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Compositional change in human enamel irradiated with MIR free electron laser

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Chinese Science Bulletin 2001年第23期46卷 2016-2018页

作者： liU Nianqing li Yonggui ZHU Junbiao ZHANG liwen WANG Mingkai WU Gang YANG Xueping li guangcheng Huang Yuying DONG Yanmei GAO Xuejun Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039China Stomatological College Peking UniversityBeijing 100081China 不详

The purpose of this study was to investigate compositional changes in human enamel irradiated with the free electron laser (FEL). The exposure on dental enamel at the wavelength of 9.64 μm was observed with the Beijing free electron laser. The distribution of elements in the irradiated or non-irradiated enamel was measured by scanning electron microscope (SEM) with energy-dispersive spectroscopy and synchrotron radiation X-ray fluorescence (SRXRF) in Beijing Synchrotron Radiation Facility (BSRF). The results showed that the P/Ca ratio in the ablation region of enamel at the maximum wavelength of infrared absorption was obviously smaller than that at the non-maximum wavelength. In the ablation region the ratios of P/Ca and Ca/Sr were smaller than those in the non-ablation region. The distributions of P, Ca and Sr in the ablation region were heterogeneous due to the element change caused by FEL irradiation.

关键词： human enamel Beijing free electron laser synchrotron radiation X-ray fluorescence ablation element distribution.

Yizhijiannao Granule and a combination of its effective monomers,icariin and Panax notoginseng saponins,inhibit early PC12 cell apoptosis induced by beta-amyloid(25-35)

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Neural Regeneration Research 2012年第24期7卷 1845-1850页

作者： Ting Zhang Zhanwei Zhang Keli Dong guangcheng li Hong Zhu Department of Traditional Chinese Medicine Xiangya Third HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Neurosurgery First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

One of our previous studies showed that Yizhijiannao Granule,a compound Chinese medicine, effectively improved the clinical symptoms of Alzheimer’s *** the present study,we established a model of Alzheimer’s disease using beta-amyloid（25-35）in PC12 cells,and treated the cells with Yizhijiannao Granule and its four monomers,i.e.,icariin,catechin,Panax notoginseng saponins,and eleutheroside *** cytometry showed that Yizhijiannao Granule-containing serum, icariin,Panax notoginseng saponins,and icariin＋Panax notoginseng saponins were protective against beta-amyloid（25-35）-induced injury in PC12 *** in combination with Panax notoginseng saponins significantly inhibited early apoptosis of PC12 cells with beta-amyloid （25-35）-induced injury compared to icariin or Panax notoginseng saponins *** effects of icariin＋Panax notoginseng saponins were similar to the effects of Yizhijiannao *** findings indicate that two of the effective monomers of Yizhijiannao Granule,icariin and Panax notoginseng saponins,can synergistically inhibit early apoptosis of PC12 cells induced by beta-amyloid（25-35）.

关键词： Alzheimer’s disease icariin Panax notoginseng Saponins Yizhijiannao Granule Chinese medicine monomer beta-amyloid protein PC12 cell Chinese medicine neural regeneration

Icariin and differential protein expression in the entorhinal area of senescence-accelerated mouse prone 8 mice

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Neural Regeneration Research 2011年第18期6卷 1370-1374页

作者： Ting Zhang Zhanwei Zhang Keli Dong guangcheng li Hong Zhu Department of Chinese Medicine Third Xiangya Hospital of Central South University Changsha 410013 Hunan Province China Department of Neurosurgery First Hospital of Hunan University of Chinese Medicine Changsha 410007 Hunan Province China

The present study sought to explore the mechanism of action by which icariin, an active component of Epimedii Herba, treats Alzheimer＇s disease at the proteomics level. Two-dimensional gel electrophoresis was used to isolate total protein from the entorhinal cortex of senescence-accelerated mouse prone 8 （SAMP8） mice, and differential protein spots were obtained. Corresponding peptide mass fingerprinting was conducted through mass spectrography to identify differential protein spots. Twenty-six differential protein spots were found in the entorhinal area of SAMP8 mice at 8 weeks following intragastdc perfusion with icariin and double distilled water. Fourteen spots were identified, which were involved in mitochondrial energy metabolism, oxidative stress, and neuronal function. The results revealed that icafiin can regulate the expression of various proteins in the entorhinal cortex of SAMP8 mice, and treat Alzheimer＇s disease by improving mitochondfial function, suppressing oxidative stress, inhibiting neural cell apoptosis, and protecting neurons.

