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Gastric splenosis mimicking a gastrointestinal stromal tumor:A case report

World Journal of Gastrointestinal Surgery 2020年第10期12卷 435-441页

作者： Claudio Isopi Giulia Vitali Federica Pieri leonardo solaini Giorgio Ercolani Department of Surgery Morgagni-Pierantoni HospitalForli 47121Italy Pathology Unit Morgagni-Pierantoni HospitalForli 47121Italy Department of Medical and Surgical Sciences University of BolognaBologna 47100Italy

BACKGROUND Mass lesions located in the wall of the stomach(and also of the bowel)are referred to as“intramural.”The differential diagnosis of such lesions can be challenging in some *** such,it may occur that an inconclusive fine needle aspiration(FNA)result give way to an unexpected diagnosis upon final surgical ***,we present a case of an intramural gastric nodule mimicking a gastric gastrointestinal stromal tumor(GIST).CASE SUMMARY A 47-year-old Caucasian woman,who had undergone splenectomy for trauma at the age of 16,underwent gastroscopy for long-lasting epigastric pain and *** revealed a 15 mm submucosal nodule bulging into the gastric lumen with smooth margins and normal overlying mucosa.A thoraco-abdominal computed tomography scan showed in the gastric fundus a rounded mass(30 mm in diameter)with an exophytic growth and intense enhancement after administration of intravenous *** ultrasound scan showed a hypoechoic nodule,and fine needle FNA was *** GIST was considered the most probable diagnosis,and surgical resection was proposed due to symptoms.A laparoscopic gastric wedge resection was *** postoperative course was uneventful,and the patient was discharged on the seventh postoperative *** final pathology report described a rounded encapsulated accumulation of lymphoid tissue of about 4 cm in diameter consistent with spleen parenchyma implanted during the previous *** Splenosis is a rare condition that should always be considered as a possible diagnosis in splenectomized patients who present with an intramural gastric nodule.

关键词： Splenosis Intramural gastric mass Gastric nodule Laparoscopic gastric surgery Gastrointestinal stromal tumor Case report

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Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation

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World Journal of Gastroenterology 2014年第26期20卷 8471-8481页

作者： Stacey J Coleman Jennifer Watt Prabhu Arumugam leonardo solaini Elisabeta Carapuca Mohammed Ghallab Richard P Grose Hemant M Kocher Centre for Tumour Biology Barts Cancer Institute - a CR-UK Centre of ExcellenceQueen Mary University of LondonJohn Vane Science CentreCharterhouse SquareLondon EC1M 6BQUnited Kingdom Barts and the London HPB Centre The Royal London HospitalBarts Health NHS TrustLondon EC1M 6BQUnited Kingdom

Pancreatic cancer carries a terrible prognosis,as the fourth most common cause of cancer death in the Western *** is clearly a need for new therapies to treat this *** of the reasons no effective treatment has been developed in the past decade may in part,be explained by the diverse influences exerted by the tumour *** tumour stroma cross-talk in pancreatic cancer can influence chemotherapy delivery and response ***,appropriate preclinical in vitro models which can bridge simple 2D in vitro cell based assays and complex in vivo models are required to understand the biology of pancreatic *** we discuss the evolution of 3D organotypic models,which recapitulare the morphological and functional features of pancreatic ductal adenocarcinoma(PDAC).Organotypic cultures are a valid high throughput preclinical in vitro model that maybe a useful tool to help establish new therapies for PDAC.A huge advantage of the organotypic model system is that any component of the model can be easily modulated in a short *** allows new therapies that can target the cancer,the stromal compartment or both to be tested in a model that mirrors the in vivo situation.A major challenge for the future is to expand the cellular composition of the organotypic model to further develop a system that mimics the PDAC environment more *** discuss how this challenge is being met to increase our understanding of this terrible disease and develop novel therapies that can improve the prognosis for patients.

