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Comprehensive effects of traditional Chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis

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World Journal of Clinical Cases 2024年第4期12卷 766-776页

作者： li-li Xia Shu-Yun Yang jun-Yao Xu Han-qing Chen Zhu-Yuan Fang Hypertension Research Institute Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210004Jiangsu ProvinceChina Department of General Practice Southeast University Affiliated Zhongda HospitalNanjing 210009Jiangsu ProvinceChina

BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and *** traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are *** study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF *** encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established *** results offer crucial insights into the potential advantages and constraints of TCM in HF *** on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and *** quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 ***,the quality of evidence was rated according to the GRADE *** A total of 1098 RCTs were initially *** screening,16 RCTs were finally included in our study,which were published between 2020 and *** RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 *** syndrome differentiation was analyzed in 11 of the included *** all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP *** meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0

关键词： Traditional Chinese medicine Heart failure Comprehensive clinical outcomes Traditional Chinese medicine syndrome score B-type natriuretic peptide level Meta-analysis©The Author(s)2024.Published by Baishideng Publishing Group Inc.

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In Vivo Voltammetric Imaging of Metal Nanoparticle-Catalyzed Single-Cell Electron Transfer by Fermi Level-Responsive Graphene

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Research 2024年第1期2023卷 271-280页

作者： qing Xia Rui liu Xueqin Chen Zixuan Chen jun-Jie Zhu State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023P.R.China Shenzhen Research Institute of Nanjing University Shenzhen 518000P.R.China

Metal nanomaterials can facilitate microbial extracellular electron transfer(EET)in the electrochemically active ***,the role of nanomaterials/bacteria interaction in this process is still ***,we reported the single-cell voltammetric imaging of Shewanella oneidensis MR-1 at the single-cell level to elucidate the metal-enhanced EET mechanism in vivo by the Fermi level-responsive graphene *** oxidation currents of~20 fA were observed from single native cells and gold nanoparticle(AuNP)-coated cells in linear sweep voltammetry *** the contrary,the oxidation potential was reduced by up to 100 mV after AuNP *** revealed the mechanism of AuNP-catalyzed direct EET decreasing the oxidation barrier between the outer membrane cytochromes and the *** method offered a promising strategy to understand the nanomaterials/bacteria interaction and guide the rational construction of EET-related microbial fuel cells.

关键词： Fermi voltammetry Electron

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Alkyl Radical Initiated Cyclization/Cascade for Synthesizing Lactam-Substituted Alkyl Sulfones

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Chinese Journal of Chemistry 2024年第16期42卷 1853-1859页

作者： li-jun Wu Kai-Yi Zhang Pei Yang Chuan-Chong Peng Jin-Hui liu qing li Da-Zhi Sun Shuangfeng Yin College of Sciences Central South University of Forestry and TechnologyChangshaHunan410004 China School of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhotInner Mongolia010021 China

An alkyl radical initiated cyclization/tandem reaction of alkyl bromides and alkyl electrophiles by using potassium metabisulphite(K_(2)S_(2)O_(5))as a connector is developed for the synthesis of various lactam-substituted alkyl ***,this process does not require a metal catalyst or metal powder reductant,highlighting its environmentally friendly *** reaction demonstrates outstanding substrate adaptability and a high tolerance towards diverse functional ***,the biologically active molecules and commercially available drugs with a late-stage modification are also highly compatible with this *** studies revealed that the reaction proceeds through a single-step process involving intramolecular radical cyclization,"SO_(2)"insertion,and external alkyl incorporation.

关键词： Alkyl radical Metal-free catalyzed Cyclization/cascade Potassium metabisulphite Electrophiles Alkyl sulfones Lactams Alkyl bromides Sodium formate

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A GAN-EfficientNet-Based Traceability Method for Malicious Code Variant Families

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Computers, Materials & Continua 2024年第7期80卷 801-818页

作者： li li qing Zhang Youran Kong School of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

