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Prediction of salinity intrusion in the sheltered estuary of Terengganu River in Malaysia using 1-D empirical intrusion model

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Acta Oceanologica Sinica 2017年第5期36卷 57-66页

作者： lee hin lee TANGANG Fredolin GISEN Jacqueline Isabella SURATMAN Saim Research Centre for Tropical Climate Change Faculty of Science and TechnologyThe National University of MalaysiaUKM Bangi 43600Malaysia Research Centre for Water Quality and Environment National Hydraulic Research Institute of MalaysiaMinistry of Natural Resources and EnvironmentSeri Kembangan 43300Malaysia Centre for Earth Resources Research and Management Faculty of Civil Engineering and Earth ResourcesThe Universiti Malaysia PahangPahang 26600Malaysia

Generally one dimensional （l-D） empirical salinity intrusion model is limited to natural alluvial estuary. However, this study attempts to investigate its ability to model a sheltered alluvial estuary of the Terengganu River in Malaysia. The constructed breakwater at the mouth of the river shelters the estuary from direct influence of the open sea. The salinity density along the estuary was collected during the wet and dry seasons for scenarios before and after the constructed breakwater. Moreover, the freshwater discharges, tidal elevations and bathymetry data were also measured as model inputs. A good fit was demonstrated between simulated and observed variables, namely salinity distribution and intrusion length for both scenarios. Thus, the results show that 1-D empirical salinity model can be utilized for sheltered estuarine condition at the Terengganu Estuary, but with an appropriate determination of an initial point. Furthermore, it was observed that the salinity intrusion in the study area is largely dependent on the freshwater discharge rather than tidal elevation fluctuations. The scale of the salinity intrusion length in the study area is proportional to the river discharge of the -1/2 power. It was appeared that the two lines of the 1-D empirical salinity model and discharge power based equation fitted well to each other, with the average predicted minimum freshwater discharge of 150 m^3/s is going to be required to maintain acceptable salinity levels during high water slack （HWS） near the water intake station, which is located at 10.63 km from river mouth.

关键词： salinity intrusion sheltered estuary freshwater discharge geometric characteristic empirical model

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Cost effectiveness analysis of population-based serology screening and ^(13)C-Urea breath test for Helicobacter pylori to prevent gastric cancer:A markov model

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World Journal of Gastroenterology 2008年第19期14卷 3021-3027页

作者： Feng Xie Nan Luo hin-Peng lee Department of Clinical Epidemiology and Biostatistics McMaster University Ontario L8P 1H 1 Canada Department of Community Occupational and Family Medicine and Research Fellow Centre for Health Services Research Yong Lop Lin School of Medicine National University of Singapore Singapore 117597 Singapore Department of Community Occupational and Family Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

AIM:To compare the costs and effectiveness of no screening and no eradication therapy, the population- based Helicobacter pylori (H pylori) serology screening with eradication therapy and 13C-Urea breath test (UBT) with eradication therapy. METHODS:A Markov model simulation was carried out in all 237 900 Chinese males with age between 35 and 44 from the perspective of the public healthcare provider in Singapore. The main outcome measures were the costs, number of gastric cancer cases prevented, life years saved, and quality-adjusted life years (QALYs) gained from screening age to death. The uncertainty surrounding the cost-effectiveness ratio was addressed by one-way sensitivity analyses. RESULTS:Compared to no screening, the incremental cost-effectiveness ratio (ICER) was $16 166 per life year saved or $13 571 per QALY gained for the serology screening, and $38 792 per life year saved and $32 525 per QALY gained for the UBT. The ICER was $477 079 per life year saved or $390 337 per QALY gained for the UBT compared to the serology screening. The cost- effectiveness of serology screening over the UBT was robust to most parameters in the model. CONCLUSION:The population-based serologyscreening for H pylori was more cost-effective than the UBT in prevention of gastric cancer in Singapore Chinese males.

