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Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing

Journal of Traditional Chinese Medicine 2019年第6期39卷 853-860页

作者： Siu Wing Sum Shiu Hoi Ting Shum Wai Ting Ko Chun Hay Lau Clara Bik San Hung leung Kim leung ping chung Institute of Chinese Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong China State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongShatinNew TerritoriesHong Kong China Department of Orthopaedics and Traumatology The Chinese University of Hong KongShatinNew TerritoriesHong Kong China

OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture ***:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was *** rats were treated with either CDR topically on the fracture site,or Sr R orally,or their *** turnover biochemical markers in serum were *** of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical ***:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of *** result was consistent with the histomorphometrical analysis on the osteoid *** of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after ***:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.

关键词： Fracture healing Osteogenesis Bone resorption Medicine,Chinese Traditional Integrative medicine Strontium ranelate

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Osteoporosis and the orthopaedic surgeon

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Chinese Medical Journal 2013年第20期126卷 3803-3805页

作者： leung, ping-chung Chinese Univ Hong Kong Jockey Club Ctr Osteoporosis Care & Control Hong Kong Hong Kong Peoples R China

Increasing human longevity is complicated by aging .related physiological deteriorations. Osteoporosis,weakening of the skeletal bony units, is one of the major concerns which has developed into a major public health problem.^1 According to the World Health Organization, osteoporosis affects approximately 75 million people in Europe, USA, and Japan. Although data are not available in China, with her large population, a vast number of people would be expected to be affected.^2

关键词： osteoporosis orthopaedic surgeon

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Happy Aging

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Chinese Journal of Integrative Medicine 2009年第6期15卷 466-469页

作者：梁秉中 Institute of Chinese Medicine the Chinese University of Hong Kong

Aging is a normal physiological process in human *** decline in the ability to repair and regenerate predisposes the aging person to develop disabling problems in the cardiovascular and skeletal *** awareness of aging problems and advocations on the means to prevent their occurrence are *** and US groups rely on scientific,target-oriented means to treat aging manifestations. Oriental medicine aims at prevention,using nutrition and exercise to maintain internal harmony.

关键词： aging nutrition Chinese medicine

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Seropharmacological Study on Osteogenic Effects of Post-Absorption Ingredients of An Osteoprotective Herbal Formula

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Chinese Journal of Integrative Medicine 2017年第1期23卷 25-32页

作者： SIU Wing-sum KO Chun-hay WONG Hing-lok GAO Si SHUM Wai-ting LAU Clara Bik-san HUNG Lung-kim leung ping-chung Institute of Chinese Medicine Chinese University of Hong KongHong KongChina State Key Laboratory of Phytochemistry and Plant Resources in West China Chinese University of Hong KongHong KongChina Department of Orthopaedics and Traumatology Chinese University of Hong KonqHong KongChina

Objective： To further investigate the in vitro effects of an osteoprotective herbal formula ＂ELP＂（Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psora/eae） using seropharmacological approach. Methods： Rats were fed with ELP or its individual component herbs for 2 days. The serum containing the post-absorbed ingredients of the herbal items were collected for cell culture using UMR106 cell, RAW264.7 cell and mesenchymal stem cell （MSC） isolated from the bone marrow of the rats. The effects of the herbal-containing serum on cell toxicity were detected by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay; bromodeoxyuridine assay was conducted to measure the cell proliferation of UMR106 cell and MSC; cell activity was measured using colorimetric method, and mRNA expression of runt-related transcription factor 2 （Runx2）, alkaline phosphatase （ALP） and osteopontin （OPN） of UMR106 and MSC as well as matrix metalloproteinase 9 （MMP-9）, tartrate-resistant acid phosphatase （TRAP） and cathepsin K of RAW264.7 were analyzed using real-time reverse-transcription polymerase chain reaction. Results： ELP and its component serum exhibited no cytotoxic effects on the cells. The ELP-containing serum increased the proliferation of UMR106 cell and MSC by 25.7% and 14.4%, respectively and the alkaline phosphatase activity of MSC was increased by 42.6%. On the contrary, it inhibited the RAW264.7 cell differentiation by 29.2%. ELP serum upregulated the Runx2 expression of UMR and MSC by 1.18 fold and 1.27 fold, respectively. It also upregulated ALP and OPN expression in MSC by 1.69- and 2.12-fold, respectively. On the other hand, ELP serum down-regulated MMP-9 and cathepsin K expression of RAW264.7 cell by 0.46- and 0.36-fold, respectively. Conclusions： The serum of the animals fed with ELP contains active ingredients which are effective in promoting osteogenesis and inhibiting osteoclastogenesis.