Due to the diversity and unpredictability of changes in malicious code,studying the traceability of variant families remains *** this paper,we propose a GAN-EfficientNetV2-based method for tracing families of malicious code *** method leverages the similarity in layouts and textures between images of malicious code variants from the same source and their original family of malicious code *** method includes a lightweight classifier and a *** classifier utilizes the enhanced EfficientNetV2 to categorize malicious code images and can be easily deployed on mobile,embedded,and other *** simulator utilizes an enhanced generative adversarial network to simulate different variants of malicious code and generates datasets to validate the model’s *** process helps identify model vulnerabilities and security risks,facilitating model enhancement and *** classifier achieves 98.61%and 97.59%accuracy on the MMCC dataset and Malevis dataset,*** simulator’s generated image of malicious code variants has an FID value of 155.44 and an IS value of 1.72±*** classifier’s accuracy for tracing the family of malicious code variants is as high as 90.29%,surpassing that of mainstream neural network *** meets the current demand for high generalization and anti-obfuscation abilities in malicious code classification models due to the rapid evolution of malicious code.

关键词： Malicious code variant traceability feature reuse lightweight neural networks code visualization attention mechanism

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Prospective life cycle assessment of CO2 conversion by photocatalytic reaction

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Green Chemical Engineering 2024年第3期5卷 383-389页

作者： jun-Qi Wang Xiang-jun liu Jing-Jing Ma Shuai Zhang Hao-Ran liu Yong-li Dong qing-Yuan Yang School of Human Settlements and Civil Engineering Xi'an Jiaotong University School of Chemical Engineering and Technology Xi'an Jiaotong University

CO2conversion is gradually seen as a better way for society to effectively use carbon sources and avoid climate crisis associated with fossil CO2emissions. And the decision to deploy CO2technology scale should be relied on its environmental impact. In this work, life cycle assessment model evaluates the environmental performance of CO2conversion by photocatalytic reaction process with two different catalysts（NiAl-LDH and Co-ZIF-9）. Six impact categories considered in this analysis, including climate change, acidification potential, depletion of abiotic resources, eutrophication potential, ozone layer depletion potential, and photochemical oxidation potential. Results indicated that CO2conversion with Co-ZIF-9 photocatalyst has a better environmental impact than the NiAl-LDH photocatalyst route. Moreover, the Co-ZIF-9 catalyst scenario also has a lower total environmental burden than the conventional CO production route. Sensitivity analysis shows that recycle performance of the catalyst is highly sensitive to the production process in two scenarios. This study could provide a framework for robust decisions in CO2conversion by photocatalytic reaction, which is useful for policymakers to decide the feasibility of industrialization.

关键词： life cycle assessment (LCA) CO 2 Photocatalytic reaction Sensitivity analysis Uncertainty analysis

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A Coupled Thermomechanical Crack Propagation Behavior of Brittle Materials by Peridynamic Differential Operator

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 339-361页

作者： Tianyi li Xin Gu qing Zhang College of Architectural Engineering Jiangsu Open UniversityNanjing210036China Department of Engineering Mechanics Hohai UniversityNanjing211100China

This study proposes a comprehensive,coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator(PDDO),eliminating the need for calibration *** model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics *** simulations conducted on granite and ceramic materials,this model demonstrates its *** successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during *** account for material heterogeneity,the model utilizes the Shuffle algorithm andWeibull distribution,yielding results that align with numerical simulations and experimental *** coupled thermomechanical model shows great promise for analyzing intricate thermomechanical phenomena in brittle materials.

关键词： Peridynamic differential operator thermomechanical coupling heterogeneity numerical simulation

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FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2440-2453页

作者： Jing-Ya Yin Tian-Yuan Yang Bing-qing Yang Chen-Xue Hou jun-Nan li Yue li Qi Wang Center of liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing institute of infectious disease Beijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),*** high-risk MASH have rarely been studied and compared in *** To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk *** A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December *** screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH *** threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were *** operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with *** MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and ***,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively *** the sub

关键词： Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis Non-invasive models liver biopsy Diagnostic value

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Reducing Operation Emissions and Improving Work Efficiency Using a Pure Electric Wheel Drive Tractor

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Engineering 2024年第6期37卷 230-245页

作者： Chang-Kai Wen Wen Ren qing-Zhen Zhu Chun-Jiang Zhao Zhen-Hao Luo Sheng-li Zhang Bin Xie Zhi-jun Meng Research Center of Intelligent Equipment Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China State Key Laboratory of Intelligent Agricultural Power Equipment Beijing 100097China BYD Company limited Shenzhen 518118China College of Agricultural Engineering Jiangsu UniversityZhenjiang 212013China College of Engineering China Agricultural UniversityBeijing 100083China

