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Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities

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Synthetic and Systems Biotechnology 2024年第1期9卷 19-25页

作者： Sai Wan Mingchi Lai Xinyu Gao Mingxin Zhou Song Yang Qiang li fuli li lin Xia Yang Tan Qingdao C1 Refinery Engineering Research Center Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101ShandongChina CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055China Shenzhen Powered Carbon Biotechnology Co. LtdShenzhen518055China School of life Sciences Qingdao Agricultural UniversityQingdao266109ShandongChina School of Biological Science and Technology University of JinanJinan250022ShandongChina

Excessive mining and utilization fossil fuels has led to drastic environmental consequences,which will contribute to global warming and cause further climate change with severe consequences for the human *** magnitude of these challenges requires several approaches to develop sustainable alternatives for chemicals and fuels *** this context,biological processes,mainly microbial fermentation,have gained particular *** example,autotrophic gas-fermenting acetogenic bacteria are capable of converting CO,CO_(2) and H_(2) into biomass and multiple metabolites through Wood-Ljungdahl pathway,which can be exploited for large-scale fermentation processes to sustainably produce bulk biochemicals and biofuels(*** and ethanol)from *** autoethanogenum is one representative of these chemoautotrophic bacteria and considered as the model for the gas ***,the development of synthetic biology toolbox for this strain has enabled us to study and genetically improve their metabolic capability in gas *** this review,we will summarize the recent progress involved in the understanding of physiological mechanism and strain engineering for ***,and provide our perspectives on the future development about the basic biology and engineering biology of this strain.

关键词： Genetic engineering Clostridium autoethanogenum Gas fermentation Carbon fixation Biofuel

改进秃鹰搜索和K均值混合迭代的点云简化算法

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西安交通大学学报 2024年第2期58卷 172-183页

作者：牛宏侠李富丽兰州交通大学自动化与电气工程学院兰州730070 兰州交通大学甘肃省高原交通信息工程及控制重点实验室兰州730070 兰州交通大学光电技术与智能控制教育部重点实验室兰州730070

针对激光雷达的固有特性和复杂环境易造成点云噪声和冗余点云,以及传统点云简化算法忽略了点云固有特征等问题,提出了一种基于改进秃鹰搜索和K均值聚类(KMC)混合迭代的点云简化算法(IBESSA)。首先,通过秃鹰搜索(BES)算法迭代阶段的竞争... 详细信息

针对激光雷达的固有特性和复杂环境易造成点云噪声和冗余点云,以及传统点云简化算法忽略了点云固有特征等问题,提出了一种基于改进秃鹰搜索和K均值聚类(KMC)混合迭代的点云简化算法(IBESSA)。首先,通过秃鹰搜索(BES)算法迭代阶段的竞争融合(CFBES),提高其收敛速度和优化精度;其次,通过CFBES和KMC算法的混合迭代,实现了点云数据的聚类;然后,在k近邻(k-NN)实现点云簇密度估计的基础上,结合香农熵实现点云信息量化;最后,删除信息量化值小于阈值的聚类簇,完成点云数据简化。使用UCI国际标准数据集和斯坦福点云数据集分别对CFBES-KMC算法的聚类效果及点云的简化效果进行验证,结果表明:与改进飞蛾扑火的K均值交叉迭代、K-means++、模糊C均值聚类算法的聚类效果相比,CFBES-KMC算法的聚类准确率分别提高了1.02%、12.31%、14.72%;在斯坦福点云数据集上,IBESSA算法在有效滤除冗余点云的基础上保留了原本点云的细节和形状特征,不失为一种高效的点云简化算法。

关键词：秃鹰搜索算法竞争融合 K均值聚类混合迭代香农熵点云简化

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高次谐波辐射与X射线量子光学(特邀)

光子学报 2024年第6期53卷 39-47页

作者：付逸飞赵迪李蓬勃李福利西安交通大学物理学院教育部物质非平衡合成与调控重点实验室陕西省量子信息与光电量子器件重点实验室西安710049

高次谐波产生过程是一种广泛、成熟、可行的制备相干量子光源的方案,在新兴的X射线量子光学领域有望得到应用。目前,量子光学已经在微波和可见光波段研发了诸如压缩态制备、诱导透明、高次谐波产生、多波混频等应用。X射线因其高精度、... 详细信息

