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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第8期22卷 647-663页

作者： hongyi li You LYU Xiaoliang CHEN Bei li Qi HUA Fusui JI Yajun YIN Hua li Cardiology Department Xuanwu HospitalCapital Medical UniversityBeijing 100053China Cardiology Department Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Radiology Department China-Japan Friendship HospitalBeijing 100029China Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Interstitial fluid(ISF)flow through vascular adventitia has been discovered ***,its kinetic pattern was *** used histological and topographical identification to observe ISF flow along venous vessels in *** magnetic resonance imaging(MRI)in live subjects,the inherent pathways of ISF flow from the ankle dermis through the legs,abdomen,and thorax were enhanced by paramagnetic *** fluorescence stereomicroscopy and layer-by-layer dissection after the rabbits were sacrificed,the perivascular and adventitial connective tissues(PACTs)along the saphenous veins and inferior vena cava were found to be stained by sodium fluorescein from the ankle dermis,which coincided with the findings by *** direction of ISF transport in a venous PACT pathway was the same as that of venous blood *** confocal microscopy and histological analysis,the stained PACT pathways were verified to be the fibrous connective tissues,consisting of longitudinally assembled ***-time observations by fluorescence stereomicroscopy revealed at least two types of spaces for ISF flow:one along adventitial fibers and another one between the vascular adventitia and its covering *** nanoparticles and surfactants,a PACT pathway was found to be accessible by a nanoparticle oflit-shaped"porous biomaterial,comprising a longitudinal transport channel and an absorptive part for *** use of surfactants suggested that interfacial tension might play an essential role in layers of continuous ISF flow along vascular vessels.A hypothetical"gel pump"is proposed based on interfacial tension and interactions to regulate ISF *** experimental findings may inspire future studies to explore the physiological and pathophysiological functions of

关键词： Vascular adventitia Interstitial fluid Connective tissue Interfacial zone

鄱阳湖平原县域耕地土壤容重的空间分布特征及其影响因素

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江西科学 2024年第3期42卷 544-550,556页

作者：耿一博胡碧峰周就猫张宏戴叶明饶建东李洪义江西财经大学财税与公共管理学院南昌330013 江西省地质局第九地质大队南昌330036

土壤容重是重要的土壤理化性质之一,同时对农作物生长具有显著性影响。研究耕层土壤容重空间分布特征及其影响因素可指导耕地改良及高质量农田建设。通过野外采样及实验测试获得了余干县423个土壤样本的土壤容重、耕层质地及成土母质等... 详细信息

土壤容重是重要的土壤理化性质之一,同时对农作物生长具有显著性影响。研究耕层土壤容重空间分布特征及其影响因素可指导耕地改良及高质量农田建设。通过野外采样及实验测试获得了余干县423个土壤样本的土壤容重、耕层质地及成土母质等相关因素的数据,应用GIS软件和地统计学方法分析了土壤容重的空间分布相关特征;同时结合地理探测器,探讨了影响余干县耕层土壤容重空间分布的影响因素。结果表明,余干县耕层土壤容重平均值为1.11 g/cm^(3),变异系数为16.0%。在空间分布方面,耕层土壤容重从西南到东北方向近似呈递减趋势。耕层厚度和成土母质对土壤容重具有显著影响,泥质岩土壤容重较低,而砂质岩容重较高。建议将禾斛岭垦殖场、瑞洪镇、古埠镇、三塘乡、东塘乡、黄金埠镇以及康山乡部分区域设为重点改良区。此研究为进一步了解鄱阳湖平原县域耕地土壤容重空间分布影响因素及耕地土壤改良区域划分提供理论依据。

关键词：耕层土壤土壤容重空间分布地理探测器

Dynamic event-triggered-based human-in-the-loop formation control for stochastic nonlinear MASs

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Security and Safety 2023年第4期2卷 49-65页

作者： Yonghua Peng Guohuai lin Guangdeng Chen hongyi li School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Province Key Laboratory of Intelligent Decision and Cooperative Control Guangdong University of TechnologyGuangzhou 510006China

The dynamic event-triggered(DET)formation control problem of a class of stochastic nonlinear multi-agent systems(MASs)with full state constraints is investigated in this *** that the human operator sends commands to the leader as control input signals,all followers keep formation through network topology *** the command-filter-based backstepping technique,the radial basis function neural networks(RBF NNs)and the barrier Lyapunov function(BLF)are utilized to resolve the problems of unknown nonlinear terms and full state constraints,***,a DET control mechanism is proposed to reduce the occupation of communication *** presented distributed formation control strategy guarantees that all signals of the MASs are semi-globally uniformly ultimately bounded(SGUUB)in ***,the feasibility of the theoretical research result is demonstrated by a simulation example.