关键词： Cost-effectiveness analysis Gastric cancer He/icobacterpy/ori 13C-Urea breath test Serology

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Organic Solar Cells at Stratospheric Condition for High Altitude Platform Station Application

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Chinese Journal of Chemistry 2022年第24期40卷 2927-2932页

作者： Ram Datt Harrison Ka hin lee Guichuan Zhang hin-Lap Yip Wing Chung Tsoi SPECIFIC Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySwanseaSA18EN United Kingdom Department of Physics City University of Hong KongKowloonHong KongSARChina School of Semiconductor Science and Technology South China Normal UniversityFoshanGuangdong528225 China State Key Laboratory of Luminescent Materials and Devices South China University of Technology381 Wushan RoadGuangzhouGuangdong510640 China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina School of Energy and Environment City University of Hong KongKowloonHong KongChina Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong KongChina

High specific power or power to mass ratio is a critical concern of photovoltaic(PV)for aerospace *** solar cells(OSCs)have advantages such as high absorption coefficient,compatibility with flexible substrate,light-weight,***,recently OSCs achieved power conversion efficiency(PCE)over 20%with the incorporation of the non-fullerene based small molecule acceptor and high specific power is believed to be *** enter the market,high-altitude platform station(HAPS)is perhaps the first place to start *** this work,we explore and compare the in-situ performance of two high performing OSCs,using the same donor but different acceptors,in mimic HAPS environment where the pressure,temperature and the illumination conditions are *** found that the use of acceptor can result in substantial difference in the performance at low temperatures.

关键词： Organic solar cells Stratosphere High-altitude platform station Low-temperature physics Donor-acceptor systems

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Cryptococcal meningitis with pulmonary cryptococcoma in an immunocompetent patient: A case report

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Asian Pacific Journal of Tropical Medicine 2020年第1期13卷 46-48页

作者： Kee Tat lee Kar Ying Yong Hock hin Chua Department of Medicine Miri General HospitalSarawakMalaysia Infectious Disease Unit Department of MedicineSarawak General HospitalSarawakMalaysia

Rationale:Cryptococcal infections commonly occur in immunosuppressed patients and are uncommon in immunocompetent *** concerns:A 32 year old lady,active smoker presented with right chest pain,dry cough and loss of *** chest radiograph showed a lobulated lung mass in the right lower *** developed headache and right cranial nerve palsy during *** investigations were done including lumbar puncture,brain and chest ***:Cryptococcal meningitis with pulmonary ***:She received five months of effective antifungal treatment;however,the patient did not respond ***,removal of pulmonary cryptococcoma was ***:Her condition improved and she no longer had any ***:Disseminated cryptococcosis is rare in immunocompetent *** case highlights the importance of high index of suspicion and we postulate that lobectomy helped in reducing the cryptococcal burden in her body,thus facilitating better response to antifungal therapy.

关键词： Cryptococcoma Meningitis Immunocompetent Antifungal Lobectomy

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Inhalation of nanoparticle-based drug for lung cancer treatment:Advantages and challenges

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Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 481-489页

作者： Wing-hin lee Ching-Yee Loo Daniela Traini Paul M.Young Respiratory Technology Woolcock Institute of Medical Research and Discipline of PharmacologySydney Medical SchoolThe University of SydneyNSW 2037Australia

Ever since the success of developing inhalable insulin,drug delivery via pulmonary administration has become an attractive route to treat chronic *** delivery system for nanotechnology is a relatively new concept especially when applicable to lung cancer ***-based systems such as liposome,polymeric nanoparticles or micelles are strategically designed to enhance the therapeutic index of anti-cancer drugs through improvement of their bioavailability,stability and residency at targeted lung *** with these benefits,nano-based systems also provide additional diagnostic advantages during lung cancer treatment,including imaging,screening and drug ***,delivery of nanobased drugs via pulmonary administration for lung cancer therapy is still in its infancy and numerous challenges are ***,immunology,toxicology and largescale manufacturing(stability and activity of drugs)are some aspects in nanotechnology that should be taken into consideration for the development of inhalable nano-based chemotherapeutic *** review will focus on the current inhalable nano-based drugs for lung cancer treatment.

