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Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2

CHINESE JOURNAL OF INTEGRATIVE MEDICINE 2025年第3期31卷 240-250页

作者： Zhang, Xiao-nan li, Yan-yang Lyu, shi-chao Jia, Qiu-jin Zhang, Jun-ping liu, Long-tao China Acad Chinese Med Sci Xiyuan Hosp Natl Clin Res Ctr Chinese Med Cardiol Dept Cardiovasc Med Beijing 100091 Peoples R China Tianjin Med Univ Dept Integrated Tradit Chinese & Western Med Canc Inst & Hosp Tianjin 300060 Peoples R China Tianjin Univ Tradit Chinese Med Dept Cardiovasc Med Teaching Hosp 1 Tianjin 300193 Peoples R China Tianjin Key Lab Tradit Res Tradit Chinese Med Pres Dept Cardiovasc Med Tianjin 300193 Peoples R China

Objective: To explore the molecular mechanism of Shenmai Injection (SMI) against doxorubicin (DOX) induced cardiomyocyte apoptosis. Methods: A total of 40 specific pathogen-free (SPF) male Sprague Dawley (SD) male rats were divided into 5 groups based on the random number table, including the control group, the model group, miR-30a agomir group, SMI low-dose (SMI-L) group, and SMI high-dose (SMI-H) group, with 8 rats in each group. Except for the control group, the rats were injected weekly with DOX (2 mg/kg) in the tail vein for 4 weeks to induce myocardial injury, and were given different regimens of continuous intervention for 2 weeks. Cardiac function was detected by echocardiography and myocardial pathological changes were observed by Van Gieson (VG) staining. Myocardial injury serum markers, including creatine kinase (CK), lactate dehydrogenase (LDH), troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), soluble ST2 (sST2), and growth differentiation factor-15 (GDF-15) were detected by enzyme linked immunosorbent assay (EliSA). Cardiomyocyte apoptosis was observed by terminal deoxynucleotidyl transferase-mediated biotinylated dUTP triphosphate nick end labeling (TUNEL) and transmission electron microscopy, and the expressions of target proteins and mRNA were detected by Western blot and quantitative real time polymerase chain reaction (qRT-RCR), respectively. Results: The treatment with different doses of SMI reduced rat heart mass index and left ventricular mass index (P<0.05), significantly improved the left ventricular ejection fraction (P<0.05), decreased the levels of serum CK, LDH, cTnT, and NT-proBNP (P<0.05 or P<0.01), reduced the levels of serum sST2 and GDF-15 (P<0.05 or P<0.01), decreased the collagen volume fraction, reduced the expressions of rat myocardial type I and type III collagen (P<0.05 or P<0.01), and effectively alleviated myocardial fibrosis. And the study found that SMI promoted the expression levels of miR-30a and Bc

关键词： Shenmai Injection doxorubicin cardiotoxicity miR-30a/Bcl-2 apoptosis

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Study on cook-off characteristics and thermal safety venting area of RBOE charge

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Defence Technology(防务技术) 2025年第1期43卷 271-287页

作者： Kebin Zhang Wenbin li Changfang Zhao Zhifang Wei Shuxia Zhang jin li School of Mechanical and Electrical Engineering North University of ChinaTaiyuan 030000China ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyNanjing 210094China Department of Engineering Mechanics CNMM and AMLTsinghua UniversityBeijing 100084China

RBOE is a new type of DNAN-based high-energy melt-cast mixed explosive,whose safety under thermal stimulation is significantly affected by heating conditions and venting area of the *** on the thermal decomposition reaction characteristics and combustion characteristics of each component of RBOE explosive,the cook-off calculation models of RBOE warhead before and after ignition were *** addition,closed and vented warheads were designed,as well as fast and slow cook-off test *** cook-off characteristics and thermal safety venting area of RBOE warhead were extensively *** results showed that the closed RBOE warhead underwent deflagration reaction under both slow and fast cook-off *** calculation result of the shell wall temperature before slow cookoff ignition response of the warhead was 454.06 K,with an error of+1.75%compared to the test result of462.15 K,and the temperature rise rate calculated was in good agreement with the *** calculated ignition time of RBOE warhead under fast cook-off was 161 s,with an error of+8.8%compared to the test result of 148 s,which verified the accuracy of cook-off model of RBOE warhead before *** to the cook-off calculation model of the warhead after ignition and cook-off test of the vented warhead,it was determined that the thermal safety venting area was 1124.61 mm^(2)for fast cook-off and 530.66 mm~2 for slow cook-off,effectively preventing the reaction of warhead above ***,this study provides a scientific basis for the thermal safety design and evaluation of insensitive warheads.

