检索结果-南通市图书馆

Type XIX collagen: a promising biomarker from the basement membranes

Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura Moreno leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz Pilar Zaragoza Pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selection of Lactic Acid Bacteria Isolated from San Simón da Costa Cheese (PDO) in Order to Develop an Autochthonous Starter Culture

引用

Advances in Microbiology 2015年第11期5卷 748-759页

作者： leticia González Araceli Fernández Cuadrillero José María Castro Ana Bernardo María Eugenia Tornadijo Department of Food Hygiene and Technology University of León León Spain Institute of Food Science and Technology (ICTAL) University of León León Spain

Traditional cheeses are an important reservoir of microbial diversity that can have important biotechnological applications, especially with a view to improving the characteristics unique to each type of cheese, and in this respect, starter cultures consisting of autochthonous lactic acid bacteria strains are of particular interest. In the present study, we investigated lactic acid bacteria population diversity in San Simón da Costa cheese (PDO, Galicia, Spain) and found a predominance of the genus Lactobacillus, which by the end of ripening accounted for 78% of the strains isolated in Rogosa agar, around 40% of those in M17 agar and about 10% of those in MSE agar. The main species of lactic acid bacteria identified were Lactococcus lactis subsp. lactis, Lactobacillus casei subsp. casei, Lb. paracasei subsp. paracasei, Leuconostoc mesenteroides and Enterococcus faecalis. Virtually all the strains studied from a technological point of view yielded more than or equal to 0.24 g 100 mL-1 lactic acid. Lactococcus lactis subsp. lactis (SS 194), Lactobacillus paracasei (SS 1695 and SS 1689) and Enterococcus faecalis (SS 1378 and SS 1449) strains exhibited the greatest proteolytic capacity. Based on the overall technological aptitude of the tested strains, we can propose starter cultures and co-cultures that include different combinations of previous strains with a view to manufacturing San Simón da Costa cheese from pasteurised milk.

关键词： Cow Milk Cheese Lactic Acid Bacteria Enzymatic Activities Autochthonous Starter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Linking Climatic Variability with Spatial Performance in Two Varieties of Quinoa Distributed in a Semi-Arid Zone

引用

American Journal of Plant Sciences 2012年第12期3卷 1682-1687页

作者： Sonia Montecinos Pablo Salinas Rómulo Oses leticia González-Silvestre Marco A. Molina-Montenegro Banco Base de Semillas-Instituto de Investigaciones Agropecuarias (INIA) Centro Regional Intihuasi La Serena Chile Centro de Estudios Avanzados en Zonas áridas (CEAZA) Colina El Pino s/n La Serena Chile Centro de Estudios Avanzados en Zonas áridas (CEAZA) Facultad de Ciencias del Mar Universidad Católica del Norte Coquimbo Chile

Different crop varieties can respond in different ways to the climatic variations at local scale. Thus, in order to maximize the yield for a determined crop, the response of different varieties submitted to local climatic conditions should be assessed. The main goal of this study was to evaluate the ecophysiological responses of two varieties of Quinoa (PRP and BO78) submitted to different conditions of thermal amplitude. We performed two experiments in both greenhouse and in 3 sites on experimental-field where were evaluated survival, photochemical efficiency, plant growth and dry biomass in both varieties and compared them with the mean of the thermal conditions recorded during the last 16 years in the Coquimbo Region, Chile. Overall, individuals of BO78 showed higher performance in the sites with lower thermal amplitude than those of PRP. By contrast, in sites with higher thermal amplitude individuals of PRP showed better survival, physiological performance and biomass and therefore higher performance. Our results suggest that while BO78 showed an ecotypic strategy, the PRP showed a plastic strategy to maintain higher performance in sites with moderate and high climatic variability. We consider that under an increase in desertification, semi-arid areas would be available for stress tolerant crops like Quinoa, but the success for the food security in these regions may depend upon the variety used.

关键词： Quinoa Thermal Amplitude Plasticity Ecophysiology Crop Yield

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ICT as an Instrument of Enhanced Banking System

引用

Journal of Computer and Communications 2017年第1期5卷 53-60页

作者： Emmanuel N. Ekwonwune Deborah U. Egwuonwu leticia C. Elebri Kanayo K. Uka Department of Computer Science Imo State University Owerri Nigeria Department of Computer Science Abia State Polytechnic Aba Nigeria Department of ICT Imo State University Owerri Nigeria

This study investigated the role of Information and Communications Technology in an enhanced banking operation using Diamond Bank Plc, Imo State as a case study. The study was motivated by the fact that most industries, financial institutions rely on gathering, processing, analyzing, and providing information in order to meet the needs of customers. It was based on data primarily, collected from both the primary and secondary sources which seek to investigate role of Information and Communications Technology in the banking industry. This piece of work, through direct investigation, interviews and questionnaires used to examine the role of Information and Communication Technology, plays in the banking industries and how it has affected the employment generation in the industries. It was gathered that ICT has positively affected the bank, the employees and the customers. The result also shows the application has improved banking services, maintained high level of proficiency and efficiency, reduced the long time spent on queues and brought about increase in employment opportunities.

