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宫颈癌结局预测

世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 42-42页

作者： leath iii c.a. Straughn Jr. J.M. Kirby T.O. 张旸 Department of Obstetrics and Gynecology Division of Gynecology Oncology University of Alabama at Birmingham 619 19th Street South Birmingham AL 35249-7333 United States

Background. To determine the impact of race and other factors on the management and outcomes of women treated for cervical cancer in a rural state. Methods. Following IRB approval, a retrospective review identified 434 eligible women treated for cervical cancer from 1994 to 2000. collected data included: demographics, clinicopathologic data, primary and adjuvant therapy, recurrence, and survival. Statistical analyses were performed with the chi-square test, Kaplan-Meier method, and cox regression. Results. 304 (70%) of the women were white and 130 (30%) were non-white. Non-whites were more likely to present with advanced stage disease Stage IIB-IVB (25%vs 13%; P ce. Non whites were more likely to have medical co-morbidities such as diabetes and hypertension. Although whites with early stage disease were more likely to undergo surgery as their primary therapy than non-whites (93%vs 84%; P comes for advanced stage disease were similar between groups. conclusions. Non-whites diagnosed with cervical cancer are more likely to present with advanced stage disease than whites; however, overall survival was similar between groups. Non-whites with early stage disease were more likely to receive primary radiation therapy than whites. The decision to use radiation therapy vs surgery does not appear to have a detrimental effect on overall survival, but may impact quality of life.

关键词：晚期宫颈癌临床病理学统计学资料人体试验生存情况统计学分析农村地区生活质量

用筋膜修复术治疗继发于产科出血的腹腔隔室综合征

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 59-59页

作者： Kendrick IV J.E. leath iii c.a. Melton S.M. Straughn Jr. J.M. 柳蕴 Department of Obstetrics and Gynecology University of Alabama at Birmingham 618 South 19th Street OHB 340 Birmingham AL 35233 United States Dr.

BAcKGROUND: Massive obstetric hemorrhage can be catastrophic, with considerable maternal morbidity and mortality. cASE: A 41-year-old term gravida experienced massive postpartum hemorrhage attributed to an amniotic fluid embolism with rapid development of disseminated intravascular c.a.ulation and resultant abdominal compartment syndrome. In this critically ill patient, a fasc.a. prosthesis used for abdominal wall closure was placed to expedite multiple abdominal explorations and packing. Additionally, this device facilitated fasc.a. closure once the abdominal compartment syndrome was resolved. cONcLUSION: Abdominal compartment syndrome resulting from overwhelming obstetric hemorrhagemay necessitate emergent decompressive laparotomy to alleviate increased intra-abdominal pressure and end-organ dysfunction. The fasc.a. prosthesis allows a staged abdominal wall closure to be performed once the abdominal compartment syndrome is resolved.

关键词：隔室综合征产科出血修复术产科大出血羊水栓塞腹腔探查减压手术腹腔内压

Efficient Vision Transformers for Autonomous Off-Road Perception Systems

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Journal of computer and communications 2024年第9期12卷 188-207页

作者： Max H. Faykus iii Adam Pickeral Ethan Marquez Melissa c. Smith Jon c. calhoun Holcombe Department of Electrical and computer Engineering Clemson University Clemson SC USA

The development of autonomous vehicles has become one of the greatest research endeavors in recent years. These vehicles rely on many complex systems working in tandem to make decisions. For practical use and safety reasons, these systems must not only be accurate, but also quickly detect c.a.ges in the surrounding environment. In autonomous vehicle research, the environment perception system is one of the key components of development. Environment perception systems allow the vehicle to understand its surroundings. This is done by using cameras, light detection and ranging (LiDAR), with other sensor systems and modalities. Deep learning computer vision algorithms have been shown to be the strongest tool for translating camera data into accurate and safe traversability decisions regarding the environment surrounding a vehicle. In order for a vehicle to safely traverse an area in real time, these computer vision algorithms must be accurate and have low latency. While much research has studied autonomous driving for traversing well-structured urban environments, limited research exists evaluating perception system improvements in off-road settings. This research aims to investigate the adaptability of several existing deep-learning architectures for semantic segmentation in off-road environments. Previous studies of two convolutional Neural Network (cNN) architectures are included for comparison with new evaluation of Vision Transformer (ViT) architectures for semantic segmentation. Our results demonstrate viability of ViT architectures for off-road perception systems, having a strong segmentation accuracy, lower inference speed and memory footprint compared to previous results with cNN architectures.

