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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan chenzhe ma Bin Qi Qingqiang Min Ming li Huabing chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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Science China Chemistry 2025年

作者： Xinyu Xu Yuan ma Hui Cao li Xu Haoming chen Sulai liu Wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-Ming Mo Xu chen Shu-Hua zhong Elena S Shubina Guo-Hong Ning Dan li College of Chemistry and materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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Metallurgical performance evaluation of space-weathered Chang’e-5 lunar soil

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International Journal of Minerals,Metallurgy and materials 2024年第6期31卷 1241-1248页

作者： chen li Wenhui ma yang li Kuixian Wei Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

Space metallurgy is an interdisciplinary field that combines planetary space science and metallurgical *** involves systematic and theoretical engineering technology for utilizing planetary resources in ***,space metallurgy on the Moon is challenging because the lunar surface has experienced space weathering due to the lack of atmosphere and magnetic field,making the mi-crostructure of lunar soil differ from that of minerals on the *** this study,scanning electron microscopy and transmission electron microscopy analyses were performed on Chang’e-5 powder lunar soil *** microstructural characteristics of the lunar soil may drastically change its metallurgical *** main special structure of lunar soil minerals include the nanophase iron formed by the impact of micrometeorites,the amorphous layer caused by solar wind injection,and radiation tracks modified by high-energy particle rays inside mineral *** nanophase iron presents a wide distribution,which may have a great impact on the electromagnetic prop-erties of lunar *** ions injected by solar wind may promote the hydrogen reduction *** widely distributed amorph-ous layer and impact glass can promote the melting and diffusion process of lunar ***,although high-energy events on the lun-ar surface transform the lunar soil,they also increase the chemical activity of the lunar *** is a property that earth samples and tradi-tional simulated lunar soil *** application of space metallurgy requires comprehensive consideration of the unique physical and chemical properties of lunar soil.

关键词： space metallurgy Chang’e-5 lunar soil space weathering metallurgical performance

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： zhong-liang Gong Hong-Jie Zhang Yan cheng Jianxun liu Yuhan Ai Yaqin li Zhihui Feng Qiong Zhang Shaolong Gong Yong chen Chang-Jiang Yao Yuan-Yuan Zhu liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic materials & CAS-HKU Joint Laboratory on New materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Morphology and structure of extremely red objects at z ～ 1 in the CANdeLS-COSMOS field

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Research in Astronomy and Astrophysics 2015年第6期15卷 811-818页

作者： Guan-Wen Fang zhong-yang ma yang chen Xu Kong Institute for Astronomy and History of Science and Technology Dali University Key Laboratory for Research in Galaxies and Cosmology University of Science and Technology of China Chinese Academy of Sciences Center for Astrophysics University of Science and Technology of China SISSA via Bonomea 265 I-34136 Trieste Italy

Using high-resolution HST/Wide Field Camera 3 F125W imaging from the CANdeLS-COSMOS field, we report the structural and morphological properties of extremely red objects （EROs） at -z 1. Based on the UVJ color criteria, we sepa- rate EROs into two types： old passive galaxies （OGs） and dusty star-forming galaxies （DGs）. For a given stellar mass, we find that the mean size of OGs （DGs） is smaller by a factor of - 2 （1.5） than that of present-day early-type （late-type） galaxies at a rest-frame optical wavelength. We derive the average effective radii of OGs and DGs, corresponding to 2.09 ± 1.13 kpc and 3.27± 1.14 kpc, respectively. Generally, the DGs are heterogeneous, with mixed features including bulges, disks and irregular structures, with relatively high M20, large size and low G. By contrast, OGs have elliptical-like compact morphologies with lower M20, smaller size and higher G, indicating a more concentrated and symmetric spatial extent of the stellar population distribution in OGs than DGs. These findings imply that OGs and DGs have different evolutionary processes, and that the minor merger scenario is the most likely mechanism for the structural properties of OGs. However, the size evolution of DGs is possibly due to the secular evolution of galaxies.

关键词： galaxies evolution -- galaxies: fundamental parameters -- galaxies structure -- galaxies high-redshift

Morphology and structure of BzK-selected galaxies at z ～ 2 in the CANdeLS-COSMOS field

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Research in Astronomy and Astrophysics 2015年第6期15卷 819-827页

Utilizing a BzK-selecfion technique, we obtain 14 550 star-forming galaxies （sBzKs） and 1763 passive galaxies （pBzKs） at z - 2 from the K-selected （KAB 〈 22.5） catalog in the COSMOS/UltraVISTA field. The differential number counts of sBzKs and pBzKs are consistent with the results from the literature. Compared to the observed results, semi-analytic models of galaxy formation and evolution provide too few （many） galaxies at the high （low） mass end. Moreover, we find that the star formation rate and stellar mass of sBzKs follow the relation of the main sequence. Based on HST/Wide Field Camera 3 F160W imaging, we find a wide range of morphological diversities for sBzKs, from diffuse to early-type spiral structures, with relatively high M20, large size and low G, while pBzKs have elliptical-like compact morphologies with lower M20, smaller size and higher G, indicating a more concentrated and symmetric spatial extent of stellar population distribution in pBzKs than sBzKs. Furthermore, the sizes of pBzKs （sBzKs） at z - 2 are on average two to three （one to two） times smaller than those of local early-type （late-type） galaxies with similar stellar mass. Our findings imply that the two classes have different evolution models and mass assembly histories.

