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CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

Signal Transduction and Targeted Therapy 2023年第4期8卷 1889-1900页

作者： Qiong yuan yunwei Sun Fan Yang Dan Yan Meihua Shen Zhigang Jin lin Zhan Guangqi Liu ling Yang Qianyi Zhou Zhijun yu Xiangyu Zhou Yang yu Yong Xu Qingming Wu Jianfang Luo Xiamin Hu Chunxiang Zhang Department of Cardiology the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular Research and Institute of Metabolic DiseasesSouthwest Medical UniversityLuzhou 646000China College of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Emergency and Critical Care Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China China Resource&WISCO General Hospital Wuhan University of Science and TechnologyWuhan 430065China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong General HospitalGuangzhouChina College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 210000China

In this study,we identified that a conserved circular RNA(circRNA)DICAR,which was downregulated in diabetic mouse *** had an inhibitory effect on diabetic cardiomyopathy(DCM),as the spontaneous cardiac dysfunction,cardiac cell hypertrophy,and cardiac fibrosis occurred in DICAR deficiency(DICAR+/−)mice,whereas the DCM was alleviated in DICARoverexpressed DICARTg *** the cellular level,we found that overexpression of DICAR inhibited,but knockdown of DICAR enhanced the diabetic cardiomyocyte *** the molecular level,we identified that DICAR-VCP-Med12 degradation could be the underlying molecular mechanism in DICAR-mediated *** synthesized DICAR junction part(DICAR-JP)exhibited a similar effect to the entire *** addition,the expression of DICAR in circulating blood cells and plasma from diabetic patients was lower than that from health controls,which was consistent with the decreased DICAR expression in diabetic *** and the synthesized DICAR-JP may be drug candidates for DCM.

关键词： diabetic endogenous cardiomyopathy

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Unraveling high efficiency multi-step sodium storage and bidirectional redox kinetics synergy mechanism of cobalt-doping vanadium disulfide anode

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Journal of Energy Chemistry 2024年第7期94卷 148-157页

作者： Enzhi Li Mingshan Wang yuanlong Feng lin Yang Qian Li Zhenliang Yang Junchen Chen Bo yu Bingshu Guo Zhiyuan Ma yun Huang Jiangtao Liu Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500SichuanChina Institute of Materials China Academy of Engineering PhysicsMianyang 621908SichuanChina State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.Ltd.Zunyi 563003GuizhouChina school of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina

Sodium-based storage devices based on conversion-type metal sulfide anodes have attracted great atten-tion due to their multivalent ion redox reaction ***,they also suffer from sodium polysul-fides(NaPSs)shuttling problems during the sluggish Na^(+) redox process,leading to"voltage failure"and rapid capacity ***,a metal cobalt-doping vanadium disulfide(Co-VS_(2))is proposed to simulta-neously accelerate the electrochemical reaction of VS_(2) and enhance the bidirectional redox of soluble *** is found that the strong adsorption of NaPSs by V-Co alloy nanoparticles formed in situ during the conversion reaction of Co-VS_(2) can effectively inhibit the dissolution and shuttle of NaPSs,and ther-modynamically reduce the formation energy barrier of the reaction path to effectively drive the complete conversion reaction,while the metal transition of Co elements enhances reconversion kinetics to achieve high ***,Co-VS_(2) also produce abundant sulfur vacancies and unsaturated sulfur edge defects,significantly improve ionic/electron diffusion ***,the Co-VS_(2) anode exhibits ultrahigh rate capability(562 mA h g^(-1) at 5 A g^(-1)),high initial coulombic efficiency(~90%)and 12,000 ultralong cycle life with capacity retention of 90%in sodium-ion batteries(SIBs),as well as impressive energy/power density(118 Wh kg^(-1)/31,250 W kg^(-1))and over 10.000 stable cycles in sodium-ion hybrid capacitors(SIHCs).Moreover,the pouch cell-type SIHC displays a high-energy density of 102 Wh kg^(-1) and exceed 600 stable *** work deepens the understanding of the electrochemical reaction mechanism of conversion-type metal sulfide anodes and provides a valuable solution to the shuttlingofNaPSs inSIBsandSIHCs.