关键词： icariin Alzheimer's disease entorhinal cortex proteomics traditional Chinese medicine neural regeneration

Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe

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Neural Regeneration Research 2014年第13期9卷 1283-1287页

作者： Hong Zhu liuyang Luo Sihang Hu Keli Dong guangcheng li Ting Zhang Department of Traditional Chinese Medicine Third Xiangya Hospital of Central South University Department of Emergency Bao-an District Hospital of Traditional Chinese Medicine

Yizhijiannao granules have been shown to improve cognitive function in Alzheimer＇s disease patients. The present study sought to explore the mechanisms involved in the cognitive enhancing effects of Yizhijiannao granule. Senescence-accelerated mouse prone 8 mice with learning and memory disorders were intragastrically treated with Yizhijiannao granule for 8 weeks. Mice intragastrically treated with double distilled water for 8 weeks were considered as the control group. 2D gel electrophoresis was used to isolate total protein from the temporal lobe of senescence-accelerated mouse prone 8 mice, and differential protein spots were obtained by mass spectrometry. Thirty-seven differential protein spots were found in the temporal lobe area of both groups. Ten protein spots were identified： high mobility group box 1, dimethylarginine dimethylaminohydrolase-1, nenroglobin, hemoglobin beta adult major chain, peroxiredoxin-6, cofilin-1, flotiUin 1, peptidylprolyl isomerase A, voltage-dependent anion channel-2 and chaperonin containing TCP1, and subunit 2. Among other functions, these proteins are separately involved in the regulation of amyloid beta production, oxidative stress, neuroinflammation, regulation of tau phosphorylation, and regulation of neuronal apoptosis. Our results revealed that Yizhijiannao granule can regulate the expression of various proteins in the temporal lobe of senescence-accelerated mouse prone 8 mice, and may be therapeutically beneficial for the treatment of Alzheimer＇s disease.

关键词： nerve regeneration traditional Chinese medicine neurodegeneration Alzheimer'sdisease Yizhijiannao granule mass spectrometry cognition neural regeneration

从岩体结构控制论到工程地质耦合论及其传承发展

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工程地质学报 2022年第1期30卷 53-58页

作者：李广诚水利部水利水电规划设计总院北京100120

本文简述了20世纪70年代谷德振先生提出的岩体结构控制论、90年代王思敬先生提出的地质环境理论和21世纪初李广诚提出的工程地质耦合理论的主要内容,阐述了上述理论的传承发展关系,并在提出时间、研究对象、研究内容、控制因素、基本思... 详细信息

本文简述了20世纪70年代谷德振先生提出的岩体结构控制论、90年代王思敬先生提出的地质环境理论和21世纪初李广诚提出的工程地质耦合理论的主要内容,阐述了上述理论的传承发展关系,并在提出时间、研究对象、研究内容、控制因素、基本思想、涉及学科和思想范畴等几个方面将3个理论进行了对比。最后依据上述理论对十三陵抽水蓄能电站地下厂房位置的选择和紫坪铺大坝位置与轴线方向的选择及所采取的工程措施进行了分析。

