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河南省许昌市消除疟疾前后输入性疟疾诊治能力比较

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现代疾病预防控制 2024年第3期35卷 218-222,226页

作者：彭金华周雅冰马莹莹吴宁李晓利许昌市疾病预防控制中心河南许昌461000

目的比较许昌市消除疟疾前后输入性疟疾诊治情况,分析存在的问题,为加强消除后疟疾监测和防止疟疾输入再传播提供科学依据。方法通过《中国疾病预防控制信息系统》收集许昌市疟疾疫情数据和个案调查资料,对消除疟疾前(2011—2016年)和... 详细信息

目的比较许昌市消除疟疾前后输入性疟疾诊治情况,分析存在的问题,为加强消除后疟疾监测和防止疟疾输入再传播提供科学依据。方法通过《中国疾病预防控制信息系统》收集许昌市疟疾疫情数据和个案调查资料,对消除疟疾前(2011—2016年)和消除疟疾后(2017—2022年)病例发病至初诊时间、初诊至确诊时间以及各级医疗卫生机构的初诊确诊率进行比较。结果2011—2022年许昌市共报告经实验室确诊的输入性疟疾118例,其中消除疟疾前67例,消除疟疾后51例。118例病例中,恶性疟占77.12%。消除疟疾前后,病例发病至初诊间隔天数的中位数均为1 d,初诊至确诊间隔天数的中位数分别为0 d和1 d,发病后0~3 d就诊的患者比例由消除疟疾前的80.60%提高至消除疟疾后的94.12%(χ^(2)=4.516,P<0.05);0~3 d确诊的疟疾患者比例由消除疟疾前的53.73%提高至消除疟疾后的72.55%(χ^(2)=4.346,P<0.05);市级医院和区(县)级医院确诊病例占比由消除疟疾前的31.3%提高至消除疟疾后的62.7%(χ^(2)=11.541,P<0.001);疟疾病例在本地诊断和治疗的比例均高于消除疟疾前(χ^(2)分别为10.529和19.383,P均<0.05)。结论消除疟疾后,许昌市市级医院和区(县)级医疗机构对疟疾的诊断能力有所提升,病例在本地诊断和治疗的比例大幅上升,发病至确诊时间逐渐缩短,但乡级及以下医疗机构的疟防意识较差,今后应加强对基层医务人员开展疟疾防治知识培训。

关键词：输入性疟疾消除初诊确诊率许昌

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Comprehensive Analysis of the Role of Forkhead Box J3(FOXJ3)in Human Cancers

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 74-84页

作者： YANG Yang li Yulong WANG xiaoli School of Public Health Shaanxi University of Chinese MedicineXianyang 712046ShaanxiChina Department of Gastroenterology Shaanxi Provincial People's hospitalXi'an 710068ShaanxiChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000ShaanxiChina

Forkhead box J3(FOXJ3)is a member of the forkhead box(Fox)***,increasing evidence has revealed the relationship between Fox family members and ***3 is involved in various types of cancer,including lung cancer,tongue squamous carcinoma,and prostate cancer;however,a comprehensive pan-cancer analysis of FOXJ3 remains ***,we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0,Sanger Box,UALCAN,GEPIA2.0,c Bio Portal,CancerSEA,STRING,Bio GRID and Metascape to analyze the role of FOXJ3 in *** expression of FOXJ3 was found in various *** genetic alteration percentage in tumors was determined,and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG),liver hepatocellular carcinoma(liHC),sarcoma(SARC)and thyroid *** FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma,LGG and ***3 expression was related to immune infiltration in several *** analysis showed that histone modification,the TGF-βsignaling pathway,and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of *** pancancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers,where it serves as a potential biomarker for prognosis,especially in LGG and ***3 is also correlated with immune infiltrates in certain human tumors.

