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World Journal of Clinical Cases 2024年第23期12卷 5320-5328页

作者： Lei Zheng li-xian yang Jing-Yi liu Zhe Jiang Xiao-Wei li Peng-Peng Pu Department of Breast Surgery Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Medical Imaging Xingtai People´s HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND Breast cancer ranks as one of the most prevalent malignant tumors among women,significantly endangering their health and *** radical surgery has been a pivotal method for halting disease progression,it alone is insufficient for enhancing the quality of life for *** To investigate the correlation between ultrasound characteristic parameters of breast cancer lesions and clinical efficacy in patients undergoing neoadjuvant chemotherapy(NAC).METHODS Employing a case-control study design,this research involved 178 breast cancer patients treated with NAC at our hospital from July 2019 to June *** to the Miller-Payne grading system,the pathological response,***,of the NAC in the initial breast lesion after NAC was *** these,59 patients achieved a pathological complete response(PCR),while 119 did not(non-PCR group).Ultrasound characteristics prior to NAC were compared between these groups,and the association of various factors with NAC efficacy was analyzed using univariate and multivariate *** In the PCR group,the incidence of posterior echo attenuation,lesion diameter≥2.0 cm,and Alder blood flow grade≥II were significantly lower compared to the non-PCR group(Plimited predictiv

关键词： Breast cancer Ultrasound Neoadjuvant chemotherapy Efficacy Pathological complete response

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皮拉尼真空计在钢瓶气充装防爆区的正压设计

电气防爆 2024年第2期 9-13页

作者：黎宪扬 Air liquide(China) 上海201108

对测量高真空皮拉尼真空计应用在压缩钢瓶气充装工厂防爆区域的设计上做了可行性研究。

关键词：皮拉尼真空计真空测量可燃气体正压防爆

全基因组水平紫花苜蓿WRKY转录因子家族鉴定与表达模式分析

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草业学报 2024年第4期33卷 154-170页

作者：李显炀刘昊何飞王雪李明娜龙瑞才康俊梅杨青川陈林中国农业科学院北京畜牧兽医研究所北京100193 哈尔滨师范大学生命科学与技术学院黑龙江哈尔滨150025

WRKY转录因子是植物中最大的基因家族之一,在植物生长发育以及非生物胁迫过程中发挥重要的作用。目前,WRKY基因家族成员已经在多个植物物种中进行了广泛的研究和分析。然而,WRKY转录因子尚未在四倍体紫花苜蓿全基因组水平上进行鉴定与... 详细信息

WRKY转录因子是植物中最大的基因家族之一,在植物生长发育以及非生物胁迫过程中发挥重要的作用。目前,WRKY基因家族成员已经在多个植物物种中进行了广泛的研究和分析。然而,WRKY转录因子尚未在四倍体紫花苜蓿全基因组水平上进行鉴定与分析。本研究系统鉴定了紫花苜蓿WRKY基因家族成员,并对其在不同胁迫处理下的表达模式进行了分析。结果显示,共有198个WRKY转录因子不均匀分布在紫花苜蓿的32条染色体上,其中7号染色体的数量最多。系统进化树结果显示,WRKY基因家族成员可以分为3个组。在这些WRKY转录因子中,有42个响应盐胁迫,7个响应碱胁迫,19个响应冷胁迫和37个响应干旱胁迫,同时发现MsWRKY154和MsWRKY166可以同时响应盐、干旱、冷以及碱胁迫。本研究的结果可为紫花苜蓿WRKY转录因子的生物学功能深入研究奠定基础,同时可为紫花苜蓿分子育种提供有价值的信息。

关键词： WRKY转录因子紫花苜蓿表达模式非生物胁迫

紫花苜蓿SAUR基因家族的鉴定及其在非生物胁迫中的表达模式研究

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草业学报 2024年第4期33卷 135-153页

作者：刘昊李显炀何飞王雪李明娜龙瑞才康俊梅杨青川陈林中国农业科学院北京畜牧兽医研究所北京100193 青岛农业大学草业学院山东青岛266109

SAUR(small auxin-up RNA)是植物早期响应生长素的一类基因,参与植物生长发育与非生物胁迫响应等一系列生物过程。在拟南芥、水稻、棉花等物种中已经对SAUR基因家族进行了系统鉴定与分析,但是,在世界上最重要的豆科牧草紫花苜蓿中关于S... 详细信息

SAUR(small auxin-up RNA)是植物早期响应生长素的一类基因,参与植物生长发育与非生物胁迫响应等一系列生物过程。在拟南芥、水稻、棉花等物种中已经对SAUR基因家族进行了系统鉴定与分析,但是,在世界上最重要的豆科牧草紫花苜蓿中关于SAUR基因家族的研究尚未开展。本研究利用生物信息学的方法在紫花苜蓿参考基因组共鉴定到433个MsSAUR成员,并对其基因组位置、基因结构、启动子顺式作用元件以及不同组织中的表达模式进行了分析。同时,利用紫花苜蓿在不同非生物胁迫下的转录组数据,发现有5、11、19以及12个MsSAUR成员分别响应干旱、盐、冷以及碱胁迫,MsSAUR14/94/254可以同时响应干旱和盐胁迫,MsSAUR297可以同时响应干旱、盐以及碱胁迫,MsSAUR306可以同时响应干旱、盐以及冷胁迫。本研究结果可为后期通过基因工程技术创制高产抗逆新种质提供重要的候选基因。

