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Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 204-212页

作者： Meng-Hua li Wan-Qi Wang li-Ting zheng Meng Bing Chen Yang Chu Miao Qiao Zuo-li Zhang Konduru Naveena Yong Pan Yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhouChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouChina Department of ENT Beijing Friendship HospitalCapital Medical UniversityBeijingChina National Key Laboratory of Chinese Medicine Modernization Tasly AcademyTasly Pharmaceutical Group Co.Ltd.TianjinChina Endoscopy Center Ankang People's HospitalAnkangChina Department of Respiratory Medicine Xuzhou Infectious Diseases HospitalAffiliated Hospital of Xuzhou Medical UniversityXuzhouChina Department of ENT The People's Hospital of Rongchang DistrictChongqingChina

Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 d B sound pressure level for 4 *** analysis and pharmacodynamic experiments were carried ***:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing ***,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed ***:Andrographolide might be a promising candidate for auditory protective drug investigation.

关键词： Andrographolide anti-inflammatory auditory protection noise-induced hearing loss traditional Chinese medicine compound

以中华文明的连续性推进中华民族现代文明建设

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山东社会科学 2024年第7期 17-26页

作者：李征中国地质大学(北京)马克思主义学院

中华文明的连续性体现为文明起源的源远流长性、文明发展过程的不断传承性和文明存续理念的守正创新性。以中华文明的连续性推进中华民族现代文明建设的内在逻辑在于稳定独特的地理环境为中华民族现代文明建设提供了发展条件、“中和”... 详细信息

中华文明的连续性体现为文明起源的源远流长性、文明发展过程的不断传承性和文明存续理念的守正创新性。以中华文明的连续性推进中华民族现代文明建设的内在逻辑在于稳定独特的地理环境为中华民族现代文明建设提供了发展条件、“中和”的文化价值理念为中华民族现代文明建设确立了核心价值、多元一体的文明发展格局为中华民族现代文明建设熔铸了特色风格。中华文明的连续性启示我们,建设中华民族现代文明必须坚持人与自然和谐共生,必须坚持物质文明与精神文明协调发展,必须坚持传承中华传统与吸纳现代智慧相统一,必须坚持人类文明新形态与世界文明交流互鉴。

关键词：中华文明连续性中华民族现代文明

不确定性时代的社会团结——基于“新部落主义”与“共同体”的思考

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天津社会科学 2024年第4期 53-61,175页

作者：郑莉哈尔滨工程大学人文社会科学学院

当今世界正处于前所未有的不确定与不安全的状态。种种变化莫测的不确定性以及由此导致的对未来的恐惧引发了“回到霍布斯”“回到部落”“回到子宫”等当下极其盛行的现象。鲍曼和马费索利对部落式“共同体”与基于活力论和冗余神话的... 详细信息

当今世界正处于前所未有的不确定与不安全的状态。种种变化莫测的不确定性以及由此导致的对未来的恐惧引发了“回到霍布斯”“回到部落”“回到子宫”等当下极其盛行的现象。鲍曼和马费索利对部落式“共同体”与基于活力论和冗余神话的“社会本能”的阐述,为我们深入认识和分析不确定性时代“新部落主义”所蕴含的内在张力,以及各种身份话语所带来的“分裂”与“隔离”,提供了新的视角和启发。破除文化和文化身份在“我们”和“他们”之间竖起的屏障,不仅要认识到其背后存在多方面的原因,还要将对话从“高层政治”带入到“日常邻近”,由此人类才有可能在不确定性时代推动实现真正的社会团结。

关键词：不确定性新部落主义身份认同社会团结日常邻近

稳定就业如何影响技能形成——基于我国企业雇佣制度的历史考察

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华东师范大学学报（教育科学版） 2024年第4期42卷 51-62页

作者：李政华东师范大学职业教育与成人教育研究所上海200062

技能,尤其是专有技能的形成,需要个体扎根某一岗位长时间的耕耘和摸索,这就需要为劳动者提供相对稳定的工作环境和就业保障。计划经济时期,我国国有企业执行统包统配的计划式就业,企业采取劳动竞赛、厂内师徒制、技术协作等方法促进个... 详细信息