关键词： Sodium-ionbatteries Sodium-ion hybrid capacitors Pouch cells Vanadium disulfide Shuttle effect

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First small-molecule PROTACs for G protein-coupled receptors:inducing α1A-adrenergic receptor degradation

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1669-1679页

作者： Zhenzhen Li yuxing lin Hui Song Xiaojun Qin Zhongxia yu Zheng Zhang Gaopan Dong Xiang Li Xiaodong Shi Lupei Du Wei Zhao Minyong Li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of PharmacyShandong UniversityJinan 250012China Department of Immunology Key Laboratory of Infection and Immunity of Shandong ProvinceSchool of Basic Medical ScienceShandong UniversityJinan 250012China Department of Chemistry University of South FloridaTampaFL 33620USA State Key Laboratory of Microbial Technology Shandong UniversityJinan 250100China

Proteolysis targeting chimeras(PROTACs)are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitinproteasome system(UPS),thereby selectively reducing the target protein level by the ubiquitinproteasome ***,small-molecule PROTACs are gaining popularity as tools to desrade pathogenic ***,we present the first small-molecule PROTACs that can induce the alA-adrenergic receptor(α1 A-AR)degradation,which is also the first small-molecule PROTACs for G proteincoupled receptors(GPCRs)to our *** degradation inducers were developed through conjugation of knownα1-adrenergic receptors(α1-ARs)inhibitor prazosin and cereblon(CRBN)ligand pomalidomide through the different *** representative compound 9 c is proved to inhibit the proliferation of PC-3 cells and result in tumor growth regression,which highlighted the potential of our study as a new therapeutic strategy for prostate cancer.

关键词： Small-molecule PROTACs α1A-Adrenergic receptor Ubiquitylation Degradation Prostate cancer

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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： Zhen-yu ZHOU Qiu-Yang ZHENG yu LI Cong DING Guang-Jian PENG Zhong-yu PIAO College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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Preparation and characterization of high uniformity zinc oxide nanosheets

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Frontiers of Optoelectronics 2014年第4期7卷 509-512页

作者： Xiaoyan LI Pei LIANG le WANG Feihong yu State Key Laboratory of Modem Optical Instrumentation Department of Optical Engineering Zhejiang University Hangzhou 310027 China College of Optical and Electronic Technology China Jiliang University Hangzhou 3 t0018 China

This paper reports a synthesis of zinc oxide （ZnO） nanosheets by hydrothermal method. ZnO nanosheets on Al substrate were generated by hydrothermal synthesis with zinc nitrate hexahydrate （Zn（NO3）2· 6H2O） and hexamethylenetetramine （HMT） as a research system, which were controlled conditions of the reaction. The energy dispersive spectroscopy （EDS）, scanning electron microscope （SEM） and transmission electron microscopy （TEM） images were achieved to determine the characterization of ZnO nanosheets. The diameter of ZnO nanofilm was from 0.5 to 1 μm, and its thickness ranged from 30 to 50 nm.

关键词： hydrothermal method zinc oxide (ZnO),nanosheets

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A data and physical model dual-driven based trajectory estimator for long-term navigation

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Defence Technology（防务技术） 2024年第10期40卷 78-90页

作者： Tao Feng yu Liu yue yu Liang Chen Ruizhi Chen School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong999077China Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Post and TelecommunicationsChongqing400065China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing(LIESMARS)Wuhan UniversityWuhan430000China

Long-term navigation ability based on consumer-level wearable inertial sensors plays an essential role towards various emerging fields, for instance, smart healthcare, emergency rescue, soldier positioning et al. The performance of existing long-term navigation algorithm is limited by the cumulative error of inertial sensors, disturbed local magnetic field, and complex motion modes of the pedestrian. This paper develops a robust data and physical model dual-driven based trajectory estimation(DPDD-TE) framework, which can be applied for long-term navigation tasks. A Bi-directional Long Short-Term Memory(Bi-LSTM) based quasi-static magnetic field(QSMF) detection algorithm is developed for extracting useful magnetic observation for heading calibration, and another Bi-LSTM is adopted for walking speed estimation by considering hybrid human motion information under a specific time period. In addition, a data and physical model dual-driven based multi-source fusion model is proposed to integrate basic INS mechanization and multi-level constraint and observations for maintaining accuracy under long-term navigation tasks, and enhanced by the magnetic and trajectory features assisted loop detection algorithm. Real-world experiments indicate that the proposed DPDD-TE outperforms than existing algorithms, and final estimated heading and positioning accuracy indexes reaches 5° and less than 2 m under the time period of 30 min, respectively.

