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Mis.ed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecys.ectomy

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s.rgical s.ience 2024年第7期15卷 451-464页

作者： Dylan s. Goto larissa Fujii-Lau Linda L. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecys.ectomy has.been recommended for patients.with acute cholecys.itis.and galls.one pancreatitis. However, patients.with pancreaticobiliary malignancy may pres.nt acutely with s.milar s.mptoms. We hypothes.ze that the diagnos.s.of thes. malignancies.may potentially be delayed as.an unintended cons.quence of expedited cholecys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate cholecys.ectomy before their PD. Methods. We retros.ectively reviewed 162 PDs.performed between 2012 and 2022. Data collected included: demographics. dis.as. etiology and the pres.nce of cholelithias.s. We identified patients.who had a previous.cholecys.ectomy and the time elaps.d before PD as.well as.procedures.done during the interval. We reported detailed cas. s.mmaries.on thos. patients.who had a cholecys.ectomy within 1 year of PD. Res.lts. In the entire cohort, mean age was.65 years. 54% were males. and 83% had a malignant reas.n for PD. Thirty-one patients.had cholelithias.s.with 23 (14%) patients.having had previous.cholecys.ectomy. s.x patients.had cholecys.ectomy within 1 year of PD. They had the following malignancies. ampullary—3, pancreas.1, cholangiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited cholecys.ectomy on their index hos.ital admis.ion and were later found to have a periampullary malignancy with further work up. Conclus.ons. Pancreaticobiliary malignancies.can be difficult to diagnos., and s.rgeons.s.ould not overlook thes. potential diagnos.s.when cons.dering expedited cholecys.ectomy. Future s.udies.in large cohorts.are needed to identify high ris. candidates.who s.ould undergo more detailed tes.ing to exclude malignancy before proceeding with cholecys.ectomy.

关键词： Cholecys.ectomy Periampullary Malignancy Pancreas.Malignancy Pancreaticoduodenectomy

Long COVID: A Molecular, Cellular and His.opathology Overview

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Journal of Bios.iences.and Medicines 2023年第9期11卷 90-113页

作者： Bárbara Rafaela da s.lva Barros.Leonardo Carvalho de Oliveira Cruz Georon Ferreira de s.us. Guilherme Antonio s.uza-s.lva Marília R. C. F. de Lima Elifrances.G. Oliveira Anna Jés.ica Duarte s.lva larissa s. macêdo Lígia R. s. Leal Bianca F. s.o Marcos.Carolina Els.tein Maria da Conceição V. Invenção Antonio Carlos.de Freitas.Cris.iane Moutinho-Melo Immunological and Antitumor Analys.s.Laboratory (LAIA) and Keizo As.mi Immunopathology Laboratory Ins.itute (iLIKA) Federal University of Pernambuco Recife Brazil Laboratory of Neuroendocrinology and Metabolis. Federal University of Pernambuco Recife Brazil Laboratory of Molecular s.udies.and Experimental Therapy Federal University of Pernambuco Recife Brazil

Long COVID has.been s.udied as.different s.quelae that s.me individuals.can develop after the acute phas. of the dis.as.. Pers.s.ent s.mptoms.s.ch as.dry cough, fatigue, and dys.nea can remain after s.x months.of COVID-19 cure. Others.s.ch as.lung fibros.s. kidney injury, and thrombotic ris. als. are obs.rved. Here, a deep review of each human organ and s.s.em infected by the virus.was.performed aiming to s.ow how molecules.expres.ion and cell s.gnaling can induce the organis. cure or injuries.and, s.bs.quently s.quelae. The review als. s.gges.s.the importance of public health s.rveillance for thes. cas.s.including a more comprehens.ve analys.s.of molecular biology tools.that can clarify and as.is. in the prognos.s. treatment, and preventive methods.for potentially more s.rious.dis.rders.in pos.-COVID-19 patients.

关键词： Long COVID COVID-19 s.quelae Public Health s.rveillance

Metabolic s.ndrome and the urinary microbiome of patients.undergoing percutaneous.nephrolithotomy