技能,尤其是专有技能的形成,需要个体扎根某一岗位长时间的耕耘和摸索,这就需要为劳动者提供相对稳定的工作环境和就业保障。计划经济时期,我国国有企业执行统包统配的计划式就业,企业采取劳动竞赛、厂内师徒制、技术协作等方法促进个体的技能形成;社会主义市场经济时期,公有制企业以编制制度,为部分技术技能人才提供了就业稳定的制度保障,同时进一步延续和创新了技能竞赛、基于专家工作室的师徒制、职称评定等制度促进员工的技能形成,而非公有制企业则通过签订长期合同、竞业禁止等给予雇员稳定雇佣的可信承诺,并通过强化员工忠诚教育、建立内部人才上升和流动通道、建立内部人才培养体系和劳动力市场等措施,提升员工专有技能的形成效率。本质上,这是社会主义市场经济环境下,企业内劳动力商品化和去商品化之间的一次再平衡。企业以稳定的雇佣承诺尊重和保护劳动者作为人的特质和需求,并通过师徒传承、生涯发展、锦标赛和内培内招四大机制,发挥劳动力作为生产要素的价值。这一机制还受到国家经济体制以及规范有序的行业内部劳动力市场的宏观影响。未来我国的就业政策、教育政策、社会保障政策应重点促进社会群体的稳定就业,通过积极创设稳定就业的制度环境、提升中小微企业的人力资源开发与技能形成能力、提升职业院校校企合作人才培养的结构性与合规性,协助企业构筑健康稳定、可预期的劳资合作关系。

关键词：稳定就业技能形成专有技能劳动力商品化社会主义市场经济

Therapeutic effects of lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-li zheng Department of Basic Medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal *** To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying *** To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with *** determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance *** a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic *** effectively controlled blood glucose and food intake while protecting islet *** analysis revealed significant differences between the HFD and HFDLGZG *** intervention reduced branched-chain amino acid *** of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased *** may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by *** Our study strongly suggests that LGZG decoction reduces HFD-induced *** may activate S6K1 via metabolic *** findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

Analysis of the Current Situation and Influencing Factors of Physical Activity Among the Elderly in the Community

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Journal of Clinical and Nursing Research 2024年第6期8卷 345-350页

作者： Wei Dong Jialiang Wang Dongmei Cui Yanling li Shaohua li zheng li Physical Examination Center Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Nursing Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Neonatology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Nephrology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To explore the current situation of physical activity among elderly individuals in the community,identify influencing factors,and provide a theoretical basis for improving their physical activity levels in the ***:A questionnaire survey was conducted among 265 elderly community residents using the Physical Activity Scale for the ***:The median(p50)score on the Physical Activity Scale for the Elderly was 220.425,indicating a high level of physical *** was no statistically significant difference in physical activity levels between ***:Elderly individuals should be supported in actively and scientifically participating in physical activities to mitigate physical function decline and achieve successful aging.

关键词： Community Elderly Physical activity

不同气候条件下预应力木梁柱节点长期转角计算方法

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土木工程学报 2024年第6期57卷 116-126页

作者：郑修知何敏娟李征同济大学上海200092

梁柱节点长期转角是评估预应力木框架结构长期适用性能的重要指标,过量的梁柱节点长期转角会引起木梁竖向变形的增大,降低结构适用性;因此准确预测预应力木梁柱节点转角的时变规律是保证预应力木结构长期安全服役的重要前提。该文提出... 详细信息

