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RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4431-4432页

作者： laura Urbach Shiv K.Singh Department of Gastroenterology Gastrointestinal Oncology and EndocrinologyUniversity Medical Center GottingenGottingenGermany Clinical Research Unit 5002 KFO5002University Medical Center GöttingenGottingenGermany

A new study published in Nature by Jbara et *** identified the splicing factor“RBFOX2,”which halts metastatic spread of pancreatic ductal adenocarcinoma(PDAC)through regulating alternative splicing events.1 The results of the study provide new insights into the molecular mechanisms underlying the start of metastatic spread of PDAC *** study also indicates that pathways involved in splicing modulation could be targeted for potential therapeutic interventions in an advanced-stage PDAC.

关键词： metastasis al. metastatic

Isoenergetic-practical and semi-purified diets for protein requirement determination in Hermetia illucens larvae:consequences on life history traits

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Journal of Animal Science and Biotechnology 2022年第3期13卷 897-906页

作者： Sara Bellezza Oddon Ilaria Biasato laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 GrugliascoTOItaly

Background:Black soldier fly(BSF)is one of the most promising species for the intensive breeding of insects given its adaptability and its efficiency in the conversion of *** maximize the production and use waste as substrates,it is essential to determine the larvae nutritional *** study aims to evaluate the effects of5 practical,semi-purified and isoenergetic diets(PSPID)with increasing protein levels(10%,CP10;14%,CP14;16%,CP16;19%,CP19)on BSF life history traits.A total of 2000 six-day-old larvae were weighed and divided into groups of 100(4 replicates/treatment[PSPID and Gainesville diet(GA)used as environmental control]).In larva-prepupa stage,sampling was carried out on 30 individuals/replicate,while in prepupa-adult stage on ***:In the whole larval stage,the CP16 treatment performed better when compared to the other ***18 days old,the CP14 treatment showed a higher weight than the CP19(P<0.01),while the CP10 and CP16weights were *** the contrary,the CP10 prepupae weight was higher than the CP19(P<0.01).The CP10 and CP14 pupae performed better in terms of weight when compared to the others(P<0.01).The dietary treatments did not affect the adult *** sex significantly influenced both the exuvia weight,which was the greatest in females(P<0.001),and the fly lifespan,longest in males(P<0.05).Fly lifespan was also influenced by the interaction between treatment and sex,with the CP19 females showing a longer life than the others(P<0.05).Conclusions:In conclusion,the optimal protein level considering the whole larval stage is 16%on dry matter(DM).At 18 days old,looking at the size intended for the meal production,it can be considered 14%on *** result obtained on adult emergence in PSPID may not be attributable to the protein *** researches on macronutrients requirements determination have to be conducted to evaluate the substrates composition effects on BSF life history traits.

关键词： Hermetia illucens Life history traits Nutritional requirements Semi-purified

Perspectives from a publishing ethics and research integrity team for required improvements

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数据与情报科学学报:英文版 2023年第3期8卷 1-14页

作者： Sabina Alam laura Wilson Publishing Ethics and Research Integrity Taylor and Francis GroupJournalsUK

It is imperative that all stakeholders within the research ecosystem take responsibility to improve research integrity and reliability of published *** on the unique experiences of a specialist publishing ethics and research integrity team within a major publisher,this article provides insights into the observed trends of misconduct and how those have evolved over time,and addresses key actions needed to improve the interface between researchers,funders,institutions and publishers to collectively improve research integrity on a global scale.

关键词： Research integrity Publishing ethics Training Education

Noise-induced hippocampal damage:potential mechanisms

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Neural Regeneration Research 2022年第3期17卷 563-564页

作者： Sonia Jazmín Molina laura Ruth Guelman Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de Buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure to noise of high intensities(> 80 dB) is considered a stressful event and might produce both auditory and extra-auditory damage,including different central nervous system(CNS) *** the CNS,the hippocampus(HC),a structure related to several cognitive functions,has shown to be particularly susceptible to the effects of noise.

关键词： damage auditory injuries

Phenotyping Key Fruit Quality Traits in Olive Using RGB Images and Back Propagation Neural Networks

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Plant Phenomics 2023年第3期5卷 484-500页

作者： Giuseppe Montanaro Angelo Petrozza laura Rustioni Francesco Cellini Vitale Nuzzo Università degli Studi della Basilicata 85100 PotenzaItaly ALSIA Agenzia Lucana Sviluppo Innovazione in AgricolturaMetapontum Agrobios Research Center75010 MetapontoItaly Department of Biological and Environmental Sciences and Technologies University of SalentoLecceItaly