关键词： FOXJ3 cancer genetic alteration prognosis

FLOCKING OF MULTI-AGENT DYNAMIC SYSTEMS WITH GUARANTEED GROUP CONNECTIVITY

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Journal of Systems Science & Complexity 2008年第3期21卷 337-346页

作者： xiaoli li Yugeng XI Department of Automation Shanghai Jiao Tong University Shanghai 200240 China

这篇论文调查在代理人之中的信息交换被随着时间变化的通讯拓扑学建模的分布式的结队的问题。关于这个问题的以前的研究由假设动态拓扑学总是被连接建立组稳定，它不能被大多数建议分布式的控制法律然而保证。在这篇论文，提取起始的通... 详细信息

这篇论文调查在代理人之中的信息交换被随着时间变化的通讯拓扑学建模的分布式的结队的问题。关于这个问题的以前的研究由假设动态拓扑学总是被连接建立组稳定，它不能被大多数建议分布式的控制法律然而保证。在这篇论文，提取起始的通讯拓扑学的一张必要潜水艇图的一个分布式的算法被介绍。这张潜水艇图盖住通讯拓扑学的所有顶点并且只要起始的通讯拓扑学被连接，被证明被连接。当在这张潜水艇图保存所有边时，一条分布式的控制法律然后被设计追求结队的动议。这样，连接能总是被保存，并且结队仅仅如果多代理人系统的起始的通讯拓扑学被连接，问题因此被解决。

关键词：连通性分布式控制多Agent系统植绒花纹信息交换

Multi-scenario Simulation and Spatial-temporal Analysis of LUCC in China's Coastal Zone Based on Coupled SD-FLUS Model

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Chinese Geographical Science 2024年第4期34卷 579-598页

作者： HOU Xiyong SONG Baiyuan ZHANG Xueying WANG xiaoli li Dong Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shanghai Fuxiong Environmental Technology Corporation Shanghai 200433China

Increased human activities in China's coastal zone have resulted in the depletion of ecological land ***,conducting current and future multi-scenario simulation research on land use and land cover change(LUCC)is crucial for guiding the healthy and sustainable development of coastal *** dynamic(SD)-future land use simulation(FLUS)model,a coupled simulation model,was developed to analyze land use dynamics in China's coastal *** model encompasses five scenarios,namely,SSP1-RCP2.6(A),SSP2-RCP4.5(B),SSP3-RCP4.5(C),SSP4-RCP4.5(D),and SSP5-RCP8.5(E).The SD model simulates land use demand on an annual basis up to the year ***,the FLUS model determines the spatial distribution of land use for the near term(2035),medium term(2050),and long term(2100).Results reveal a slowing trend in land use changes in China's coastal zone from 2000–*** these changes,the expansion rate of construction land was the highest and exhibited an annual *** 2100,land use predictions exhibit high accuracy,and notable differences are observed in trends across *** summary,the expansion of production,living,and ecological spaces toward the sea remains *** A emphasizes reduced land resource dependence,benefiting ecological land *** B witnesses an intensified expansion of artificial *** C sees substantial land needs for living and production,while Scenario D shows coastal forest and grassland ***,in Scenario E,the conflict between humans and land *** study presents pertinent recommendations for the future development,utilization,and management of coastal areas in *** research contributes valuable scientific support for informed,long-term strategic decision making within coastal regions.

关键词： land use and land cover change(LUCC) multi-scenario simulation system dynamic-future land use simulation(SD-FLUS)model SSP-RCP scenarios model coupling China's coastal zone

Numerical simulation of microwave-induced cracking and melting of granite based on mineral microscopic models

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1512-1524页

作者： xiaoli Su Diyuan li Junjie Zhao Mimi Wang Xing Su Aohui Zhou School of Resources and Safety Engineering Central South UniversityChangsha 410083China

This study introduces a coupled electromagnetic–thermal–mechanical model to reveal the mechanisms of microcracking and mineral melting of polymineralic rocks under microwave *** tests validate the rationality of the proposed *** microscopic mineral sections into the granite model for simulation shows that uneven temperature gradients create distinct molten,porous,and nonmolten zones on the fracture ***,the varying thermal expansion coefficients and Young's moduli among the minerals induce significant thermal stress at the mineral *** and biotite with higher thermal expansion coefficients are subjected to compression,whereas plagioclase with smaller coefficients experiences tensile *** the molten zone,quartz undergoes transgranular cracking due to theα–βphase *** local high temperatures also induce melting phase transitions in biotite and *** numerical study provides new insights into the distribution of thermal stress and mineral phase changes in rocks under microwave irradiation.

