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感兴趣区大小对乳腺实时剪切波弹性成像诊断效能的影响

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中国超声医学杂志 2024年第5期40卷 511-515页

作者：刘雅静齐修竹钱雨常才李娜高毅陈雅玲复旦大学附属肿瘤医院超声科复旦大学上海医学院肿瘤学系

目的研究乳腺实时剪切波弹性成像(SWE)选择不同大小感兴趣区(ROI)对诊断效能的影响。方法对276个乳腺病灶(174个恶性，102个良性)进行传统超声和SWE检查，SWE定量分析分别选取几乎包括整个病灶的大ROI和病灶最硬处2 mm的小ROI,测量弹... 详细信息

目的研究乳腺实时剪切波弹性成像(SWE)选择不同大小感兴趣区(ROI)对诊断效能的影响。方法对276个乳腺病灶(174个恶性，102个良性)进行传统超声和SWE检查，SWE定量分析分别选取几乎包括整个病灶的大ROI和病灶最硬处2 mm的小ROI,测量弹性最大值(Emax)、平均值(Emean)、标准差(Esd)和弹性比值(Eratio)。比较两种ROI定量参数的受试者工作特征(ROC)曲线下面积(AUC)。结果按两种不同ROI测量，恶性组的Emax、Emean、Esd和Eratio均高于良性组(P<0.001);小ROI的Emean和Eratio大于大ROI(P<0.001),Esd低于大ROI(P<0.001)。大ROI的Esd的AUC大于小ROI,小ROI的Emean和Eratio的AUC大于大ROI(P<0.05),最大径≥15 mm的大病灶亦存在以上差异(P<0.05),小病灶差异无统计学意义。结论 ROI大小的选择影响各定量参数的诊断效能。大ROI的Esd、小ROI的Emean和Eratio诊断效能较高。ROI大小的选择影响最大径≥15 mm的大病灶的诊断效能，而对小病灶无显著影响。

关键词：乳腺超声检查剪切波弹性成像感兴趣区

盐度对全氟和多氟烷基物质(PFAS)在海水-沉积物界面吸附行为的影响

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中国环境科学 2024年第1期44卷 462-473页

作者：姜舒祺毕宇杰张涛冯志华耿倩倩谭志军郭萌萌江苏海洋大学海洋科学与水产学院江苏连云港222005 中国水产科学研究院黄海水产研究所山东青岛266071 海水养殖生物育种与可持续产出全国重点实验室山东青岛266071

模拟海水-沉积物环境,分析了不同盐度影响下5种全氟和多氟烷基物质(PFAS)含量变化,并解析了PFAS的吸附动力学和热力学等吸附行为.在设置的不同盐度实验组中,全氟辛烷磺酸(PFOS)在沉积物中的吸附能力强于相同碳氟链长度的全氟辛酸(PFOA)... 详细信息

模拟海水-沉积物环境,分析了不同盐度影响下5种全氟和多氟烷基物质(PFAS)含量变化,并解析了PFAS的吸附动力学和热力学等吸附行为.在设置的不同盐度实验组中,全氟辛烷磺酸(PFOS)在沉积物中的吸附能力强于相同碳氟链长度的全氟辛酸(PFOA),其中PFOS在沉积物中的吸附量大于其替代物9-氯十六氟-3-氧杂壬烷-1-磺酸钾(9Cl-PF3ONS);PFOA在沉积物中的吸附量大于其替代物六氟环氧丙烷二聚酸(HFPO-DA),而小于另一替代物六氟环氧丙烷三聚酸(HFPO-TA).PFAS的沉积物分配系数(Kd)与盐度呈正相关,随着盐度的升高,PFAS在沉积物中的吸附量随之增加.PFAS的吸附过程涉及了疏水和静电相互作用.

