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Engineering vascularised organoid-on-a-chip: strategies, advances and future perspectives

Biomaterials Translational 2024年第1期5卷 21-32页

作者： li z. Yu D. z.ou C. Wang F. Lu K. liu Y. Xu J. Xuan L. Wang X. Department of Micro/Nano Electronics School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong University Shanghai China National Center for Translational Medicine (Shanghai) SHU Branch Shanghai University Shanghai China

In recent years, advances in microfabrication technology and tissue engineering have propelled the development of a novel drug screening and disease modelling platform known as organoid-on-a-chip. This platform integrates organoids and organ-on-a-chip technologies, emerging as a promising approach for in vitro modelling of human organ physiology. Organoid-on-a-chip devices leverage microfluidic systems to simulate the physiological microenvironment of specific organs, offering a more dynamic and flexible setting that can mimic a more comprehensive human biological context. However, the lack of functional vasculature has remained a significant challenge in this technology. Vascularisation is crucial for the long-term culture and in vitro modelling of organoids, holding important implications for drug development and personalised medical approaches. This review provides an overview of research progress in developing vascularised organoid-on-a-chip models, addressing methods for in vitro vascularisation and advancements in vascularised organoids. The aim is to serve as a reference for future endeavors in constructing fully functional vascularised organoid-on-a-chip platforms. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： drug screening microfluidic chip organoids tissue engineering vascularisation

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The Joint Control of Variable Speed and On-Ramp Metering for Urban Expressway

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Journal of Systems Engineering and Electronics 2001年第3期12卷 25-30页

作者： Ma, J. liu, X. Rong, J. li, z. Transportation Research Center Beijing Polytechnic University Beijing 100022 China

The traffic performance of urban expressway is subject to non-recurring and recurring events, which may cause heavy congestion and vehicles long queuing on ramps. The low performance may bring more traffic delay to the whole network of urban road. This paper presents a new method, the joint control of variable speed control and on-ramp metering, which attempts to improve the level of traffic operations on urban expressway. By analyz.ng traffic flow on urban expressway, an optimum control strategy of variable speed and on-ramp metering is established in the paper.

关键词： Function evaluation Highway traffic control Intelligent control Mathematical models Motor transportation Parameter estimation Ramp generators Speed control

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SURFACE COMPOSITE GEAR AND PIPE MADE BY SEPARATED EUTECTIC TECHNOLOGY

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Acta Metallurgica Sinica(English Letters) 2000年第3期13卷 883-887页

作者： Cao, z.Q. Piao, L.Y. z.ang, X.G. li, z. Jin, J.z. Dalian Univ of Technology Dalian China

It is found that the anomalous eutectics can be separated on macroscopic scale by flow caused by electromagnetic stirring, and the separated phase is the leading faceted phase with the solution entropy over 23 J/(mol·K). By using this technology, a new kind of composite pipe and gear with good abrasive properties were made without adding any reinforced particles. Emphases were paid on the researches about formation mechanism of separated eutectic and abrasive property of the composite pipe or gear. The result shows that the entropy of solution controlling the eutectic microstructure is also valid and useful as a criterion of separated eutectic, and the kind and its chemical scope of the off-eutectic used to make composite can be calculated according to this theory.

关键词： Binary alloys Eutectics Gears Microstructure Pipe Rotational flow Separators Solidification

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NUMERICAL SIMULATION OF MOLTEN POOL AND CONTROL STRATEGY OF KISS POINT IN A TWIN-ROLL STRIP CASTING PROCESS

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Acta Metallurgica Sinica(English Letters) 2008年第6期21卷 459-468页

作者： G.M. Cao C.G. li z. Y. liu D. Wu G.D. Wang X.H. liu State Key Laboratory of Rolling ＆ Automation Northeastern University Shenyang 110004 China

Coupled turbulent flow, temperature fields of the twin-roll casting strip process were simulated by three-dimensional finite element method. Based on the heat balance calculation and using inverse methods between the simulations and real experiments, the relational models among casting speed, location, and coefficient of heat transfer between molten metal and rolls in different regions are given. In the simulation, the calculated surface temperatures are in good agreement with the measured values. An on-line model of kiss point is derived by simulations and the geometry of molten pool, corresponding control strategy is also proposed.

