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正铌酸镧颗粒复合增韧氧化铝陶瓷

稀有金属材料与工程 2005年第Z1期34卷 128-131页

作者：张志力翟洪祥周洋李世波周浪北京交通大学材料科学与工程研究所北京100044 北京交通大学材料科学与工程研究所北京100044 北京交通大学材料科学与工程研究所北京100044 北京交通大学材料科学与工程研究所北京100044 南昌大学化学与材料学院江西南昌330047

采用热压烧结工艺制备了添加一系列不同含量LaNbO4相的氧化铝基复合陶瓷(Al2O3-LaNbO4),并对它们的相组成、显微组织和力学性能进行了分析测试.结果表明:经高温烧结后LaNbO4相能够与基体保持稳定共存,并且对材料的烧结性能有一定的促进... 详细信息

采用热压烧结工艺制备了添加一系列不同含量LaNbO4相的氧化铝基复合陶瓷(Al2O3-LaNbO4),并对它们的相组成、显微组织和力学性能进行了分析测试.结果表明:经高温烧结后LaNbO4相能够与基体保持稳定共存,并且对材料的烧结性能有一定的促进作用;LaNbO4相对氧化铝基体产生了显著的增韧效果,在适当的添加量下,相比同样条件下制备的纯氧化铝,复合陶瓷的断裂韧性KIC提高约80%.对LaNbO4相的增韧机理进行了分析讨论,提出LaNbO4相内部畴结构在应力作用下发生切换而产生相应应变,这一过程将释放材料内部应力,宏观上产生增韧效果.透射电镜分析显示了在多晶LaNbO4陶瓷晶粒内大量存在的均匀平行排列的畴结构.

关键词：正铌酸镧增韧氧化铝基体畴切换

Targeted drug approvals in 2023:breakthroughs by the FDA and NMPA

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Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： lang Zheng Wenjing Wang Qiu Sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of China’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in China in 2023,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/***].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3CL protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,***,the world’s first allosteric inhibitor targeting TYK2,Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in China for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in China is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

A model for linking grain-size component to lake level status of a modern clastic lake

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A model for linking grain-size component to lake level statu...

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Jule xiao Jiawei Fan lang zhou Dayou Zhai Ruilin Wen Xiaoguang Qin Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences

Grain-size distributions of fluvial,eolian and marine sediments were explicated decades *** lake sediments,however,there is still great uncertainty in explaining the genesis of grain-size components due to the inherent complexity of their polymodal *** this study,the grain-size components of the surface sediments of Daihai Lake,Inner Mongolia,were partitioned using a lognormal distribution function and the relationship between the identity of each component and the specific sedimentary environment was *** daLa indicate that the modern clastic sediments of Daihai Lake contain five distinct unimodal grain-size distributions representing five grain-size *** of the components retains its identity including modal size,manner of transportation and environment of deposition although the relative percentage varies with the hydraulic condition throughout the *** components are specified from fine to coarse modes as long-term suspension clay,offshore-suspension fine silt and medium-to-coarse silt,and nearshore-suspension fine sand and saltation medium sand. The percentage of the components interpreted as an indication of nearshore environments displays a negative correlation with water depth across the modern lakebed,suggesting a model for linking the nearshore components in sediment cores to the lake level staLus in the geological *** model was applied to a sediment core from the lake where high percentages of the nearshore components in the core sediments were correlated with low regional precipitations reconstructed on the pollen profile of the same *** coincidences between two independent proxies do not only demonstrate the validity of lognormal distribution function in partitioning polymodal sediments but also reveals the potential of the grain-size component-lake level status model for lake’s paleohydrological reconstruction.