关键词： ICT Banks Information Technology Efficiency Technological Innovation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do Pregnant Teens Have Higher Risk of Intimate Partner Violence than Pregnant Adult Women in Mexico?

引用

Health 2014年第20期6卷 2814-2824页

作者： Rosario Valdez Santiago Mariana Mojarro Iñ iguez Elisa Hidalgo Solorzano leticia Avila Burgos Luz Arenas Monreal WHO Collaborating Centre for Injuries and Violence Research National Institute of Public Health (INSP/Mexico) Cuernavaca Mexico

Objective: The objective of the study is to estimate the prevalence of Intimate Partner Violence (IPV) and identify factors linked to it in pregnant Mexican adult and adolescent women. Methods: Data were gathered by the National Survey of Violence against Women (2006), applied to women between the ages 15-49, users of Mexican public health institutions. Multinomial logistic regression analyses were performed to explore the significant factors associated with IPV against pregnant women. Results: Both adolescent and adult study participating women showed a 24% prevalence of current IPV (during the previous 12 months). The study’s multivariate model for adult women revealed the following as main predictors for IPV: a woman’s agreement with traditional gender roles (OR = 4.35, CI95% = 2.20 - 8.60), and women with a history of childhood sexual abuse (OR = 2.76, CI95% = 1.68 - 4.55). The main predictor of IPV in pregnant adolescents was their partners’ frequency of alcohol consumption: often/usually (OR = 6.49, CI95% = 2.18 - 19.33). Conclusion: To this date, Mexico has not been able to guarantee universal screening methods for IPV as a part of prenatal care protocols. The phenomenon of IPV towards pregnant women neither has been followed-up by further research nor has been identified as a public health problem in spite of the seriousness of its implications for women and their offspring.

关键词： Partner Violence in Pregnancy Adolescents & Adults Mexico

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applications of endoscopic ultrasound in pancreatic cancer

引用

World Journal of Gastroenterology 2014年第24期20卷 7808-7818页

作者： leticia Perondi Luz Mohammad Ali Al-Haddad Michael Sai Lai Sey John M DeWitt Division of Gastroenterology and Hepatology Indiana UniversityMedical CenterRoudebush VA Medical CenterIndianapolisIN 46202United States

Since the introduction of endoscopic ultrasound guided fine-needle aspiration(EUS-FNA),EUS has assumed a growing role in the diagnosis and management of pancreatic ductal adenocarcinoma(PDAC).The objective of this review is to discuss the various applications of EUS and EUS-FNA in ***,its use for detection,diagnosis and staging will be *** and EUS-FNA are highly accurate modalities for detection and diagnosis of PDAC,this high accuracy,however,is decreased in specific situations particularly in the presence of chronic *** techniques such as contrast-enhanced EUS,elastography and analysis of DNA markers such as k-ras mutation analysis in FNA samples are in progress and might improve the accuracy of EUS in the detection of PDAC in this setting and will be *** and EUS-FNA have recently evolved from a diagnostic to a therapeutic technique in the management of *** developments in therapeutic EUS have occurred including advances in celiac plexus interventions with direct injection of ganglia and improved pain control,EUS-guided fiducial and brachytherapy seed placement,fine-needle injection of intra-tumoral agents and advances in EUS-guided biliary *** future role of EUS and EUS in management of PDAC is still emerging.

关键词： Pancreatic ductal carcinoma Pancreatic neoplasm En

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arginine: New and Exciting Developments for an“Old”Amino Acid

引用

Biomedical and Environmental Sciences 1996年第2期9卷 296-315页

作者： LOUIS BEAUMIER leticia CASTILLO YONG-MING YU ALFRED M. AJAMI AND VERNON R. YOUNG(Laboratory of Human Nutrition, School of Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA Shriners Burns Institute,Boston, MA, 02114 USA mass Tra Laboratory of Human Nutrition School of Science Massachusetts Institute of Technology Cambridge 02139 USA.

Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed

关键词： Amino Acid USA Old Arginine New and Exciting Developments for an

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

文化外交与旅游外交对旅游地的影响研究——以“墨西哥电影业”为例

文化外交与旅游外交对旅游地的影响研究——以“墨西哥电影业”为...