关键词： Twin-roll strip casting Coupled temperature and flow field Numerical simulation Kiss point Control strategy

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THE MAGNETORESISTANT BEHAVIOR OF Ni_(85)Fe_(15) ALLOY FILM IMPLANTED BYCo^+

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Acta Metallurgica Sinica(English Letters) 1999年第4期12卷 562-565页

作者： G.Q. li, S. z. Sun , z. Xianyu , L.H. Sun and D. R. li Departmentof Physics, Northeastern University,Shenyang 110006 ,China

Implanting 1 ×1016 to1 ×1017 Co+/cm2 into Ni85 Fe15 alloy film anditschangesof mag netoresistantcharacters were researched . The results show that Co+ is very spectacular on modifying Ni85 Fe15 alloyfilm’s magnetoresistancecharacters. Atlower dose,theanisotrop ic magnetoresistivity ratio( AMR) and thesaturated magnetic field didn’tchange almost. ATmedium dose, the saturated magnetic field does not have great change either, butits AMRisraised from 1 % upto 3% . Thisiscomparabletothebest AMRvalueof permalloy based magnetoresistant material prepared by other methods. But the ion implantation tech niqueisrathersimpler. Whentheimplanting doseishigher,its AMRisalsoenhanced notice ably. However,theincreaseof saturated field saysthe material’sstructurecharacters have changed radically.

关键词： anisotropic magnetoresistivityratio, Ni85 Fe15 alloy, film ,ionimplanta tion

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TcPO2 changes are more pronounced than SpO2 changes during simulated altitude changes in a hypobaric oxygen chamber: a nonrandomiz.d controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： li Y. Chen L. Fu z. Wang z. Sun S. Luan X. Ma D. Hu T. School of Nursing and Rehabilitation Shandong University Shandong Jinan China Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of State Grid Shandong Electric Power Company Shandong Jinan China School of Nursing and Rehabilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School of Mechanical Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is a significant risk factor of hypertension. However, no studies have used transcutaneous tissue partial pressure of oxygen (TcPO2) and partial pressure of carbon dioxide (TcPCO2) monitors to measure the respective partial pressures in healthy individuals. Oxygen saturation (SpO2) is often used for traditional monitoring of vital signs. This study investigated the changes in TcPO2 and SpO2 values during rapid changes in altitude. The trial was registered at *** (registration no. NCT06076057). Methods: Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber, which ascended from 0 m to 2500 m at a uniform speed within 10 min. The Danish Radiometer TCM4 was used to measure TcPO2 and TcPCO2 with the ventral side of the upper arm as the measurement site. The Shenz.en Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO2, with values recorded once every 500 m. Results: Altogether, 49 healthy volunteers were recruited between March 2023 and August 2023. With increasing altitude, TcPO2 and SpO2 decreased significantly (P 500 m, statistical significance was identified between TcPO2 in both sexes (P < 0.05). Statistical significance in TcPCO2 and heart rate was observed at the different elevations (P < 0.05). Conclusion: In acutely changing low-pressure hypoxic environments, TcPO2 changed more dramatically than SpO2 © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

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NUMERICAL SIMULATION OF PENETRATION PROCESS BASED ON THE VARIATION OF HEAT TRANSFER CONDITION

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Acta Metallurgica Sinica(English Letters) 2000年第1期13卷 157-161页

作者： L. Q. li L. Y. li and z. Geng (National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 1500001, China)

In this paper, the process of dynamic heat output in a welding pool and the variation of the penetration caused by the section change of the workpiece are analyz.d using numerical simulation technique of thermal field. It is concluded that the variation of temperature gradient in HAz.along the length and width direction reflects the heat output of the welding pool, and that the output of the welding pool has a homogenous relationship to the pool penetration.

