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冶钢译丛 1993年第2期 5-7页

作者： lebrun,c 邹涛新

通过分子生物学方法确诊Turcot综合征(法)

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 38-39页

作者： Jeannin S lebrun c Van Den Bos F. 赵天智 Service de Neurologie Hpital Pasteur 30 voie romaine06002 Nice France

Introduction. Turcot’s syndrome is characterized clinically by the concurrence of a primary brain tumor and a familial adenomatous polyposis or a hereditary nonpolyposis colorectal cancer. Observation. We report a case of a 45-year-old woman who underwent in 1995 neuro-oncological treatment for an anaplastic astrocytoma (grade III according to the World Health Organization classification). Treatment included complete surgery, radiotherapy, a first-line nitrosourea-based chemotherapy regimen and a second-line platinium salt-based regimen. It was then noted that the patient’s brother had colorectal cancer. A genetic study detected a germ-line mutation on the hMSH2 gene specific of HNPcc syndrome (Human Non Polyposis colorectal cancer). colonoscopy was normal. Eight years after the diagnosis, the patient developed a gliomatosis cerebri and died. conclusion. Relevant personal and familial history can provide the clue to the diagnosis of Turcot’s syndrome. Molecular diagnosis may contribute to appropriate care of affected patients.

关键词：综合征综合病症结肠直肠癌 Turcot

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用次级束流对硅望远镜的时间和能量定标

核技术 1993年第12期16卷 705-709页

作者：贺智勇 Steckmeyer Jc Kerambrun A Angelique Jc Bizard G Brou R cussol D Patry JP Peter J Regimbart R Tamain B Vient E cabot c Auger G crema E Peghaire A Saint-Laurent F Gonin M Hagel K Wada R Eudes P lebrun c Rosato E Masri Y El 中国科学院近代物理研究所 LPc caen ISMRAIN2P3-CNRSF-14050 CaenFrance GANIL BP5027F-14021 CaenFrance cyclotron Institute Texas A and M UniversityCollege StationTX77843USA LPN Universite de Names44072 Nantes Cedex 03France Dipartimento di Scienze Fisiche Universita di NapoliI-80125 NaplesItaly ULB BruxellesBelgium

利用95MeV/u的^(16)O束产生的次级束流对半导体硅探测器进行了时间和能量定标。实验结果表明,由于次级束流提供的次级粒子种类多,飞行距离长,因此,能给探测器带来非常精确的定标。

关键词：时间定标能量定标探测器定标

Reaction Plane Determination for ^(64)Zn+^(27)Al collisions at Intermediate Energy

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chinese journal of nuclear physics 1994年第3期 207-210页

作者： A.Buta J.c.Angelique G.Bizard R.Brou D.cussol A.Kerambrun J.P.Patry J.Peter R.POpescu R.Regimbart J.c.Steckmeyer B.Tamain E.Vient G.Auger c.cabot E.crema A.Peghaire F.Saint-Laurent M.Gonin K.Hagel R.Wada P.Eudes c.lebrun E.Rosato Y.El Masri LPc caen ISMRAIN2P3-CNRSF-14050 CaenFrance IFAHeavy Ion DepartmentBucharestRomania. LPc caen ISMRAIN2P3-CNRSF-14050 CaenFrance GANIL BP5027F-14021 CaenFrance cyclotron Institute Texas A & M UniversityCollege StationTX77843USA LPN Universite de Nantes44072 Nantes Cedex 03France Dipartimento di Scienze Fisiche Universita di Napoli1-80125 NaplesItaly UcL Louvain-la-NeuveBelgium

The collective flow for 64Zn+27Al system is measured at intermediate energyby using a 4π multidetector array in conjunction with an array of Si *** have been sorted versus the impact parameter by means of global *** methods of reaction plane determination are compared:sphericity tensor method,transverse momentum analysis,and azimuthal correlation *** this system,thetransverse momentum analysis method is the best one.