关键词： Daihai Lake Polymodal sediment Grain-size component Water depth Offshore distance Lake-level status

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基于序列轮廓线的凸面目标全自动重构方法

自动化学报 2015年第4期41卷 725-734页

作者：周朗明张小虎关棒磊国防科学技术大学航天科学与工程学院长沙410073 湖南省图像测量与视觉导航重点实验室长沙410073

凸面目标在成像时会表现尺寸较小、纹理稀疏或缺乏、透光、反光等特点.在对其进行三维重构时,传统的立体视觉匹配、主动视觉扫描(激光或结构光)等重构方法无法提供良好的解决方案.针对此类目标的重构难题,本文提出一种基于序列轮廓线的... 详细信息

凸面目标在成像时会表现尺寸较小、纹理稀疏或缺乏、透光、反光等特点.在对其进行三维重构时,传统的立体视觉匹配、主动视觉扫描(激光或结构光)等重构方法无法提供良好的解决方案.针对此类目标的重构难题,本文提出一种基于序列轮廓线的全自动重构方法.该方法首先采集目标的序列轮廓影像,然后提取高精度的轮廓线,再利用多个视角的轮廓线对初始外包体进行空间切割得到目标的初始三维模型,接着根据角度和面积约束对初始三维模型中的面进行合并,最后利用合并后的面重新对外包体进行精细切割得到目标的精确三维刻面模型.通过对凸面目标(注射器针头,直径约为3 mm)的重构实验证明,利用本文的方法重构得到的模型角度误差小于0.7,执行时间小于15 s,重构过程无需人工干预,能有效解决凸面目标的三维重构及视觉测量难题.

关键词：计算机视觉序列轮廓线空间切割凸面目标轮廓重构视觉测量

Spatial heterogeneity of the population age structure of the ostracode Limnocythere inopinata in Hulun Lake,Inner Mongolia and its implications

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Spatial heterogeneity of the population age structure of the...

Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Dayou Zhai Jule Xiao Jiawei Fan lang zhou Ruilin Wen Qiqing Pang Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences College of Resources Shijiazhuang University of Economics

Most existing studies of lacustrine ostracodes have been focused on species composition,and little attention has been paid to population *** this study,39 surface-sediment samples from Hulun Lake,Inner Mongolia,were analyzed for ostracode species composition and 17 of them also for population structure of Limnocythere inopinata,which is the dominant ostracode in the lake.A total of nine ostracode species were recovered,most of which show high abundances at sites with rich plant detritus,implying the possible control of food supply on ostracode species occurrence in the *** the other hand,both the subfossil and the living populations of *** have greater numbers of early instars in deeper waters,while middle and late instars occur mostly in shallower waters, which is related to the grainsize composition of the substrate,denoting a hydraulic control on population ***- and post-mortem transport of ostracodes may be responsible for the observed within-lake changes in the population stracture,although other factors such as migration,intrinsic population dynamics, and life cycle could also be *** data provide insights into the interpretation of lake conditions when using ostracodes in paleolimnological research of lakes with similar natural settings.

关键词： Hulun Lake Surface sediment Ostracode Population structure Water depth Taphonomy

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Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-lang Jin Yi-Ting Ma Jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-Feng Deng Hong-Wei zhou Wei-Xing Chen Wen-Huan Huang School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-Jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

关键词： Covalent organic framework(COF) Excited-state intramolecular proton transfer(ESIPT) Copper ion detection Copper ion adsorption Renewability

基于PSO-BP和GA-BP神经网络再生砖骨料混凝土强度模型的对比研究

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材料导报 2021年第15期35卷 15026-15030页

作者：黄炜周烺葛培杨涛西安建筑科技大学西部绿色建筑国家重点实验室西安710055 西安建筑科技大学土木工程学院西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室西安710055

采用两种混合算法人工神经网络模型(PSO-BP和GA-BP)预测具有不同砖骨料替代率的再生砖骨料混凝土(RBAC)的抗压强度。以RBAC的水泥质量、水灰比、碎瓷砖(CT 0—5,CT 5—32.5)替代率、碎砖(CB 0—5,CB 5—32.5)替代率及天然骨料(NA 0—5,N... 详细信息

采用两种混合算法人工神经网络模型(PSO-BP和GA-BP)预测具有不同砖骨料替代率的再生砖骨料混凝土(RBAC)的抗压强度。以RBAC的水泥质量、水灰比、碎瓷砖(CT 0—5,CT 5—32.5)替代率、碎砖(CB 0—5,CB 5—32.5)替代率及天然骨料(NA 0—5,NA 5—32.5)替代率等八个参数作为混合神经网络模型的输入参数,28 d立方体抗压强度作为输出参数。使用均方根误差(RMSE)、相关系数(R)和平均误差率对两种模型进行验证和对比分析。结果表明,PSO-BP模型与GA-BP模型都能实现高精度的预测,具有强大的泛化能力,总体而言,PSO-BP模型稍好于GA-BP模型,且都优于BP模型。同时,这也证明提出的混合算法神经网络有助于寻找最佳的RBAC配合比设计,提高实验效率。

