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BIOCELL 2021年第1期45卷 1-16页

作者： EMILIA MANOLE laura DUMITRESCU cristina NICULIȚE BOGDAN OVIDIU POPESCU laura cristina ceafalan Victor Babeș”National Institute of Pathology Bucharest050088Romania Colentina Clinical Hospital Bucharest020125Romania Carol Davila”University of Medicine and Pharmacy Bucharest020021Romania

An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative *** neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein,known as Lewy *** gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system,which can then spread to the brain in a prion-like fashion through the vagus *** may interfere with neuroinflammatory pathways and susceptibility to *** this review,we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson’s disease,with a special emphasis on functional bacterial amyloid proteins,bacterial biosurfactants,endotoxins and short-chain fatty *** possible roles of molecular hydrogen,a common byproduct of bacterial fermentation,are also addressed.

关键词： Alpha-synuclein Endotoxins Short-chain fatty acids

New neuroprotective perspectives in fighting oxidative stress and improving cellular energy metabolism by oleocanthal

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Neural Regeneration Research 2019年第7期14卷 1217-1218页

作者： cristina Angeloni laura Giusti Silvana Hrelia School of Pharmacy University of Camerino Department of Clinical and Experimental Medicine University of Pisa Department for Life Quality Studies Alma Mater Studiorum-University of Bologna

Neurodegenerative diseases are a heterogeneous group of disorders characterized by a progressive dysfunction and death of neural cells which lead to compromised motor or cognitive ***,the loss of neuron is associated with both gliosis and,frequently,with abnormal accumulation of extracellular and intracellular filamentous deposit in specific cell *** a rapidly increasing aging population,these diseases are becoming a primary health problem(Albers and Beal,2000).

关键词： New neuroprotective fighting oxidative

Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?

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Neural Regeneration Research 2024年第9期19卷 1967-1972页

作者： laura Carrero DesireéAntequera cristina Municio Eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain

Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic ***,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional ***,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.

关键词： Alzheimer’s disease amyloid circadian rhythm neurodegeneration retina

Evolutionary consequences of deception： Complexity and informational content of colony signature are favored by social parasitism

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Current Zoology 2014年第1期60卷 137-148页

作者： Maria cristina LORENZI laura AZZANI Anne-Genevieve BAGNRRES Department of Life Sciences and Systems Biology University of Turin via Accademia Albertina 13 10123 Torino Italy I.R.B.I. - UMR CNRS 7261 - Universit6 de Tours Facult6 des Sciences Parc Grandmont 37200 Tours France

Nestmate recognition codes show remarkable chemical complexity, involving multiple biochemical pathways. This complexity provides the opportunity to evaluate the ecological and social conditions that favor the evolution of complex signaling. We investigated how the chemical signatures of three populations of the social paper wasp Polistes biglumis differed in terms of concentration of hydrocarbons, proportions of branched hydrocarbons and overall variation. We tested whether the variation in chemical signatures among populations could be explained by the prevalence of social parasites or whether this was just an effect of local abiotic conditions which influenced the composition of the hydrocarbon cuticular layer. We studied the chemical signa- ture in three populations in which obligate social parasites differed in the selection pressures they imposed on host populations. Within each population, we restricted our analyses to non-parasitized hosts, to avoid potential short-term effects of parasite pres- ence on the host chemical signatures. We found that host colonies in parasitized populations had more diverse profiles than the parasite-free population. Moreover, the overall concentration of hydrocarbons and the relative proportion of branched hydrocar- bons were larger in the parasitized populations, relative to the non-parasitized one. This is to our knowledge the first evidence in favour of the hypothesis that different traits in the host chemical signatures as a whole undergo evolutionary changes resulting from directional or balancing selection imposed by social parasites. We conclude that obligate social parasites act as ＇engines of diversity＇ on host chemical signatures and operate in favor of a geographic mosaic of diverging communication codes

关键词： Polistes Brood parasitism Cipher Nestmate recognition Hydrocarbons Geographic mosaic Crozier's paradox

Methane oxidation and attenuation of sulphur compounds in landfill top cover systems: Lab-scale tests

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Journal of Environmental Sciences 2018年第3期30卷 317-326页

作者： Roberto Raga Alberto Pivato Maria cristina Lavagnolo laura Megido Raffaello Cossu DII-Department of Industrial Engineering University of Padova Department of Chemical and Environmental Engineering Polytechnic School of Engineering Gijón Campus University of Oviedo