关键词： galaxies evolution -- galaxies fundamental parameters -- galaxies structure -- galaxies high-redshift

Ni_(3)Fe/Ni_(4)S_(3)/Ni/C Mixed Crystal Composite Nanofibers Prepared by Electrospinning and Heat Treatment Methods for Oxygen Evolution Reaction

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Journal of Wuhan University of Technology(materials Science) 2023年第2期38卷 267-273页

作者： li Tao zhong Shujie LOU Qiongyue liNG Shuai chen Jian ma Guohua yang mao WU Xiaoqiang department of materials Engineering School of Mechanical EngineeringChengdu UniversityChengdu610106China material Corrosion and Protection Key Laboratory of Sichuan Province Zigong643000China Analysis and Testing Center Southwest University of Science and TechnologyMianyang621010China

OER catalyst of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C(NiFeSC series)mixed crystal composite nanofibers was prepared by electrospinning and atmospheric heat treatment *** testing results indicate that the diameters of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C composite nanofibers is about 200 nm,the grains size is about 1-3 nm,and the fiber surface is *** electrochemical test results show that the heterojunction of the prepared Ni_(3)Fe/Ni_(4)S_(3)/Ni/C hybrid crystal composite nanofiber has synergistic effect with sulfide,and exhibits good electrocatalytic activity of water decomposition and OER in alkaline *** OER electrocatalytic performance of Ni_(3)Fe/Ni_(4)S_(3)/Ni/C composite electrode prepared via a heat treatment at 1000℃process was tested in 1 mol/L KOH *** results show that the overpotential is about 298 mV,the Tafel slope is about 74 mV?dec-1,and the surface resistance is about 1.69Ω·cm^(2),at the current density of 10 ma·cm^(-2).

关键词： mixed crystal composite material nanofiber NiFeSC oxygen evolution reaction(OER)

Dynamic optimization oriented modeling and nonlinear model predictive control of the wet limestone FGD system

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Chinese Journal of Chemical Engineering 2020年第3期28卷 832-845页

作者： Lukuan yang Wenqi zhong li Sun Xi chen Yingjuan Shao Key Laboratory of Energy Conversion and Process Measurement and Control Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Nonlinear model predictive control(NMPC)scheme is an effective method of multi-objective optimization control in complex industrial *** this paper,a NMPC scheme for the wet limestone flue gas desulphurization(WFGD)system is proposed which provides a more flexible framework of optimal control and decision-making compared with PID *** first,a mathematical model of the FGD process is deduced which is suitable for NMPC *** equipoise the model’s accuracy and conciseness,the wet limestone FGD system is separated into several *** on the conservation laws,a model with reasonable simplification is developed to describe dynamics of different modules for the purpose of controller ***,by addressing economic objectives directly into the NMPC scheme,the NMPC controller can minimize economic cost and track the set-point *** accuracy of model is validated by the field data of a 1000 MW thermal power plant in Henan Province,*** simulation results show that the NMPC strategy improves the economic performance and ensures the emission requirement at the same *** the meantime,the control scheme satisfies the multiobjective control requirements under complex operation conditions(e.g.,boiler load fluctuation and set point variation).The mathematical model and NMPC structure provides the basic work for the future development of advanced optimized control algorithms in the wet limestone FGD systems.

关键词： Wet limestone flue gas desulphurization(WFGD)system Modeling Nonlinear model predictive control(NMPC) Multi-objective optimization

Formal Analysis and Improvement on Ultralightweight Mutual Authentication Protocols of RFID

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Chinese Journal of Electronics 2019年第5期28卷 1025-1032页

作者： XIAO Meihua li Wei zhong Xiaomei yang Ke chen Jia School of Software East China Jiaotong University Product development Center CRRC ZHUZHOU LOCOMOTIVE CO.LTD

Ultralightweight mutual authentication protocols(UmaP) of Radio frequency identification(RFID) systems have attracted much attention from researchers. many studies reveal that most of UmaP suffer malicious attack. To improve security of UmaP,formal analysis is performed with Simple promela interpreter(SPIN). Two typical UmaPs, which are RCIA and RAPP, are selected as our case study. A protocol abstract modeling method is presented to make UmaP can be formalized simply. Using SPIN, verification results show that RCIA and RAPP are both vulnerable against desynchronization attack. A Generalized model of UmaP(G-UmaP) and a general patching scheme are presented for resisting the attack. To validate the patching scheme,formal verification is then performed for the improved protocol. SPIN verification shows that the improved RCIA and RAPP both gain higher security. The above proposed modeling method has great significance for similar UmaP analyzing, and the proposed patching scheme is proved to be practical and reliable.

关键词： UmaP RCIA RAPP Key synchronization patching scheme Model checking