： zheng Lv li li Zhongwei Man Zhenzhen Xu Hongtu Cui rui Zhan Qihua He Lemin zheng Hongbing Fu Beijing Key Laboratory for Optical Materials and Photonic Devices Capital Normal UniversityBeijing 100048China Tianjin Key L aboratory of Molecular Optoelectronic Sciences Institute of Molecular PlusTianjin UniversityTianjin 300072China 3 The Institute of Cardiovascular Sciences and Institute of Systems BiomedicineSchool of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Sciences of Ministry of Education NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesHealth Science CenterPeking UniversityBeijing 100191China China National Clinical Research Center for Neurological Diseases Tiantan HospitalAdvanced Innovation Center for Human Brain ProtectionThe Capital Medical UniversityBeijing 100050China

The formation of amyloid plaques usually occurs in the early-stage of Alzheimer’s disease(AD).Stimulated emission depletion(STED)imaging provided a powerful tool for visualizing amyloid structures on the nanometer ***,many commercial probes adopted in detecting amyloid fibrils are inapplicable to STED imaging,owing to their unmatched absorption and emission wavelengths,small Stokes'shift,easy photo-bleaching,***,we demonstrated a polarity-activated STED probe based on an intramolecular charge transfer donor(D)-7c-acceptor(A)*** electron-rich carbazole group and the electron-poor pyridinium bromide group,linked by 7i-conjugated thiophen-bridge,ensure strong near infrared(NIR)emission with a Stokes'shift larger than 200 *** tiny change in polarity before and after binding with amyloid plaques leads to a transition from weakly emission charge-transfer(CT)state(Φlity and high depletion efficiency,the super-resolution imaging of the formation and morphology of amyloid fibrils in vitro based on this probe was realized with a lateral spatial resolution better than 33 nm at an extremely low depletion ***,the ex-vivo super-resolution imaging of(E)-1-butyl-4(2-(5-(9-ethyl-9Hcarbazol-3-yl)thiophen-2-yl)vinyl)pyridinium bromide(CTPB)probe in Aβ plaques in the brain slices of a Tg mouse was *** research provides a demonstration of the super resolution imaging probe of amyloid fibrils based on polarity-response mechanism,providing a new approach to the development of future amyloid probes.

关键词： polarity-activated amyloid fibrils super-resolution imaging charge transfer near infrared(NIR)emission

Analysis of LMW-GS,α-and γ-Gliadin Gene Coding Sequences from Triticum macha

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Agricultural Sciences in China 2010年第2期9卷 163-169页

作者： XIONG li-juan WANG Ji-rui zheng You-liang Triticeae Research Institute Sichuan Agricultural University Ya＇an 625014 P.R.China Key Laboratory of Southwestern Crop Germplasm Utilization Ministry of Agriculture Ya＇an 625014 P.R.China

Novel LMW-GS （low molecular weight glutenin subunit）,α- and γ-gliadin from Triticum macha accessions were characterized via genomic PCR, which can do favor to improve the wheat quality. The complete coding regions of two α-gliadin, two γ-gliadin and two LMW-GS gene sequences, which designed as Gli-Mal, Gli-Ma2, Gli-Mrl, Gli-Mr2, Glu-LM1 and Glu-LM2, encoded the mature proteins with 307, 241, 348, 302, 474 and 377 amino acid residues, respectively. Gli-Mal and Gli-Ma2 were recognized as pseudogenes due to the in-frame stop codons. The amino acid sequences deduced from these gene sequences were characterized with the typical structure of α- or γ-gliadin or LMW- m type proteins with the exception of Gli-Ma2. Phylogenetic analysis showed Gli-Mal was closely related to those from T. aestivum, whereas Gli-Ma2 seemed to be more homologous with the gene sequences from Dasypyrum breviaristatum. Gli-Mrl was closely related to those from T. turgidum ssp. dicoccoides, while Gli-Mr2 was the nearest to those from T. aestivum. Glu-LM1 was closely related to those from Aegilops tauschii, whereas GIu-LM2 seemed to be more homologous with those from T. durum.

关键词： T. macha α-gliadin γ-gliadin LMW-GS gene clone sequence analysis

Oxidation of glyoxal to glyoxylic acid by oxygen over V_2O_5/C catalyst

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Chinese Chemical Letters 2008年第2期19卷 245-248页

作者： Yu Lan Niu zheng Xu Min li rui Feng li Key Laboratory of Coal Science and Technology MOE Institute of Special Chemicals Taiyuan University of TechnologyTaiyuan 030024 PR China Department of Chemical Engineering Taiyuan Institute of Technology Taiyuan 030008 PR China

A novel vanadium oxide catalyst supported on active carbon was prepared by an incipient wetness impregnation method, and the precursor was obtained from oxalic acid aqueous solutions of NH4VO3. The catalyst was applied liquid phase oxidation of glyoxal to glyoxylic acid. It was found that V2O5/C catalyst exhibited obvious activity for glyoxal oxidation. Glyoxylic acid could be obtained without pH regulation during the reaction. By using this catalyst, the conversion of glyoxal and the yield of glyoxalic acid were 29.2% and 13.6%, respectively at 313 K and oxygen flow 0.1 L/rain after reaction for 10 h.