关键词： Semantic Segmentation Off-Road Vision Transformers cNNs Autonomous Driving

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sciences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Timothy S. Goebel Dennis c. Gitz iii John E. Stout cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin county, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commerc.a.ly available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWS and to compare these to measurements obtained with an automatic weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water conservation Meteorological Tower that was used as our AWS, located at USDA-ARS cropping Systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and calculated values of dewpoint temperature (Tdew). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on clear days, but PWS measurements were higher on cloudy days. There was no statistical difference between PWS and AWS hourly average measurements of Tair, RH, and calculated Tdew. Hourly average measurements of Rg and WS were more variable. We concluded that the PWS we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation Sensors citizen Weather Station Mesonet Rainfall Weather Variables

Knowledge‐based deep learning system for c.a.sifying Alzheimer's disease for multi‐task learning

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c.a. Transactions on Intelligence Technology 2024年第4期9卷 805-820页

作者： Amol Dattatray Dhaygude Gaurav Kumar Ameta Ihtiram Raza Khan Pavitar Parkash Singh Renato R.Maaliw iii Natrayan Lakshmaiya Mohammad Shabaz Muhammad Attique Khan Hany S.Hussein Hammam Alshazly Department of Data Science University of WashingtonSeattleWashingtonUSA Department of computer Science&Engineering Parul Institute of TechnologyParul UniversityVadodaraGujaratIndia Department of computer Science Jamia HamdardDelhiIndia Department of Management Lovely Professional UniversityPhagwaraIndia 5 college of Engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of Mec.a.ical Engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia Model Institute of Engineering and Technology JammuJ&KIndia Department of computer Science HITEC UniversityTaxilaPakistan Department of computer Science and Mathematics Lebanese American UniversityBeirutLebanon Electrical Engineering Department College of EngineeringKing Khalid UniversityAbhaSaudi Arabia Electrical Engineering Department Aswan UniversityAswanEgypt Faculty of computers and Information South Valley UniversityQenaEgypt

Deep learning has recently become a viable approach for c.a.sifying Alzheimer's disease(AD)in medical ***,existing models struggle to efficiently extract features from medical images and may squander additional information resources for illness *** address these issues,a deep three‐dimensional convolutional neural network incorporating multi‐task learning and attention mec.a.isms is *** upgraded primary c3D network is utilised to create rougher low‐level feature *** introduces a new convolution block that focuses on the structural aspects of the magnetORcID:ic resonance imaging image and another block that extracts attention weights unique to certain pixel positions in the feature map and multiplies them with the feature map ***,several fully connected layers are used to achieve multi‐task learning,generating three outputs,including the primary c.a.sification *** other two outputs employ backpropagation during training to improve the primary c.a.sification *** findings show that the authors’proposed method outperforms current approaches for c.a.sifying AD,achieving enhanced c.a.sification accuracy and other in-dicators on the Alzheimer's disease Neuroimaging Initiative *** authors demonstrate promise for future disease c.a.sification studies.

关键词： c.a.sification deep learning

Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreochromis mossambicus

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Aquaculture and Fisheries 2024年第3期9卷 339-346页

作者： Jyoti A.Kumbar c.B.Ganesh Neuroendocrinology Research Laboratory Department of Studies in ZoologyKarnatak UniversityDharwad580003India

Urotensin-I(UI)is a peptide belonging to the corticotropin-releasing hormone family,produced in the urophysis of *** investigation was undertaken to examine the effect of UI on the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,a cichlid *** the first experiment,administration of UI(2μg/100μL saline)for 22 days caused a significant reduction in the number of follicles at stages I,II,iii(previtellogenic),IV(vitellogenic),and V(preovulatory),concomitant with a significant increase in the percent atresia of follicles at stages II,iii,and IV than in *** the pituitary,gonadotropin-releasing hormone(GnRH)-positive fibres were detected in the proximal pars distalis(PPD)in both controls and UI-treated fish;however,there was a significant reduction in the intensity and percent area of GnRH-immunoreactive fibres in fish treated with UI compared with *** serum luteinizing hormone(LH)level was significantly lower,whereas a significant rise in the serum level of cortisol was noticed in UI-treated fish compared with *** the second experiment,treatment with a low dose of UI(10 mM)did not affect the number of AcTH-secreting cells in vitro,but the number of these cells was significantly higher in high-dose UI(50 mM)-treated pituitaries compared to ***,the present investigation reveals for the first time that the treatment of UI affects the follicular development process through the downregulation of the GnRH-LH axis and activation of the pituitary-interrenal pathway in teleosts.

