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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 365-374页

作者： lei ZHANG peng LIU yu-ling LIU Fei-hong yu State Key Lab of Modern Optical Instrumentation Department of Optical Engineering Zhejiang University Hangzhou 310027 China

A novel multi-focus polychromatic image fusion algorithm based on filtering in the frequency domain using fast Fourier transform(FFT) and synthesis in the space domain(FFDSSD) is presented in this ***,the original multi-focus images are transformed into their frequency data by FFT for easy and accurate clarity *** a Gaussian low-pass filter is used to filter the high frequency information corresponding to the image *** an inverse FFT,the filtered images are *** deviation between the filtered images and the original ones,representing the clarity of the image,is used to select the pixels from the multi-focus images to reconstruct a completely focused *** operations in space domain preserve the original information as much as possible and are relatively insensitive to misregistration scenarios with respect to transform domain *** polychromatic noise is well considered and successfully avoided while the information in different chromatic channels is preserved.A natural,nice-looking fused microscopic image for human visual evaluations is obtained in a dedicated *** experimental results indicate that the proposed algorithm has a good performance in objective quality metrics and runtime efficiency.

关键词： Multi-focus image Polychromatic image Image fusion Fast Fourier transform(FFT)

Cu,N codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of Energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai feng Min yu Minjia Meng lei Liu Dewei Rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(NPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-N-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)NPs in Cu@Cu-N-C have high PDO dehydrogenation activity while N-coordinated Cu(Cu-N)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-N-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

Developing China's roadmap for air quality improvement:A review on technology development and future prospects

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Journal of Environmental Sciences 2023年第1期123卷 510-521页

作者： yueyi feng Miao Ning Wenbo Xue Miaomiao Cheng yu lei Institute of Atmospheric Environment Chinese Academy of Environmental PlanningBeijing 100012China Chinese Research Academy of Environmental Sciences Beijing 100012China

Air pollution control policies in China have been experiencing profound changes,highlighting a strategic transformation from total pollutant emission control to air quality improvement,along with the shifting targets starting from acid rain and NO_(x)emissions to PM_(2.5)pollution,and then the emerging O_(3)*** marvelous achievements have been made with the dramatic decrease of SO_(2)emission and fundamental improvement of PM_(2.5)*** these achievements,China has proposed Beautiful China target through 2035 and the goal of 2030 carbon peak and 2060 carbon neutrality,which impose stricter requirements on air quality and synergistic mitigation with Greenhouse Gas(GHG)*** this background,an integrated multi-objective and multi-benefit roadmap is required to provide decision support for China’s long-term air quality improvement *** paper systematically reviews the technical system for developing the air quality improvement roadmap,which was integrated from the research output of China’s National Key R&D Program for Research on Atmospheric Pollution Factors and Control Technologies(hereafter Special NKP),covering mid-and long-term air quality target setting techniques,quantitative analysis techniques for emission reduction targets corresponding to air quality targets,and pathway optimization techniques for realizing reduction *** experience and lessons derived from the reviews have implications for the reformation of China’s air quality improvement roadmap in facing challenges of synergistic mitigation of PM_(2.5)and O_(3),and the coupling with climate change mitigation.

关键词： Air quality management Air quality targets Mitigation pathway optimization Dynamic emission scenario Cost-benefit evaluation Integrated decision-support model

Therapeutic effects of thalidomide in hematologic disorders:a review

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Frontiers of Medicine 2013年第3期7卷 290-300页

作者： Miao Xu yu Hou lei Sheng Jun peng Department of Hematology Qilu HospitalShandong UniversityJinan 250012China Shandong University School of Medicine JinanShandong250012China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China

The extensive autoimmune,anti-inflammatory,and anticancer applications of thalidomide have inspired a growing number of studies and clinical *** an inexpensive agent with relatively low toxicity,thalidomide is regarded as a promising therapeutic candidate,especially for malignant *** review its therapeutic effects in hematology,including those on multiple myeloma,Waldenstroem macroglobulinemia,lymphoma,mantle-cell lymphoma,myelodysplastic syndrome,hereditary hemorrhagic telangiectasia,and graft-versus-host *** studies have shown satisfactory results,although several have reported the *** from optimal outcomes,the toxicities and adverse effects of thalidomide should also be *** current work includes a discussion of the mechanisms through which the novel biological effects of thalidomide occur,although more studies should be devoted to this *** appropriate safeguards,thalidomide may benefit patients suffering from a broad variety of disorders,particularly refractory and resistant diseases.

