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Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan Zhu Luo Shuangqing li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi liu ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen li Yang Yalun li Dan liu weimin li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,plizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

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Genesis of lower strain S-L-type tectonitesin Daqingshan area, Inner Mongolia

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Global Geology 2016年第2期19卷 69-77页

作者： SHAO Yilun liU Yongjiang JIA Jie li weimin JIN Wei College of Earth Sciences Jilin University Changchun 130061China China-Japan Union Hospital of Jilin University Changchun 133033 China

Usual ductile shear zone has relatively high strain magnitude. However,for high-grade metamorphic rocks in Daqingshan area,the related strain is very low with weakly developed lineation. Significantly,the finite strain type with a K-value slightly lower than 1 and is characterized by compressional strain. Because the special tectonic environment with high temperature,the percentage of melt is relatively higher,which leads to a series of microscopic phenomenon such as multi-grain quartz bands,feldspar three edges equilibrium-like texture,granular flow,etc. As a consequence,the tectonites in the studied area illustrate a unique character: obvious rheological meso-deformation structure but with very weak intracrystalline micro-deformation.

关键词： Daqingshan area high-grade metamorphic rocks deformation strain partial melting

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Novel tools for early diagnosis and precision treatment based on artificial intelligence

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第3期1卷 148-160页

作者： Jun Shao Jiaming Feng Jingwei li Shufan liang weimin li Chengdi Wang Department of Pulmonary and Critical Care Medicine Med-X Center for ManufacturingWest China HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China

Lung cancer has the highest mortality rate among all cancers in the ***,early diagnosis and personal-ized treatment plans are crucial to improving its 5-year survival *** computed tomography(CT)serves as an essential tool for lung cancer screening,and pathology images are the gold standard for lung cancer ***,medical image evaluation relies on manual labor and suffers from missed diagnosis or misdiagnosis,and physician *** rapid development of artificial intelligence(AI)has brought a whole novel op-portunity for medical task processing,demonstrating the potential for clinical application in lung cancer diagnosis and *** technologies,including machine learning and deep learning,have been deployed extensively for lung nodule detection,benign and malignant classification,and subtype identification based on CT ***,AI plays a role in the non-invasive prediction of genetic mutations and molecular status to provide the optimal treatment regimen,and applies to the assessment of therapeutic efficacy and prognosis of lung cancer patients,enabling precision medicine to become a ***,histology-based AI models assist patholo-gists in typing,molecular characterization,and prognosis prediction to enhance the efficiency of diagnosis and ***,the leap to extensive clinical application still faces various challenges,such as data sharing,standardized label acquisition,clinical application regulation,and multimodal ***,AI holds promising potential in the field of lung cancer to improve cancer care.

关键词： Lung cancer Artificial intelligence Diagnosis Treatment Precision medicine

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Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction

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Chinese Medical Journal 2014年第9期127卷 1677-1683页

作者： Xue Jingyi Du Guoqing Shi Jing li Yue Masahiro Yasutake liu Lei li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang li weimin Department of Cardiology the First Clinical Hospital Harbin Medical University Harbin Heilongjiang 150001 China Department of Ultrasound the Second Clinical Hospital HarbinMedical University Harbin Heilongjiang 150086 China Department of Cardiovascular Medicine Nippon Medical SchoolTokyo Japan

Background Erythropoietin （EPO） and granulocyte colony-stimulating factor （G-CSF） are both potential novel therapeutics for use after myocardial infarction （MI）.However,their underlying mechanisms remain unclear and the efficacy of monotherapy with EPO or G-CSF is also ***,we investigated the effects of combined treatment with EPO and G-CSF on neovascularization and cardiac function in post-infarction rats and explored the potential *** Four groups of rats were used：control （saline injection after MI,i.h.）,EPO （a single dose of 5 000 IU/kg after MI,i.h.）,G-CSF （a dose of 50 μg· kg-1· d-1 for 5 days after MI,i.h.）,and both EPO and G-CSF （EPO＋G-CSF,using the same regiment as above）.Cardiac function was assessed by echocardiography before and 1 day,7 days,14 days and 21 days after ***34＋/Flk-1＋ cells in the peripheral blood were evaluated by flow cytometry before and 3 days,5 days and 7 days after *** infarct area and angiogenesis in the peri-infarct area were *** mRNA and protein expression of vascular endothelial growth factor （VEGF） and stromal-derived factor-1α （SDF-1α） in the peri-infarct area were detected by real-time quantitative RT-PCR and Western *** Compared with the control and monotherapy groups,the EPO＋G-CSF group had significantly increased CD34＋/ Flk-1＋ endothelial progenitor calls （EPCs）in the peripheral blood （P ＜0.05）,up-regulated VEGF and SDF-1α levels in the peri-infarct region （P ＜0.05）,enhanced capillary density （P ＜0.05）,reduced infarct size （P ＜0.05） and improved cardiac structure and function （P ＜0.05）.G-CSF alone did not dramatically increase EPCs in the peripheral blood,enhance capillary density in the peri-infarct area or reduce infarct size compared with the control *** Combined treatment with EPO and G-CSF increased EPCs mobilization,up-regulated VEGF and SDF-1α levels in the post-infarction microenvironment,subsequently enhanced neovascularization in the peri-inf

