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Influence of particle size on the breaking of aluminum particle shells

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Chinese Physics B 2022年第7期31卷 454-460页

作者： Tian-Yi Wang Zheng-Qing zhou Jian-Ping Peng yu-Kun Gao Ying-Hua Zhang School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Zhaojin Mining Industry Co. LtdZhaoyuan 265400China

Rupturing the alumina shell(shell-breaking)is a prerequisite for releasing energy from aluminum *** stress overload in a high-temperature environment is an important factor in the rupture of the alumina *** Multiphysics was used to simulate and analyze the shell-breaking response of micron-scale aluminum particles with different particle sizes at 650℃in *** simulation results show that the thermal stability time and shell-breaking response time of 10μm–100μm aluminum particles are 0.15μs–11.44μs and 0.08μs–3.94μs,*** also reveal the direct causes of shell breaking for aluminum particles with different particle *** the particle size is less than 80μm,the shell-breaking response is a direct result of compressive stress *** the particle size is between80μm and 100μm,the shell-breaking response is a direct result of tensile stress *** article provides useful guidance for research into the energy release of aluminum powder.

关键词： aluminum particle shell–core structure thermal stress shell-breaking

Solitary fibrous tumor of the liver:A case report and review of the literature

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World Journal of Clinical Cases 2022年第20期10卷 7097-7104页

作者： Guang-yuan Xie Huan-Bing Zhu yun Jin Bai-zhou Li yuan-Quan yu Jiang-Tao Li Department of Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangZhou 310000Zhejiang ProvinceChina

BACKGROUND Hepatic solitary fibrous tumor(SFT)is a rare *** to now,only 90 cases have been reported in the English language *** report describes a case of SFT of the liver misdiagnosed as hepatocellular *** SUMMARY A 42-year-old male had a two-year history of a gradually enlarging intrahepatic *** preoperative imaging revealed a mass with a size of 2.7 cm×2.3 cm located in the segment IV of the *** patient was subjected to the resection of the segment IV,such as the medial segment of the left lobe of the *** histological examination of the mass showed various spindled cells irregularly arranged in the *** immunohistochemistry of this mass revealed a positive staining for CD34 and *** history of intracranial tumor and postoperative pathological results led to the diagnosis of SFT of the liver(SFTL)due to a metastasis from the *** SFTL is an uncommon mesenchymal neoplasm that can be easily overlooked or *** best treatment choice is the complete surgical resection of the mass.A regular follow-up after the surgery should be performed due to the poor prognosis of metastatic or recurrent SFT.

关键词： Solitary fibrous tumor Liver Surgical treatment Mesenchymal neoplasm Metastasis Case report

MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 119-134页

作者： Wenyi Chen Feiyan Lin Xudong Feng Qigu Yao Yingduo yu Feiqiong Gao Jiahang zhou Qiaoling Pan Jian Wu Jinfeng Yang Jiong yu Hongcui Cao Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117China Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China

Primary sclerosing cholangitis(PSC)is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis,with no curative treatment available,and liver transplantation is inevitable for end-stage *** placentalmesenchymal stem cell(hpMSC)-derived exosomes have demonstrated the ability to prevent fibrosis,inhibit collagen production and possess immunomodulatory properties in autoimmune liver ***,we prepared hpMSC-derived exosomes(Exo^(MSC))and further investigated the anti-fibrotic effects and detailed mechanism on PSC based on Mdr2^(−/−)mice and multicellular organoids established from PSC *** results showed that Exo^(MSC) ameliorated liver fibrosis in Mdr2^(−/−)mice with significant collagen reduction in the preductal area where Th17 differentiation was inhibited as demonstrated by RNAseq analysis,and the percentage of CD4+IL-17A+T cells was reduced both in Exo^(MSC)-treated Mdr2^(−/−)mice(Mdr2^(−/−)-Exo)in vivo and Exo^(MSC)-treated Th17 differentiation progressed in ***,Exo^(MSC) improved the hypersecretory phenotype and intercellular interactions in the hepatic Th17 microenvironment by regulating PERK/CHOP signaling as supported by multicellular ***,our data demonstrate the antifibrosis effect of Exo^(MSC) in PSC disease by inhibiting Th17 differentiation,and ameliorating the Th17-induced microenvironment,indicating the promising potential therapeutic role of Exo^(MSC) in liver fibrosis of PSC or Th17-related diseases.