关键词： collective flow Reaction plane Transverse momentum analysis Azimuthal correlation

Polysaccharide-based chromatographic adsorbents for virus purification and viral clearance

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Journal of Pharmaceutical Analysis 2020年第4期10卷 291-312页

作者： Guy-Alain Junter Laurent lebrun Normandie Univ UNIROUENINSA RouenCNRSPBS76000RouenFrance

Viruses still pose a significant threat to human and animal health *** the fight against viral infections,high-purity viral stocks are needed for manufacture of safer *** is also a priority to ensure the viral safety of biopharmaceuticals such as blood *** techniques are widely implemented at both academic and industrial levels in the purification of viral particles,whole viruses and virus-like particles to remove viral contaminants from biopharmaceutical *** paper focuses on polysaccharide adsorbents,particulate resins and membrane adsorbers,used in virus purification/removal chromatography *** chromatographic modes are surveyed,with particular attention to ion exchange and affinity/pseudo-affinity adsorbents among which commercially available agarose-based resins(Sepharose®)and cellulose-based membrane adsorbers(Sartobind®)occupy a dominant *** built on the development of new ligands coupled to conventional agarose/cellulose matrices,the development perspectives of polysaccharide-based chromatography media in this antiviral area are stressed in the conclusive part.

关键词： Polysaccharide chromatography Virus particle Biopharmaceuticals purification Vaccine

复发缓解型多发性硬化症还是多相播散性脑脊髓炎(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 9-9页

作者： lebrun c. Ghetau G. Bourg V. 方伯言 Service de Neurologie Hpita l Pasteur 30 voie romaine 06002 NiceFrance

Introduction. The imaging presentation of some forms of multiple sclerosis may be misleading. In patients with a history of recent infection or vaccination, e specially for adolescents or young adults, the differential diagnosis with acute disseminated encephalomyelitis can be difficult. case report. We report an unus ual clinical and radiological presentation of multiple sclerosis,mimicking acute disseminated encephalomyelitis. We discuss clinical and radiological differenti al diagnosis, and the outcome after immunosuppressive treatment. conclusion. Dis tinguishing between acute disseminated ncephalomyelitis and the first relapse of multiple sclerosis can be diffficult. Brain imaging is a precious tool for diff erentiating between the two diseases.

关键词：脑脊髓炎播散性多发性硬化症影像检查疫苗接种史鉴别诊断免疫抑制剂令人

中能区64Zn+27Al反应中集体流的实验研究

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中能区64Zn+27Al反应中集体流的实验研究

china’s collaboration in Space Exploration and Research with the European-Union

第九届全国核物理大会

作者：贺智勇 J.Peter J.c.Angelique A.Auger G.Bizard R.Brou A.Buta c.cabot E.crema D.cussol Y.El Masri Ph.Eudes M.Gonin K.Hagel A.Kerambrum c.lebrun A.Peghaire R.Popescu R.Regimbart E.Rosato F.Saint-Laurent J.c,Steckmeyer B.Tamain E.Vient R.Wada 中国科学院近代物理研究所 LPc caen ISMRAIN2P3—CNRS14050 CAEN CEDEXFRANCE GANIL BP5027 14021 CAEN CEDEXFRANCE Institut de Physique Nuclear UCL1348 Louvain—La—NeuveBELGIUM LPN Universite de Nantes44072 NANTES CEDEXFRANCE cyclotron Institut Texas A&M UniversityCollege StationTX77843USA

核物质集体流的研究是重离子碰撞中很重要的一个研究课题,通过它可以探讨核物质状态方程．压缩效应和重离子碰撞动力学等．最近,我们在中能区观察到了集体流及其消失,买验是在法国 GANIL 加速器上进行的,用49,57,69和79 MeV/u 的“Zn ...

核物质集体流的研究是重离子碰撞中很重要的一个研究课题,通过它可以探讨核物质状态方程．压缩效应和重离子碰撞动力学等．最近,我们在中能区观察到了集体流及其消失,买验是在法国 GANIL 加速器上进行的,用49,57,69和79 MeV/u 的“Zn 束轰击Al 靶．前角3°至30°间粒子的探测由96块塑料闪烁体片组成的塑闪墙完成,塑闪墙分七环,靶距210cm．中后角30°至150°间

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China’s Collaboration in Space Exploration and Research wit...

