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A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： leonid N.Maslov Natalia v.Naryzhnaya Sergey v.Popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

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基于显著感知与一致性约束的目标跟踪算法

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北京航空航天大学学报 2023年第9期49卷 2244-2257页

作者：国强吴天昊徐伟 CHORNOGOR leonid 哈尔滨工程大学信息与通信工程学院哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室哈尔滨150001 哈尔科夫国立大学无线电物理学院哈尔科夫61166

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧... 详细信息

针对空间正则相关滤波(SRDCF)算法正则权重固定和模型退化等问题,提出了一种基于显著感知与一致性约束的目标跟踪算法。提取方向梯度直方图特征、浅层特征及中层特征进行融合,提升物体外观模型的表达能力;通过显著性检测算法获得初始帧的显著感知参考权重,建立正则权重在相邻2帧之间的关联;最小化实际一致性响应与理想一致性响应之间的差异,约束一致性水平防止滤波器模板退化;提出一种动态约束策略,进一步提高跟踪器在复杂场景下的适应性。在OTB2015、TempleColor128和UAv20L公开数据集上对所提算法进行测试,实验结果表明:相比于SRDCF算法,所提算法在OTB2015数据集上距离精度提高了0.108,AUC提高了0.077,速度为22.41帧/s,实时性较好。

关键词：机器视觉目标跟踪相关滤波显著感知一致性约束

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High-voltage Nanosecond Pulse Generators of the ＂PROTEUS＂ Line for Discharge with Runaway Electrons Applications

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高电压技术 2013年第10期39卷 2506-2513页

作者： Anatoly N. Maltsev Maxim v. Martynov Alexey v. Mikov viktor G. Podkovyrov leonid L. Zhukov Alexander Yu. Ivanov Institute of Atmospheric Optics Russian Academy of Sciences Tomsk 634021 Russia Electrodynamic Systems & Technologies LLC Tomsk 634021 Russia Institute of High-current Electronics Russian Academy of Sciences Tomsk 634021 Russia

Many applications of gas discharge with runaway electrons (DRE) require high-voltage pulse generators (HvPG) with very high increasing rate of output voltage (up to 100 kv/ns), long operation life and low cost. Such HvPGs have to be controlled by external computer for working in combination with other modern equipment. In this paper, some HvPGs development for DRE application in industry and medicine are described. The functional structure and operation principles are discussed for the HvPG of "PROTEUS' line. It is shown that on different loads, the "PROTEUS" generators can produce high-voltage nanosecond pulse with energy up to 1 J, output voltage amplitude from zero to 150 kv, and pulse repetition frequency from zero to 2 000 Hz. Four models of the "PROTEUS" generators are described. The output voltage leading front duration is 150 ns for the "PROTEUS-I" model, 10-20 ns for the "PROTEUS-II", 2 ns for the "PROTEUS-IH" and 0.5 ns for the "PROTEUS-Iv". DRE parameters obtained by using "PROTEUS" HvPGs are demonstrated. Some results of DRE application in solid-state surface modification of natural textile and polymer films are shown as well.

关键词： PROTEUS 纳秒脉冲发生器电子应用气体放电高压失控输出电压脉冲重复频率

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Determining the Drying Out of Coniferous Trees Using Airborne and Satellite Data

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Advances in Remote Sensing 2021年第2期10卷 25-46页

作者： Sviatlana I. Guliaeva Ilya I. Bruchkousky leonid v. Katkovsky Department of Aerospace Research A.N. Sevchenko Research Institute of Applied Physical Problems of the Belarusian State University Minsk Republic of Belarus

In recent decades, the problem of drying out of conifers has become a subject of significant importance due to the widespread mortality of trees caused by stem pest’s damage. Early detection of areas affected by insect outbreaks is of great relevance for preventing the further spread of pests. Forests of Belarus are largely affected by conifers dieback caused by the bark beetle. The aim of the study was to identify drying out conifers using a TripleSat satellite multispectral image of a woodland area in Belarus based on preliminary airborne measurements. Spectrometers operating in a spectral range of 400 - 900 nm were used in airborne measurements, resulting in distinguishing various drying out stages with an accuracy of 27%verdana;"> - 74% for aerial data. In this study, a supervised classification of the TripleSat image based on the method of linear discriminant analysis (LDA) was performed. The input data for LDA algorithm is a set of remote sensing vegetation indices. Results of the study demonstrate that about 90% of the test site is at the green-attack stage that is confirmed by ground surveys of this area.