In response to the problems of excessive greenhouse-gas and particulate emissions and the low traction efficiency of conventional diesel tractors in the field,a purely electric wheel-side drive tractor was studied,including an electric motor drive system,a battery ballast system,and an electro–hydraulic suspension *** paper develops a dynamics model of an electric tractor-ploughing unit under complex soil conditions,leading to the proposal of an active control method for drive wheel torque and a joint control method for the traction force of the suspension system and the front-and rear-axle loads of a ***,the tractor is prototyped and assembled,and ploughing tests are carried *** ploughing results show that the active torque-distribution control method proposed in this study reduces the tractor slip by 14.83%and increases the traction efficiency by 10.28%compared with the average torquedistribution *** with the conventional traction control mode,the joint control method for traction and ballast proposed in this paper results in a 3.7%increase in traction efficiency,a 15.05%decrease in slip,and a 4.9%reduction in total drive motor energy *** study will help to improve the operation quality and traction efficiency of electric tractors in complex soil conditions.

关键词： Electric tractor Ploughing unit Torque distribution Active ballast Traction performance

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A Method for Evaluating the Maximum Bending Degree of Flexural Toppling Rock Masses Based on the Rock Tensile Strain-Softening Model

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Journal of Earth Science 2024年第4期35卷 1243-1253页

作者： Jiongchao Wang jun Zheng Jichao Guo qing Lü Jianhui Deng Department of Civil Engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

Flexural toppling occurs when a series of layered rock masses bend towards their free *** is important to evaluate the maximum bending degree and the requirement of supports of flexural toppling rock mass to prevent rock mass cracking and even failure leading to a *** on the rock tensile strain-softening model,this study proposes a method for calculating the maximum curvature(C_(ppmax))of flexural toppling rock *** applying this method to calculate Cppmax of 9 types of rock masses with different hardness and rock layer thickness,some conclusions are drawn:(1)the internal key factors affecting C_(ppmax)are E^(⋆)(E^(⋆)=E_(ss)/E_(0),where E_(0)and E_(ss)are the mean deformation moduli of the rock before and after reaching its peak tensile strength,respectively),the strainεt corresponding to the tensile strength of rock,and the thickness(h)of rock layers;(2)hard rock layers are more likely to develop into block toppling than soft rock layers;and(3)thin rock layers are more likely to remain in flexural toppling state than thick rock *** addition,it is found that C_(ppmax)for flexural toppling rock masses composed of bedded rocks such as gneiss is related to the tensile direction.

关键词： flexural toppling rock mass maximum bending degree strain-softening model curvature rock mechanics

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Mechanism of microarc oxidation on AZ91D Mg alloy induced byβ-Mg_(17)Al_(12) phase

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 712-724页

作者： Dajun Zhai Xiaoping li jun Shen College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

This work proposed a strategy of indirectly inducing uniform microarc discharge by controlling the content and distribution ofβ-Mg_(17)Al_(12)phase in AZ91D Mg *** kinds of nano-particles(ZrO_(2)and TiO_(2))were designed to be added into the substrate of Mg alloy by friction stir processing(FSP).Then,Mg alloy sample designed with different precipitated morphology ofβ-Mg_(17)Al_(12)phase was treated by microarc oxidation(MAO)in Na_(3)PO_(4)/*** characteristics and performance of the MAO coating was analyzed using scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),contact angle meter,and potentiodynamic *** was found that the coarseα-Mg grains in extruded AZ91D Mg alloy were refined by FSP,and theβ-Mg_(17)Al_(12)phase with reticular structure was broken and *** nano-ZrO_(2)particles were pinned at the grain boundary by FSP,which refined theα-Mg grain and promoted the precipitation ofβ-Mg_(17)Al_(12)phase in *** effectively inhibited the“cascade”phenomenon of microarcs,which induced the uniform distribution of discharge *** MAO coating on Zr-FSP sample had good wettability and corrosion ***,TiO_(2)particles were hardly detected in the coating on TiFSP sample.

关键词： AZ91D Mg alloy microarc oxidation friction stir processing ZrO_(2) TiO_(2) β-Mg_(17)Al_(12)

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