关键词： erythropoietin granulocyte colony-stimulating factor acute myocardial infarction endothelial progenitor cells mobilization neovascularization

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文学经典的学习与理想中作家教育--中国作家协会文学讲习所稀见系列油印史料“‘莎士比亚’学习参考资料”考论

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戏剧（中央戏剧学院学报） 2024年第5期 38-53页

作者：李伟民浙江越秀外国语学院

根据中国作家协会文学讲习所稀见系列油印史料“‘莎士比亚’学习参考资料”,从莎学专题报告,编辑印发的自学参考资料等史料出发,探讨了莎士比亚的影响力和马克思主义莎学在中国的深刻影响。中国作家协会文学讲习所的莎士比亚课程贯彻... 详细信息

根据中国作家协会文学讲习所稀见系列油印史料“‘莎士比亚’学习参考资料”,从莎学专题报告,编辑印发的自学参考资料等史料出发,探讨了莎士比亚的影响力和马克思主义莎学在中国的深刻影响。中国作家协会文学讲习所的莎士比亚课程贯彻了学习莎氏必须以马克思主义文艺思想为指导,运用辩证唯物主义与历史唯物主义观点、阶级与阶级斗争方法、以“莎士比亚化”和社会主义现实主义作为课程学习的主体内容。这批稀见系列油印莎学专题报告及其自学参考资料,弥补了中国作家协会文学讲习所和中国莎学研究中的缺失,并以此文纪念莎士比亚诞辰460周年。

关键词：中国作家协会文学讲习所莎士比亚油印史料

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“惊骇小子”残酷而又野蛮的游戏——萨拉·凯恩的《摧毁》与后现代主义

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当代外国文学 2014年第4期35卷 75-81页

作者：李伟民四川外国语大学

萨拉·凯恩《摧毁》中的性叙事曾经引起了戏剧界、评论界极大的震撼。该剧在后现代主义的政治性语境中隐喻了权力和暴力对于人、人格和人性的摧毁。该剧以性和暴力的呈现与批判为目标,揭示了人们在后现代社会中人生的迷茫、绝望情绪,以... 详细信息

萨拉·凯恩《摧毁》中的性叙事曾经引起了戏剧界、评论界极大的震撼。该剧在后现代主义的政治性语境中隐喻了权力和暴力对于人、人格和人性的摧毁。该剧以性和暴力的呈现与批判为目标,揭示了人们在后现代社会中人生的迷茫、绝望情绪,以及人类面临着战争与暴力威胁时的无望与无助。

关键词：萨拉·凯恩《摧毁》后现代性暴力

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莎士比亚喜剧批评在中国

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国外文学 2006年第2期26卷 51-59页

作者：李伟民 <四川外语学院学报>编辑部

对莎士比亚喜剧的批评经历了一个从政治概念出发,以社会学批评为主,强调“人民性”,以及阶级与阶级斗争理论的批评方式过渡到美学、文艺学批评的过程。在这一过程中,对莎士比亚喜剧的认识不断深化。在研究中冲破了“人性”和“爱”的禁... 详细信息

对莎士比亚喜剧的批评经历了一个从政治概念出发,以社会学批评为主,强调“人民性”,以及阶级与阶级斗争理论的批评方式过渡到美学、文艺学批评的过程。在这一过程中,对莎士比亚喜剧的认识不断深化。在研究中冲破了“人性”和“爱”的禁区,将莎士比亚喜剧的主题定位于“爱”、“友谊”,强调莎士比亚喜剧对封建禁欲主义的批判和对美好爱情、婚姻的讴歌,并对莎士比亚喜剧的艺术特点和创作手法进行了比较深入的研究。

关键词：莎士比亚喜剧批评文学评论封建禁欲主义艺术特点创作手法

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Function and molecular mechanism analysis of CaLasSDE460 effector involved in the pathogenesis of“Candidatus liberibacter asiaticus”in citrus

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Molecular Horticulture 2023年第1期3卷 197-213页