关键词： thalidomide multiple myeloma lymphoma

Sulfite as the substrate of C-sulfonate metabolism ofα,β-unsaturated carbonyl containing andrographolide:analysis of sulfite in rats'intestinal tract and the reaction kinetics of andrographolide with sulfite

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Chinese Journal of Natural Medicines 2021年第9期19卷 706-712页

作者： HUO Zhi-peng feng Xin-Chi WANG yu TIAN yu-Ting QIU feng School of Chinese Materia Medica and State Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China ~TCM Research Center Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300402China State Key Laboratory of Critical Technology in Innovative Chinese Medicine Tasly Pharmaceutical Co.Ltd.Tianjin 300402China Institute of Pharmacy China Pharmaceutical UniversityNanjing 210009China Institute of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China

One-sixth of the currently known natural products containα,β-unsaturated carbonyl *** previous studies reported a rare C-sulfonate metabolic *** groups were linked to theβ-carbon ofα,β-unsaturated carbonyl-based natural compounds through this ***,the mechanism of this type of metabolism is still not fully understood,especially whether it is formed through enzyme-mediated biotransformation or direct sulfite *** this work,the enzyme-mediated and non-enzymatic pathways were ***,the sulfite content in rat intestine was determined by LC-MS/*** results showed that the amount of sulfite in rat intestinal contents was from 41.5 to 383μg·g^(-1),whereas the amount of sulfite in rat feed was lower than the lower limit of quantitation(20μg·g^(-1)).Second,the reaction kinetics of sulfite-andrographolide reactions in phosphate buffer solutions(pH 6-8)was *** half-lives of andrographolide ranged from minutes to *** was suggested that the C-sulfonate reaction of andrographolide was very ***,the C-sulfonate metabolites of andrographolide were both detected when andrographolide and L-cysteine-S-conjugate andrographolide were incubated with the rat small intestine contents or sulfite,indicating that the sulfite amount in rat intestine contents was high enough to react with andrographolide,which assisted a significant portion of andrographolide ***,the comparison of andrographolide metabolite profiles among liver homogenate(with NADPH),liver S9(with NADPH),small intestine contents homogenate(with no NADPH),and sulfite solution incubations showed that the C-sulfonate metabolites were predominantly generated in the intestinal tract by non-enzymatic *** summary,sulfite can serve as a substrate for C-sulfonate metabolism,and these results identified non-enzymatically nucleophilic addition as the potential mechanism for C-sulfonate metabolism of compounds containingα,β-unsaturated carbonyl moie

关键词： Sulfite C-Sulfonate metabolites α,β-Unsaturated carbonyl Reaction kinetics Andrographolide Non-enzymatic

CHD1 deletion stabilizes HIF1α to promote angiogenesis and glycolysis in prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 152-157页

作者： yu-Zhao Wang yu-Chen Qian Wen-Jie yang lei-Hong Ye Guo-Dong Guo Wei Lv Meng-Xi Huan Xiao-yu feng Ke Wang Zhao yang yang Gao lei Li yu-Le Chen Department of Urology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Oncology Research Laboratory Key Laboratory of Environment and Genes Related to DiseasesMinistry of EducationXi’an 710061China

Chromodomain-helicase-DNA-binding protein 1(CHD1)deletion is among the most common mutations in prostate cancer(PCa),but its role remains *** this study,RNA sequencing was conducted in PCa cells after clustered regularly interspaced palindromic repeat(CRISPR)/CRISPR-associated protein 9(Cas9)-based CHD1 *** set enrichment analysis(GSEA)indicated upregulation of hypoxia-related pathways.A subsequent study confirmed that CHD1 deletion significantly upregulated hypoxia-inducible factor 1α(HIF1α)*** investigation revealed that CHD1 deletion upregulated HIF1αby transcriptionally downregulating prolyl hydroxylase domain protein 2(PHD2),a prolyl hydroxylase catalyzing the hydroxylation of HIF1αand thus promoting its degradation by the E3 ligase von Hippel–Lindau tumor suppressor(VHL).Functional analysis showed that CHD1 deletion promoted angiogenesis and glycolysis,possibly through HIF1αtarget *** together,these findings indicate that CHD1 deletion enhances HIF1αexpression through PHD2 downregulation and therefore promotes angiogenesis and metabolic reprogramming in PCa.

关键词： angiogenesis CHD1 HIF1α metabolism prostate cancer

Direct growth of single-walled carbon nanotubes on substrates

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Chinese Science Bulletin 2012年第2期57卷 225-233页

作者： peng Fei LIU yu CUI RongLi GAO DongLiang yang feng LI Yan Beijing National Laboratory for Molecular Sciences National Laboratory of Rare Earth Material Chemistry and ApplicationKey Laboratory forthe Physics and Chemistry of NanodevicesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

As one of the most promising candidate material for next generation electronic devices,the reliable and controllable synthesis of high quality single-walled carbon nanotubes(SWNTs) has long been an essential and important issue in the *** growth of SWNTs on flat substrates by chemical vapor deposition(CVD) process is the best way to obtain SWNTs because it is immediately ready for building *** orientation of the SWNTs has been well controlled by gas flow or substrate lattice during the CVD growth *** chirality and structure control of SWNTs is still a big ***,the conductivity selective growth has already partially *** catalysts have been explored to obtain SWNTs of higher *** with the further progress in the study of the SWNT growth,the precise control over the orientation,position and conductivity of SWNTs is expected to meet the requirements of carbon-based nanoelectronics.