关键词：全氟和多氟烷基物质(PFAS) 海水沉积物盐度吸附新污染物

Ethylene purification in a metal–organic framework over a wide temperature range via pore confinement

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Green Energy & Environment 2023年第6期8卷 1703-1710页

作者： Xue-qian Wu Peng-Dan Zhang Xin Zhang jing-Hao liu tao He Jiamei yu Jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering Faculty of Environment and LifeBeijing University of TechnologyBeijing100124China The Key Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing100124China

The separation of C2H4from C_(2)H_(6)/C_(2)H_(4)mixture is of great importance but difficult and energy intensive. Adsorptive separation provides an alternative approach to ameliorate this situation. Here, we report a microporous metal–organic framework(MOF) BUT-315-a as a C_(2)H_(6)-selective adsorbent for the separation of C2H6/C2H4gas mixture. BUT-315-a combines good IAST selectivity of 2.35 with high C_(2)H_(6)uptake of 97.5 cm^(3)g^(-1), giving superior high separation potential ΔQ(2226 mmol L^(-1)) for equimolar C_(2)H_(6)/C_(2)H_(4) at 298 K. Impressively, such excellent performance can be preserved at higher temperatures of 313 and 323 K to accommodate industrial conditions. Efficient dynamic separation performance of BUT-315-a has been demonstrated by column breakthrough experiments under varied temperatures and gas ratios. Theoretical calculations further reveal multiple synergistic interactions between C_(2)H_(6) and the framework. This work highlights a new benchmark material for C_(2)H_(6)/C_(2)H_(4)separation and provides guidance for designing adsorbent for separation applications.

关键词： Metal–organic framework Adsorptive separation Ethylene purification Temperature adaptability Pore confinement

Polyp recurrence after colonoscopic polypectomy

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Chinese Medical Journal 2020年第17期133卷 2114-2115页

作者： qi-Pu Wang Xu-Xia He tao Xu Wen Ji Jia-Ming qian jing-Nan li Department of Gastroenterology Key Laboratory of Gut Microbiota Translational Medicine ResearchChinese Academy of Medical SciencesPeking Union Medical College HospitalBeijing 100730China Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Gastroenterology Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing University Cancer HospitalChongqing 400030China

Colorectal cancer(CRC)is the third most commonly diagnosed malignant tumor in the *** past few years have seen a remarkable increase in both incidence and mortality of CRC in developing countries like China,posing a serious threat to human *** is currently believed that about 70%of colorectal cancers are derived from conventional adenomas and 30%are derived from serrated adenomas.[1]As reported,CRC incidence rates per 10,000 person-years were 20.0 for advanced adenoma and 9.1 for non-advanced adenoma.[2]Colonoscopy,as an important tool for CRC screening and follow-up,can prevent the development of CRC by detecting and removing precancerous lesions,thereby effectively reducing the incidence and *** guidelines for post-polypectomy surveillance mostly recommend a 3-to 10-year interval according to baseline risk stratification.[3]However,there is no such guideline in China yet and doctors tend to perform the next colonoscopy within 1 year,which is much shorter than current international recommendations.

关键词： mortality colon removing

A promising method to recover spent V_(2)O_(5)-WO_(3)/TiO_(2) catalyst: treatment by vanadium-titanium magnetite sintering process

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Journal of Iron and Steel Research International 2022年第8期29卷 1176-1184页

作者： Hong-ming Long yu-dong Zhang tao Yang li-xin qian Zheng-wei yu School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina Anhui Province Key Laboratory of Metallurgy Engineering and Resources Recycling Anhui University of TechnologyMa’anshan 243002AnhuiChina

A large number of spent selective catalytic reduction(SCR)denitration catalysts are produced after the ultra-low emission transformation of coal-fired power plants in *** to the China’s“Directory of National Hazardous Wastes(Version 2021)”,these spent vanadium-tungsten-titanium catalysts are classified as“HW50”hazardous waste,and their disposal and utilization processes have been strictly ***,an effective and low-cost technique was developed to treat and utilize these spent SCR catalysts by the vanadium-titanium magnetite sintering *** of adding spent SCR catalysts on the sintering production process and product quality indexes of sinter were *** results showed that adding spent SCR catalysts can improve the sintering granulation and green feed permeability,thereby increasing the productivity and flame front *** the addition proportion of spent SCR catalysts is less than 1 wt.%,the performance indexes of the finished sinter are basically equal to those of the finished sinter without adding spent SCR *** increasing the proportion of spent SCR catalysts to 2.0 wt.%results in a decrease in product quality indexes,which could be attributed to the increase in perovskite content in the finished sinter.