关键词： osteoporosis seropharmacology osteogenesis herbal formula

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Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment

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Chinese Medical Journal 2013年第1期126卷 27-33页

作者： leung Kwok-sui TANG Ning James Griffith CHOY Tak-Kee HUNG Vivian Wing-Yin MOK Hoi-Wa SHI Lin leung ping-chung CHEUNG Wing-Hoi Department of Orthopaedics and Traumatology and Bone Quality and Health Center The Chinese University of Hong Kong Shatin Hong Kong SAR China Department of Imaging and Interventional Radiology The Chinese University of Hong Kong Shatin Hong Kong SAR China The Jockey Club Center for Osteoporosis Care and Control The Chinese University of Hong Kong Shatin Hong Kong SAR China Orthopaedic Research Laboratory of Translational MedicineResearch and Development Center Institute of Biomedical andHealth Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences China

Background The association of long-term bisphosphonate treatment for osteoporosis and related safety problems such as atypical fractures were not clearly defined. This study was to evaluate the structural, densitometric and biomechanical properties of the prolonged bisphosphonate-loaded bones. Methods Bone mineral density （BMD） at hip and femoral midshaft, bone cross-sectional area, moment of inertia of both femurs, bone formation and resorption biochemical markers were compared between 28 elderly with at least 4 years of bisphosphonate treatment from 2002 through 2006 and age-matched group of 37 elderly. Results The total hip BMD and t-score were found not different between two groups. However, bisphosphonate treated patients were found to have significantly lower bone mineral content in the femoral shaft （P 〈0.05）; morphological study showed lower cross-sectional area in subtrochanteric and mid-diaphyseal region and thus significantly lower moment of inertia （P 〈0.01）. High resolution-peripheral quantitative computed tomography showed significantly decreased trabeculardensity, bone volume ratio, trabecular number but increased trabecular spacing in tibia and distal radius. Finite element analysis further confirmed significantly lower stiffness and failure load in tibia. Biochemical studies also showed lower bone resorption and severely suppressed bone formation activity （P 〈0.001）. Conclusions The unchanged total hip BMD between two groups confirmed the beneficial effects of bisphosphonate on trabecular bone, thus preventing osteoporotic fractures at large in previous studies. However, the inferior structural, densitometric and biomechanical properties at cortical bones, especially femur midshaft, need a special attention to look into the association between long-term bisphosphonate intake and the occurrence of stress fractures. When patients taking bisphosphonate complain of proximal thigh pain or discomfort, plain X-ray film can be the first line screening. All

关键词： bisphosphonate bone mineral density moment of inertia HR-pQCT cortical bone

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Acupuncture:Complications Are Preventable not Adverse Events

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Chinese Journal of Integrative Medicine 2009年第3期15卷 229-232页

作者：梁秉中张浪梁景辉 Institute of Chinese Medicine the Chinese University of Hong Kong

If adverse effects are understood as'something that happened unexpectedly'while receiving drug treatment,there is no difference between adverse effects and ***,acupuncture is a process different from the use of *** acupuncture procedures should not be taken for granted as safe,complications causing harm are usually,according to the authors,the result of negligence,and should be differentiated from other adverse *** complications noted consisted of bleeding and damage to...

关键词： acupuncture complications adverse effects

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女贞子对去卵巢大鼠钙代谢及维生素D依赖型基因表达的影响

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中草药 2006年第4期37卷 558-561页

作者：张岩黄文秀陈斌梁秉中吴春福姚新生沈阳药科大学药学院辽宁沈阳110016 中药及分子药理国家重点实验室沈阳药科大学中药学院辽宁沈阳110016 香港中文大学矫形外科及创伤学系

目的研究补肾中药女贞子对去卵巢大鼠钙代谢及维生素D依赖型基因表达的影响。方法大鼠去卵巢手术处理4周后,ig给药治疗14周。血清、尿液及粪便中钙水平采用比色法测定。RT-PCR技术分析小肠及肾脏基因表达。结果大鼠去卵巢后体内钙流失... 详细信息

目的研究补肾中药女贞子对去卵巢大鼠钙代谢及维生素D依赖型基因表达的影响。方法大鼠去卵巢手术处理4周后,ig给药治疗14周。血清、尿液及粪便中钙水平采用比色法测定。RT-PCR技术分析小肠及肾脏基因表达。结果大鼠去卵巢后体内钙流失显著增加,表现在血钙下降,尿钙及粪钙排泄增加。女贞子可以有效防止尿钙及粪钙排泄增加,并恢复血钙水平。RT-PCR分析表明雌二醇和女贞子都可以抑制去卵巢引起的小肠维生素D受体(VDR)mRNA表达下降。女贞子对肾脏25-羟基维生素D 1-羟化酶(1-OH ase)及25-羟基维生素D 24-羟化酶(24-OH ase)mRNA无明显作用,但却可以提高肾脏钙结合蛋白-9k(C aBP-9k)及钙结合蛋白-28 k(C aBP-28k)的基因表达。结论女贞子能够改善雌激素缺乏所引起的钙失衡状态,主要是通过提高小肠对活性维生素D的敏感性及加强肾脏对钙的重吸收而发挥作用的。