关键词： Dynamic event-triggered(DET)control formation control full state constraints human-in-the-loop(HiTL) multi agent systems(MASs)

Emerging hierarchical mesoporous materials of covalent organic frameworks

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Science China Chemistry 2024年第9期67卷 2796-2802页

作者： lingyan Huang Wenda li hongyi Zhang Shanzhe Ke Hao Chen Jianwei Fu Chengbin Jing Jiangong Cheng Shaohua liu State Key Laboratory of Precision Spectroscopy/Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052China State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

Benefiting from abundant exposed active sites,minimized diffusion resistance of guest molecules,facilitated mass transfer process and enhanced storage capacity,covalent organic frameworks(COFs)have gained widespread scientific attention[1–4].Further construction of mesopores regarding pore engineering(pore size,pore geometry,pore volume,and framework compositions)in COFs can improve mass transport,accessibility as well as size-selectivity of the special guest moieties,thus exhibiting potential in catalysis,energy storage and separation and so on[5,6].

关键词： gained catalysis separation

Characterization of Fault Zones by Analysis of Aftershock Waveform Data

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Journal of Earth Science 2009年第6期20卷 985-994页

作者：李红谊李松林赖晓玲 Key Laboratory of Geo-detection (China University of Geosciences Beijing)Ministry of Education School of Geophysics and Information Technology China University of GeosciencesBeijing Geophysical Prospecting Center China Earthquake Administration

Large property contrasts between materials in a fault zone and the surrounding rock are often produced by repeating earthquakes. Fault zones are usually characterized by fluid concentration, clay-rich fault gouge, increased porosity, and dilatant cracks. Thus, fault zones are thought to have reduced seismic velocities than the surrounding rocks. In this article, we first investigated the synthetic waveforms at a linear array across a vertical fault zone by using 3D finite difference simulation. Synthetic waveforms show that when sources are close to, inside, or below the fault zone, both arrival times and waveforms of P-and S-waves vary systematically across the fault zone due to reflections and transmissions from boundaries of the low-velocity fault zone. The arrival-time patterns and waveform characteristics can be used to determine the fault zone structure. Then, we applied this method to the aftershock waveform data of the 1992 Landers M7.4 and the 2008 Wenchuan （汶川） M8.0 earthquakes. Landers waveform data reveal a low-velocity zone with a width of approximately 270-370 m, and P-and S-wave velocity reductions relative to the host rock of approximately 35%-60%; Wenchuan waveform data suggest a low-velocity zone with a width of approximately 220-300 m, and P-and S-wave velocities drop relative to the host rock of approximately 55%.

关键词： waveform characteristics seismic-wave propagation fault zone structure.

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支持多源遥感数据格式的抽象库DFAL

遥感学报 2016年第2期20卷 197-204页

作者：李宏益唐娉中国科学院遥感与数字地球研究所北京100101 中国科学院大学北京100049

针对当前遥感数据缺乏统一文件格式标准,多源遥感产品的生产使用涉及多种文件格式的现状,在研究多种遥感数据格式及对应库GDAL、HDF4、HDF5的基础上,参考国家气象局的NOAA AVHRR 1B格式标准,利用工厂模式,设计和实现了一个具有统一操作... 详细信息

针对当前遥感数据缺乏统一文件格式标准,多源遥感产品的生产使用涉及多种文件格式的现状,在研究多种遥感数据格式及对应库GDAL、HDF4、HDF5的基础上,参考国家气象局的NOAA AVHRR 1B格式标准,利用工厂模式,设计和实现了一个具有统一操作接口的多源遥感数据格式抽象库DFAL,在更高的抽象层次解决了GDAL和HDF4、HDF5库不能一致使用的问题。使用DFAL库进行不同文件格式的读写,专家无需了解这些文件格式的差别,以便从繁杂的遥感数据格式中解放出来,将更多精力投入到遥感科学研究的层面上。在DFAL库的基础上实现了两类常用遥感数据格式Geo TIFF和HDF5之间的转换工具,方便工程应用。DFAL库及转换工具在国家高技术研究发展计划《星机地综合定量遥感系统与应用示范》的多尺度按需定量遥感产品生产系统中进行了应用测试,取得了很好的实际效果,证明了DFAL库稳定性和可用性,并大大减少了多源数据协同使用时多种文件格式读写的工作量。

关键词： GDAL HDF5 遥感数据格式集成 DFAL

GAN-DIRNet:A Novel Deformable Image Registration Approach for Multimodal Histological Images

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Computers, Materials & Continua 2024年第7期80卷 487-506页

作者： Haiyue li Jing Xie Jing Ke Ye Yuan Xiaoyong Pan hongyi Xin Hongbin Shen Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of ChinaShanghai200240China Department of Pathology Ruijin HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200025China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai200240China

Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of *** neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image ***,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s *** argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator *** this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image *** begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific ***,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise ***,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s *** results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.