关键词： Spent selective catalytic reduction catalyst Hazardous waste Vanadium-titanium magnetite sintering Recovery Utilization

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夏玉米施用含锌尿素效应及对后茬小麦的影响

中国土壤与肥料 2024年第4期 199-205页

作者：周琦张银杰张露露李岚涛张倩王宜伦河南农业大学资源与环境学院河南郑州450046

为明确新型肥料含锌尿素在夏玉米上的施用效果及其在冬小麦上的后效,采用田间试验,研究了施用含锌尿素、普通尿素、普通尿素+土施锌肥、普通尿素+喷施锌肥下夏玉米产量、养分吸收积累、土壤养分含量变化及其后效对冬小麦产量的影响。结... 详细信息

为明确新型肥料含锌尿素在夏玉米上的施用效果及其在冬小麦上的后效,采用田间试验,研究了施用含锌尿素、普通尿素、普通尿素+土施锌肥、普通尿素+喷施锌肥下夏玉米产量、养分吸收积累、土壤养分含量变化及其后效对冬小麦产量的影响。结果表明,普通尿素+喷施锌肥夏玉米产量较高,较不施氮显著增产17.5%,含锌尿素较不施氮显著增产16.7%,较普通尿素显著提高5.6%,与传统施锌无显著差异;含锌尿素地上部氮、锌素积累量较普通尿素分别显著提高9.0%、47.8%;夏玉米收获后含锌尿素处理土壤有效锌含量为1.83 mg·kg^(-1),较普通尿素处理提高88.6%;普通尿素+土施锌肥后茬冬小麦产量较高,较普通尿素显著增产11.9%,施用含锌尿素冬小麦产量较普通尿素提高4.7%,轮作周年产量提高5.2%;夏玉米利润和周年轮作利润分别提高826.2和1490.4元·hm^(-2)。含锌尿素较普通尿素提高了土壤有效锌含量,对后茬冬小麦、周年产量也有一定增产增收效果,夏玉米产量、干物质积累和氮肥利用效率等与传统施锌无显著差异。含锌尿素投入成本较传统施锌(氮肥和锌肥)降低26.1%,含锌尿素较普通尿素提高了产量和效益,具有在夏玉米-冬小麦轮作体系中推广应用的潜力。

关键词：夏玉米含锌尿素冬小麦后效产量肥料利用率

Overhead supplemental far-red light stimulates tomato growth under intra-canopy lighting with LEDs

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Journal of Integrative Agriculture 2019年第1期18卷 62-69页

作者： ZHANG Ya-ting ZHANG yu-qi YANG qi-chang li tao Key Laboratory of Energy Conservation and Waste Management of Agricultural Structures Ministry of Agriculture and Rural Affairs/Institute of Environment and Sustainable Development in AgricultureChinese Academy of Agriculture Sciences

Far-red(FR) light regulates phytochrome-mediated morphological and physiological plant *** study aims to investigate how greenhouse tomato morphology and production response to different durations of FR light during daytime and at the end of day(EOD).High-wire tomato plants were grown under intra-canopy lighting consisting of red(peak wavelength at 640 nm) and blue(peak wavelength at 450 nm) light-emitting diodes(LEDs) with photosynthetic photon flux density(PPFD) of 144 μmol m–2 s–1 at 10 cm away from the lamps,and combined with overhead supplemental FR light(peak wavelength at 735 nm) with PPFD of 43 μmol m–2 s–1 at 20 cm below the *** were exposed to three durations of FR supplemental lighting including: 06:00–18:00(FR12),18:00–19:30(EOD-FR1.5),18:00–18:30(EOD-FR0.5),and control that without supplemental FR *** results showed that supplemental FR light significantly stimulated stem elongation thereby resulting in longer plants compared with the ***,FR light altered leaf morphology toward higher leaf length/width ratio and larger leaf *** altered plant architecture in FR supplemented plants led to a more homogeneous light distribution inside the *** plant biomass was increased by 9–16% under supplemental FR light in comparison with control,which led to 7–12% increase in ripe fruit *** sugar content of the ripe tomato fruit was slightly decreased by longer exposure of the plants to FR *** matter partitioning to different plant organs were not substantially affected by the FR light *** significant differences were observed among the three FR light treatments in plant morphology as well as yield and biomass *** conclude that under intra-canopy lighting,overhead supplemental FR light stimulates tomato growth and *** supplementary of EOD-FR0.5 is more favorable,as it consumes less electricity but induces similar effects on plant morphology and yield.