关键词： Inhalation Lung cancer Liposome Nanoparticle

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A Rhizobium bacterium and its population dynamics under different culture conditions of its associated toxic dinoflagellate Gambierdiscus balechii

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Marine Life Science & Technology 2021年第4期3卷 542-551页

作者： Zhen Wu Xiaohong Yang Senjie Lin Wai hin lee Paul K.S.Lam State Key Laboratory of Marine Pollution City University of Hong KongHong KongChina Department of Chemistry City University of Hong KongHong KongChina State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China Department of Marine Sciences University of ConnecticutGrotonCT 06340USA Department of Biomedical Sciences City University of Hong KongHong KongChina Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity Research Centre for the Oceans and Human HealthCity University of Hong Kong Shenzhen Research InstituteShenzhen 518057China

Rhizobium bacteria are known as symbionts of legumes for developing nodules on plant roots and fixing N2 for the host plants but unknown for associations with ***,we detected,isolated,and characterized a Rhizobium species from the marine toxic dinoflagellate Gambierdiscus *** 16S rRNA gene(rDNA)is 99%identical to that of Rhizobium rosettiformans,and the affiliation is supported by the phylogenetic placement of its cell wall hydrolase-encoding gene(cwh).Using quantitative PCR of 16S rDNA and cwh,we found that the abundance of this bacterium increased during the late exponential growth phase of Gambierdiscus and under nitrogen limitation,suggesting potential physiological interactions between the dinoflagellate and the *** is the first report of dinoflagellate-associated Rhizobium bacterium,and its prevalence and ecological roles in dinoflagellate-Rhizobium relationships remain to be investigated in the future.

关键词： Rhizobium Gambierdiscus 16S rRNA gene Cell wall hydrola Edited by Chengchao Chen

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Down-conversion materials for organic solar cells:Progress,challenges,and perspectives

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Aggregate 2022年第3期3卷 59-79页

作者： Ram Datt Swati Bishnoi Harrison Ka hin lee Sandeep Arya Sonal Gupta Vinay Gupta Wing Chung Tsoi Faculty of Science and Engineering Sustainable Product Engineering Centre for Innovative Functional Industrial CoatingsSwansea UniversityBay CampusFabian WaySwansea SA18ENUK Advanced Materials and Metrology Division Council of Scientific And Industrial Research-National Physical LaboratoryDr.K.S.Krishnan MargNew Delhi 110012India Department of Physics University of JammuJammuJammu and Kashmir 180006India Department of Conducting Polymers Institute of Macromolecular ChemistryCzech Academy of SciencesPrague 616206Czech Republic Department of Physics Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Organic solar cells(OSCs)in terms of power conversion efficiency(PCE)and operational lifetime have made remarkable progress during the last decade by improving the active layer materials and introducing new *** newly developed wide bandgap organic donor and low bandgap acceptor molecules covered the absorption from the visible to the near-infrared *** the incident high energy region(UV)is not in favor of *** absorption causes thermalization losses and photoinduced degradation,which hinders the PCE and lifetime of ***,lanthanide and non-lanthanide-based down-conversion(DC)materials have been introduced,which can effectively convert the high-energy photons(UV)to low-energy photons(visible)and resolve the spectral mismatch losses that limit the absorption of OSCs in high energy incident ***,the DC materials also protect the OSCs from UV-induced *** DC materials were also proposed to cross the Shockley-Queisser efficiency limit of the solar *** this review,the need for DC materials and their processing method for OSCs have been thoroughly ***,the main emphasis has been given to developing lanthanides and non-lanthanides-based DC materials for OSCs,their applications,and their impact on photovoltaic device performance,stability,and future perspectives.

关键词： down-conversion down-shifting lanthanides organic solar cells photostability

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Metallosis with spinal implant loosening after spinal instrumentation:A case report

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世界骨科杂志:英文版 2023年第8期14卷 651-661页

作者： Yiu hin Kwan Hong lee Terry Teo Shree Kumar Dinesh Wee Lim Loo Department of Orthopaedic Surgery Changi General HospitalSingapore 529889Singapore

BACKGROUND Spinal metallosis is a rare complication following spinal instrumentation whereby an inflammatory response to the metal implants results in the development of granulomatous *** SUMMARY We describe the case of a 78-year-old woman who had recurrence of back pain 5 years after lumbar spine posterior decompression and instrumented *** spine radiographs showed hardware loosening and magnetic resonance imaging showed adjacent segment *** surgery revealed evidence of metallosis *** Spinal metallosis can present several years after *** and computed tomography may demonstrate hardware loosening secondary to *** metal concentrations associated with spinal metallosis have yet to be ***,metallosis is still an intraoperative and histopathological *** presence of metallosis after spinal instrumentation likely indicates a more complex underlying problem:Pseudarthrosis,failure to address sagittal balance,infection,and cross-threading of set ***,identifying metallosis is important,but initiating treatment promptly for symptomatic implant loosening is of greater paramount.

