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Microwave-Assisted Confining Growth and liquid Exfoliation of sp^(3)-Hybrid Carbon Nitride Nano/Micro-Crystals

Energy & Environmental Materials 2024年第6期7卷 399-408页

作者： chenglong Shen Qing Lou Kaikai liu Guangsong Zheng Runwei Song Jinhao Zang Xigui Yang Xing li lin Dong Chongxin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and Laboratory of Zhongyuan LightZhengzhou UniversityZhengzhou 450052China

As one promising carbon-based material,sp^(3)-hybrid carbon nitride has been predicted with various novel physicochemical ***,the synthesis of sp^(3)-hybrid carbon nitride is still limited by the nanaoscale,low crystallinity,complex source,and expensive ***,we have presented a facile approach to the sp^(3)-hybrid carbon nitride nano/micro-crystals with microwave-assisted confining growth and liquid ***,the carbon nitride nano/micro-crystals can spontaneously emerge and grow in the microwave-assisted polymerization of citric acid and urea,and the liquid exfoliation can break the bulk disorder polymer to retrieve the highly crystalline carbon nitride nano/*** obtained carbon nitride nano/micro-crystals present superior blue light absorption strength and surprising photoluminescence quantum yields of 57.96%in ethanol and 18.05%in solid *** experimental characterizations and density functional theory calculations reveal that the interface-trapped localized exciton may contribute to the excellent intrinsic light emission capability of carbon nitride nano/micro-crystals and the interparticle staggered stacking will prevent the aggregation-caused-quenching ***,the carbon nitride nano/micro-crystals are demonstrated to be potentially useful as the phosphor medium in light-emitting-diode for interrupting blue light-induced eye *** work paves new light on the synthesis strategy of sp^(3)-hybrid carbon nitride materials and thus may push forward the development of multiple carbon nitride research.

关键词： confining growth density functional theory liquid exfoliation luminescence sp^(3)-hybrid carbon nitride

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Low levels of low-density lipoprotein cholesterol and cognitive decline

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Science Bulletin 2021年第16期66卷 1684-1690,M0004页

作者： Rong Hua Yanjun Ma chenglong li Baoliang Zhong Wuxiang Xie Heart and Vascular Health Research Center Peking University Clinical Research InstitutePeking University First HospitalBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China Department of Geriatric Psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430030China

The relationship between low levels of serum low-density lipoprotein cholesterol(LDL-C)and subsequent cognitive decline remains *** present study aimed to evaluate the longitudinal association between low LDL-C levels and cognition decline in the context of the current aggressive guideline-recommended targets(LDL-C levels less than 55 mg/dL for individuals at very high risk of cardiovascular events,and less than 70 mg/dL for high risk individuals).Data from wave 13(2016)to wave 14(2018)of the Health and Retirement Study(HRS)were ***-C concentrations measured at wave 13 were categorized into 5 levels,reflecting currently recommended values for lipid lowering *** 7129 included participants(mean age:69.0±9.9 years,60.3%female),we found that compared to participants with LDL-C levels of 70.0-99.9 mg/dL,those with LDL-C levels ofline rates in global cognitive function(0.244 point/year;95%confidence interval(CI):0.065-0.422;P=0.008),working memory(0.068 point/year;95%CI:0.004-0.133;P=0.038),and borderline significantly in episodic memory(0.155 point/year;95%CI:-0.004-0.315;P=0.057).Similarly,significantly slower decline rates were observed in those with LDL-C levels of 55.0-69.9 mg/*** present study demonstrated that compared with LDL-C levels 70.0-99.9 mg/dL,low LDL-C levels(line in population-based *** randomized controlled trials are warranted to ascertain the safety and benefit of current aggressive guideline-recommended targets on cognitive function.