关键词： 3D organotypic model Pancreatic cancer Pancreatic stellate cell Stroma Preclinical models

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Hyperthermic intraperitoneal chemotherapy and colorectal cancer:From physiology to surgery

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World Journal of Clinical Cases 2022年第30期10卷 10852-10861页

作者： Giorgio Ammerata Rosalinda Filippo Carmelo Laface Riccardo Memeo leonardo solaini Davide Cavaliere Giuseppe Navarra Girolamo Ranieri Giuseppe Currò Michele Ammendola Department Digestive Surgery UnitUniversity“Magna Graecia”Medical SchoolCatanzaro 88100Italy Interventional Oncology Unit with Integrated Section of Translational Medical Oncology National Cancer Research Centre“Giovanni Paolo Ⅱ”Bari 70124Italy Hepato-Biliary and Pancreatic Surgical Unit “F.Miulli”HospitalAcquaviva delle FontiBari 70124Italy Department of Medical and Surgical Sciences University of BolognaForlì40126Italy Department of General and Oncologic Surgery Morgagni-Pierantoni HospitalForlì47121Italy Department of Human Pathology of Adult and Evolutive Age Surgical Oncology Division“G.Martino”HospitalUniversity of MessinaMessina 98122Italy

The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy(HIPEC) and cytoreductive surgery(CRS) used in colorectal cancer(CRC).We focus on principal biological aspects of CRC,hyperthermia effects,and surgical *** searched PubMed/MEDLINE for the principal reviews and systematic reviews published from 2010 to 2021 regarding the bimodal treatment(CRS + HIPEC) against local and advanced *** the literature,from several studies,it seems that the efficacy of bimodal treatment with an accurate CRS can extend overall *** these studies,there are not still any straight guidelines more detailed and scheduled about the use of combined treatment in patients with *** if the concept is still not very clear and shared,after a careful evaluation of the published data,and after some technical and pathophysiological descriptions,we concluded that it is possible to improve the overall survival and quality of life and to reduce the tumor relapse in patients affected by locally advanced(pT4) CRC with peritoneal metastases.

关键词： Hyperthermic intraperitoneal chemotherapy Colorectal cancer Peritoneum Cytoreductive surgery

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Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

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World Journal of Clinical Cases 2022年第24期10卷 8556-8567页

作者： Fabrizio D'Acapito leonardo solaini Daniela Di Pietrantonio Francesca Tauceri Maria Teresa Mirarchi ElenaAntelmi Francesca Flamini Alessio Amato Massimo Framarini Giorgio Ercolani Department of General and Oncologic Surgery Morgagni-Pierantoni HospitalAUSL RomagnaForlì47121Italy Department of Medical and Surgical Sciences University of BolognaBologna 40126Italy

BACKGROUND Incidence of gallstones in those aged≥80 years is as high as 38%-53%.The decision-making process to select those oldest old patients who could benefit from cholecystectomy is *** To assess the risk of morbidity of the“oldest-old”patients treated with cholecystectomy in order to provide useful data that could help surgeons in the decision-making process leading to surgery in this *** A retrospective study was conducted between 2010 and *** variables were collected and compared between patients who had postoperative complications.A model was created and tested to predict severe postoperative *** The 269 patients were included in the study(193 complicated).The 9.7%of complications were grade 3 or 4 according to the Clavien-Dindo *** levels were lower in patients who did not have any postoperative *** Society of Anesthesiologists scale 4 patients,performing a choledocholithotomy and bilirubin levels were associated with Clavien-Dindo>2 complications(P<0.001).The decision curve analysis showed that the proposed model had a higher net benefit than the treating all/none options between threshold probabilities of 11%and 32%of developing a severe *** Patients with American Society of Anesthesiologists scale 4,higher level of bilirubin and need of choledocholithotomy are at the highest risk of a severely complicated postoperative *** endoscopic or percutaneous treatments should be considered in this subgroup of octogenarians.

关键词： Cholecystitis Gallstones Choledocholithotomy Elderly Post-operative complications

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Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?

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World Journal of Gastroenterology 2018年第36期24卷 4152-4163页

作者： Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo leonardo solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini Biosciences Laboratory Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS Department of Medical and Surgical Sciences Alma Mater StudiorumUniversity of Bologna General and Oncologic Surgery Morgagni-Pierantoni Hospital Section of Gastroenterology DI.BI.M.I.S.University of Palermo Department of Internal Medicine Degli Infermi Hospital Department of Medical Oncology Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS Department of Medical Oncology University of Cagliari

Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC.