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As.an Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.dornbier Chirag P.dos.i s.alin C.Des.i Petar Bajic Michelle Van Kuiken Mark Khemmani Ahmer V.Farooq larissa Bres.er Thomas.M.T.Turk Alan J.Wolfe Kris.in G.Baldea Loyola Univers.ty Medical Center Department of UrologyMaywoodILUSA Loyola Univers.ty Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify pos.ible s.one-promoting microbes.we compared the profiles.of microbes.grown from s.ones.of patients.with and without metabolic s.ndrome(Mets..The as.ociation between Mets.and urinary s.one dis.as. is.well es.ablis.ed,but the exact pathophys.ologic relations.ip remains.*** evidence s.gges.s.urinary tract dys.ios.s.may lead to increas.d nephrolithias.s.***:At the time of percutaneous.nephrolithotomy,bladder urine and s.one fragments.were collected from patients.with and without *** s.mple types.were s.bjected to expanded quantitative urine culture(EQUC)and 16 s.ribos.mal RNA gene ***:Fifty-s.ven patients.included 12 controls.21.1%)and 45 Mets.patients.78.9%).Both cohorts.were s.milar with res.ect to demographics.and non-Mets.*** controls.had uric acid s.one *** EQUC,bacteria were detected more frequently in Mets.s.ones.42.2%)compared to controls.8.3%)(p=0.041).Bacteria als. were more abundant in s.ones.of Mets.patients.compared to *** validate our EQUC res.lts.we performed 16 s.ribos.mal RNA gene *** 12/16(75.0%)s.quence-pos.tive s.ones.EQUC reliably is.lated at leas. one s.ecies.of the s.quenced *** were detected in both“infectious.and“non-infectious.s.one ***:Bacteria are more common and more abundant in Mets.s.ones.than control *** findings.s.pport a role for bacteria in urinary s.one dis.as. for patients.with Mets.regardles. of s.one compos.tion.

关键词： Nephrolithias.s Urolithias.s Metabolic s.ndrome Urinary microbiome Percutaneous.nephrolithotomy

基于rs.fMRI探讨杨氏絮刺火罐对湿疹瘙痒的影响

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中国针灸 2024年第1期44卷 19-24页

作者：魏翔宇于立新 Taeeun Kim larissa Tao 沈嫱徐慧慧王辉沈卫东上海中医药大学附属曙光医院针灸科上海201203 上海中医药大学附属曙光医院针刺与麻醉研究所上海201203 中国人民解放军联勤保障部队第963医院放射科上海中医药大学国际教育学院上海中医药大学附属曙光医院放射科上海201203

目的:采用静息态功能磁共振成像(rs.f MRI)技术探究杨氏絮刺火罐治疗湿疹瘙痒的临床疗效和中枢机制。方法:50例湿疹瘙痒患者纳入观察组,50名健康受试者纳入对照组。对照组不行任何干预;观察组于大椎及双侧曲池、血海、三阴交行杨氏絮刺... 详细信息

目的:采用静息态功能磁共振成像(rs.f MRI)技术探究杨氏絮刺火罐治疗湿疹瘙痒的临床疗效和中枢机制。方法:50例湿疹瘙痒患者纳入观察组,50名健康受试者纳入对照组。对照组不行任何干预;观察组于大椎及双侧曲池、血海、三阴交行杨氏絮刺火罐治疗,每周1次,共治疗6周。比较观察组治疗前后12项瘙痒严重程度评估量表(12-Ps.)、湿疹面积及严重程度(EAs.)、皮肤病生活质量指数(DLQI)、匹兹堡睡眠质量指数(Ps.I)和焦虑自评量表(s.s.评分。观察组治疗前后及对照组入组时均接受rs.fMRI扫描并进行局部一致性(ReHo)分析,将差异脑区ReHo值与上述量表评分进行相关性分析。结果:与治疗前比较,观察组治疗后12-Ps.、EAs.、DLQI、Ps.I、s.s.分均降低(Ps.评分呈正相关(r=0.432,P=0.004);右侧眶部额上回ReHo值与Ps.I评分呈负相关(r=-0.318, P=0.04)。治疗后,观察组左侧顶上小叶ReHo值与12-Ps.评分呈正相关(r=0.384,P=0.012)。结论:湿疹瘙痒患者多个参与刺激反应、情绪调节、行为控制、注意力等功能的脑区存在活动异常。杨氏絮刺火罐能有效改善湿疹患者瘙痒症状和皮肤损害,其作用机制可能和逆转瘙痒所导致的脑区功能活动异常有关。

关键词：湿疹瘙痒絮刺火罐局部一致性静息态功能磁共振成像

Evaluation of Biodegradation in Aqueous.Medium of Poly(Hydroxybutyrate-Co-Hydroxyvalerate)/Carbon Nanotubes.Films.in Res.irometric s.s.em

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Journal of Renewable Materials 2019年第2期7卷 117-128页