关键词： Low-density lipoprotein cholesterol Cognitive decline Longitudinal cohort study The Health and Retirement Study

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不同频次针刺对恢复期贝尔氏面瘫疗效的影响

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上海针灸杂志 2024年第3期43卷 295-300页

作者：茅伟李成龙张国庆张君宇吴海洋张利达韩为王颖安徽中医药大学合肥230031 安徽中医药大学第二附属医院合肥230001 广州医科大学附属脑科医院广州510370

目的观察每日针刺1次与隔日针刺1次治疗恢复期贝尔氏面瘫(Bell’s palsy, BP)的临床疗效。方法将184例恢复期BP患者随机分为A组和B组,每组92例。两组均接受相同的基础治疗和针刺治疗,A组每次针刺1次,B组隔日针刺1次。治疗4周后,观察... 详细信息

目的观察每日针刺1次与隔日针刺1次治疗恢复期贝尔氏面瘫(Bell’s palsy, BP)的临床疗效。方法将184例恢复期BP患者随机分为A组和B组,每组92例。两组均接受相同的基础治疗和针刺治疗,A组每次针刺1次,B组隔日针刺1次。治疗4周后,观察两组治疗前后Sunnybrook(多伦多)面神经评定系统评分、House-Brackmann(H-B)面神经功能评级及面部残疾指数(facial disability index, FDI)量表各项评分[躯体功能(facial disability index physical function, FDIp)评分及社会生活功能(facial disability index social function, FDIs)评分]的变化情况,评定两组临床疗效。结果 A组治愈率明显高于B组,差异具有统计学意义(P0.05)。两组治疗后Sunnybrook面神经评定系统评分及FDIp评分均较同组治疗前显著升高,FDIs评分均显著下降,H-B面神经功能评级均显著改善,差异均具有统计学意义(P<0.05)。A组治疗后Sunnybrook面神经评定系统评分、H-B面神经功能评级及FDI量表各项评分与B组比较,差异均具有统计学意义(P<0.05)。两组治疗前后Sunnybrook面神经评定系统评分及FDI量表各项评分的差值比较,差异均具有统计学意义(P<0.05)。结论在基础治疗的基础上,针刺能有效改善恢复期BP患者临床症状,提高其生活质量,且每日针刺1次较隔日针刺1次疗效显著。

关键词：针刺疗法贝尔麻痹恢复期面神经麻痹 Sunnybrook面神经评定系统 House-Brackmann面神经功能评级面部残疾指数

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Isolation and Identification of Symbiotic Bacteria from <i>Brasenia schreberi</i>and Analysis of their Polysaccharide Producing Characteristics and Antioxidant Activity

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American Journal of Plant Sciences 2020年第3期11卷 307-322页

作者： chenglong li Xueyang Song Qiuyu Zhang Hanyu Gong Guanghui Yu China Brasenia schreberi Research Institute College of Life Sciences South-Central University for Nationalities Wuhan China Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China South-Central University for Nationalities Wuhan China

Brasenia schreberi (water shield), a perennial freshwater aquatic plant of the family Nymphaeaceae, is rich in polysaccharides with positive biological activity and potential application value. As an indicator plant of the environment in wetlands, B. schreberi original and wild water environment faced increasing deterioration and has been listed as a critically endangered species in several countries of East Asia. Seeking an alternative method to produce B. schreberi mucilage polysaccharide is of top priority. The morphological structure of the stem and leaf of B. schreberi was studied. Well-developed glandular cells and aerenchyma tissue were observed in the stem and leaves of water shield, which were related to its aquatic habitat and polysaccharide secretion and then three endophytic bacteria were successfully isolated and purified from its stem and leaf and identified as Micromonospora sp. YG-1, Xylariaceae sp. strain UT-X and Psychrobacter pulmonis strain T-15. Symbiotic bacteria from B. schreberi produced polysaccharides with similar spectral peaks and chemical functional groups to those of B. chinensis. Further, analysis of hydroxyl free radicals showed that symbiotic bacteria in water shield had significant antioxidant activity against hydroxyl free radicals. This study provides a theoretical and practical basis for further study using symbiotic bacteria to produce polysaccharides to overcome the environmental limitations of the growth and development of B. schreberi.

