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Workshop on Dynamics, Transport and Chemistry of the UTlS Asian Monsoon

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Advances in Atmospheric Sciences 2016年第9期33卷 1096-1098页

作者： William J.RANDEl laura l.pan Jianchun BIAN National Center for Atmospheric Research Key laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences

1. Overview The upper troposphere-lower stratosphere （UTlS） of the Asian summer monsoon （ASM） region is characterized by a continental-scale anticyclonic circulation, which is dynami- cally active and coupled to monsoonal convection. The monsoon anticyclone exhibits anomalous chemical and aerosol characteristics, linked to the outflow of deep convection and the large-scale circulation, and strongly influences the global UTlS composition during boreal summer.

关键词： Transport and Chemistry of the UTlS Asian Monsoon Workshop on Dynamics ASM

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

台风对夏季亚洲季风反气旋对流层上部大气成分的影响——以2013年拉萨观测为例

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台风对夏季亚洲季风反气旋对流层上部大气成分的影响——以2013年...

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

第34届中国气象学会年会

作者：李丹 Baerbel Vogel 卞建春 Rolf Mueller laura l.pan Gebhard Guenther 白志宣李倩张金强范秋君 Holger Voemel 中国科学院大气物理研究所中层大气和全球环境探测重点实验室德国于利希研究中心中国科学院大学地球科学学院美国国家大气科学研究中心美国国家大气科学研究中心地球观测实验室

应用2013年8月SWOP（sounding water vapour,ozone,and particle）观测计划在拉萨获得的臭氧和水汽廓线资料,分析臭氧和水汽的相关关系,发现近一半的观测资料在上对流层–下平流层区域出现异常。应用Cla MS（the Chemical lagrangian Mo... 详细信息

应用2013年8月SWOP（sounding water vapour,ozone,and particle）观测计划在拉萨获得的臭氧和水汽廓线资料,分析臭氧和水汽的相关关系,发现近一半的观测资料在上对流层–下平流层区域出现异常。应用Cla MS（the Chemical lagrangian Model of the Stratosphere Model）轨迹模式,计算探空廓线的20天后向轨迹来分析相关异常。模拟结果表明发生在西太平洋的3个热带气旋（Jebi、Utor和Trami）可以输送边界层低臭氧浓度空气到夏季亚洲季风（ASM）反气旋对流层上部,进而对臭氧和水汽产生影响。边界层空气通过台风强垂直输送作用到达对流层顶附近后,进入到ASM反气旋内部拉萨测站通过两条输送路径,一是快速直接水平输送,二是沿着反气旋运动一周的缓慢长距离输送。同时,ASM反气旋和热带气旋的空间相对位置关系决定了空气块的输送路径。近一个月的观测数据表明,台风的影响作用主要发生在拉萨测站上空14.5–17 km/365–370 K高度附近。

关键词：台风输送大气成分夏季亚洲季风反气旋

来源： cnki会议评论

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding pan pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Atmospheric boundary layer sources for upper tropospheric air over the Asian summer monsoon region

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Atmospheric and Oceanic Science letters 2017年第5期10卷 358-363页

作者： FAN Qiu-Jun BIAN Jian-Chun pan laura l. Key laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of SciencesBeijing China University of Chinese Academy of Sciences Beijing China National Center for Atmospheric Research Boulder CO USA

Previous satellite measurements and model simulations have shown that the Asian summer monsoon（ASM） anticyclone is co-located with higher concentrations of pollutants, which are emitted in the continental atmospheric boundary layer（ABl）. Backward trajectory calculations show that the air at the 150-hPa level has the maximum frequency of ABl sources within 30 days over the most intensive convection regions and their downwind areas, which are not located within the ASM anticyclone,but rather at the southern flank or periphery of the ASM anticyclone. The upper tropospheric airs originated from the ABl sources include two parts： one from the ocean, which has the dominant impact to the south of 20°N, particularly over the South China Sea（SCS） and the west tropical Pacific Ocean; and another from the continent, which is dominant between 10°N and 30°N, particularly over the Bay of Bengal（BoB）, continental India, the Arabian Sea, and the Arabian Peninsula. It is the latter part that forms the higher pollutant concentration within the ASM anticyclone as shown by satellite measurements. Air in the ABl sources（both polluted and unpolluted） converges to the intensive convection region in the lower troposphere, and then traverses the middle troposphere through a wide group of upward pipes, and finally to the upper troposphere. These pipes in the middle troposphere are defined by the ASM intensive convections and cover the south of continental India,the BoB, the Tibetan Plateau, the Indochina Peninsula, the SCS, and the Philippine Sea.