梁柱节点长期转角是评估预应力木框架结构长期适用性能的重要指标,过量的梁柱节点长期转角会引起木梁竖向变形的增大,降低结构适用性;因此准确预测预应力木梁柱节点转角的时变规律是保证预应力木结构长期安全服役的重要前提。该文提出了不同气候条件下预应力木梁柱节点长期转角的数值计算方法,该方法包括木材水分传输、时变预应力计算、弹性转角计算、蠕变和环境变形计算、节点长期转角更新五个模块。随后利用长期试验数据验证了计算方法的准确性。最后,基于验证的数值计算方法分析了不同气候条件、木材初始含水率和构件尺寸对预应力木梁柱节点长期转角的影响规律,依据50年服役期内的最大转角蠕变系数评估了节点长期变形的性能等级。结果表明:该文所提出的数值计算方法与试验结果吻合良好;气候年平均相对湿度越大,节点发生中等或严重变形的比例越高;木材初始含水率越高,节点发生中等或严重变形的比例越低;构件理论尺寸越大,节点长期变形越小。

关键词：预应力木梁柱节点长期性能节点转角气候变化数值计算方法

scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling

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Asian Journal of Andrology 2024年第1期26卷 46-56页

作者： Shi-Wei liu Jia-Qiang Luo liang-Yu Zhao Ning-Jing Ou Chao-Yang Yu-Xiang Zhang Hao-Wei Bai Hong-Fang Sun Jian-Xiong Zhang Chen-Cheng Yao Peng li Ru-Hui Tian zheng li Zi-Jue Zhu Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining *** single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upregulated in *** scRNAseq analysis,we identified the spermatogonia upregulated gene origin recognition complex subunit 6(Orc6),which is involved in DNA replication and cell cycle regulation;its protein expression in the human and mouse testis was detected by western blot and *** explore the potential function of Orc6 in spermatogonia,the C18-4 cell line was transfected with control or Orc6 ***,5-ethynyl-2-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,flow cytometry,and western blot were used to evaluate its effects on proliferation and *** was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 *** RNA sequencing and bioinformatics analysis indicated that Orc6 was involved in the activation of wingless/integrated(Wnt)/β-catenin *** blot revealed that the expression ofβ-catenin protein and its phosphorylation(Ser675)were significantly decreased when silencing the expression of *** findings indicated that Orc6 was upregulated in spermatogonia,whereby it regulated proliferation and apoptosis by activating Wnt/β-catenin signaling.

关键词： cell proliferation ORCG scRNA-seq analysis spermatogonia Wnt/β-catenin signaling

有机碱催化ω-十五内酯开环聚合制备类聚乙烯性质的可降解塑料

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高分子学报 2024年第8期55卷 976-985页

作者：黄炳政韩瑞李峥李志波青岛科技大学化工学院青岛266042 青岛科技大学高分子科学与工程学院青岛266042

以环三磷腈碱(CTPB)为催化剂,以苄醇(BnOH)为引发剂,实现了ω-十五内酯(PDL)的高效可控开环聚合.通过优化实验条件,得到了高分子量的聚ω-十五内酯(PPDL).示差扫描量热法(DSC)表征证明了PPDL聚酯材料较好的结晶性.高分子量的PPDL不仅有... 详细信息

以环三磷腈碱(CTPB)为催化剂,以苄醇(BnOH)为引发剂,实现了ω-十五内酯(PDL)的高效可控开环聚合.通过优化实验条件,得到了高分子量的聚ω-十五内酯(PPDL).示差扫描量热法(DSC)表征证明了PPDL聚酯材料较好的结晶性.高分子量的PPDL不仅有与聚乙烯相似的力学性质、结晶性和高熔点(T_(m)=95.5℃),而且还具有聚酯类材料的降解性.合成了PDL与ε-己内酯(ε-CL)的无规共聚物,证明可以通过改变ε-CL的含量实现共聚物的熔点、力学性质和降解性可控调节.进一步通过双官能团引发剂合成中低分子量的双羟基端PPDL,证明可以通过与二异氰酸酯进行扩链反应制备高分子量PPDL(PPDL-E),力学性能能够得到有效提升.最后在碱性条件下实现了PPDL共聚酯的水解,验证了PPDL及其与ε-CL共聚物的水解性能.

关键词：开环聚合有机碱类聚乙烯高分子可降解聚酯