关键词： Mesenchymal stem cell Exosomes Primary sclerosing cholangitis Fibrosis Organoids Th17

Experimental evidence of anomalously large superconducting gap on topological surface state of b-Bi2Pd film

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Science Bulletin 2019年第17期64卷 1215-1221页

作者： Jian-yu Guan Lingyuan Kong Li-Qin zhou Yi-Gui Zhong Hang Li Hai-Jiang Liu Cen-Yao Tang Da-yu Yan Fa-Zhi Yang Yao-Bo Huang You-Guo Shi Tian Qian Hong-Ming Weng yu-Jie Sun Hong Ding Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China School o f Physics University of Chinese Academy of Sciences Beijing 100190 China Shanghai Synchrotron Radiation Facility Shanghai Institute o f Applied Physics Chinese Academy of Sciences Shanghai 201204 China CAS Center for Excellence in Topological Quantum Computation University o f Chinese Academy of Sciences Beijing 100190 China Songshan Lake Materials Laboratory Dongguan 523808 China

Connate topological superconductor(TSC) combines topological surface states with nodeless superconductivity in a single material, achieving effective p-wave pairing without interface complication. By combining angle-resolved photoemission spectroscopy and in-situ molecular beam epitaxy, we studied the momentum-resolved superconductivity in b-Bi2 Pd film. We found that the superconducting gap of topological surface state(DTSS$ 3.8 meV) is anomalously enhanced from its bulk value(Db$ 0.8 meV). The ratio of 2 DTSS/kBTc$ 16.3, is substantially larger than the BCS value. By measuring b-Bi2 Pd bulk single crystal as a comparison, we clearly observed the upward-shift of chemical potential in the film. In addition, a concomitant increasing of surface weight on the topological surface state was revealed by our first principle calculation, suggesting that the Dirac-fermion-mediated parity mixing may cause this anomalous superconducting enhancement. Our results establish b-Bi2 Pd film as a unique case of connate TSCs with a highly enhanced topological superconducting gap, which may stabilize Majorana zero modes at a higher temperature.

关键词： Topological surface state Multiband superconductivity Thin film Photoemission spectroscopy

Determination of an Appropriate Endoscopic Monitoring Interval for Patients with Gastric Precancerous Conditions in China

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Current Medical Science 2023年第2期43卷 268-273页

作者： Kai ZHAO Li-na FENG Su-hong XIA Wang-dong zhou Ming-yu ZHANG yu ZHANG Ruo-nan DONG De-an TIAN Mei LIU Jia-zhi LIAO Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Gastric precancerous conditions such as atrophic gastritis(AG)and intestinal metaplasia(IM)are considered independent risk factors for gastric cancer(GC).The suitable endoscopic monitoring interval is unclear when we attempt to prevent GC *** study investigated the appropriate monitoring interval for AG/IM *** Totally,957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the *** and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia(HGIN)/GC in AG/IM patients,and to determine an appropriate endoscopic monitoring *** During follow-up,28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia(LGIN)(0.7%),HGIN(0.9%),and GC(1.3%).Multivariate analysis identified *** infection(P=0.022)and extensive AG/IM lesions(P=0.002)as risk factors for HGIN/GC progression(P=0.025).Conclusion In our study,HGIN/GC was present in 2.2%of AG/IM *** AG/IM patients with extensive lesions,a 1–2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.

关键词： atrophic gastritis endoscopic monitoring gastric cancer gastric precancerous conditions high-grade intraepithelial neoplasia intestinal metaplasia

Role of the immune microenvironment in bone,cartilage,and soft tissue regeneration:from mechanism to therapeuticopportunity

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Military Medical Research 2023年第4期10卷 499-528页

作者： yuan Xiong Bo‑Bin Mi Ze Lin Yi‑Qiang Hu le yu Kang‑Kang Zha Adriana CPanayi Tao yu Lang Chen Zhen‑Ping Liu Anish Patel Qian Feng Shuan‑Hu zhou Guo‑Hui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of Chemical and Biomolecular Engineering Ohio UniversityAthensOH 45701USA Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityShapingbaChongqing 400044China Department of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Orthopaedics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Physics Center for Hybrid Nanostructure(CHyN)University of HamburgHamburg 22761Germany Joint Laboratory of Optofluidic Technology and System National Center for International Research on Green OptoelectronicsSouth China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Skeletal Biology Laboratory Department of Orthopedic SurgeryBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02120USA Harvard Stem Cell Institute Harvard UniversityCambridgeMA 02138USA.