关键词： microwave numerical modeling microcracking phase change granite

基于多花黄精转录组的HIPPs/HPPs基因家族鉴定与表达调控

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应用与环境生物学报 2024年第1期30卷 133-143页

作者：李小利朱田圆班景洁王庆爽陈翠蓉张慧朱建明叶炜赖钟雄林玉玲陈裕坤福建农林大学园艺植物生物工程研究所福州350002 现代设施农业福建省高等学校工程研究中心福清350300 福建金湖源生态农业有限公司邵武354099 三明市农业科学研究院药用植物研究所三明365509

PcHIPPs/PcHPPs是一类细胞内可溶性金属结合蛋白,在调节植物重金属稳态、解毒机制、重金属耐受等方面发挥重要作用,目前关于HIPPs/HPPs基因家族在多花黄精中还未有人研究.基于多花黄精不同转录组数据,采用生物信息学进行理化性质分析、... 详细信息

PcHIPPs/PcHPPs是一类细胞内可溶性金属结合蛋白,在调节植物重金属稳态、解毒机制、重金属耐受等方面发挥重要作用,目前关于HIPPs/HPPs基因家族在多花黄精中还未有人研究.基于多花黄精不同转录组数据,采用生物信息学进行理化性质分析、亚细胞定位和保守基序及系统进化树分析,并对其功能进行初步分析,研究HIPPs/HPPs基因在不同铅处理下的表达情况.结果表明:从多花黄精中鉴定出68个PcHIPPs和43个PcHPPs基因;PcHIPPs基因家族的氨基酸数为134-501,分子量介于15.53-53.09 ku之间,等电点介于5.12-9.88;PcHPPs基因的氨基酸数为101-352,分子量介于11.46-38.23 ku,等电点介于5.58-10.41;亚细胞定位预测表明,PcHIPPs/PcHPPs基因有73个分布在细胞核内;通过KEGG分析发现PcHPP3、PcHIPP28-5、PcHIPP28-6、PcHPP1-5参与到代谢过程;PcHIPPs/PcHPPs基因在多花黄精根状茎中主要发挥作用,在盐胁迫处理48 h下大部分PcHIPPs/PcHPPs基因表现出明显的下调现象;多花黄精组培苗在铅处理中叶片萎缩、枯黄逐渐加重,并且低浓度的铅胁迫对植物叶绿素含量具有一定的促进作用,而高浓度的铅胁迫对植物叶绿素含量具有抑制作用;此外,PcHIPPs/PcHPPs基因总体上随着铅浓度的增加呈现出先升高后降低的表达趋势.本研究表明PcHIPPs/PcHPPs基因在多花黄精铅胁迫中起重要调控作用,为PcHIPPs/PcHPPs基因在重金属胁迫响应中的功能奠定基础.(图7表3参43)

关键词：多花黄精 HIPPs基因 HPPs基因生物信息学分析表达分析

A novel high-Cr CoNi-based superalloy with superior high-temperature microstructural stability, oxidation resistance and mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1373-1381页

作者： Xiaorui Zhang Min Zou Song Lu Longfei li xiaoli Zhuang Qiang Feng Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced MetalsUniversity of Science and Technology BeijingBeijing 100083China