关键词： Glyoxal Glyoxylic acid Vanadium catalyst Oxidation

Modeling of Rectangular Microchannel Heat Sink with Non-Uniform Channels and Multi-Objective Optimization

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Journal of Thermal Science 2024年第5期33卷 1701-1711页

作者： SHANG Xueshuo WANG Yixin li Qingwen WANG rui CUI zheng SHAO Wei Institute of Advanced Technology Shandong UniversityJi'nan 250014China Institute of Thermal Science and Technology Shandong UniversityJi'nan 250014China Shandong Institute of Advanced Technology Ji'nan 250100China

Rectangular microchannel heat sinks(MCHS)are widely used to cool high-heat-flux electronic ***,previous studies focused mainly on MCHS with uniform channels(UCs).This study considers a microchannel heat sink with non-uniform channels(NUCs).A mathematical model is developed based on energy equations and the Darcy flow *** expressions for total thermal resistance and coolant pressure drop are derived using the thermoelectric *** and numerical simulations are performed to verify the mathematical *** non-uniformity increases,total coolant pressure drop decreases but at the cost of higher thermal *** overall performance of NUCs is better than that of UCs because of their lower ratio of pumping power to cooling *** transfer performance of NUCs changes little for more than 120 channels and depends mainly on channel arrangement.A multi-objective optimization is conducted to minimize the thermal resistance and pumping power of an *** optimal NUC saves 64%pumping power compared with a conventional UC for the total thermal resistance of 0.1℃/W,indicating that the use of non-uniform channels could be very helpful to reduce the flow resistance of MCHS.

关键词： microchannel heat sink non-uniform channel mathematical model multi-objective optimization

Proteomic analysis of seed germination under salt stress in soybeans

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 507-517页

作者： Xiao-yan XU rui FAN rui zheng Chun-mei li De-yue YU National Center for Soybean Improvement National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China) Foundation Department Jiangsu Polytechnic College of Agriculture and Forestry Jurong 212400 China) College of life Sciences Ningxia University Yinchuan 750021 China)

Soybean (Glycine max (L.) Merrill) is a salt-sensitive crop,and its production is severely affected by saline ***,the response of soybean seeds to salt stress during germination was investigated at both physiological and proteomic *** salt-tolerant cultivar Lee68 and salt-sensitive cultivar N2899 were exposed to 100 mmol/L NaCl until radicle protrusion from the seed *** both cultivars,the final germination percentage was not affected by salt,but the mean germination times of Lee68 and N2899 were delayed by 0.3 and 1.0 d,respectively,compared with *** response to salt stress,the abscisic acid content increased,and gibberellic acid (GA1+3) and isopentenyladenosine ***-3-acetic acid increased in Lee68,but remained unchanged in *** proteins extracted from germinated seeds were separated using two-dimensional gel electrophoresis (2-DE),followed by Coomassie brilliant blue G-250 *** 350 protein spots from 2-DE gels of pH range 3 to 10 and 650 spots from gels of pH range 4 to 7 were reproducibly resolved,of which 18 protein spots showed changes in abundance as a result of salt stress in both *** matrix-assisted laser desorption ionization-time of flight-mass spectroscopy (MALDI-TOF-MS) analysis of the differentially expressed proteins,the peptide mass fingerprint was searched against the soybean UniGene database and nine proteins were successfully *** and 20S proteasome subunit β-6 were up-regulated in both *** 3-phosphate dehydrogenase,glutathione S-transferase (GST) 9,GST 10,and seed maturation protein PM36 were down-regulated in Lee68 by salt,but still remained at a certain ***,these proteins were present in lower levels in control N2899 and were up-regulated under salt *** results indicate that these proteins might have important roles in defense mechanisms against salt stress during soybean seed germination.

关键词： Proteomics Salt stress Seed germination Soybean

Decay of the 2D Periodic Stationary Viscous Surface Waves

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Acta Mathematica Sinica,English Series 2018年第12期34卷 1837-1862页

作者： Yun rui zheng School of Mathematical Sciences Qufu Normal University

We consider the evolution of viscous fluids in a 2D horizontally periodic slab bounded above by a free top surface and below by a fixed fiat bottom. This is a free boundary problem. The dynamics of the fluid are governed by the incompressible stationary Navier-Stokes equations under the influence of gravity and the effect of surface tension. We develop the global theory of solutions in low regularity Sobolev spaces for small data by nonlinear energy estimates.

关键词： Free boundary problems global existence Navier Stokes equations