关键词：女贞子钙代谢维生素D 基因表达去卵巢

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人肥大细胞系白细胞介素4的产生及药物对其的影响

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中华耳鼻咽喉头颈外科杂志 2005年第2期40卷 124-127页

作者：赵宇 C.Andrew van Hasselt 吴港生黄约爱梁传余梁秉中香港中文大学威尔斯亲王医院耳鼻咽喉科香港中文大学中医中药研究所四川大学华西医院耳鼻咽喉科

目的了解人肥大细胞系(humanmastcellline,HMC1)在佛波醇酯(phorbol12myristate13acetate,PMA)+钙离子通道(A23187)激发下能否产生白介素(Interleukin,IL)4,并且观察布地奈得、地氯雷他定和地塞米松等药物对IL4的产生和表达的影响。方法HMC1在10-6~10-10mol/L浓度的药物中孵育1h后,以25ng/mlPMA+25×10-7mol/LA23187激发细胞因子生成,再分别孵育6、12或24h,提取上清液,采用酶联免疫吸附法(enzymelinkedimmunosorbentassays,ELISA)测定IL4水平,并采用半定量逆转录聚合酶链反应(reversetranscriptionpolymerasechainreaction,RTPCR)观察药物对IL4mRNA表达水平的影响。结果HMC1在激发后可产生IL4,IL4mRNA的表达也很明显。布地奈得、地氯雷他定和地塞米松在各时间点和浓度下,均对HMC1IL4的产生有明显的抑制作用(同未加药物的对照组比较,P值均<005),抑制率在(361±40)%到(679±38)%之间。布地奈得和地塞米松对IL4mRNA的表达无抑制作用,而地氯雷他定则能明显抑制IL4mRNA的表达水平。结论HMC1经激发可表达和产生IL4,布地奈得、地氯雷他定和地塞米松能显著抑制IL4的产生,地氯雷他定还能抑制IL4mRNA的表达。

关键词：肥大细胞系白细胞介素4 地氯雷他定地塞米松

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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis leung Qi-Man Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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卵白蛋白经鼻致敏建立变应性鼻炎动物模型

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中华耳鼻咽喉头颈外科杂志 2005年第3期40卷 176-180页

作者：赵宇 C.Andrew vanHasselt 吴港生黄约爱梁传余梁秉中香港中文大学威尔斯亲王医院耳鼻咽喉科香港中文大学中医中药研究所四川大学华西医院耳鼻咽喉科

目的　建立豚鼠变应性鼻炎动物模型,并对其速发和迟发症状、病理学和免疫学指标进行观察。方法　实验豚鼠分为模型组、治疗组和阴性对照组,每组 12只。阴性对照组未予致敏和激发,模型组和地氯雷他定治疗组由卵白蛋白经鼻反复致敏和激发... 详细信息

目的　建立豚鼠变应性鼻炎动物模型,并对其速发和迟发症状、病理学和免疫学指标进行观察。方法　实验豚鼠分为模型组、治疗组和阴性对照组,每组 12只。阴性对照组未予致敏和激发,模型组和地氯雷他定治疗组由卵白蛋白经鼻反复致敏和激发后,对其喷嚏、抓鼻、鼻腔分泌物及鼻塞做动态症状学观察;通过被动皮肤过敏实验,测定血清IgG1和IgE水平;计量鼻腔灌洗液中白细胞总数、嗜酸粒细胞数及组胺水平;并且观察鼻腔组织的病理改变。结果　经抗原激发后,模型组出现典型的喷嚏、抓鼻、鼻塞和分泌物增多的表现;鼻腔灌洗液中炎性细胞和嗜酸粒细胞增多、组胺水平升高、血清IgG1和IgE滴度升高。上述表现与阴性对照组比较差异有统计学意义 (P<0.05或<0.01),也比治疗组明显增高(P<0.05或<0.01)。模型组的鼻腔黏膜嗜酸粒细胞浸润明显,小血管扩张,杯状细胞扩大。此外,模型组还可观察到迟发相鼻塞。结论　此模型能良好地反映变应性鼻炎的各项表现,方法简易,建模时间短,亦能观察迟发性鼻塞,且对组胺H1受体拮抗剂的治疗反应明确,是研究变应性鼻炎的良好工具。

关键词：变应性鼻炎动物模型卵白蛋白致敏经鼻组胺H1受体拮抗剂嗜酸粒细胞增多鼻腔灌洗液皮肤过敏实验 IgG1 0.05 免疫学指标地氯雷他定症状学观察鼻腔分泌物 IgE水平白细胞总数抗原激发后分泌物增多粒细胞浸润

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