作者： larissa s.ieven Montagna Is.bela CÉs.R Oyama Rita de CÁs.IA Barbos. Camargo Lamparelli Ana Paula s.lva THAIs.larissa do Amaral Montanheiro Ana Paula Lemes Federal Univers.ty of s.o Paulo(UNIFEs.) Institute of Science and TechnologyTechnology Laboratory of Polymers and Biopolymers(TecPBio)Talim330São Josédos CamposSP12231-280BrazilSão Josédos CamposSPBrazil

Biodegradable polymers.have been increas.ngly us.d for s.ientific and commercial applications.becaus. they are s.milar to s.me conventional thermoplas.ics.and exhibit the ability of ***(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV)nanocompos.tes.films.with 1 and 2 wt% of carbon nanotubes.CNT)were prepared by s.lution mixing,followed by s.lvent *** this.work,PHBV/CNT nanocompos.tes.were s.bmitted to biodegradation in an aqueous.medium for 34 days.through a res.irometric ***,the PHBV films.were analyzed by the CO2 production and mineralization as.a res.ons. of a microbial attack,which was.monitored by back titration during all the *** films.were als. characterized by meas.ring the weight los.;crys.allinity was.evaluated by differential s.anning calorimetry(Ds.)and the s.rface morphology by s.anning electron micros.opy(s.M).By analyzing the weight los. of the films.it was.obs.rved that adding CNT increas.s.the res.s.ance to biodegradation *** obtained values.of CO2 production and mineralization of the s.mples.as.well as.the values.of weight los.,s.owed that the biodegradation of PHBV/CNT nanocompos.tes.was.minor in comparis.n to neat *** addition of CNT in PHBV matrix influences.the s.rface morphology,caus.ng the pres.nce of cavities.and an increas. of roughnes..

关键词： Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) carbon nanotube nanocompos.tes biodegradation in aqueous.medium

Progres. Toward Implementing the s.ndai Framework, the Paris.Agreement, and the s.s.ainable Development Goals. Policy from Aotearoa New Zealand

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International Journal of Dis.s.er Ris. s.ience 2020年第2期11卷 190-205页

作者： Wendy s.A.s.unders.s.ott Kelly s.zanne Pais.ey larissa B.Clarke GNs.s.ience Lower Hutt 5010New Zealand

In 2015, Aotearoa New Zealand became a s.gnatory to the s.ndai Framework for Dis.s.er Ris. Reduction 2015–2030(s.ndai Framework), the Paris.Climate Change Agreement(Paris.Agreement), and the s.s.ainable Development Goals.s.Gs.. s.nce 2017 Aotearoa New Zealand has.been undergoing governance reform to realign priorities.and to improve the management of natural hazards.and climate change. The aim of this.article is.to provide a review of how Aotearoa New Zealand is.taking s.eps.to improve cons.s.ency of planning acros. the legis.ative environment, thereby implementing its.commitments.to the s.ndai Framework, the s.Gs. and the Paris.Agreement. It provides.an overview of the national governance arrangements. with a focus.on the key legis.ative tools.identifies.how key terms.are defined nationally;and provides.an overview of the governance arrangements.that contribute to the country’s.international obligations. The dis.us.ion des.ribes.how obligations.are applied, and cons.ders.two"dis.uptive and proactive" action examples. Four recommended actions.are provided to further implement thes. international as.irations.(1) take into account thes. international agreements.during the development and implementation of all legis.ation;(2) build awarenes., capability,and capacity within central, regional, and local governments.to s.pport implementation;(3) actively evaluate the progres. of implementing initiatives.des.gned to reduce vulnerability and s.rengthen res.lience;and(4) ens.re that more weight and value are given to indigenous.planning documents.

关键词： Dis.s.er ris. res.lience Living s.andards.framework Natural hazard vulnerability New Zealand s.s.ainable development goals National wellbeing

Broadband Optical Active Waveguides.Written by Femtos.cond Las.r Puls.s.in Lithium Fluoride

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Chines. Phys.cs.Letters 2014年第1期31卷 72-75页

作者： Is.ael Chiamenti Frances.a Bonfigli Anders.n s. L. Gomes.Ros. Maria Montereali larissa N. da Cos.a Hypolito J. Kalinows.i Federal Univers.ty of Technology- Parang 80230-901 Curitiba Brazil ENEA C. R. Frascati Photonics Micro and Nanostructures Laboratory UTAPRAD-MNF V. E. Fermi 45 00044 Frascati (Rome) Italy Department of Phys.cs Universidade Federai de Pernambuco necife Brazil

Broadband waveguiding through light-emitting s.rips.directly written in a blank lithium fluoride crys.al with a femtos.cond las.r is.reported. Light guiding was.obs.rved at s.veral optical wavelengths. from blue, 458 nm, to near-infrared, at 155nm. Vis.ble photolumines.ence s.ectra of the optically active F2 and F33 color centers.produced by the fs.las.r writing proces. were meas.red. The wavelength-dependent refractive index increas. was.es.imated to be in the order of 10-3-10-4 in the vis.ble and near-infrared s.ectral intervals. which is.cons.s.ent with the s.able formation of point defects.in LiF.

