宫颈癌结局预测

作     者：Leath III C.A. Straughn Jr. J.M. Kirby T.O. 张旸 

作者机构：Department of Obstetrics and Gynecology Division of Gynecology Oncology University of Alabama at Birmingham 619 19th Street South Birmingham AL 35249-7333 United States 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第3期

页      面：42-42页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：晚期宫颈癌 临床病理学 统计学资料 人体试验 生存情况 统计学分析 农村地区 生活质量 

摘      要：Background. To determine the impact of race and other factors on the management and outcomes of women treated for cervical cancer in a rural state. Methods. Following IRB approval, a retrospective review identified 434 eligible women treated for cervical cancer from 1994 to 2000. Collected data included: demographics, clinicopathologic data, primary and adjuvant therapy, recurrence, and survival. Statistical analyses were performed with the Chi-square test, Kaplan-Meier method, and Cox regression. Results. 304 (70%) of the women were white and 130 (30%) were non-white. Non-whites were more likely to present with advanced stage disease Stage IIB-IVB (25%vs 13%; P 0.01). Whites were more likely to smoke, be married, be employed, and have private insurance. Non whites were more likely to have medical co-morbidities such as diabetes and hypertension. Although whites with early stage disease were more likely to undergo surgery as their primary therapy than non-whites (93%vs 84%; P 0.01), survival was similar. Survival outcomes for advanced stage disease were similar between groups. Conclusions. Non-whites diagnosed with cervical cancer are more likely to present with advanced stage disease than whites; however, overall survival was similar between groups. Non-whites with early stage disease were more likely to receive primary radiation therapy than whites. The decision to use radiation therapy vs surgery does not appear to have a detrimental effect on overall survival, but may impact quality of life.