关键词： Remote Sensing Forest Monitoring Stem Pest Spruce Dieback Spectral Clas-sification vegetation Indices Belarus

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The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

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The Journal of Biomedical Research 2023年第4期37卷 230-254页

作者： Natalia v.Naryzhnaya leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical CenterRussian Academy of ScienceTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Biochemistry and Biotechnology Faculty of ScienceAnnamalai UniversityAnnamalainagarTamilnadu 608002India Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatialaPunjabi 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan Kyrgyz-Indian Mountain Biomedical Research Center Bishkek 720033Kyrgyzstan Department of Internal Medicine Excellence Cluster Cardio-Pulmonary Institute(CPI)Member of the German Center for Lung Research(DZL)Justus Liebig University of GiessenGiessenHessen 35392Germany Department of Mountain and Sleep Medicine and Pulmonary Hypertension National Center of Cardiology and Internal MedicineBishkek 720040Kyrgyzstan.

The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed *** development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these *** hypoxia exerts both positive and adverse *** positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in *** adverse effects are pulmonary hypertension and right ventricular *** review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/*** is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

关键词： heart vessels infarct size arrhythmias chronic hypoxia

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Do reactive oxygen species damage or protect the heart in ischemia and reperfusion?Analysis on experimental and clinical data

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The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： leonid N.Maslov Natalia v.Naryzhnaya Maria Sirotina Alexandr v.Mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei viacheslav N.Azev vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

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Medical Ethics in the Context of the Teachings of *** About the Earth’s Biosphere and Living Matter

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Journal of Philosophy Study 2023年第9期13卷 369-374页

作者： Antipenko leonid Grigoryevich RAS Institute of Philosophy MoscowRussian Federation

The subject of medical ethics is usually considered within the binary doctor-patient *** the context of ***’s teaching about the Earth’s biosphere and living matter,this relationship turns into a tripartite *** third party is the natural environment around us,primarily the Earth’s ***,the problem of developing and improving medical ethics is connected with entropy-ecological *** the background of this issue,the article draws attention to three issues:the issue of maintaining the chiral purity of living matter,the issue of coexistence and the fight against the world of viruses,and the issue of the danger of degradation of human intelligence under the influence of digitalization and *** three questions relate to the physical and mental health of a person and correspond to what is included in the content of the concept of medical ethics.

关键词： medicine ethics biosphere living matter virology digitalization

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Myorelaxation in the training process of skilled athletes

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Open Journal of Molecular and Integrative Physiology 2013年第2期3卷 83-86页

作者： Yuriy P. Denisenko Yuriy v. vysochin leonid G. Yatsenko Department of Physical Education St. Petersburg State Technological University of Vegetative Polymers St. Petersburg Russia Department of Theory and Methods of Sports Games Branch of Povolzhskaya State Academy of Physical Culture Sports and Tourism Naberezhnye Chelny Russia

At the present time, a number of various ways of sportspersons’ special physical capability (SPC) based mainly on training and competitive loadings ramp up. They are effective enough to reach the main goal, but none of them provides sportspersons’ health safety. Moreover, with the increase in volume and intensity of the loadings, which in sport have almost reached their limits, the sport traumatism and morbidity rate grow progressively. Proceeding from this, there was an evident necessity for the search of conceptually new ways for a simultaneous solution of these two the most complex and, in the opinion of many research workers, almost incompatible problems—the problem of achieving the highest levels of special physical working capacity, and the problem of sportspersons’ health maintenance and improving-associated by us into one general problem of human motor activity efficiency enhancement. Therefore it is necessary to physiologically substantiated the basic methods and principles of special relaxation training, directed on increase of efficiency of process of training of sportsmen at all stages of the development of athletic skills. Under the efficiency of the motor activity, we understand achieve the highest levels of the special physical performance while maintaining sports longevity and health of athletes.

关键词： Extreme Conditions Protection Functional System Muscle Relaxation Rate Physical Efficiency Central Nervous System Relaxation

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改进算术优化算法用于稀布平面阵列综合

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西安电子科技大学学报 2023年第3期50卷 202-212页

作者：国强刘从业王亚妮王勇 CHERNOGOR leonid 哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室黑龙江哈尔滨150001 乌克兰哈尔科夫国立大学空间无线电物理系乌克兰哈尔科夫61022

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个... 详细信息

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个体进行勘探开发,并引入精英变异策略,以增强算法跳出局部最优的能力,提高算法的收敛精度;最后,提出了一种自适应矩阵映射法则,对当前阵元分布进行判断,若其不满足最小阵元间距约束,则通过调整策略对其进行调整,在避免不可行解的同时保证了阵元的自由度。与现有文献中的算法相比,改进的算术优化算法对单峰和多峰标准测试函数的优化精度和稳定性均有一定的提高;在稀布平面阵列旁瓣电平抑制实验和零陷综合实验中,所提算法可以综合出更优的峰值旁瓣电平和零陷深度,证明了所提算法的有效性。

关键词：阵列综合稀布阵列矩阵映射法则算术优化算法

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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor vivian Szymczuk Brendan Boyce Daniel Martin vardit Kram Rebeca Galisteo Kamran Melikov leonid v.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

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