关键词： Atmospheric boundary layer source Asian summer monsoon anticyclone main pathway upper troposphere

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through l-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Terahertz band simulations using two different radiative transfer models

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Science China Earth Sciences 2018年第10期61卷 1482-1490页

作者： linjun pan Daren lü laboratory for Middle Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences

A high-resolution dual-band terahertz(THz) radiometer was designed to measure vertical distributions of chemical elements in the middle atmosphere of the Tibetan Plateau. A forward simulation, which always should be conducted firstly for the development of a matching retrieval algorithm, has not been done before. We use two radiative transfer models, ARTS and AM, to simulate the water vapor, ozone and carbon monoxide spectra on the plateau based on the spectral design of the THz radiometer. The emission line characteristics of the three gases in this spectral band are identified. Reasons for the differences in the spectral simulations between the two models are analyzed for individual gases. The impact of several different spectral parameter settings on the simulations are evaluated through a series of sensitivity experiments. This study suggests that the ARTS is more suitable for the development of the THz radiometer retrieval algorithm. An optimal parameter setting of the ARTS for the three elements are given.

关键词： Terahertz radiation Radiometer Radiative transfer model Spectral simulation Plateau

A new method for retrieving equivalent cloud base height and equivalent emissivity by using the ground-based Atmospheric Emitted Radiance Interferometer (AERI)

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Science China Earth Sciences 2013年第1期56卷 43-53页

作者： pan linJun lü DaRen laboratory for Middle Atmosphere and Global Environment Observation (lAGEO) Institute of Atmospheric Physics Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

In the paper, we propose a new method of identifying the clear sky based on the Atmospheric Emitted Radiance Interferometer （AERI）. Using the Atmospheric Radiation Measurement （ARM） Mobile Facility （AFM） dataset in Shouxian in 2008, we sim- ulate the downwelling radiances on the surface in the 8-12 μm window region using line-By-line Radiative Transfer Model （lBlRTM）, and compare the results with the AERI radiances, The differences larger （smaller） than 3 mW （cm2 sr cm-1）-1 suggest a cloudy （clear） sky. Meanwhile, we develop the new algorithms for retrieving the zenith equivalent cloud base height （CBHe） and the equivalent emissivity （ee）, respectively. The retrieval methods are described as follows. （1） An infinitely thin and isothermal blackbody cloud is simulated by the lBlRTM. The cloud base height （H） is adjusted iteratively to satisfy the situation that the contribution of the blackbody to the downwelling radiance is equal to that of realistic cloud. The final H is considered as CBHe. The retrieval results indicate that the differences between the CBHe and observational cloud base height （CBH） are much smaller for thick low cloud, and increase with the increasing CBH. （2） An infinitely thin and isothermal gray body cloud is simulated by the lBlRTM, with the CBH specified as the observed value. The cloud base emissivity （co） is ad- justed iteratively until the contribution of the gray body to the downwelling radiance is the same as that of realistic cloud. The corresponding εc is εe. The average εe for the low, middle, and high cloud is 0.967, 0.781, and 0.616 for the 50 cases, respec- tively. It decreases with the increasing CBH. The retrieval results will be useful for studying the role of cloud in the radiation budget in the window region and cloud parameterizations in the climate model.

关键词： AERI lBlRTM equivalent cloud base height equivalent emissivity

Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： long pan Guoqiang li Xiaoyan Wang Ming Jin Xinrong He luo Qin Zhong Wang Wenwei Zhao Chunzhu Chen Yuanlu liu Jin Yang lele Shu Key laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， lanzhou University College of Earth Sciences， Chengdu University of Technology School of Geographic Science， Nantong University Key laboratory of land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi lake salinity varied between 2 g/l and 47 g/l during the late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi lake has a low salinity of average value of ～15 g/l. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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