关键词： RBOE explosive Cook-off model Temperature distribution Pressure growth Venting area

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究竟谁是谁非?——《以讹传讹一例》辨证

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中国文学研究 2006年第2期 104-106页

作者：李士金淮阴师院中文系江苏淮安223001

写文章引用文献固然需要标明原始文献的出处,但该文用以作为核心证据的论据和论点却是站不住脚的, 对原文的理解有明显的错误。经过后人标点的“原典”并不能作为文献内容标点正确与否的根据。

关键词：《以讹传讹一例》文献内容中国文学史艺术魅力价值观念

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A Correntropy-Based Echo State Network With Application to Time Series Prediction

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 425-435页

作者： Xiufang Chen Zhenming Su Long jin Shuai li the School of Information Science and Engineering Lanzhou University IEEE the Hangzhou Institute for Advanced Study University of Chinese Academy of Science

As a category of recurrent neural networks, echo state networks(ESNs) have been the topic of in-depth investigations and extensive applications in a diverse array of fields, with spectacular triumphs achieved. Nevertheless, the traditional ESN and the majority of its variants are devised in the light of the second-order statistical information of data(e.g., variance and covariance), while more information is neglected. In the context of information theoretic learning, correntropy demonstrates the capacity to grab more information from data. Therefore, under the guidelines of the maximum correntropy criterion, this paper proposes a correntropy-based echo state network(CESN) in which the first-order and higher-order information of data is captured, promoting robustness to noise. Furthermore, an incremental learning algorithm for the CESN is presented, which has the expertise to update the CESN when new data arrives, eliminating the need to retrain the network from scratch. Finally, experiments on benchmark problems and comparisons with existing works are provided to verify the effectiveness and superiority of the proposed CESN.

关键词： Correntropy echo state network (ESN) noise time series prediction

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钱伟长大学素质教育观及其时代意义

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云南民族大学学报（哲学社会科学版） 2006年第5期23卷 237-240页

作者：李士金淮阴师范学院中文系江苏淮安223001

钱伟长教授以其渊博的学识和切身的研究经验探讨了大学素质教育的深刻内涵和本质意义。具体包括培养“合格的人”的前提条件、创新精神的科学内涵、教师创新精神的价值、学生自学能力的不可替代的意义等,对今天的大学教育管理有深刻的... 详细信息

钱伟长教授以其渊博的学识和切身的研究经验探讨了大学素质教育的深刻内涵和本质意义。具体包括培养“合格的人”的前提条件、创新精神的科学内涵、教师创新精神的价值、学生自学能力的不可替代的意义等,对今天的大学教育管理有深刻的时代意义。

关键词：钱伟长合格的人创新精神创新教育

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Absorption mechanism of SO_(3)on various alkaline absorbents in the presence of SO_(2)

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Journal of Environmental Sciences 2025年第3期149卷 268-277页

作者： Junxiang Guo jin Xiong Yuran li Jirigele Qinggele Tingyu Zhu Shougang Group Research Institute of Technology Beijing 100043China Beijing Key Laboratory of Green Recyclable Process for Iron&Steel Production Technology Beijing 100043China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringInnovation Academy for Green ManufactureChinese Academy of SciencesBeijing 100190China WISDRI City Environment Protection Engineering limited Company Wuhan 430205China

Sulfur trioxide(SO_(3))as a condensable particle matter has a significant influence on atmospheric visibility,which easily arouses formation of *** is imperative to control the SO_(3)emission from the industrial flue *** commonly used basic absorbents,including Ca(OH)_(2),MgO and NaHCO_(3)were selected to explore the effects of temperature,SO_(2)concentration on the SO_(3)absorption,and the reaction mechanism of SO_(3)absorption was further *** suitable reaction temperature for various absorbents were proposed,Ca(OH)_(2)at the high temperatures above 500°C,MgO at the low temperatures below 320°C,and NaHCO_(3)at the temperature range of 320–500°*** competitive absorption between SO_(2)and SO_(3)was found that the addition of SO_(2)reduced the SO_(3)absorption on Ca(OH)_(2)and NaHCO_(3),while had no effect on *** order of the absorption selectivity of SO_(3)follows MgO,NaHCO_(3)and Ca(OH)_(2)under the given conditions in this *** absorption process of SO_(3)on NaHCO_(3)follows the shrinking core model,thus the absorption reaction continues until NaHCO_(3)was exhausted with the utilization rate of nearly 100%.The absorption process of SO_(3)on Ca(OH)_(2)and MgO follows the grain model,and the dense product layer hinders the further absorption reaction,resulting in low utilization of about 50%for Ca(OH)_(2)and *** research provides a favorable support for the selection of alkaline absorbent for SO_(3)removal in application.

关键词： Alkali absorbent Sulfur trioxide Selectivity Shrinking core model Grain model

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黄檀属模式指定及新异名(英文)

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植物分类学报 2007年第3期45卷 383-387页

作者：李世晋吴鸿张奠湘中国科学院华南植物园广州510650 华南农业大学生命科学学院广州510642

指定了黄檀属Dalbergia黄檀*** Hance、滇黔黄檀*** Franch.、*** Prain和多裂黄檀*** Roxb.四个名称的后选模式。分别将上海黄檀*** Prain、高原黄檀*** ***(Prain)Thoth.和勐梭黄檀*** ***处理为黄檀***、滇黔黄檀***和多裂黄檀***的... 详细信息