关键词：紫花苜蓿 SAUR基因全基因组鉴定非生物胁迫表达模式

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深水薄覆盖层区大型双壁钢围堰施工技术

中国港湾建设 2024年第6期44卷 83-90页

作者：穆清君李贤仰杨武潘传宗中交第二航务工程局有限公司湖北武汉430040

以长沙香炉洲大桥索塔墩基础施工为依托,综合考虑桥址区的地质、水文、沿岸地形地貌、吊装能力等因素,对双壁钢围堰制造、下水、浮运、精确定位、着床等施工关键技术进行研究,提出竖向分节、水平成环接高、整体浮运、平台拉锚系统精确... 详细信息

以长沙香炉洲大桥索塔墩基础施工为依托,综合考虑桥址区的地质、水文、沿岸地形地貌、吊装能力等因素,对双壁钢围堰制造、下水、浮运、精确定位、着床等施工关键技术进行研究,提出竖向分节、水平成环接高、整体浮运、平台拉锚系统精确定位大型钢围堰施工工艺。工程实践证明,提出的深水薄覆盖层场域钢围堰精确定位施工成套技术是成功的,可为类似工程提供参考。

关键词：深水薄覆盖层桥梁基础双壁钢围堰定位系统

Biometric-based personal identity-authentication system and security analysis

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 43-47页

作者： li Chao yang Yi-xian NIU Xin-xin Information Security Centre Key Laboratory of Networking and Switching Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

The traditional authentication system is based on the secret key, and is mainly based on public key infrastructure （PKI）. Unfortunately, a key has many disadvantages, for example, the key can be forgotten or stolen, and can be easily cracked. Nowadays, authentication systems using biometric technology have become more prevalent because of the advantages over password-based authentication systems. In this article, several biometfic authentication models are presented, upon which most biometric authentication systems are based. Biometric authentication systems based-on these models provide high security for access control in non-face-to-face environment such as e-commerce, over open network.

关键词： biometric identity authentication PKI security

rs3735664 Polymorphism Affecting ELFN1-AS1 Adsorption on miR-1231 is Associated with Colorectal Cancer Susceptibility and Tumor Stage

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Biomedical and Environmental Sciences 2023年第4期36卷 381-383页

作者： li xian yang HUANG Zhi Jun li Jian Ping GAO Xue Ren School of Pharmacy Yancheng Teachers'UniversityYancheng 224007JiangsuChina Department of Surgery Yancheng First People's HospitalYancheng 224007JiangsuChina Department of Oncology Yancheng First People's HospitalYancheng 224007JiangsuChina

Colorectal cancer(CRC)is a common and deadly disease,with over two million new cases and one million deaths in 2020[1].Risk factors include lack of exercise,obesity,high red meat consumption,low intake of fiber,smoking,and alcohol consumption,as well as genetic factors[2,3].ELFN1-AS1,located on chromosome 7p22.3,expresses a pro-oncogenic lncRNA[4-7].Wang et al.

关键词： Colorectal intake Cancer

Behavior of axially loaded tubular X-joints using bolted connection:mechanical model and validation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第12期14卷 880-889页

作者： Yong CHEN Ji-yang WANG Yong GUO Guo-hui SHEN li-xian yang Bin-nan SUN College of Civil Engineering and Architecture Zhejiang University Zhejiang Electric Power Design Institute

X-joints are one of the fundamental joint configurations used in a wide range of transmission tubular *** investigation of four tubular X-joints with bolted connection was conducted in this study,and it was found that the annular plate was the main yielding control member of such ***,the portion outside the effective width of the chord member still had a restriction effect on the annular plate,which led to reducing the yielding strength of the joint,while the gusset plate could help to improve the yield strength *** the current design code of steel structures,the contribution to the strength capacity of the gusset plate has not been taken into ***,based on some mechanical assumptions,a general mechanical model was *** the introduction of the gusset plate strength capacity factor,the yield capacity simplified calculation method of such X-joints was *** the analyses of such X-joints with various diameters and thicknesses,it was concluded that a simple mechanical model could predict test results very well and that the contribution of the gusset plate was also taken into account.

关键词： Steel tubular X-joint Bolted connection Annular plate Gusset plate Strength capacity

Clinical Significance and Function of MALAT1 Gene Expression and the rs619586 Polymorphism in Colorectal Cancer

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Biomedical and Environmental Sciences 2022年第8期35卷 768-771页

作者： GAO Xue Ren WANG Xin Yu li xian yang SUN Yu Qi ZHANG Shu Long School of Pharmacy Yancheng Teachers'UniversityYancheng 224007JiangsuChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYancheng 224007JiangsuChina Department of General Surgery Xuhui District Central HospitalZhongshan-Xuhui HospitalFudan UniversityShanghai 200030China

Colorectal cancer(CRC) is a malignant tumor of the digestive system that poses a serious threat to human health. In 2018, around 1.8 million people were newly diagnosed with CRC, and 881,000 people died from the disease. The identification of CRCrelated genes and genetic polymorphisms will aid in the prevention and treatment of this disease.

关键词： MALAT1 prevention Colorectal

Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer

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Biomedical and Environmental Sciences 2023年第1期36卷 109-111页

作者： GAO Xue Ren PAN Jun Jie NIE Wan Jia li xian yang ZHANG Shu Long School of Pharmacy Yancheng Teachers'UniversityYancheng 224007JiangsuChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers'UniversityYancheng 224007JiangsuChina Department of General Surgery Xuhui District Central HospitalZhongshan-Xuhui HospitalFudan UniversityShanghai 200030China

Colorectal cancer(CRC) is a malignancy of the digestive system that poses a serious threat to human life and health. Approximately 1.93 million new CRC cases were identified in 2020, including0.94 million CRC-related deaths worldwide, which accounted for 10% of the global cancer incidence and 9.4% of all cancer-related fatalities[1].

关键词： Colorectal cancer Cancer