In this study,a top cover system is investigated as a control for emissions during the aftercare of new landfills and for old landfills where biogas energy production might not be *** materials were studied as landfill cover system in lab-scale columns：mechanical–biological pretreated municipal solid waste（MBP）;mechanical–biological pretreated biowaste（PB）;fine（PBSf）and coarse（PBSc）mechanical–biological pretreated mixtures of biowaste and sewage sludge,and natural soil（NS）.The effectiveness of these materials in removing methane and sulphur compounds from a gas stream was tested,even coupled with activated carbon *** of CO2,CH4,O2,N2,H2S and mercaptans were analysed at different depths along the *** degradation was assessed using mass balance and the results were expressed in terms of methane oxidation rate（MOR）.The highest maximum and mean MOR were observed for MBP（17.2 g CH4/m^2/hr and 10.3 g CH4/m^2/hr,respectively）.Similar values were obtained with PB and *** lowest values of MOR were obtained for NS（6.7 g CH4/m^2/hr）and PBSf（3.6 g CH4/m^2/hr）,which may be due to their low organic content and void index,*** membranes with high load capacity did not seem to have an influence on the methane oxidation process：MBP coupled with 220 g/m^2and 360 g/m^2membranes gave maximum MOR of 16.5 g CH4/m^2/hr and 17.4 g CH4/m^2/hr,*** carbon membranes proved to be very effective on H2S ***,carbonyl sulphide,ethyl mercaptan and isopropyl mercaptan seemed to be easily absorbed by the filling materials.

关键词： Emission reduction Greenhouse gas emissionLandfill Methane oxidation H2S Soil cover

Murine models based on acute myeloid leukemia-initiating stem cells xenografting

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World Journal of Stem Cells 2018年第6期10卷 57-65页

作者： cristina Mambet Mihaela Chivu-Economescu Lilia Matei laura Georgiana Necula Denisa laura Dragu Coralia Bleotu Carmen cristina Diaconu Cellular and Molecular Pathology Department Stefan S. Nicolau Institute of Virology Nicolae Cajal Institute Titu Maiorescu University

Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop "humanized mice" that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models.

关键词： Acute myeloid leukemia Leukemia-initiating stem cells Antigen markers Murine models Xenografts

Benthic diatom community response to metal contamination from an abandoned Cu mine:Case study of the Gromolo Torrent(Italy)

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Journal of Environmental Sciences 2019年第1期31卷 233-246页

作者： Raffaella Tolotti Sirio Consani cristina Carbone Greta Vagge Marco Capello laura Cutroneo Department of Earth Environment and Life Sciences University of Genoa

Environmental contamination has become a global problem of increasing intensity due to the exponential growth of industrialization. One main debated issue is the metal contamination of rivers receiving Acid Mine Drainage(AMD) from active/abandoned mines. In order to assess the quality of lotic systems, diatoms are commonly used, as their assemblage modifies on the basis of changes in environmental parameters. Benthic diatom changes were analyzed along the metal-impacted Gromolo Torrent(Liguria, NW Italy) with the aim of understanding the effects of input from the abandoned Libiola Cu mine. The results support the hypothesis that metals from AMD lead to massive changes in diatoms, resulting in low biological diversity and in a shift of dominance, passing from the genera Cymbella and Cocconeis to more tolerant and opportunistic species, such as Achnanthidium minutissimum and Fragilaria rumpens. The high concentrations of labile metals, measured through Diffusion Gradients in Thin-films(DGT) immediately downstream of the two AMD inputs in the torrent, corresponded to a sudden decrease in the presence of diatoms, indicating the possible reaching of acute toxic levels. In particular,A. minutissimum dominated the mining area and was positively correlated with Cu and Zn;whereas F. rumpens bloomed downstream of this area, where the metal content was diluted,and was positively correlated with As and Pb. Finally, an important abundance of Nitzschia palea and teratological forms of A. minutissimum and F. rumpens were observed downstream from the mine, indicating that metals may have an important impact on diatoms up to the torrent mouth.