关键词： Urotensin-I cRH family Gonadotropin-releasing hormone Luteinizing hormone Ovary Oreochromis mossambicus

Prediction and control of cholera outbreak:Study case of

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Infectious Disease Modelling 2024年第3期9卷 892-925页

作者： c.Hameni Nkwayep R.GlèlèKakaï S.Bowong Laboratory of Mathematics Department of Mathematics and Computer ScienceUniversity of DoualaPO Box 24157DoualaCameroon IRD Sorbonne UniversityUMMISCOF-93143BondyFrance Biomathematics and Forest Modeling University of Abomey-CalaviCalaviBenin

This paper deals with the problem of the prediction and control of cholera outbreak using real data of *** first develop and analyze a deterministic model with seasonality for the cholera,the novelty of which lies in the incorporation of undetected *** present the basic properties of the model and compute two explicit threshold parametersR_(0)and R_(0).that bound the effective reproduction number,from below and above,that is R_(0)≤R_(0)≤R_(0).We prove that cholera tends to disappear whenR_(0)≤1,while when R_(0)>1,cholera persists uniformly within the ***,assuming that the cholera transmission rates and the proportions of newly symptomatic.a.e unknown,we develop the EnKf approach to estimate unmeasurable state variables and these unknown parameters using real data of cholera from 2014 to 2022 in *** use this result to estimate the upper and lower bound of the effective reproduction number and reconstructed active asymptomatic.a.d symptomatic cholera cases in cameroon,and give a short-term forecasts of cholera in cameroon until *** simulations show that(i)the transmission rate from free Vibrio cholerae in the environment is more important than the human transmission and begin to be high few week after May and in October,(ii)90%of newly cholera infected cases that present the symptoms of cholera are not diagnosed and(iii)60.36%of asymptomatic.a.e detected at 14%and 86%of them recover *** future trends reveals that an outbreak appeared from July to November 2023 with the number of cases reported monthly peaked in October *** impulsive control strategy is incorporated in the model with the aim to avoid or prevent the cholera *** the first year of monitoring,we observed a reduction of more than 75%of incidences and the disappearance of the peaks when no control are available in cameroon.A second monitoring of control led to a further reduction of around 60%of incidences the following year,showing how

关键词： Vibrio cholerae Mathematical models Ensemble Kalman filterBasic reproduction number Impulsive control

Envita’s Precision cancer care: 35-Fold Improvement in Response Rates

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Journal of cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John c. Oertle iii Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart christopher Aussems Jon Moma Shannon Miller Zach Poteet conner coffin courtney Middleton Erika Ware Phylic.a.Zarnosky Julie Nowak Winlove Suasin Daniel conway c.a. Burk Ruth Tan-Lim Dino Prato Envita Medical centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National comprehensive cancer Network (NccN) guidelines, utilized by prominent cancer institutions. cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical centers over a two-year period. compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic.a.gorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical centers Late-stage cancer Overall Response Rate Quality of Life circulating Tumor cells (cTcs) Mutant Allele Frequency (MAF) Precision care

Rationale and design of Tenecteplase Reperfusion Therapy in Acute Isc.a.mic cerebrovascular Events iii (TRAcE iii): a randomised, phase iii, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce c V campbell Marc Fisher Lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina china National clinical Research center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and comprehensive Stroke center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for isc.a.mic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an isc.a.mic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Isc.a.mic cerebrovascular Events-iii(TRAcE iii)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an isc.a.mic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(isc.a.mic core volumech ratio≥1.8 and mismatch volume≥15mL)based on cT perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improvement on Tmax>6s at 24 hours and NIHSS score c.a.ge from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRAcE iii will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an isc.a.mic strokes due to anterior circulation LVO beyond *** registration number NcT05141305.

关键词： Therapy random Rational