A novel multicomponent high-Cr CoNi-based superalloy with superior comprehensive performance was prepared,and the evaluation of its high-temperature microstructural stability,oxidation resistance,and mechanical properties was conducted mainly using its cast polycrystalline *** results disclosed that the morphology of theγ′phase remained stable,and the coarsening rate was slow during the long-term aging at 900–1000℃.The activation energy forγ′precipitate coarsening of alloy 9CoNi-Cr was(402±51)kJ/mol,which is higher compared with those of CMSX-4 and some other Ni-based and Co-based ***,there was no indica-tion of the formation of topologically close-packed phases during this *** these factors demonstrated the superior microstructural stability of the *** mass gain of alloy 9CoNi-Cr was 0.6 mg/cm^(2) after oxidation at 1000℃ for 100 h,and the oxidation resistance was comparable to advanced Ni-based superalloys CMSX-4,which can be attributed to the formation of a continuous Al_(2)O_(3) protective ***,the compressive yield strength of this cast polycrystalline alloy at high temperatures is clearly higher than that of the conventional Ni-based cast superalloy and the compressive minimum creep rate at 950℃ is comparable to that of the conventional Ni-based cast superalloy,demonstrating the alloy’s good mechanical properties at high *** is partially because high Cr is bene-ficial in improving theγandγ′phase strengths of alloy 9CoNi-Cr.

关键词： CoNi-based superalloys microstructure coarsening oxidation mechanical properties

9S管理结合色系管理在消毒供应中心外来医疗器械管理中的应用

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医疗装备 2024年第2期37卷 69-72页

作者：张玉凤李晓利庄玲玲陈燕桦解放军联勤保障部队第九一〇医院福建泉州362000

目的探讨9S管理结合色系管理在消毒供应中心外来医疗器械管理中的应用效果。方法选取2022年7月至2023年6月医院的1000个骨科手术外来医疗器械包作为研究对象。将2022年7—12月的500个外来医疗器械包作为对照组,采用传统色系管理;将2023... 详细信息

目的探讨9S管理结合色系管理在消毒供应中心外来医疗器械管理中的应用效果。方法选取2022年7月至2023年6月医院的1000个骨科手术外来医疗器械包作为研究对象。将2022年7—12月的500个外来医疗器械包作为对照组,采用传统色系管理;将2023年1—6月的500个外来医疗器械包作为观察组,采用9S管理结合色系管理。比较两组未按时送洗、反洗、湿包、指示卡漏放发生率,器械装载耗时、包装整理耗时、无菌发放耗时,以及9S管理结合色系管理实施前后护理人员对器械及植入物的认知、器械整理与封包技能考核成绩。结果观察组未按时送洗、反洗、湿包、指示卡漏放发生率低于对照组,差异有统计学意义(P<0.05);观察组器械装载耗时、包装整理耗时、无菌发放耗时均短于对照组,差异有统计学意义(P<0.05)。实施9S管理结合色系管理后,护理人员对器械及植入物的认知、器械整理与封包技能考核成绩均高于实施前,差异有统计学意义(P<0.05)。结论实施9S管理结合色系管理后,消毒供应中心外来医疗器械的接收、清点、打包、发放流程更加标准化、规范化、科学化。

关键词： 9S管理色系管理外来医疗器械消毒供应中心

Metabolic plasticity of T cell fate decision

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Chinese Medical Journal 2024年第7期137卷 762-775页

作者： xiaoli Pan Jiajia Wang lianjun Zhang Guideng li Bo Huang National Key Laboratory of Immunity and Inflammation Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhouJiangsu 215123China Key Laboratory of Synthetic Biology Regulatory Element Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhouJiangsu 215123China Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijing 100005China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanHubei 430030China

The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T *** antigen exposure,T cells undergo metabolic reprogramming,leading to the development of functional effectors or memory ***,within the tumor microenvironment(TME),metabolic stress impairs CD8+T cell anti-tumor immunity,resulting in exhausted *** studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell *** this review,we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory ***,we delved into the different metabolic switches that occur during T cell exhaustion,exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion,ultimately leading to a persistently exhausted *** the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer.

关键词： T cell immunotherapy T cell differentiation T cell exhaustion Metabolic reprogramming Tumor microenvironment