关键词： Benthic diatom community Biomarkers Metal contamination Diatom teratologies Acid Mine Drainage Libiola mine (Liguria,NW Italy)

Amine-rich carbon nitride nanoparticles:Synthesis,covalent functionalization with proteins and application in a fluorescence quenching assay

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Nano Research 2019年第8期12卷 1862-1870页

作者： Gabriele Capilli Simone Cavalera laura Anfossi cristina Giovannoli Marco Minella Claudio Baggiani Claudio Minero Department of Chemistry and NIS Center of Excellence University of Torino10125 TorinoItaly

Carbon nitride nanoparticles (CNNPs) have been employed as fluorescent sensing tools owing to their unique features, e.g. low cost production, high stability in water and high photoluminescence quantum yield. Here, an easy and versatile synthetic approach was exploited to design fluorescent nanoparticles with surface functionalities suitable for covalent binding to bioligands. High hydrophilic, brightly fluorescent CNNPs, rich of superficial amines, were obtained from the thermal condensation of urea and lysine (CNNP^Lys) and by tuning the precursor ratio and the heating time. Structure and size of the functionalized nanoparticles were characterized through infrared (IR) spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). Their optical properties were studied by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy. The superficial primary amino groups, furnished by the lysine co-precursor, enabled for covalently linking CNNP^Lys to model proteins. The CNNP^Lys-protein conjugates excited under UV irradiation emit in the 400-450 nm visible range (quantum yield 24%). The applicability of CNNP^Lys as novel fluorescent probes was demonstrated by a fluorescence quenching assay, in which gold nanoparticles (GNPs) were attached to Staphylococcal protein A and employed to quench the CNNP^Lys fluorescence by Forster resonant energy transfer (FRET). The quenching occurred upon formation of the specific binding between the GNP-linked protein A and CNNP^Lys-tagged immunoglobulins, while the inhibition of the binding resulted in the recovery of CNNP^Lys luminescence. The synthetic strategy, based on combining a "conjugated polymer"-forming unit (urea) and a co-precursor able to provide the desired functional group (lysine), allows designing innovative materials for the development of new generation fluorescence biosensors in which easily functionalized fluorophores are needed.

关键词： fluorescent probe carbon nitride nanoparticles quenching assay fluorescent materials g-C3N4 Forster resonant energy transfer (FRET)

Hepatitis A:Epidemiology and prevention in developing countries

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World Journal of Hepatology 2012年第3期4卷 68-73页

作者： Elisabetta Franco cristina Meleleo laura Serino Debora Sorbara laura Zaratti Department of Public HealthUniversity Tor Vergata Specialization School for Hygiene and Preventive Medicine University Tor Vergata

Hepatitis A is the most common form of acute viral hepatitis in the *** geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socioeconomic *** anti-hepatitis A virus(HAV)seroprevalence rate is presently decreasing in many parts of the world,but in less developed regions and in several developing countries,HAV infection is still very common in the first years of life and seroprev-alence rates approach 100%.In areas of intermediate endemicity,the delay in the exposure to the virus has generated a huge number of susceptible adolescents and adults and significantly increased the average age at *** the severity of disease increases with age,this has led to outbreaks of hepatitis *** factors contribute to the decline of the infection rate,including rising socioeconomic levels,increased access to clean water and the availability of a hepatitis A vaccine that was developed in the *** populations with a high proportion of susceptible adults,implementing vaccination programs may be *** this report,we review available epidemiological data and implementation of vaccination strategies,particularly focusing on developing countries.

关键词： Hepatitis A Developing countries Endemic-ity Seroprevalence Vaccine

Uncommon late presentation of platypnea-orthodeoxia syndrome

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Journal of Geriatric Cardiology 2015年第6期12卷 687-689页

作者： laura Toffetti Marco Centola laura Massironi cristina Pipia Fabiano Di Marco Alessandro Colombo Emanuela Piccaluga Division of Cardiology Ospedale San Paolo University of Milan Italy Divison of Internal Medicine Ospedale San Paolo Italy Division of Respiratory Medicine University of Milan Italy Division of Cardiology Azienda Ospedaliera 'Luigi Sacco ' Milan Italy

A 79-year-old man presented with progressive dyspnea, gradually worsening over a period of several weeks. His past medical history included hypertension, chronic hepatitis C without cirrhosis, ischemic stroke occurred at the age of 68 and chronic obstructive pulmonary disease （COPD） caused by long-term cigarette smoking. The patient was alert and oriented and not in acute distress. The physical examination of the chest revealed decreased breath sounds at the bases of the lungs, without crackles or wheezes. Heart sounds were regular without murmurs. The respiration rate was normal.

关键词： Platypnea-orthodeoxia Patent foramen ovale The elderly