关键词：工程地质理论岩体结构控制论地质环境理论工程地质耦合理论传承与发展

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基于多维动态S盒和LFSR的分组密码算法

华中科技大学学报（自然科学版） 2015年第5期43卷 119-123页

作者：赵国生李光程王健哈尔滨师范大学计算机科学与信息工程学院黑龙江哈尔滨150025 哈尔滨理工大学计算机科学与技术学院黑龙江哈尔滨150001

提出一种基于多维动态S盒混淆替换和n级联动线性反馈移位寄存器(LFSR)的分组密码算法.首先,通过矩阵变换初步将明文扰乱,进而进行多维动态S盒混淆替换,以此增强密文的非线性安全度;然后,通过列混淆函数进行组字节位循环移位,增强密文的... 详细信息

提出一种基于多维动态S盒混淆替换和n级联动线性反馈移位寄存器(LFSR)的分组密码算法.首先,通过矩阵变换初步将明文扰乱,进而进行多维动态S盒混淆替换,以此增强密文的非线性安全度;然后,通过列混淆函数进行组字节位循环移位,增强密文的扩散性;最后,使用n级联动线性反馈移位寄存器组生成动态密钥,增强每一轮迭代时的密钥随机性,使算法具有密码分组链接模式.性能分析结果表明:相对于AES算法和DES算法,本算法在增强安全性的同时对算法加解密速度影响较小.相关系数检验和差分分析实验进一步证明了算法可有效抵抗线性密码分析攻击和差分分析攻击等目前主流的密码算法攻击手段.

关键词：混淆替换 S盒流密码线性反馈移位寄存器分组密码

基于通信的列车控制信号系统安全控制平台的架构

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城市轨道交通研究 2017年第B08期20卷 68-70,90页

作者：李广诚上海自仪泰雷兹交通自动化系统有限公司上海工程师201206

为了保证计算的安全性、可靠性和高可用性,地铁信号系统广泛采用2取2、3取2的安全控制平台。对安全控制平台的基本架构从应用业务层、核心安全层、操作系统内核层和硬件层等进行了分析,并给出了一种主备两系切换的解决方案。

关键词：地铁信号系统无缝切换安全控制平台

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略论西北地区旅游业的发展问题

干旱区地理 2000年第1期23卷 86-90页

作者：肖星李广成西北师范大学地理系兰州730070 酒泉教育学院酒泉735000

中国西北地区旅游资源丰富多彩 ,极具特色。改革开放以来 ,这里的旅游业虽有较快发展 ,但目前仍不发达 ,与自身突出的资源优势极不相称。西北旅游业要在即将到来的 2 1世纪获得大发展 ,心须彻底转变思想观念 ,科学制定发展规划 ,整体优... 详细信息

中国西北地区旅游资源丰富多彩 ,极具特色。改革开放以来 ,这里的旅游业虽有较快发展 ,但目前仍不发达 ,与自身突出的资源优势极不相称。西北旅游业要在即将到来的 2 1世纪获得大发展 ,心须彻底转变思想观念 ,科学制定发展规划 ,整体优化空间布局和多方采取有效措施。

关键词：西北地区旅游业发展问题

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单频GPS整周模糊度动态快速求解的研究

武汉大学学报（信息科学版） 2005年第10期30卷 885-887页

作者：刘立龙刘基余李光成武汉大学测绘学院武汉市珞喻路129号430079 北京遥测技术研究所北京市南大红门路1号100076

提出了一种动态快速求解整周模糊度的方法,即先对系数阵进行QR分解,然后通过矩阵变换使模糊度参数和位置参数分离,从而降低矩阵的维数,满足实时动态求解的要求,最后应用LAMBDA方法搜索模糊度。为验证该算法,用单频GPS接收机进行了静态... 详细信息

提出了一种动态快速求解整周模糊度的方法,即先对系数阵进行QR分解,然后通过矩阵变换使模糊度参数和位置参数分离,从而降低矩阵的维数,满足实时动态求解的要求,最后应用LAMBDA方法搜索模糊度。为验证该算法,用单频GPS接收机进行了静态定位和动态定位两种试验。结果表明,静态定位误差小于1cm,动态定位误差小于3cm。由此可见,该方法能够为动态用户快速而精确地实施GPS单频动态定位。

关键词： GPS载波相位测量整周模糊度 QR分解