关键词： numerical simulation welding pool temperature gradient heat output

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中红外量子级联激光器输运特性的仿真(英文)

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红外与毫米波学报 2012年第6期31卷 486-490页

作者：李营营茹国平李湛明复旦大学微电子研究院集成电路与系统国家重点实验室上海200433 Crosslight软件有限公司

基于一种非局域化的输运模型,对不同结构不同温度下的中红外量子级联激光器的输运特性进行了仿真。在这个模型中,利用量子隧穿、微带隧穿以及热载流子输运等长程载流子输运模型,对传统的扩散-漂移方程进行了矫正.并将基于上述集成模型... 详细信息

基于一种非局域化的输运模型,对不同结构不同温度下的中红外量子级联激光器的输运特性进行了仿真。在这个模型中,利用量子隧穿、微带隧穿以及热载流子输运等长程载流子输运模型,对传统的扩散-漂移方程进行了矫正.并将基于上述集成模型的计算结果和实验结果进行了比较,通过拟合参数的合理设置,计算结果和实验结果得到了很好的吻合.

关键词：量子级联激光器仿真输运特性非局域化输运模型

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RNA modifications in the progression of liver diseases:from fatty liver to cancer

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Science China(life Sciences) 2024年第10期67卷 2105-2119页

作者： Simiao li Wajahat z.Mehal Xinshou Ouyang Department of Internal Medicine Section of Digestive DiseasesYale University School of MedicineNew Haven CT 06520USA

Non-alcoholic fatty liver disease(NAFLD)has emerged as a prominent global health concern associated with high risk of metabolic syndrome,and has impacted a substantial segment of the *** disease spectrum ranges from simple fatty liver to non-alcoholic steatohepatitis(NASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)and is increasingly becoming a prevalent indication for liver *** existing therapeutic options for NAFLD,NASH,and HCC are limited,underscoring the urgent need for innovative treatment *** into gene expression,particularly RNA modifications such as N6methyladenosine(m^(6)A),hold promising avenues for *** modifications play integral roles in RNA metabolism and cellular functions,encompassing the entire NAFLD-NASH-HCC *** review will encompass recent insights on diverse RNA modifications,including m^(6)A,pseudouridine(Ψ),N^(1)-methyladenosine(m^(1)A),and 5-methylcytidine(m^(5)C)across various RNA *** will uncover their significance in crucial aspects such as steatosis,inflammation,fibrosis,and ***,prospective research directions and therapeutic implications will be explored,advancing our comprehensive understanding of the intricate interconnected nature of these pathological conditions.

关键词： m^(6)A RNA modification NASH NAFLD HCC fatty liver

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倍半萜生物碱Dendrobine的全合成研究进展

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有机化学 2021年第7期41卷 2636-2649页

作者：肖检彭羽李卫东西南交通大学生命科学与工程学院四川省天然药物仿生合成工程研究中心成都610031 伊犁师范大学新疆天然产物化学与应用重点实验室新疆伊宁835000

石斛碱(Dendrobine)是一类从传统中药金钗石斛中分离得到的具有Picrotoxane倍半萜碳骨架的生物碱类天然产物.由于该化合物具有多环稠合和七个连续立体中心的结构特点,以及镇痛和退热等药理活性,引起了众多有机合成化学家和药物化学家的... 详细信息

石斛碱(Dendrobine)是一类从传统中药金钗石斛中分离得到的具有Picrotoxane倍半萜碳骨架的生物碱类天然产物.由于该化合物具有多环稠合和七个连续立体中心的结构特点,以及镇痛和退热等药理活性,引起了众多有机合成化学家和药物化学家的关注.五十年来,天然产物Dendrobine的药理活性研究和化学合成不断涌现,主要总结了天然产物Dendrobine的生源途径和合成研究进展.

关键词：天然产物倍半萜生物碱石斛碱全合成木防己毒烷

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