关键词：人工神经网络粒子群算法遗传算法再生砖骨料抗压强度混凝土

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硅异质结太阳电池的物理机制和优化设计

物理学报 2017年第10期66卷 309-318页

作者：肖友鹏王涛魏秀琴周浪南昌大学光伏研究院/材料科学与工程学院南昌330031

硅异质结太阳电池是一种由非晶硅薄膜层沉积于晶硅吸收层构成的高效低成本的光伏器件,是一种具有大面积规模化生产潜力的光伏产品.异质结界面钝化品质、发射极的掺杂浓度和厚度以及透明导电层的功函数是影响硅异质结太阳电池性能的主要... 详细信息

硅异质结太阳电池是一种由非晶硅薄膜层沉积于晶硅吸收层构成的高效低成本的光伏器件,是一种具有大面积规模化生产潜力的光伏产品.异质结界面钝化品质、发射极的掺杂浓度和厚度以及透明导电层的功函数是影响硅异质结太阳电池性能的主要因素.针对这些影响因素已经有大量的研究工作在全世界范围内展开,并且有诸多研究小组提出了器件效率限制因素背后的物理机制.洞悉物理机制可为今后优化设计高性能的器件提供准则.因此及时总结硅异质结太阳电池的物理机制和优化设计非常必要.本文主要讨论了晶硅表面钝化、发射极掺杂层和透明导电层之间的功函数失配以及由此形成的肖特基势垒;讨论了屏蔽由功函数失配引起的能带弯曲所需的特征长度,即屏蔽长度;介绍了硅异质结太阳电池优化设计的数值模拟和实践;总结了硅异质结太阳电池的研究现状和发展前景.

关键词：硅异质结太阳电池物理机制优化设计

苦荞萌发过程中蛋白质变化及其对胆酸盐吸附能力的影响

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中国食品学报 2018年第3期18卷 284-290页

作者：周小理夏珂黄琳文浪周一鸣上海应用技术大学香料香精技术与工程学院上海201418

以苦荞为原料,采用化学评价法对萌发处理前、后的蛋白质含量、氨基酸组成和其营养价值(AAS值)进行比较。利用G-75凝胶色谱分离技术,通过测定胆酸盐吸附能力,对萌发后苦荞分离蛋白对胆酸盐吸附能力的影响进行研究。试验结果表明:苦荞萌... 详细信息

以苦荞为原料,采用化学评价法对萌发处理前、后的蛋白质含量、氨基酸组成和其营养价值(AAS值)进行比较。利用G-75凝胶色谱分离技术,通过测定胆酸盐吸附能力,对萌发后苦荞分离蛋白对胆酸盐吸附能力的影响进行研究。试验结果表明:苦荞萌发过程中蛋白质含量不断下降,趋势随萌发时间的增加逐渐放缓;总氨基酸含量和非必需氨基酸在萌发第5天时达到最大值,分别增加了17.6%和13.4%,必需氨基酸含量在第6天时达到最大值,增加了26.3%。随着萌发时间的增加,必需氨基酸的AAS值都有所上升(蛋氨酸和胱氨酸除外);萌发4 d后的必需氨基酸含量/非必需氨基酸含量(E/N)和必需氨基酸含量/总氨基酸含量(E/T)与标准模式最接近,表明苦荞萌发4 d后采食具有更高的营养价值。同时,将萌发4 d的苦荞蛋白用G-75凝胶色谱分离后得到4个主要收集峰(P1、P2、P3和P4),经测试均具有胆酸盐吸附能力,其中P2吸附能力显著(P≤0.05)。氨基酸分析结果表明,苦荞分离蛋白中甘氨酸、精氨酸的含量的变化对胆酸盐吸附能力具有重要影响。

关键词：苦荞萌发蛋白质氨基酸胆酸盐吸附