引用

作者：罗惠雅（Victoria leticia Rubio Cortes）华中师范大学

学位级别：硕士

近年来墨西哥在如火如荼地开展文化外交与旅游外交活动。尤其是全球贸易盛行和多元文化的交织更是为这两外交培育了沃土,而且文化产品通过国际贸易的渠道实现文化的交流及传播成为了文化外交与旅游外交的热门途径。基于这些,本研究以“... 详细信息

近年来墨西哥在如火如荼地开展文化外交与旅游外交活动。尤其是全球贸易盛行和多元文化的交织更是为这两外交培育了沃土,而且文化产品通过国际贸易的渠道实现文化的交流及传播成为了文化外交与旅游外交的热门途径。基于这些,本研究以“墨西哥电影业”为研究对象,以“墨西哥电影业海外各国演出”为例,提出一个针对“墨西哥电影业”文化产品国际贸易有益于增加各国赴墨西哥旅游人数。这将有利于墨西哥经济的全面发展。本研究通过实证研究和经验研究发现了文化产品的国际贸易,如墨西哥电影业产品海外各国演出与墨西哥旅游人数呈现正相关关系。因此假设一成立,这表示通过文化外交与旅游外交相结合及用墨西哥电影业演出对增加各国赴墨西哥旅游人数。

关键词：影视旅游文化外交旅游外交墨西哥电影业墨西哥

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Correlation between the Six-Minute Walk Test and Subjective Functional Class in Patients with Heart Failure

引用

World Journal of Cardiovascular Diseases 2023年第4期13卷 205-213页

作者： Davi Muzi Rios Gabriela Lira Devens leticia Admiral Louzada Priscila Cabral Gomes Coelho Lima Rodolfo Costa Sylvestre Vinicius Angelo Astolpho Lucas Crespo de Barros Larissa Novaes Paganini Lucas Martins Frizzera Borges Renato Giestas Serpa Osmar Araujo Calil Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Department of Cardiology Santa Casa de Misericórdia de Vitória Hospital Vitória Brazil School of Medicine Santa Casa de Misericórdia Vitória Brazil

Introduction: The Six-Minute Walk Test (6MWT) is an inexpensive method to objectively evaluate physical capacity or limitation and stratify prognosis in patients with Heart Failure (HF). Since the clinical perception of symptoms may be adapted or compromised, regular evaluation from medical interviews often fails to determine functional classification. This study aimed to assess the correlation between New York Heart Association Functional Class (NYHA-FC) and the distance walked in the 6MWT. Methods: We conducted a cross-sectional observational study that included patients with HF with reduced ejection fraction followed up at an outpatient service of a teaching hospital, from August 2018 to April 2019. Patients in NYHA-FC I, II, or III were included. We compared NYHA-FC subjectively obtained during the consultation with the 6MWT performed after medical consultation, and the correlation between these two parameters was assessed. Results: The study included 70 patients with HF, 41 (58.6%) of whom were female. The mean age was 61.2 ± 12.7 years. The most prevalent etiologies were dilated idiopathic cardiomyopathy (35.7%) followed by ischemic cardiomyopathy (25.7%). The mean ejection fraction was 34.1% ± 9.8%. The average distance walked in the 6MWT by NYHA-FC I patients was 437.8 ± 95.8 meters, NYHA-FC II 360.1 ± 96.4, and NYHA-FC III 248.4 ± 98.3. Functional class measured by the 6MWT was different than that estimated by NYHA-FC in 34 patients (48.6%), 23 (32.9%) for a higher functional class and 11 (15.7%) for a lower one (p = 0.07). Pearson’s correlation coefficient between NYHA-FC and the 6MWT was -0.55. Conclusion: There was a moderate correlation between the subjective NYHA-FC and the 6MWT. The 6MWT revealed a different classification from NYHA-FC in almost half of the patients. Among those who presented discrepancies between methods, 6MWT reclassification towards a higher functional class was more common.

关键词： Heart Failure Six-Minute Walk Test Functional Class

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一种评价果汁掺假的方法

引用

山西食品工业 1997年第1期 17-18,22页

作者： leticia spilanko 毛立新山西省食品工业研究所 030024

1 前言近年来,国际果汁市场上浓缩水果汁进出口贸易出现了稳步增长的势头。我国苹果浓缩汁出口也呈稳步上升趋势。果汁饮料销量越来越大,对水果浓缩汁的需求也逐年增加。大多数果汁饮料厂是以购买浓缩汁进行果汁饮料生产。因此,浓缩果... 详细信息

1 前言近年来,国际果汁市场上浓缩水果汁进出口贸易出现了稳步增长的势头。我国苹果浓缩汁出口也呈稳步上升趋势。果汁饮料销量越来越大,对水果浓缩汁的需求也逐年增加。大多数果汁饮料厂是以购买浓缩汁进行果汁饮料生产。因此,浓缩果汁的好坏直接影响着饮料的质量。如何鉴别浓缩果汁掺假对果汁饮料企业来说,将是一个重要的课题。

关键词：果汁掺假检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：