作者： Shuai Wang Meixia Du liting Dong Rongrong Qu Danlu Ran Juanjuan Ma Xuefeng Wang Lanzhen Xu weimin li Yongrui He Xiuping Zou Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City Citrus Research InstituteSouthwest University/National Citrus Engineering Research CenterChongqingPeople’s Republic of China Key Laboratory for Northern Urban Agriculture of Ministry of Agriculture and Rural AffairsBeijing University of AgricultureBeijingPeople’s Republic of China

Citrus Huanglongbing(HLB),caused by Candidatus liberibacter asiaticus(CaLas),is the most serious disease ***460 was previously characterized as a potential virulence factor of ***,the function and mechanism of CaLasSDE460 involved in CaLas against citrus is still ***,we showed that transgenic expression of CaLasSDE460 in Wanjincheng oranges(*** Osbeck)contributed to the early growth of CaLas and the development of *** the temperature increased from 25℃to 32℃,CaLas growth and symptom development in transgenic plants were slower than those in WT ***-seq analysis of transgenic plants showed that CaLasSDE460 affected multiple biological *** 25℃,transcription activities of the“Protein processing in endoplasmic reticulum”and“Cyanoamino acid metabolism”pathways increased while transcription activities of many pathways decreased at 32℃.124 and 53 genes,separately annotated to plant-pathogen interaction and MAPK signaling pathways,showed decreased expression at 32℃,compared with these(38 for plant-pathogen interaction and 17 for MAPK signaling)at 25℃.Several important genes(MAPKKK14,HSP70b,NCED3 and WRKY33),remarkably affected by CaLasSDE460,were ***,our data suggested that CaLasSDE460 participated in the pathogenesis of CaLas through interfering transcription activities of citrus defense response and this interfering was temperature-dependent.

关键词： Citrus HLB CaLasSDE460 Transcriptome Ectopic expression

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《民法典》视域中区块链的法律性质与规制

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上海师范大学学报（哲学社会科学版） 2020年第5期49卷 46-57页

作者：李伟民武汉大学法学院中国政法大学知识产权研究中心北京100088

区块链是互联网高速发展的产物,目前,理论和实务界在定义区块链时,多数研究存在把区块链和区块链技术混用的情形,往往从技术层面,以区块链的技术特征来定义区块链,认为区块链是一种具有分类记账、去中心化、不可篡改等特征的计算机系统... 详细信息

区块链是互联网高速发展的产物,目前,理论和实务界在定义区块链时,多数研究存在把区块链和区块链技术混用的情形,往往从技术层面,以区块链的技术特征来定义区块链,认为区块链是一种具有分类记账、去中心化、不可篡改等特征的计算机系统,或者是一种数据库和技术数据。未能正确反映区块链的本质,淡化了“人”在区块链中的重要地位和作用,更深层次掩盖了区块链以民事主体为主导所引发系列法律关系的本质。应该以法律理性定义区块链:区块链是由两个以上主体参与,以数据为支撑,以算法为工具,去中心化、分式记账、不可篡改,以发生特定交易行为为目的的民事法律行为。区块链技术只是实现法律行为的工具,遵循“技术中立”原则,区块链的本质是一种行为模式,是一种民事法律关系。区块链不是法外之地,应该运用技术伦理和法律,让区块链发挥更大的作用。

关键词：区块链区块链技术智能合约大数据和算法区块链规制

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玄武岩纤维对混凝土的增强和增韧效应

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硅酸盐学报 2008年第4期36卷 476-481,486页

作者：李为民许金余空军工程大学工程学院机场建筑工程系西安710038

采用φ100mm分离式Hopkinson压杆试验装置,研究了玄武岩纤维混凝土在冲击荷载作用下的动态力学性能,并将其与相同纤维掺量的碳纤维混凝土的冲击力学性能进行对比分析。结果表明:冲击荷载作用下,玄武岩纤维混凝土与碳纤维混凝土的强度与... 详细信息

采用φ100mm分离式Hopkinson压杆试验装置,研究了玄武岩纤维混凝土在冲击荷载作用下的动态力学性能,并将其与相同纤维掺量的碳纤维混凝土的冲击力学性能进行对比分析。结果表明:冲击荷载作用下,玄武岩纤维混凝土与碳纤维混凝土的强度与比能量吸收随平均应变率的增加而近似线性增长,体现了显著的应变率相关性;均匀分布的玄武岩纤维与碳纤维能够在混凝土内部形成致密的纤维网状结构,限制了混凝土内部微裂纹的产生和发展,对混凝土的冲击力学性能具有一定的改善效果;玄武岩纤维对混凝土的增强、增韧效果总体上优于碳纤维;当纤维掺量为0.1%(体积分数)时,玄武岩纤维对混凝土的增强、增韧效果最佳。

关键词：玄武岩纤维碳纤维混凝土分离式Hopkinson压杆试验装置动态力学性能

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