Layers of interstitial fluid flow along a“slit-shaped”vascular adventitia

作     者：Hongyi LI You LYU Xiaoliang CHEN Bei LI Qi HUA Fusui JI Yajun YIN Hua LI Hongyi LI;You LYU;Xiaoliang CHEN;Bei LI;Qi HUA;Fusui JI;Yajun YIN;Hua LI

作者机构：Cardiology DepartmentXuanwu HospitalCapital Medical UniversityBeijing 100053China Cardiology DepartmentBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Radiology DepartmentChina-Japan Friendship HospitalBeijing 100029China Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2021年第22卷第8期

页      面：647-663页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82050004 and 81141118) the Beijing Hospital Clinical Research 121 Project(No.121-2016002) the National Basic Research Program of China(No.2015CB554507) Ms.Siu TUEN,Lucy Chan LAU,Mr.Waichun TIN,and Weiwu HU for their financial support 

主　　题：Vascular adventitia Interstitial fluid Connective tissue Interfacial zone 

摘      要：Interstitial fluid(ISF)flow through vascular adventitia has been discovered ***,its kinetic pattern was *** used histological and topographical identification to observe ISF flow along venous vessels in *** magnetic resonance imaging(MRI)in live subjects,the inherent pathways of ISF flow from the ankle dermis through the legs,abdomen,and thorax were enhanced by paramagnetic *** fluorescence stereomicroscopy and layer-by-layer dissection after the rabbits were sacrificed,the perivascular and adventitial connective tissues(PACTs)along the saphenous veins and inferior vena cava were found to be stained by sodium fluorescein from the ankle dermis,which coincided with the findings by *** direction of ISF transport in a venous PACT pathway was the same as that of venous blood *** confocal microscopy and histological analysis,the stained PACT pathways were verified to be the fibrous connective tissues,consisting of longitudinally assembled ***-time observations by fluorescence stereomicroscopy revealed at least two types of spaces for ISF flow:one along adventitial fibers and another one between the vascular adventitia and its covering *** nanoparticles and surfactants,a PACT pathway was found to be accessible by a nanoparticle of100 nm and contained two parts:a transport channel and an absorptive *** calculated velocity of continuous ISF flow along fibers of the PACT pathway was 3.6-15.6 mm/*** data revealed that a PACT pathway was aslit-shapedporous biomaterial,comprising a longitudinal transport channel and an absorptive part for *** use of surfactants suggested that interfacial tension might play an essential role in layers of continuous ISF flow along vascular vessels.A hypotheticalgel pumpis proposed based on interfacial tension and interactions to regulate ISF *** experimental findings may inspire future studies to explore the physiological and pathophysiological functions of