关键词： Biomarker Angiopoietin Neutrophil-tolymphocyte ratio Polymorphisms Sorafenib MicroRNA Adverse events Hepatocellular carcinoma Vascular endothelial growth factor

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Domenico Losurdo on Stalin:A Dialectical and Comparative Perspective on a Controversial Legacy

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Fudan Journal of the Humanities and Social Sciences 2024年第3期17卷 399-416页

作者： leonardo Pegoraro Melbourne Australia

This article explores the insights of the Italian Marxist philosopher Domenico Losurdo on Stalin,with a focus on his controversial work:Stalin:History and Cri-tique of a Black *** sheds light on the metamorphosis of Stalin's image from a revered leader into a human monster”and challenges the equation of Stalin with Hitler(the“twin monsters theory”).He advocates for a balanced perspective that refutes the veneration-demonisation dichotomy and offers original criticism on various facets of the“black legend”:Stalin's alleged self-cult of personality;the common juxtaposition of Soviet Gulags with Nazi camps;and accusations of geno-cide against Ukrainians(known as the Holodomor)and *** article also highlights Losurdo's methodology,consisting of a comprehensive comparative approach that calls into question the liberal tradition to reveal parallels between its darker aspects and *** demonstrates how the twin monsters theory eventually serves to bolster liberalism's claim of moral ***,his work extends beyond Stalin to provide a wider assessment and criticism of most of the contemporary historiography's themes and approaches,revealing how history is often manipulated for political reasons.

关键词： Stalin Losurdo Communism Nazism Liberalism

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Assistive Robotics for Upper Limb Physical Rehabilitation:A Systematic Review and Future Prospects

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 50-73页

作者： Andrés Guatibonza leonardo Solaque Alexandra Velasco Lina Peñuela Department of Engineering Mechatronics EngineeringMilitar Nueva Granada UniversityBogotá1101111Colombia

Physical assistive robotics are oriented to support and improve functional capacities of *** physical rehabilitation,robots are indeed useful for functional recovery of affected ***,there are still open questions related to technological *** work presents a systematic review of upper limb rehabilitation robotics in order to analyze and establish technological challenges and future directions in this area.A bibliometric analysis was performed for the systematic literature *** from the last six years,conducted between August 2020 and May 2021,was *** methodology for the literature search and a bibliometric analysis of the metadata are *** a preliminary search resulted in 820 articles,a total of 66 articles were included.A concurrency network and bibliographic analysis were *** an analysis of occurrences,taxonomy,and rehabilitation robotics reported in the literature is *** review aims to provide to the scientific community an overview of the state of the art in assistive robotics for upper limb physical *** literature analysis allows access to a gap of unexplored options to define the technological prospects applied to upper limb physical rehabilitation robotics.

关键词： Upper limb Rehabilitation Assistive robotics Human-machine interaction Robotic systems Virtual reality Rehabilitation monitoring

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Assessment of compressive strength of jet grouting by machine learning

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 102-111页

作者： Esteban Diaz Edgar leonardo Salamanca-Medina Roberto Tomas Departamento de Ingeniería Civil Escuela Politécnica SuperiorUniversidad de AlicanteP.O.Box 99E-03080AlicanteSpain

Jet grouting is one of the most popular soil improvement techniques,but its design usually involves great uncertainties that can lead to economic cost overruns in construction *** high dispersion in the properties of the improved material leads to designers assuming a conservative,arbitrary and unjustified strength,which is even sometimes subjected to the results of the test *** present paper presents an approach for prediction of the uniaxial compressive strength(UCS)of jet grouting columns based on the analysis of several machine learning algorithms on a database of 854 results mainly collected from different research *** selected machine learning model(extremely randomized trees)relates the soil type and various parameters of the technique to the value of the compressive *** the complex mechanism that surrounds the jet grouting process,evidenced by the high dispersion and low correlation of the variables studied,the trained model allows to optimally predict the values of compressive strength with a significant improvement with respect to the existing ***,this work proposes for the first time a reliable and easily applicable approach for estimation of the compressive strength of jet grouting columns.