高次谐波产生过程是一种广泛、成熟、可行的制备相干量子光源的方案,在新兴的X射线量子光学领域有望得到应用。目前,量子光学已经在微波和可见光波段研发了诸如压缩态制备、诱导透明、高次谐波产生、多波混频等应用。X射线因其高精度、高衍射极限、鲁棒性、穿透性和聚焦能力在理论上优于目前广泛采用的微波和可见光波段,在X射线波段下研发量子光学模型、量子信息单元和量子光学元件,有助于推动其向精密化,小型化发展。最近的研究将量子光学推广至X射线波段,产生了诸如X能标下的量子系统、单光子、脉冲、高次谐波产生相干X射线脉冲等创新性研究成果,发展了阿秒级的相干X射线量子光源。X射线光学与量子光学的交叉正在引来越来越多的关注,成为一个具有显著突破意义和应用前景的研究领域。

关键词：量子光学谐波产生非线性光学超快激光 X射线光学

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中国女性运动员媒介形象的架构分析

语文学刊 2024年第2期44卷 81-90页

作者：纪燕李馥丽江苏科技大学外国语学院江苏镇江212100

本项研究基于认知语言学架构理论分析《中国日报(英文版)》女性运动员相关报道,形成了以下发现:第一,报道主要包括“战争,旅程,表演,自然和建筑”隐喻性架构和“能力、竞争、自信、努力、成果、伤病”非隐喻性表层架构;第二,这些表层架... 详细信息

本项研究基于认知语言学架构理论分析《中国日报(英文版)》女性运动员相关报道,形成了以下发现:第一,报道主要包括“战争,旅程,表演,自然和建筑”隐喻性架构和“能力、竞争、自信、努力、成果、伤病”非隐喻性表层架构;第二,这些表层架构激活了“为国争光与自我价值相统一”“技能价值与精神价值相融合”的深层架构;第三,报道整合了连贯、凸显、递进升格等多种架构机制,塑造了多元化的女性运动员媒介形象,展示了中国以人为本的体育人文精神和积极活力的国家形象,其报道策略能为其他媒体讲好中国体育故事提供借鉴。

关键词：中国女性运动员形象架构媒体话语

Antibody-activated trans-endothelial delivery of mesoporous organosilica nanomedicine augments tumor extravasation and anti-cancer immunotherapy

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Bioactive Materials 2021年第7期6卷 2158-2172页

作者： Tinglei Huang Shuang li Jianchen Fang fuli li Shuiping Tu Department of Oncology State Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Department of Stomatology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China

Tumor vasculature constitutes a formidable hurdle for the efficient delivery of cancer nanomedicine into *** leverage of passive pathway through inter-endothelial gaps in tumor blood vessels might account for limited extravasation of nanomedicine into tumor microenvironment(TME).Herein,Annexin A1 antibody-installed mesoporous organosilica nanoplatforms carrying immunotherapeutics of anti-PD-L1 antibody(aPD-L1)and Indoximod are developed to target at caveolar Annexin-A1 protein of luminal endothelial cells and to trigger the active trans-endothelial transcytosis of nanomedicine mediated by *** strategy enables rapid nanomedicine extravasation across tumor endothelium and relatively extensive accumulation in tumor ***-L1 and Indoximod release from aPD/IND@MON-aANN in a reduction-responsive manner and synergistically facilitate the intratumoral infiltration of cytotoxic T lymphocytes and reverse the immunosuppressive TME,thus demonstrating substantial anti-tumor efficacy in subcutaneous 4T1 breast tumors and remarkable anti-metastatic capacity to extend the survival of 4T1 tumor metastasis ***,aPD/IND@MON-aANN nanomedicine also exhibits distinct superiority over the combination therapy of free drugs to potently attenuate the progression of urethane-induced orthotopic lung ***,aPD/IND@MON-aANN nanoplatforms with boosted delivery efficiency via antibody-activated trans-endothelial pathway and enhanced immunotherapeutic efficacy provides perspectives for the development of cancer nanomedicines.