关键词： Solanum lycopersicum far-red light LEDs intro-canopy lighting morphology yield

CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway

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Current Medical Science 2022年第5期42卷 1022-1032页

作者： Xue-qi CHEN Jia-yu MAO Chun-saier WANG Wen-bin li tao-tao HAN Ke LV jing-nan li Department of Medical Ultrasound Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Gastroenterology Beijing HospitalNational Center of GerontologyInstitute of Geriatrics MedicineChinese Academy of Medical SciencesBeijing100730China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical Science Key Laboratory of Gut Microbiota Translational Medicine Research Chinese Academy of Medical ScienceBeijing100730China

Objective While the upregulation of cytochrome P450 family 24 subfamily A member 1(CYP24A1)gene expression has been reported in colon cancer,its role in tumorigenesis remains largely *** this study,we aimed to investigate the involvement of CYP24A1 in Wnt pathway regulation via the nuclear factor kappa B(NF-κB)*** The human colon cancer cell lines HCT-116 and Caco-2 were subjected to stimulation with interleukin-6(IL-6)as well as tumor necrosis factor alpha(TNF-α),with subsequent treatment using the NF-κB pathway-specific inhibitor ammonium pyrrolidinedithiocarbamate(PDTC).Furthermore,CYP24A1 expression was subjected to knockdown via the use of small interfering RNA(siRNA).Subsequently,NF-κB pathway activation was determined by an electrophoretic mobility shift assay,and the transcriptional activity ofβ-catenin was determined by a dual-luciferase reporter assay.A mouse ulcerative colitis(UC)-associated carcinogenesis model was established,wherein TNF-αand the NF-κB pathway were blocked by anti-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides,*** the tumor size and protein level of CYP24A1 were *** IL-6 and TNF-αupregulated CYP24A1 expression and activated the NF-κB pathway in colon cancer *** significantly inhibited this increase in CYP24A1 ***,knockdown of CYP24A1 expression by siRNA could partially antagonize Wnt pathway *** CYP24A1 expression was observed in the colonic epithelial cells of UC-associated carcinoma mouse ***-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides decreased the tumor size and suppressed CYP24A1 *** Taken together,this study suggests that inflammatory factors may increase CYP24A1 expression via NF-κB pathway activation,which in turn stimulates Wnt signaling.

关键词： CYP24A1 Wnt/β-catenin signaling pathway colorectal neoplasms

层状液晶乳化技术包载天然活性物质用于功能化妆品的研究进展

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药学学报 2024年第2期59卷 350-358页

作者：张毅陈微韩艳琪孙倩雯高越叶军王洪亮高丽丽刘玉玲杨艳芳中国医学科学院北京协和医学院药物研究所北京100050

由于与人体皮肤角质细胞间的脂质层高度相似性的特点,包载天然活性物质的液晶乳化技术制备的层状液晶结构的功能化妆品成为近年的研究热点。该类化妆品往往具备水润清爽的涂抹肤感、优异的皮肤屏障修复功能和高效的保湿作用等特点,极具... 详细信息

由于与人体皮肤角质细胞间的脂质层高度相似性的特点,包载天然活性物质的液晶乳化技术制备的层状液晶结构的功能化妆品成为近年的研究热点。该类化妆品往往具备水润清爽的涂抹肤感、优异的皮肤屏障修复功能和高效的保湿作用等特点,极具应用前景。目前,关于液晶乳化技术应用于功能化妆品的研究尚处于初始阶段,具有参考价值的相关报道较少。基于此,本论文拟从人体皮肤结构、液晶尤其是层状液晶的结构组成、层状液晶包载天然活性物质用于功能化妆品的优势、含有层状液晶结构功能化妆品的制备工艺及相关上市功能化妆品等进行了全面的综述。最后,对液晶乳化技术在功能化妆品中的应用前景进行了展望,以期为从事液晶乳化技术相关功能化妆品的研究提供有益的参考。

关键词：功能化妆品液晶乳化技术层状液晶天然活性物质