关键词： Brasenia schreberi Endosymbiont HPLC IR Spectrum Polysaccharide

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Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis

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Chinese Medical Journal 2022年第12期135卷 1438-1443页

作者： Zheng Zhao lin Cai Si Zhang Heng Zhang Xiaoyang liu chenglong li Yan Zhao Jianzhong Zhang Department of Dermatology Peking University People's HospitalBejing 100044China Department of Dermatology Peking University International HospitalBeijing 102206China Peking University Clinical Research Instute Beijing 100191China

Background:Psoriasis is a chronic systemic inflammatory disease,and hyperuricemia is a common comorbidity in patients with ***,there are limited reports on the relationship between serum uric acid levels and biological treatment *** purposes of this study were to compare the differences in serum uric acid levels between patients with psoriasis and healthy controls and analyze the risk of ***:A total of 196 patients with psoriasis and 191 age-and sex-matched healthy controls were enrolled in this retrospective cohort *** hundred and twenty-seven patients with severe psoriasis were treated with ***-eight patients received adalimumab,and 59 patients received *** uric acid levels were measured at baseline,week 24,and week 48 of ***:Patients with psoriasis had higher serum uric acid levels than healthy controls(6.4±1.7 mg/dL vs.5.7±1.5 mg/dL,P0.05).No significant changes in serum uric acid levels and hyperuricemia were observed following adalimumab treatment(P>0.05).The serum uric acid level in patients treated with secukinumab was 6.7±1.6 mg/dL at week 24,which was not statistically different from that at baseline(6.6±1.4 mg/dL,P=0.885).Serum uric acid levels were significantly decreased at week 48(6.3±1.5 mg/dL vs.6.6±1.4 mg/dL,P=0.007)in patients treated with *** had no significant effect on hyperuricemia either(P>0.05).Conclusions:The serum uric acid levels and prevalence of hyperuricemia in patients with psoriasis were significantly higher than those in healthy *** treatment for 48 weeks successfully decreased serum uric acid levels in patients with psoriasis,whereas adalimumab had no significant effe

关键词： Psoriasis Serum uric acid Adalimumab Secukinumab Hyperuricemia

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北京市某地区家畜养殖业有害风险形势分析报告

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现代畜牧科技 2024年第2期 98-101页

作者：胡鑫李成龙马长永郑金梅梁锐萍王涛纪辰晨王天坤北京市昌平区动物疫病预防控制中心家畜产业体系北京市创新团队昌平区综合试验站北京102200 北京市昌平区兴寿镇农服中心北京102200 北京市昌平区崔村镇农服中心北京102200 北京市昌平区东小口镇农服中心北京102200

水源环境的污染加上高温高湿的气候使病原微生物得到繁殖与扩散所需要的理想条件。洪涝灾害区的情况不仅使畜禽的自身免疫力降低,同时也增加某些疫病在该地区的传播和流行的风险。尤其是对于人兽共患病,如炭疽、血吸虫病、猪链球菌Ⅱ型... 详细信息

水源环境的污染加上高温高湿的气候使病原微生物得到繁殖与扩散所需要的理想条件。洪涝灾害区的情况不仅使畜禽的自身免疫力降低,同时也增加某些疫病在该地区的传播和流行的风险。尤其是对于人兽共患病,如炭疽、血吸虫病、猪链球菌Ⅱ型和钩端螺旋体病等,它们的发生风险进一步加大,给动物健康带来显著威胁。这种情况对公共卫生安全提出巨大的挑战。为保护公众健康安全,结合2023年9月的灾害情况,评估2023年9月自然灾害的风险形势和所采取的主要预防措施。目的是确保未来能采取有针对性的综合防控措施来应对潜在的危机。

关键词：家畜养殖业有害风险形势分析

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Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution

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Science China(life Sciences) 2022年第9期65卷 1811-1823页

作者： ling Zhong Xiao Yang Yu Zhou Jialing Xiao Huan li Jiang Tao Qian Xi Chen Chu chenglong li Xi Yang Chen Yang Yi Zhang Ping Shuai Yuping liu Man Yu Yi Shi Jiang Hu Wei Zhang Bo Gong Zhenglin Yang Department of Health Management Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610075China The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengdu 610072China Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610072China Department of Orthopaedics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of hematology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Cancer Biology Dana-Farber Cancer Institute and Department of GeneticsBlavatnik InstituteHarvard Medical SchoolBostonMA 02115USA