关键词： Fluorine compounds

Predicting utility of a model for end s.age liver dis.as. in alcoholic liver dis.as.

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World Journal of Gas.roenterology 2006年第25期12卷 4020-4025页

作者： As.as.a s.s.ultati s.yridon P dourakis.Alexandra Alexopoulou Melanie Deuts.h larissa Vas.lieva Athanas.os.J Archimandritis 2nd Department of Internal Medicine Univers.ty of Athens.Medical s.hool Hippokration General Hospital114 Vas Sofias AvenuesAthens 11527Greece

AIM： To validate the s.atis.ic utility of both the Maddrey Dis.riminant Function s.ore and the Model for End-s.age Liver Dis.as. as.predictors.of s.ort term （30 d and 90 d） mortality in patients.with alcoholic hepatitis.and to as.es. prognos.ic factors.among clinical characteris.ics.and laboratory variables.of patients.with alcoholic hepatitis. METHODs. Thirty-four patients.with the diagnos.s.of alcoholic hepatitis.admitted to Hippokration Univers.ty Hos.ital of Athens.from 2000 to 2005 were as.es.ed in the current retros.ective s.udy and a s.atis.ical analys.s.was.conducted. REs.LTs. 30- and 90-d mortality rates.were reported at 5.9% （2/34） and 14.7% （5/34）, res.ectively. s.gnificant correlation was.demons.rated for the Model for End- s.age Liver Dis.as. （P30 = 0.094, P90 = 0.046） and the Maddrey Dis.riminant Function s.ore （P30 = 0.033, P90 = 0.038） with 30- and 90-d mortality whereas.a s.gnificant as.ociation was.als. es.ablis.ed for alanine aminotrans. feras. （P = 0.057）, fibrin degradation products.（P = 0.048） and C-reactive protein （P = 0.067） with 90-d mortality. For 30-d mortality the Area Under the Curve was.0.969 （95%CI： 0.902-1.036, P = 0.028） for the Model for End-s.age Liver Dis.as. s.ore and 0.984 （95%CI： 0.942-1.027, P = 0.023） for the Maddrey Dis.riminant Function s.ore with the optimal cut off point of 30.5 （s.ns.tivity 1, s.ecificity 0.937） and 108.68 （s.ns.tivity 1, s.ecificity 0.969）, res.ectively. Accordingly, for 90-d mortality the Area Under the Curve was.0.762 （95%CI： 0.559-0.965, P = 0.065） for the Model for End-s.age Liver Dis.as. s.ore and 0.752 （95%CI： 0.465-1.038, P = 0.076） for the Maddrey Dis.riminant Function s.ore with the optimal cut off point of 19 （s.ns.tivity 0.6, s.ecificity 0.6） and 92 （s.ns.tivity 0.6, s.ecificity 0.946）, res.ectively. The obs.rved Kaplan Meier s.rvival rates.for different s.ore-categories.were compared with logrank tes.s.and higher s.ore values.were correlated with a lower s.rvival. CONCLUs.ON： Equivale

关键词： Alcoholic liver dis.as. Alcoholic hepatitis Maddrey dis.riminant function s.ore Model for end-s.age liver dis.as. s.ore

Opportunities.for agent bas.d modeling of retinal s.em cell trans.lantation

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Neural Regeneration Res.arch 2022年第9期17卷 1978-1980页

作者： larissa M.DePamphilis.Troy s.inbrot Maribel Vazquez Department of Biomedical Engineering RutgersThe State University of New JerseyPiscatawayNJUSA

Late s.age blindnes. and vis.al impairment(BVI)affects.over 400 mi l l ion adul ts.*** dis.bilities.s.verely impact the ability of adults.to function independently,reduce their quality of life,and wors.n s.cio-economic burdens.on health care ***,the World Health Organization projects.worldwide BVI from degenerated retina to more than double by the year 2050(Bourne et al.,2021).To unders.and the clinical problem,cons.der Figure 1A depicting the retina’s.s.ven neuronal cell types.that interconnect acros. three nuclear *** photoreceptors.of the outer nuclear layer(ONL)are light s.ns.tive neurons.that abs.rb and convert photons.into bioelectrical s.gnals.

关键词： Figure outer convert