Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis

作     者：Zheng Zhao Lin Cai Si Zhang Heng Zhang Xiaoyang Liu Chenglong Li Yan Zhao Jianzhong Zhang Zheng Zhao;Lin Cai;Si Zhang;Heng Zhang;Xiaoyang Liu;Chenglong Li;Yan Zhao;Jianzhong Zhang

作者机构：Department of DermatologyPeking University People's HospitalBejing 100044China Department of DermatologyPeking University International HospitalBeijing 102206China Peking University Clinical Research InstuteBeijing 100191China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第12期

页      面：1438-1443页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：Psoriasis Serum uric acid Adalimumab Secukinumab Hyperuricemia 

摘      要：Background:Psoriasis is a chronic systemic inflammatory disease,and hyperuricemia is a common comorbidity in patients with ***,there are limited reports on the relationship between serum uric acid levels and biological treatment *** purposes of this study were to compare the differences in serum uric acid levels between patients with psoriasis and healthy controls and analyze the risk of ***:A total of 196 patients with psoriasis and 191 age-and sex-matched healthy controls were enrolled in this retrospective cohort *** hundred and twenty-seven patients with severe psoriasis were treated with ***-eight patients received adalimumab,and 59 patients received *** uric acid levels were measured at baseline,week 24,and week 48 of ***:Patients with psoriasis had higher serum uric acid levels than healthy controls(6.4±1.7 mg/dL vs.5.7±1.5 mg/dL,P0.05).No significant changes in serum uric acid levels and hyperuricemia were observed following adalimumab treatment(P0.05).The serum uric acid level in patients treated with secukinumab was 6.7±1.6 mg/dL at week 24,which was not statistically different from that at baseline(6.6±1.4 mg/dL,P=0.885).Serum uric acid levels were significantly decreased at week 48(6.3±1.5 mg/dL vs.6.6±1.4 mg/dL,P=0.007)in patients treated with *** had no significant effect on hyperuricemia either(P0.05).Conclusions:The serum uric acid levels and prevalence of hyperuricemia in patients with psoriasis were significantly higher than those in healthy *** treatment for 48 weeks successfully decreased serum uric acid levels in patients with psoriasis,whereas adalimumab had no significant effe