作者： lebrun Pierre 上海交通大学

学位级别：硕士

The aim of this thesis is to analyze the key factors influencing cooperative possibilities in SinoEuropean relations to identify constraining elements of their relations in *** this analysis are presented the policies and environments surrounding each national space ***’s innovation and development in space science have been developed by know-how after the coldWar era and the nation is now close to become a leader in space-science,resulting into behavioral changes among other nations in *** thesis analyzes the relationship between governments and the socioeconomic benefits for both parties realizing a cooperation,including cost sharing,innovation and *** methodology consists of a case-study analysis and in-depth interviews to obtain reliable data and compare them with past results.A total of 12 indepth interviews have been conducted among decision influencers of space programs: Joint cooperation programs,private entities and *** respondents participated in spacerelated activities and expressed their knowledge about space ***,the results exposed the constraining elements of Sino-European relations in space-related *** security development remains a major constraint affecting their cooperative *** conclusion this thesis argues that transnational threats can provide a good scope for strengthened Sino-European relations in space-related ***,global threats such as climate change and space-debris modify the international structure of States,supporting a double-need for international *** research hopes to provide a clear insight of the relationships between European economies and china as the chinese space programs evolve quickly.

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Development of Mathematical Model for control Wear in Backup Roll for Hot Strip Mill

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Journal of Iron and Steel Research International 2014年第1期21卷 46-51页

作者： R.Servin-castaeda A.M.Garcia-Lara R.D.Mercado-Solís c.A.Vega-lebrun UAdec University UANL University UPAEP University

The precision of strip flatness depends on several factors; wear of rolls is one of the main variables that have influence on the surface quality of the strip. The wear of the roils represents a complex friction condition, sometimes the wear in the backup roll is not analyzed because the strip is not in contact with the backup roll; however, after several campaigns of rolling, the wear in the backup roll becomes dangerous because the pressure distribution is not uniform. Investigation of mechanism of the surface deterioration of the backup roll for the hot strip rolling is very important for the development of the automatic strip shape control system used in hot strip mills. A mathematical model is developed considering the Hertzian pressure distribution between two cylinders with parallel axes. It is used in real time for calculating the wear in the backup roll and in this manner take deci- sions for preventing finished product reworking or damage of equipments, which result in accidents caused by excessive wear in the backup rolls.

关键词： strip flatness backup roll dress crown rolling campaign

Acousto-optically driven lensless single-shot ultrafast optical imaging

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Light(Science & Applications) 2022年第4期11卷 628-643页

作者： Mohamed Touil Said Idlahcen Rezki Becheker Denis lebrun claude Roze Ammar Hideur Thomas Godin ORIA CNRS UMR6614-University de Rouen Normandie-INSA Rouen76800 Saint Etienne du RouvrayFrance

Driven by many applications in a wide span of scientifc fields,a myriad of advanced ultrafast imaging techniques have emerged in the last decade,featuring record-high imaging speeds above a trllion-frame-per-second with long sequence *** bringing remarkable insights into various ultrafast phenomena,their application out of a laboratory environment is however limited in most cases,either by the cost,complexity of the operation or by heavy data *** then report a versatile single-shot imaging technique combining sequentially timed lloptical mapping photography(STAMP)with acousto-optics programmable dispersive fhItering(AOPDF)and digital in-line holography(DIH).On the one hand,a high degree of simplicity is reached through the AOPDF,which enables full control over the acquisition parameters via an electrically driven phase and amplitude spectro-temporal tailoring of the imaging ***,contrary to most single-shot techniques,the frame rate,exposure time,and frame intensities can be independently adjusted in a wide range of pulse durations and chirp values without resorting to complex shaping stages,making the system remarkably agile and *** the other hand,the use of DIH,which does not require any reference beam,allows to achieve an even higher technical simplicity by allowing its lensless operation but also for reconstructing the object on a wide depth of field,contrary to classical techniques that only provide images in a single *** imaging speed of the system as well as its flexibility are demonstrated by visualizing ultrashort events on both the picosecond and nanosecond *** virtues and limitations as welll as the potential improvements of this on-demand ultrafast imaging method are critically discussed.

关键词： simplicity resort bringing