Bone,cartilage,and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types,whose activity and interplay must be precisely mediated for effective healing *** extensive strides have been made in the understanding of the immune microenvironment processes governing bone,cartilage,and soft tissue regeneration,effective clinical translation of these mechanisms remains a *** of the immune microenvironment is increasingly becoming a favorable target for bone,cartilage,and soft tissue regeneration;therefore,an in-depth understanding of the communication between immune cells and functional tissue cells would be ***,we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone,cartilage,and soft tissue repair and *** discuss the roles of various immune cell subsets in bone,cartilage,and soft tissue repair and regeneration processes and introduce novel strategies,for example,biomaterial-targeting of immune cell activity,aimed at regulating *** the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone,cartilage,and soft tissue regeneration through regulation of the immune microenvironment.

关键词： Immune microenvironment Regeneration Cell-cell interaction Tissue engineering Biomaterials

Nyström kernel algorithm based on least logarithmic hyperbolic cosine loss

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Journal of Electronic Science and Technology 2023年第3期21卷 82-93页

作者： Shen-Jie Tang yu Tang Xi-Feng Li Bo Liu Dong-Jie Bi Guo Yi Xue-Peng Zheng Li-Biao Peng Yong-le Xie School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu611731China Shanghai Spaceflight Precision Machinery Institute Shanghai201600China

Kernel adaptive filters(KAFs)have sparked substantial attraction for online non-linear learning *** is noted that the effectiveness of KAFs is highly reliant on a rational learning *** this,the logarithmic hyperbolic cosine(lncosh)criterion with better robustness and convergence has drawn attention in recent ***,existing lncosh loss-based KAFs use the stochastic gradient descent(SGD)for optimization,which lack a trade-off between the convergence speed and *** recursion-based KAFs can provide more effective filtering ***,a Nyström method-based robust sparse kernel recursive least lncosh loss algorithm is derived in this *** via measures and synthetic data against the non-Gaussian noise confirm the superiority with regard to the robustness,accuracy performance,and computational cost.

关键词： Kernel adaptive filter(KAF) logarithmic hyperbolic cosine (lncosh)loss Nyström method Recursive

PandA(Box)flies on Bluesky:maintainable and user-friendly fly scans with Mamba at HEPS

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Radiation Detection Technology and Methods 2023年第4期7卷 493-501页

作者： Peng-Cheng Li Cheng-Long Zhang yu-Jun Zhang Chun Li Zhi-Ying Guo Ge lei Yi Zhang Ai-yu zhou Xiao-Xue Bi yu Liu Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China

Purpose Fly scans are indispensable in many experiments at the High Energy Photon Source(HEPS).PandABox,the main platform to implement fly scans at HEPS,needs to be integrated into Mamba,the experiment control system developed at HEPS based on *** In less than 600 lines of easily customisable and extensible backend code,provided are full control of PandABox’s TCP server in native ophyd,automated configuration(also including wiring)of“PandA blocks”for constant-speed mapping experiments of various dimensions,as well as generation of scans deliberately fragmented to deal with hardware limits in numbers of exposure frames or sequencer table *** The upper-level control system for PandABox has been ported to Bluesky,enabling the combination of both components’flexibility in fly-scan *** on this backend,a user-friendly Mamba frontend is developed for X-ray fluorescence(XRF)mapping experiments,which provides fully online visual feedback.

关键词： Fly scan PandABox Bluesky Mamba XRF mapping

Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 806-814页

作者： Si-Rui zhou yu-Sheng Zhu Wen-Ting yuan Xiao-Yan Pan Tong Wang Xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effects of hepatocyte growth factor(HGF)on retinal pigment epithelium(RPE)cell ***:The human adult retinal pigment epithelial cell line-19(ARPE-19)were treated by HGF or mesenchymalepithelial transition factor(MET)inhibitor SU11274 in *** viability was detected by a Cell Counting Kit-8 *** proliferation and motility was detected by a bromodeoxyuridine incorporation assay and a wound healing assay,*** expression levels of MET,phosphorylated MET,protein kinase B(AKT),and phosphorylated AKT proteins were determined by Western blot *** MET and phosphorylated MET proteins were also determined by immunofluorescence ***:HGF increased ARPE-19 cells’viability,proliferation and migration,and induced an increase of phosphorylated MET and phosphorylated AKT ***11274 significantly reduced cell viability,proliferation,and migration and decreased the expression of MET and AKT ***11274 suppressed HGF-induced increase of viability,proliferation,and migration in ARPE-19 ***,SU11274 also blocked HGF-induced phosphorylation of MET and AKT ***:HGF enhances cellular viability,proliferation,and migration in RPE cells through the MET/AKT signaling pathway,whereas this enhancement is suppressed by the MET inhibitor ***-induced MET/AKT signaling might be a vital contributor of RPE cells survival.

关键词： hepatocyte growth factor mesenchymal epithelial transition factor SU11274 retinal pigment epithelial cells