The Revised International Staging System(R-ISS)is a simple and powerful prognostic tool for multiple myeloma(MM).However,heterogeneity in R-ISS stage is still poorly characterised,hampering improvement of *** used single-cell RNA-seq to examine novel cellular heterogeneity and regular networks in nine MM patients stratified by *** cells were clustered into nine groups(P1–P9)based on gene expression,where P1–P5 were almost enriched in stage ***6 was significantly upregulated in P3 and LETM1was enriched in P1,and they were validated to be upregulated in the MM cell line and in 22 other patients’myeloma ***,in progression,PDIA6 was newly found and verified to be activated by UQCRB through oxidative phosphorylation,while LETM1 was activated by STAT1 via the C-type lectin receptor-signalling ***,a subcluster of monocytes was exclusively found in stage III specifically expressed chemokines modulated by ATF3.A few ligand-receptor pairs(CCL3/CCL5/CCL3L1-CCR1)were obviously active in monocyte-plasma communications in stage ***,this study identified novel molecules,networks and crosstalk pairs in different R-ISS stages of MM,providing significant insight for its prognosis and treatment.

关键词： multiple myeloma the revised international staging system single-cell RNA-seq

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桩周土开挖状态下钢筋混凝土桩稳定性研究

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建筑结构学报 2019年第11期40卷 247-254页

作者：贾强李成龙张鑫山东建筑大学土木工程学院山东济南250100 菏泽学院基建处山东菏泽274015

开展了桩周土开挖状态下钢筋混凝土桩受压稳定性试验,通过改变桩的配筋率、边长、受压偏心距和桩身加支撑等参数,研究桩的受压稳定性变化规律。研究结果表明,桩开挖深度由0.6 m增加到1.8 m时,桩的极限荷载降低11%~32%;桩初始偏心距由0... 详细信息

开展了桩周土开挖状态下钢筋混凝土桩受压稳定性试验,通过改变桩的配筋率、边长、受压偏心距和桩身加支撑等参数,研究桩的受压稳定性变化规律。研究结果表明,桩开挖深度由0.6 m增加到1.8 m时,桩的极限荷载降低11%~32%;桩初始偏心距由0增大到50 mm时,桩的极限荷载降低42%~68%。在相同开挖深度条件下,随着桩配筋率的增加、桩截面尺寸的增大以及设置桩身支撑,其受压极限荷载明显增大。其中,桩截面尺寸由80 mm增大到120 mm能使极限荷载提高74%,效果最好。基于试验结果,提出了钢筋混凝土桩受压承载力的计算方法。将所提出的计算方法得到的桩身承载力与试验结果比较可知,轴心受压时,计算值与试验结果平均偏差仅为3.6%;偏心受压时,在桩的开挖深度较大时吻合较好,而开挖深度较小时会出现较大的偏差。

关键词：钢筋混凝土桩桩周土开挖开挖深度受压试验屈曲稳定性极限荷载

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New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling ZHANG Shejiang WANG linhui li Wei HE Yingshuai JIN Peiqi ZhANG Bing XU chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

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国内外职业网球赛事赞助品牌比较研究

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武汉体育学院学报 2016年第10期50卷 52-57页

作者：李承龙武汉体育学院研究生院湖北武汉430079

运用文献资料法和比较分析法,将2015年世界网球四大满贯赛事与中国网球公开赛和武汉网球公开赛赞助品牌的行业分布、赞助契合度、赞助行为进行比较研究。研究认为,中网和武网赞助品牌中工业产品行业比例过高;四大满贯赛事与赞助品牌具... 详细信息

运用文献资料法和比较分析法,将2015年世界网球四大满贯赛事与中国网球公开赛和武汉网球公开赛赞助品牌的行业分布、赞助契合度、赞助行为进行比较研究。研究认为,中网和武网赞助品牌中工业产品行业比例过高;四大满贯赛事与赞助品牌具有较好的契合度,中网与武网部分赞助品牌与赛事契合度较差;四大满贯赛事以及中网、武网的赞助品牌多归属性表现明显,但均未严格遵循行业排他性;相比四大满贯赛事,中网和武网未能与赞助品牌达成长期合作关系。对国内网球赛事开展提出的建议有:突出地域文化特色,丰富赛事文化内涵;优化赞助行业结构,合理把握赞助契合;精心策划赞助方案,切实维护赞助权益;深入展开交流沟通,着力培养长期合作。

关键词：四大满贯赛事中网武网赞助品牌体育产业网球

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