指定了黄檀属Dalbergia黄檀*** Hance、滇黔黄檀*** Franch.、*** Prain和多裂黄檀*** Roxb.四个名称的后选模式。分别将上海黄檀*** Prain、高原黄檀*** ***(Prain)Thoth.和勐梭黄檀*** ***处理为黄檀***、滇黔黄檀***和多裂黄檀***的异名。

关键词：黄檀属豆科命名法模式指定新异名

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Metagenomics reveals the resistance patterns of electrochemically treated erythromycin fermentation residue

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Journal of Environmental Sciences 2025年第2期148卷 567-578页

作者： Jieya Zhou HaoWu Haiyan Wang ZongruWu lihu shi Shulei Tian li-an Hou State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Inner Mongolia Autonomous Region Solid Waste and Soil Ecological Environment Technology Center Hohhot 010020China

Erythromycin fermentation residue(EFR)represents a typical hazardous waste produced by the microbial pharmaceutical *** electrolysis is promising for EFR disposal,its microbial threats remain ***,metagenomics was coupled with the random forest technique to decipher the antibiotic resistance patterns of electrochemically treated *** showed that 95.75%of erythromycin could be removed in 2 *** temporarily influenced EFRmicrobiota,where the relative abundances of Proteobacteria and Actinobacteria increased,while those of Fusobacteria,Firmicutes,and Bacteroidetes decreased.A total of 505 antibiotic resistance gene(ARG)subtypes encoding resistance to 21 antibiotic types and 150 mobile genetic elements(MGEs),mainly including plasmid(72)and transposase(52)were assembled in *** linear regression models were identified among microbial richness,ARG subtypes,and MGE numbers(r^(2)=0.50-0.81,plicibacterium were the primary drivers of the resistance dissemination *** study also proposes efficient resistance mitigation measures,and provides recommendations for future management of antibiotic fermentation residue.

关键词： Erythromycin fermentation residue (EFR) Microbial pharmaceutical industry Disposal strategy Metagenomics Antibiotic fermentation residue management

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Bond length and interface failure mechanism of anchor cable under continuous radial pressure conditions

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International Journal of Mining Science and Technology 2025年第2期35卷 231-247页

作者： Jian Ouyang Xiuzhi shi Xianyang Qiu Zongguo Zhang Zeyu li School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The anchoring capacity of the anchor cable is closely related to the bonding length and radial pressure *** field pull-out tests,theoretical analysis,numerical simulation,and industrial tests,this study clarifies the relationship between radial pressure and bonding length for the ultimate pullout force and reveals the microscopic failure process of the resin-rock interface in the anchoring *** results show that the ultimate load increases with the increase of bonding length in three different stages:rapid,slow,and uniform *** new mechanical model developed considering radial pressure describes the inverse relationship between radial pressure and the plastic zone on the bonding section,and quantifies the reinforcing effect of confining pressure on the anchoring *** the pull-out process of the anchor cable,the generation of failure cracks is in the order of orifice,bottom,and middle of the *** pressure can effectively enhance the ultimate pull-out force,alleviate the oscillation increase of pull-out force,and inhibit resin cracking,but will produce an external crushing *** also reveals the synergistic effect between bonding length and radial pressure,and successfully carries out industrial tests of anchor cable support,which ensures the stability of the stope roof and provides an important reference for the design of anchor cable support in deep high-stress mines.

关键词： Radial pressure Anchor cable Bond length Numerical simulation Interface failure Microscopic process

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Oxalate modification enabled advanced phosphate removal of nZVI:In Situ formed surface ternary complex and altered multi-stage adsorption process

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Journal of Environmental Sciences 2025年第3期149卷 79-87页

作者： shiyu Cao Jiangshan li Yanbiao shi Furong Guo Tingjuan Gao lizhi Zhang Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Institute of Environmental&Applied ChemistryCollege of ChemistryCentral China Normal UniversityWuhan 430079China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China

Nano zero-valent iron(nZVI)is a promising phosphate adsorbent for advanced phosphate ***,the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal performance,accounting for its inapplicability to meet the emission criteria of 0.1 mg P/L *** this study,we report that the oxalate modification can inhibit the passivation of nZVI and alter the multi-stage phosphate adsorption mechanism by changing the adsorption *** expected,the stronger antipassivation ability of oxalate modified nZVI(OX-nZVI)strongly favored its phosphate ***,the oxalate modification endowed the surface Fe(III)sites with the lowest chemisorption energy and the fastest phosphate adsorption ability than the other adsorption sites,by in situ forming a Fe(III)-phosphate-oxalate ternary complex,therefore enabling an advanced phosphate removal *** an initial phosphate concentration of 1.00 mg P/L,pH of 6.0 and a dosage of 0.3 g/L of adsorbents,OX-nZVI exhibited faster phosphate removal rate(0.11 g/mg/min)and lower residual phosphate level(0.02 mg P/L)than nZVI(0.055 g/mg/min and 0.19 mg P/L).This study sheds light on the importance of site manipulation in the development of high-performance adsorbents,and offers a facile surface modification strategy to prepare superior iron-basedmaterials for advanced phosphate removal.

关键词： Oxalate modification Advanced phosphate removal Nano zero-valent iron(nZVI) Surface ternary complex Multi-stage adsorption

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