To predict oil and phenol concentrations in olive fruit,the combination of back propagation neural networks(BPNNs)and contact-less plant phenotyping techniques was employed to retrieve RGB image-based digital proxies of oil and phenol *** of cultivars(×3)differing in ripening time were sampled(~10-day interval,×2 years),pictured and analyzed for phenol and oil *** to this,fruit samples were pictured and images were segmented to extract the red(R),green(G),and blue(B)mean pixel values that were rearranged in 35 RGB-based colorimetric *** BPNNs were designed using as input variables(a)the original 35 RGB indexes,(b)the scores of principal components after a principal component analysis(PCA)pre-processing of those indexes,and(c)a reduced number(28)of the RGB indexes achieved after a sparse *** results show that the predictions reached the highest mean R^(2) values ranging from 0.87 to 0.95(oil)and from 0.81 to 0.90(phenols)across the *** addition to the R^(2),other performance metrics were calculated(root mean squared error and mean absolute error)and combined into a general performance indicator(GPI).The resulting rank of the GPI suggests that a BPNN with a specific topology might be designed for cultivars grouped according to their ripening *** present study documented that an RGB-based image phenotyping can effectively predict key quality traits in olive fruit supporting the developing olive sector within a digital agriculture domain.

关键词： Image image supporting

Second-Order Invariant Domain Preserving ALE Approximation of Euler Equations

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Communications on Applied Mathematics and Computation 2023年第2期5卷 923-945页

作者： Jean-Luc Guermond Bojan Popov laura Saavedra Department of Mathematics Texas A&M UniversityCollege StationUSA Departamento de Matemática Aplicada a la Ingeniería Aeroespacial Universidad Politécnica de MadridMadridSpain

An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is *** numerical scheme is explicit in time and the approximation in space is done with continuous finite *** method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks.

关键词： Conservation equations Hyperbolic systems Arbitrary Lagrangian-Eulerian Moving meshes Invariant domains High-order method Convex limiting Finite element method

Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： Alexandra Chovsepian laura Empl Florence M.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

Design of Multi-layered Protection Against Guided Mortar Threats Yhrough Numerical Modeling

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Defence Technology（防务技术） 2023年第11期29卷 55-65页

作者： Bonny Thawani Seng Kiat Lim laura Brown Richard Critchley Rachael Hazael Cranfield Forensic Institute Cranfield UniversityDefence Academy of the United KingdomShrivenhamSN68LAUK

The trade—off between protection and weight is a constant consideration when designing a portable protective *** mobility is a desirable attribute and protection must therefore adapt,prompting a demand for lightweight,simple to construct,low-cost and effective ballistic protection *** strength and ductility,wave spreading capability and good energy absorption are key properties for ballistic *** materials,polycarbonate,Kevlar?-epoxy,polyurethane foam,and aluminium alloy,possess these properties and were selected for analysis by numerical *** configurations were proven to be an optimal solution,by exploiting the advantages of each material without having large penalties of mass and *** modelling using ANSYS AUTODYN?is used to simulate monolithic and multi-layered target configurations,to obtain the penetration mitigation *** results are analysed to select configurations based on different requirements,such as lowest cost,lowest mass,best performance,and optimal configuration which balanced the three key parameters *** optimal configuration of Aluminium,Kevlar-Epoxy,Polyurethane,and Polycarbonate has layers with thickness of 7,3,38,2 mm respectively with a total mass of 7.97 kg,total cost of$39.86 and penetration of 29.34%(14.67 mm).Polynomial relationships between performance and mass/cost are also determined.

关键词： Hydrocode Fragmentation High velocity Composite structures Foams

Conversion of CO_(2)to added value products via rWGS using Fe-promoted catalysts:Carbide,metallic Fe or a mixture?

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Journal of Energy Chemistry 2022年第3期31卷 635-646,I0017页

作者： Q iZhang laura Pastor-Pérez Qiang Wang Tomas Ramirez Reina Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUnited Kingdom College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China

Fe-based catalysts are efficient systems for CO_(2)conversion via reverse water-gas shift(rWGS)***,the nature of the active phase,namely metallic iron,iron oxide or iron carbide remains a subject of debate which our paper is meant to ***0 is a much better catalyst for the rWGS than Fe_(3)*** activity of Fe0 can be promoted by the addition of Cs and Cu whose presence hinders iron carburisation while favouring both higher conversion and enhanced *** the samples are aged in the rWGS reaction mixture during stability test a new phase appear:Fe_(5)C_(2),resulting in a more active but less selective catalysts than Fe0 for the rWGS *** our results indicate that we could potentially achieve an optimal activity/selective balance upon finely tuning the proportion Fe/Fe_(5)C_(2).Beyond the fundamental information concerning active phase we have observed the presence of advanced Fischer-Tropsch-like products at ambient pressure opening new opportunities for the design of hybrid rWGS/Fischer-Tropsch systems.

关键词： CO_(2)conversion rWGS Fe carbide Fe catalysts Hybrid catalysts