关键词：单壁碳纳米管直接生长衬底化学气相沉积结构控制 SWNTs 纳米电子学电子设备

Theoretical study of ullage washing with mixed inert gas in a non-equilibrium state

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Chinese Journal of Aeronautics 2020年第12期33卷 3167-3175页

作者： Shiyu feng Xiaotian peng lei SHAO Yan YAN Chen CHEN Weihua LIU Key Laboratory of Aircraft Environment Control and Life Support of MIIT College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China College of Aeronautics Chongqing Jiaotong UniversityChongqing 400074China College of Mechanical and Electrical Engineering Xi'an Polytechnic UniversityXi'an 710000China

The Mixed Inert Gas(MIG)produced by the novel Green On Board Inerting Gas Generation System(GOBIGGS)mainly consists of carbon dioxide,nitrogen and *** of the large solubility of carbon dioxide in jet fuel compared with nitrogen,the no gas release or equilibrium model could not be employed any *** this paper,first,a mathematical model of the ullage washing was set up to predict the variation of the oxygen concentration on ullage and in the fuel,and the gas evolution and dissolution rate were calculated by Fick's second ***,an experimental apparatus was constructed to verify the accuracy of the ***,the numerical comparisons of ullage washing using Nitrogen Enriched Air(NEA)and MIG are presented under various flow rates and fuel loads,and the result reveals that the variation of the oxygen concentration on ullage is nearly identical whatever the inert gas is NEA or ***,the variation of the oxygen concentration in the fuel is disparate,and the oxygen concentration decreases rapidly if the inert gas is MIG,especially when the fuel load is low or the flow rate of the inert gas is ***,MIG could suppress the rising trend of the oxygen concentration on ullage when the aircraft ascends if the fuel tank is fully washed into an equilibrium state on ground.

关键词： Inert gas Mixed inert gas Nitrogen enriched air Non-equilibrium Washing

Materials design by generalized stability

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Journal of Materials Science & Technology 2023年第16期147卷 153-164页

作者： yu Zhang Haoran peng Linke Huang feng Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityShaanxi 710072China Northwest Institute for Nonferrous Metal Research Xi’an 710016China Analytical&Testing Center Northwestern Polytechnical UniversityShaanxi 710072China

***,Understanding and predicting microstructure and its relationship with the mechanical properties of metallic materials require detailed knowledge of phase transformations(PTs)and plastic deformations(PDs).These two processes,as central topics in material science,can be fundamentally described to a large extent by a framework of thermodynamic and kinetics(thermo-kinetics).The situation of PTs arises when the microstructure is losing phase stability,whereas the issue of PDs corresponds to the break of mechanical stability,all of which can be uniformly defined as the so-called loss of thermodynamic stability(TS).In this context,the higher TS will lead to the higher driving force G essentially required for the PT and/or PD forming and/or changing the *** the case of PTs,extensive examples showing the high TS can be found,such as martensite transformations(MTs)upon continuous cooling or strain[1,2],coherent precipitation[3,4],so-called Schwarz crystal[5],etc.

关键词： microstructure martensite stability

3D Network nanostructured NiCoP nanosheets supported on N-doped carbon coated Ni foam as a highly active bifunctional electrocatalyst for hydrogen and oxygen evolution reactions

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 417-424页

作者： Miaomiao Tong lei Wang peng yu Xu Liu Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongiiang University Harbin 150080 China

A highly active bi-functional electrocatalyst towards both hydrogen and oxygen evolution reactions is critical for the water splitting. Herein, a self-supported electrode composed of 3D network nanostructured NiCoP nanosheets grown on N-doped carbon coated Ni foam （NiCoP/NF@NC） has been synthesized by a hydrothermal route and a subsequent phosphorization process. As a bifunctional electrocatalyst, the NiCoP/NF@NC electrode needs overpotentials of 31.8 mV for hydrogen evolution reaction and 308.2 mV for oxygen evolution reaction to achieve the current density of 10 mA·cm^-2 in 1 mol·L^-1 KOH electrolyte. This is much better than the correspond- ing monometal catalysts of CoP/NF@NC and NiP/ NF@NC owing to the synergistic effect. NiCoP/NF@NC also exhibits low Tafel slope, and excellent long-term stability, which are comparable to the commercial noble catalysts of Pt/C and RuO2.

关键词： bimetallic phosphides N-doped carbon self-support hydrogen evolution oxygen evolution