关键词： Active transcytosis Extravasation Drug delivery Cancer immunotherapy Stimulus-responsive nanomedicine

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CBL教学法对产科实习考核促进作用的研究

中国高等医学教育 2024年第1期 83-84页

作者：吕小梅刘梦瑶李福丽梁莉田庆芬济南市中心医院山东济南250014

目的:研究CBL教学法对产科实习生多模式出科考核的促进作用。方法:选择在我科实习的100名临床医学本科实习生作为研究对象,随机分为试验组和对照组,各50人。其中试验组按照CBL教学法进行临床实习,对照组按照传统带教模式进行临床实习。... 详细信息

目的:研究CBL教学法对产科实习生多模式出科考核的促进作用。方法:选择在我科实习的100名临床医学本科实习生作为研究对象,随机分为试验组和对照组,各50人。其中试验组按照CBL教学法进行临床实习,对照组按照传统带教模式进行临床实习。结果:3周实习后,试验组学生的Mini-CEX和DOPS出科考核成绩均明显高于对照组,差异有统计学意义(P<0.05),且学生满意度更高。结论:CBL教学法对产科实习生多模式出科考核成绩和学生满意程度均有促进作用。

关键词： CBL Mini-CEX DOPS 产科实习

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Perforated nitrogen-rich graphene-like carbon nanolayers supported Cu-In catalyst for boosting CO_(2) electroreduction to CO

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Journal of Energy Chemistry 2022年第12期75卷 383-390,I0010页

作者： Xinxin Zhang Yuxiao Zhu Ziyong liu fuli li Wei Zhou Zichao Dong Jingxin Fan licheng liu Chunhua Du Laboratory of Reaction and Separation Technology Qingdao Agricultural UniversityQingdao 266109ShandongChina CAS Key Laboratory of Bio-based Materials Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101ShandongChina CenterTech Tianjin Chemical Research and Design Institute Co. Ltd.Tianjin 300131China

The combination of a powerful CO_(2)-enriching carrier and robust active component provides a new idea for the construction of efficient catalysts for electrocatalytic CO_(2)***,novel perforated nitrogen-rich graphene-like carbon nanolayers(PNGC)are prepared from biomass derivatives,which promotes the oriented deposition of In-doped Cu_(2)(OH)_(3)(NO_(3))nanosheet patches.A robust Cu-In/PNGC composite catalyst is then obtained via simple in-situ electrochemical ***,CuIn/PNGC exhibits a CO Faradaic efficiency(FECO)of 91.3%and a remarkable CO partial current density(jCO)of 136.4 m A cm^(-2)at a moderate overpotential of 0.59 V for electrocatalytic CO_(2)reduction reaction(CO_(2)RR).DFT calculations and experimental studies indicate that the strong carrier effect of PNGC makes PNGC carried Cu-In nanosheets improved the adsorption capacity of CO_(2)gas,reconfigured electronic structure,and reduced free energy of key intermediate formation,thereby the CO_(2)activation and conversion are promoted.

关键词： CO_(2)electroreduction CO Cu-In/PNGC Patch Perforated nitrogen-rich graphene-like carbon nanolayers

Controllable speckle compression in atomic vapor by frequency modulation and its application in ghost imaging

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Science China(Physics,Mechanics & Astronomy) 2018年第9期61卷 91-94页

作者： JinWen Wang Xin Yang ShuWei Qiu Ming Tao Cao Dong Wei Hong Gao fuli li Shaanxi Key Laboratory of Quantum Information and Quantum Optoelectronic Devices Xi'an Jiaotong University

An image undergoes a paraxial diffraction spreading when propagating in free *** reduction of diffraction is critical for many potential applications[1-3].Recently,it has been recognized that optical diffraction can b... 详细信息

关键词：频率调整原子压缩点缀控制蒸汽成像光衍射

Probing the fractional topological charge of a vortex light beam by using dynamic angular double slits

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Photonics Research 2016年第5期4卷 187-190页

作者： Jing Zhu Pei Zhang Dongzhi Fu Dongxu Chen Ruifeng liu Yingnan Zhou Hong Gao fuli li Laboratory of Quantum Information and Quantum Optoelectronic Devices Shaanxi ProvinceXian Jiaotong University Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of Science

Vortex beams with fractional topological charge(FTC) have many special characteristics and novel ***, one of the obstacles for their application is the difficulty of precisely determining the FTC of fractional vortex beams. We find that when a vortex beam with an FTC illuminates a dynamic angular double slit(ADS), the far-field interference patterns that include the information of the FTC of the beam at the angular bisector direction of the ADS vary periodically. Based on this property, a simple dynamic ADS device and data fitting method can be used to precisely measure the FTC of a vortex light beam with an error of less than 5%.

关键词： Probing the fractional topological charge of a vortex light beam by using dynamic angular double slits