关键词： Histological images registration deformable registration generative adversarial network cushing’s disease machine learning computer vision

环状RNA circAZIN1在骨关节炎中调控软骨细胞退变的作用机制

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重庆医学 2024年第10期53卷 1446-1453页

作者：王湘江韩嘉跞杨浪温国洪关鸿王贵清利洪艺广州医科大学附属清远医院/清远市人民医院骨科五区广东清远511518

目的研究环状RNA(circRNA)hsa_circ_0003304(circAZIN1)在骨关节炎(OA)中调控软骨细胞退变的作用及机制。方法基因芯片检测人脂肪源性干细胞(hADSC)成软骨分化过程中circRNA的表达水平变化。从基因芯片检测差异化表达最明显的前10位circ... 详细信息

目的研究环状RNA(circRNA)hsa_circ_0003304(circAZIN1)在骨关节炎(OA)中调控软骨细胞退变的作用及机制。方法基因芯片检测人脂肪源性干细胞(hADSC)成软骨分化过程中circRNA的表达水平变化。从基因芯片检测差异化表达最明显的前10位circRNA中,用IL-β及TNF-α构建的软骨细胞炎症模型进一步筛选出circAZIN1,过表达circAZIN1(转染pcDNA3.1-circAZIN1-EF1-ZsGreen质粒)后实时荧光定量PCR(qPCR)检测其对软骨细胞外基质(ECM)代谢的影响。RNA-蛋白体外结合(RNA pull down)试验检测circAZIN1结合的蛋白,miRNA-circRNA Interactions预测circAZIN1可能海绵吸附的微RNA(miRNA)及其位点,进一步利用TargetMiner、miRDB及TargetScan数据库预测circAZIN1可能海绵吸附的miRNA及下游mRNA,过表达miRNA后检测circAZIN1、miRNA及下游的mRNA是否存在镜像调控现象。结果circAZIN1在hADSC成软骨分化过程中(第3天和第21天)、IL-β及TNF-α构建的软骨细胞炎症模型中差异化表达最明显(第3天组vs.第21天组、对照组***-β组、对照组***-α组);过表达circAZIN1可促进软骨细胞ECM的合成、抑制其分解;RNA-Pull down试验检测到circAZIN1明显结合AGO2蛋白,提示circAZIN1海绵吸附miRNAs的可能性大,进一步数据库预测circAZIN1的下游miRNA为hsa-miR-654-3p,而hsa-miR-654-3p的下游mRNA为CACNA1I,最后过表达hsa-miR-654-3p后qPCR检测证实circAZIN1、hsa-miR-654-3p及CACNA1I间存在镜像调控现象。结论circAZIN1通过海绵吸附hsa-miR-654-3p继而抑制CACNA1I的沉默效应从而发挥抑制软骨细胞退变的作用,这为circRNA在OA发生、发展中的调控机制研究提供了参考。

关键词：骨关节炎软骨退变软骨细胞环状RNA 海绵吸附

基于知识点模块整合的情景案例教学法在急诊与灾难医学教学中的应用研究

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广西中医药大学学报 2024年第1期27卷 76-78页

作者：唐晓何锦轶伍民生陈盛奎康雪莹胡炳全李宏一梁皓广西中医药大学附属瑞康医院广西南宁530011

[目的]探讨基于知识点模块整合的情景案例教学法在急诊与灾难医学教学中的应用效果。[方法]将60名实习生按随机数字表法分为对照组和试验组各30名,对照组接受传统教学法,试验组接受基于知识点模块整合的情景案例教学法。对比两组的整体... 详细信息

[目的]探讨基于知识点模块整合的情景案例教学法在急诊与灾难医学教学中的应用效果。[方法]将60名实习生按随机数字表法分为对照组和试验组各30名,对照组接受传统教学法,试验组接受基于知识点模块整合的情景案例教学法。对比两组的整体临床实践能力评分、理论考核成绩和操作考核成绩。[结果]试验组的整体实践能力评分高于对照组(P<0.05或P<0.01),基础理论、基本知识等理论成绩均高于对照组(P<0.01),现场急救、创伤急救、疾病救治、心肺复苏、急性中毒处理、理化环境损伤处理等操作成绩均高于对照组(P<0.01)。[结论]基于知识点模块整合的情景案例教学法,可提高急诊与灾难医学的临床带教效果,有助于实习生掌握理论知识与操作技能,促进整体实践能力的提高。

关键词：急诊与灾难医学教学情景案例教学法知识点模块