关键词： Long-term navigation Wearable inertial sensors Bi-LSTM QSMF Data and physical model dual-driven

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An integrated pipeline model for biomedical entity alignment

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Frontiers of Computer Science 2021年第3期15卷 81-95页

作者： yu HU Tiezheng NIE Derong SHEN yue KOU Ge yu School of Computer Science and Engineering Northeastern UniversityShenyang 110819China

Biomedical entity alignment,composed of two subtasks:entity identification and entity-concept mapping,is of great research value in biomedical text mining while these techniques are widely used for name entity standardization,information retrieval,knowledge acquisition and ontology *** works made many efforts on feature engineering to employ feature-based models for entity identification and ***,the models depended on subjective feature selection may suffer error propagation and are not able to uti-lize the hidden *** rapid development in health-related research,researchers need an effective method to explore the large amount of available biomedical ***,we propose a two-stage entity alignment process,biomedical entity exploring model,to identify biomedical entities and align them to the knowledge base *** model aims to automatically obtain semantic information for extracting biomedical entities and mining semantic relations through the standard biomedical knowledge *** experiments show that the proposed method achieves better performance on entity *** proposed model dramatically improves the FI scores of the task by about 4.5%in entity identification and 2.5%in entity-concept mapping.

关键词： entity alignment biomedical text mining neural network model

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新媒体环境下公共图书馆古籍阅读推广研究

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图书馆工作与研究 2023年第12期 100-107页

作者：虞乐江西省图书馆

文章以我国部分省级公共图书馆为研究样本，对公共图书馆古籍阅读推广现状进行调查，总结分析新媒体环境下公共图书馆古籍阅读推广面临的挑战，并提出创新策略，即转变观念，构建长效推广机制；加强古籍资源库建设，增强用户黏性；细分... 详细信息

文章以我国部分省级公共图书馆为研究样本，对公共图书馆古籍阅读推广现状进行调查，总结分析新媒体环境下公共图书馆古籍阅读推广面临的挑战，并提出创新策略，即转变观念，构建长效推广机制；加强古籍资源库建设，增强用户黏性；细分目标用户，打造立体式媒体服务矩阵；深化多元合作，推动服务创新；重视人才培养与引进，组建专业服务团队。

关键词：公共图书馆古籍阅读推广新媒体短视频古籍修复古籍推广

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Estimating posterior inference quality of the relational infinite latent feature model for overlapping community detection

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Frontiers of Computer Science 2020年第6期14卷 55-69页

作者： Qianchen yu Zhiwen yu Zhu WANG Xiaofeng WANG Yongzhi WANG School of Computer Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Shanxi Provincial Key Laboratory for Embedded System Xi'an 710072China College of Computer Science and Engineering North Minzu UniversityYinchuan 750021China College of Earth Exploration Science and Technology Jilin UniversityChangchun 130025China

Overlapping community detection has become a very hot research topic in recent decades,and a plethora of methods have been ***,a common challenge in many existing overlapping community detection approaches is that the number of communities K must be predefined *** propose a flexible nonparametric Bayesian generative model for count-value networks,which can allow K to increase as more and more data are encountered instead of to be fixed in *** Indian buffet process was used to model the community assignment matrix Z,and an uncol-lapsed Gibbs sampler has been ***,as the community assignment matrix Zis a structured multi-variable parameter,how to summarize the posterior inference results andestimate the inference quality about Z,is still a considerable challenge in the *** this paper,a graph convolutional neural network based graph classifier was utilized to help tosummarize the results and to estimate the inference qualityabout *** conduct extensive experiments on synthetic data and real data,and find that empirically,the traditional posterior summarization strategy is reliable.

关键词： graph convolutional neural network graph classification overlapping community detection nonparametric Bayesian generative model relational infinite latent feature model Indian buffet process uncollapsed Gibbs sampler posterior inference quality estimation

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2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides

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Chinese Journal of Chemistry 2022年第4期40卷 443-452页

作者： Xianglai Liu Yetong lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao yu Wei Li Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical University639 Longmian AvenueNanjingJiangsu 211198China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate ***,their stereochemistry control in glycosylation represe... 详细信息

关键词： Glycosylation Diastereoselectivity Hydrogen bonds 2-Diphenylphosphinoyl-acetyl 2-Deoxy sugars

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