关键词： Metallosis Spine Instrumentation Implant loosening Corrosion Case report

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Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles

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Bioactive Materials 2023年第9期27卷 98-112页

作者： Yanmeng Yang Yingnan Wu Dahou Yang Shu Hui Neo Nurul Dinah Kadir Doreen Goh Jian Xiong Tan Vinitha Denslin Eng hin lee Zheng Yang Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore NUS Tissue Engineering Program Life Sciences InstituteNational University of SingaporeSingapore Critical Analytics for Manufacturing Personalised-Medicine Singapore-MIT Alliance for Research and TechnologySingapore

Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as the physiologic environment of MSCs, has great potential to enhance MSCs paracrine therapeutic effect. In our study, the paracrine effects of secretome derived from MSCs preconditioned in normoxia and hypoxia was compared through both in vitro functional assays and an in vivo rat osteochondral defect model. Specifically, the paracrine effect of total EVs were compared to that of soluble factors to characterize the predominant active components in the hypoxic secretome. We demonstrated that hypoxia conditioned medium, as well as the corresponding EVs, at a relatively low dosage, were efficient in promoting the repair of critical-sized osteochondral defects and mitigated the joint inflammation in a rat osteochondral defect model, relative to their normoxia counterpart. In vitro functional test shows enhancement through chondrocyte proliferation, migration, and matrix deposition, while inhibit IL-1β-induced chondrocytes senescence, inflammation, matrix degradation, and pro-inflammatory macrophage activity. Multiple functional proteins, as well as a change in EVs’ size profile, with enrichment of specific EV-miRNAs were detected with hypoxia preconditioning, implicating complex molecular pathways involved in hypoxia pre-conditioned MSCs secretome generated cartilage regeneration.

关键词： Hypoxia preconditioned MSCs Secretome Extracellular vesicles Cartilage regeneration Joint inflammation

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Perpendicular magnetic clusters with configurable domain structures via dipole-dipole interactions

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Nano Research 2015年第11期8卷 3639-3650页

作者： Weimin Li Seng Kai Wong Tun Seng Herng lee Koon Yap Cheow hin Sim Zhengchun Yang Yunjie Chen Jianzhong Shi Guchang Han Junmin Xue Jun Ding Department of Materials Science and Engineering National University of Singapore BLK EA#03-09 9 Engineering Drive 1 117575 Singapore Data Storage Institute Agency for Science Technology and Research (A'STAR) DSl Building 5 Engineering Drive 1 117608 Singapore

Magnetic single-domain islands based on in-plane anisotropy （usually, shape anisotropy） and their dipole-dipole interactions have been investigated extensively in recent years. This has been driven by potential applications in magnetic recording, spintronics, magneto-biology, etc. Here, we propose a concept of out- of-plane magnetic dusters with configurable domain structures （multi-flux states） via dipole-dipole interactions. Their flux stages can be switched through an external magnetic field. The concept has been successfully demonstrated by patterned [Co/Pd] islands. A [Co/Pd] multilayer exhibits a large perpendicular anisotropy, a strong physical separation, and uniform intrinsic properties after being patterned into individual islands by electron beam lithography. A three- island cluster with six stable flux states has been realized by optimizing island size, thickness, gap, anisotropy, saturation magnetization, etc. Using [Co/Pd] multilayers, we have optimized the island structure by tuning magnetic properties （saturation magnetization and perpendicular anisotropy） using Landau-Liftshitz- Gilbert （LLG） simulation/calculation. Potential applications have been proposed, including a flexi-programmable logic device with AND, OR, NAND, and NOR functionalities and a magnetic domino, which can propagate magnetic current as far as 1 μm down from the surface via vertical dipole-dipole interactions.

关键词： perpendicular anisotropy dipole-dipole interaction multistate magnetic recording logic device magnetic domino

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