关键词： Jet grouting Ground improvement Compressive strength Machine learning

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Is tuberous sclerosis complex-associated autism a preventable andtreatabledisorder?

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World Journal of Pediatrics 2024年第1期20卷 40-53页

作者： Paolo Curatolo Mirte Scheper leonardo Emberti Gialloreti Nicola Specchio Eleonora Aronica Child Neurology and Psychiatry Unit Systems Medicine DepartmentTor Vergata UniversityRomeItaly Department of Neuropathology Amsterdam NeuroscienceAmsterdam UMC Location University of AmsterdamAmsterdamTheNetherlands Department of Biomedicine and Prevention University of Rome Tor VergataVia Montpellier 100133 RomeItaly Clinical and Experimental Neurology Bambino Gesù Children's HospitalIRCCSFull Member of European ReferenceNetworkEpiCAREPiazza S.Onofrio400165 RomeItaly Stichting Epilepsie Instellingen Nederland(SEIN) HeemstedeAmsterdamThe Netherlands

Background Tuberous sclerosis complex(TSC)is a genetic disorder caused by inactivating mutations in the TSCl and TSC2 genes,causing overactivation of the mechanistic(previously referred to as mammalian)target of rapamycin(mTOR)signaling pathway in fetal *** mTOR pathway plays a crucial role in several brain processes leading to TSC-related epilepsy,intellectual disability,and autism spectrum disorder(ASD).Pre-natal or early post-natal diagnosis of TSC is now possible in a growing number of pre-symptomatic *** sources We searched PubMed for peer-reviewed publications published between January 2010 and April 2023 with the terms“tuberous sclerosis",“autism",or“autism spectrum disorder""animal models",“preclinical studies",“neurobiology",and“treatment".Results Prospective studies have highlighted that developmental trajectories in TSC infants who were later diagnosed with ASD already show motor,visual and social communication skills in the first year of life *** genetic,cellular,electroencephalography and magnetic resonance imaging biomarkers can identify pre-symptomatic TSC infants at high risk for having autism and *** Preventing epilepsy or improving therapy for seizures associated with prompt and tailored treatment strategies for autism in a sensitive developmental time window could have the potential to mitigate autistic symptoms in infants with TSC.

关键词： Animal model-Autism spectrum disorders Developmental and epileptic encephalopathy Mechanisms mTOR Risk Tuberos sclerosis complex

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Stochastic seismic inversion and Bayesian facies classification applied to porosity modeling and igneous rock identification

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Petroleum Science 2024年第2期21卷 918-935页

作者： Fábio Júnior Damasceno Fernandes leonardo Teixeira Antonio Fernando Menezes Freire Wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsFederal Fluminense UniversityNiter oiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20231-030Brazil National Institute of Science and Technology of Petroleum Geophysics(INCT-GP/CNPQ) Niter oiRJ24210-346Brazil

We apply stochastic seismic inversion and Bayesian facies classification for porosity modeling and igneous rock identification in the presalt interval of the Santos Basin. This integration of seismic and well-derived information enhances reservoir characterization. Stochastic inversion and Bayesian classification are powerful tools because they permit addressing the uncertainties in the model. We used the ES-MDA algorithm to achieve the realizations equivalent to the percentiles P10, P50, and P90 of acoustic impedance, a novel method for acoustic inversion in presalt. The facies were divided into five: reservoir 1,reservoir 2, tight carbonates, clayey rocks, and igneous rocks. To deal with the overlaps in acoustic impedance values of facies, we included geological information using a priori probability, indicating that structural highs are reservoir-dominated. To illustrate our approach, we conducted porosity modeling using facies-related rock-physics models for rock-physics inversion in an area with a well drilled in a coquina bank and evaluated the thickness and extension of an igneous intrusion near the carbonate-salt interface. The modeled porosity and the classified seismic facies are in good agreement with the ones observed in the wells. Notably, the coquinas bank presents an improvement in the porosity towards the top. The a priori probability model was crucial for limiting the clayey rocks to the structural lows. In Well B, the hit rate of the igneous rock in the three scenarios is higher than 60%, showing an excellent thickness-prediction capability.

关键词： Stochastic inversion Bayesian classification Porosity modeling Carbonate reservoirs Igneous rocks

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